Global warming is caused by increased carbon dioxide (CO2)resulting in a greenhouse effect with enhanced warming of the earth. Measurements of CO2 show a steady increase over the past 30 years caused by the burning of fossil fuels and from the loss of natural CO2 sinks. A 100-year increase in global temperature by 0.3 to 0.6 degrees C is reflected in atmospheric warming, glacier shrinkage, and rising sea levels. Planetary ecosystem dynamics are being altered, challenging public health. It is predicted that morbidity and mortality will increase as a result of heat stress, as seen in recent heat waves in the U.S. Weather disaster effects will increase in number and magnitude, and both noninfectious and infectious diseases may flourish. A significant challenge will be the changes in life cycles of microbial species due to the warmer environs. Specific increases in incidence have been noted for vector-borne diseases, in addition to pulmonary findings, cardiovascular morbidity, neurological diseases, and occupational diseases. Warming can be demonstrated by the observed changes that have already occurred in the environment, particularly the thinning of polar ice caps. The United States Global Research Program has been established to coordinate research activities, which responds to issues deemed important by the United Nations Framework Convention on Climate Change. Research issues pertain to the scientific uncertainties in the greenhouse effect, temperature measurements at various atmospheric levels and latitudes, and impact on biota redistribution. The Kyoto Protocol has mandated specific solutions, e.g., a 7% reduction in CO2 levels within 10 years. Future recommendations involve supporting new technologies that are available to decrease emissions as well as understanding the role that occupational and environmental specialists have in global warming recognition.