Aspects Of Attentional Function Research Articles

Cortical signature related to psychometric properties of pain vigilance in healthy individuals: A voxel-based morphometric study

The Pain Vigilance and Awareness Questionnaire (PVAQ) is a questionnaire for non-clinical and clinical cases of patients, such as those suffering from chronic pain. Moreover, it is used for evaluation of two aspects of habitual attention to pain: attention to pain and attention to changes in pain. As the PVAQ assesses two different aspects of attention function, different neural basis may present. However, it remains unclear which brain regions are involved. Here, we performed voxel-based morphometry (VBM) in 30 healthy participants to determine the regional morphology associated with the two attention states. Multiple regression analysis was conducted between each score and the regional grey matter (GM) volume, which revealed that a decreased GM volume in the left anterior insular cortex (AIC) was associated with a higher attention to pain score. In contrast, no brain region was correlated with the attention to changes in pain score. Our VBM results demonstrate that attention to pain scores assessed by PVAQ are associated with morphological features of the left AIC. Moreover, they may contribute to the elucidation of the complex psychological and neurophysiological characteristics of patients with chronic pain.

Attention in Schizophrenia.

Attention is clearly a core area of cognitive dysfunction in schizophrenia, but the concept of "attention" is complex and multifaceted. This chapter focuses on three different aspects of attentional function that are of particular interest in schizophrenia. First, we discuss the evidence that schizophrenia involves a reduction in global alertness, leading to an inward focusing of attention and a neglect of external stimuli and tasks. Second, we discuss the control of attention, the set of processes that allow general goals to be translated into shifts of attention toward task-relevant information. When a goal is adequately represented, people with schizophrenia often show no deficit in using the goal to direct attention in the visual modality unless challenged by stimuli that strongly activate the magnocellular processing pathway. Finally, we discuss the implementation of selection, the processes that boost relevant information and suppress distractors once attention has been directed to a given source of information. Although early evidence indicated an impairment in selection, more recent evidence indicating that people with schizophrenia actually focus their attention more narrowly and more intensely that healthy individuals (hyperfocusing). However, this hyperfocused attention may be directed toward goal-irrelevant information, creating the appearance of impaired attentional filtering.

A study of attention networks in patients with obstructive sleep apnea-hypopnea syndrome

To explore the different aspects of attention function in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) and further to investigate the factors related to the impairments. After one night polysomnography (PSG) monitoring, a total of 50 patients with OSAHS and 40 demographic-matched healthy controls received basic cognitive assessment with a neuropsychological battery and then performed the attention networks test (ANT) was performed. Compared with healthy controls, patients with OSAHS performed significantly worse on cognitive tests and emotion evaluation including Montreal Cognitive Assessment (MoCA), stroop, verbal fluency, digital span, Hamilton anxiety scale (HAMA) and Beck depression inventory (BDI). With regard to ANT, significant group differences were found in executive control network [(138 ± 58) ms vs (104 ± 37) ms, P=0.003], but not in alertness [(33 ± 36) ms vs (33 ± 18)ms, P=0.975] or orientation [(48 ± 30)ms vs (51 ± 22) ms, P=0.674]. Correlation analysis indicated that the scores of the executive control network was positively correlated with the longest apnea time during the night (r=0.620, P=0.006), but was negatively correlated with the average oxygen saturation(r=-0.869, P=0.000) and the lowest oxygen saturation (r=-0.577, P=0.019). Patients with OSAHS were associated with impaired attention function, especially in the executive control network efficiency. Chronic hypoxia and apnea during the sleep may be the key factors that could diminish their attention and executive function.

The Interruptive Effect of Pain on Attention

Pain is known to disrupt attentional performance in both healthy adults and patients with chronic pain. Exactly which aspects of attentional function are affected are, however, still to be determined. The primary aim of this investigation was to systematically examine the effects of experimentally induced pain on a range of attentional performance tasks. Following a review of tests of attentional disruption, seven best candidate tasks were selected and examined across seven experiments. The tasks were: continuous performance, flanker, endogenous precueing, n-back, inhibition, attentional switching, and divided attention. Healthy adult participants performed each of these tasks under three different conditions: a painful heat sensation, a warm heat sensation, and a nonheat control. Pain differentially affected attentional performance across these tasks; pain-related attentional impairment was found on the n-back, attentional switching, and divided attention tasks, but not on the other tasks. This finding suggests that the aspects of attention most affected by pain are those essential for the completion of complex tasks that require the processing of multiple cues and control over attentional deployment. These results are discussed in the context of an emerging view of pain as a demand for executive control and the development of measures that could be used to examine attentional disruption in the context of pain.

