Aspermia is the complete lack of semen with ejaculation, which is associated with infertility. Many different causes were reported such as infection, congenital disorder, medication, retrograde ejaculation, iatrogenic aspemia, and so on. The main treatments based on these etiologies include anti-infection, discontinuing medication, artificial inseminization, intracytoplasmic sperm injection (ICSI), in vitro fertilization, and reconstructive surgery.