Five choice serial reaction time performance in the HdhQ92 mouse model of Huntington's disease

Huntington's disease is an autosomal dominant genetic disorder, with motor, cognitive and psychiatric symptoms. To date there is no cure. In order to understand better this disease and to develop novel treatments, many genetically modified animal models of Huntington's disease have been created. However, to utilize these models fully, appropriate functional assays need to be developed for behavioural assessments of the mice. Various facets of attention have been reported to be affected in Huntington's disease patients, and the Hdh(Q92/Q92) mice have been shown to have deficits on operant tasks which have attentional components. In the present study, the Hdh(Q92/Q92) mouse model is assessed on a well established test of attentional function, the operant 5-choice serial reaction time task (5-CSRT), in which the mice must respond with a nose poke to light stimuli presented randomly across a 5 hole light array to receive a reward. In the present paper, the Hdh(Q92/Q92) mice exhibited deficits on the 5-CSRT when pseudorandomly presented with stimuli of different durations. However, alterations in the pacing of the task, therefore requiring an increase in sustained attention, did not affect the Hdh(Q92/Q92) mice more than their wildtype littermates. This study indicates that the Hdh(Q92/Q92) mice may have deficits in aspects of attentional function, in particular disruption in the ability to maintain attention in the visuospatial domain, suggesting that this knock-in mouse model of Huntington's disease may be a relevant model of the disease for the testing of novel therapeutic interventions.

Orexin/hypocretin modulation of the basal forebrain cholinergic system: Role in attention

The basal forebrain cholinergic system (BFCS) plays a role in several aspects of attentional function. Activation of this system by different afferent inputs is likely to influence how attentional resources are allocated. While it has been recognized for some time that the hypothalamus is a significant source of projections to the basal forebrain, the phenotype(s) of these inputs and the conditions under which their regulation of the BFCS becomes functionally relevant are still unclear. The cell bodies of neurons expressing orexin/hypocretin neuropeptides are restricted to the lateral hypothalamus and contiguous perifornical area but have widespread projections, including to the basal forebrain. Orexin fibers and both orexin receptor subtypes are distributed in cholinergic parts of the basal forebrain, where application of orexin peptides increases cell activity and cortical acetylcholine release. Furthermore, disruption of orexin signaling in the basal forebrain impairs the cholinergic response to an appetitive stimulus. In this review, we propose that orexin inputs to the BFCS form an anatomical substrate for links between arousal and attention, and that these interactions might be particularly important as a means by which interoceptive cues bias allocation of attentional resources toward related exteroceptive stimuli. Dysfunction in orexin–acetylcholine interactions may play a role in the arousal and attentional deficits that accompany neurodegenerative conditions as diverse as drug addiction and age-related cognitive decline.

Lesions of the basal forebrain impair reversal learning but not shifting of attentional set in rats

The cholinergic neurons of the basal forebrain, which project to cortex, the thalamic reticular nucleus and the amygdala, are implicated in many aspects of attentional function, while the intrinsic neurons of the basal forebrain are implicated in learning and memory. This study compared the effects of lesions of the basal forebrain made with either the immunotoxin 192-IgG-saporin (which selectively destroys cholinergic neurons), or the non-selective excitotoxin, ibotenic acid (which destroys both cholinergic and non-cholinergic neurons) on a task which measure the acquisition and shifting of attentional set as well as the ability to learn reversals of specific stimulus-reward pairings. Rats learned to obtain food reward by digging in small bowls containing distinctive digging media that were differentially scented with distinct odours. They performed a series of two-choice discriminations, with the bait associated with either the odour or the digging medium. Rats with 192-IgG-saporin lesions of the basal forebrain were not impaired relative to control rats at any stage of the task. Rats with ibotenic acid lesions of the basal forebrain were impaired the first time stimulus-reward contingencies were reversed. They were not impaired in acquisition of new discriminations, even when an attentional-shift was required. These data are consistent with data from marmosets and so highlight the functional similarity of monkey and rodent basal forebrain. They also confirm the likely involvement of non-cholinergic neurons of the basal forebrain in reversal learning.

Prolonged neglect following unilateral disruption of a prefrontal cortical–dorsal striatal system

We investigated the potential function of the system formed by connections between the medial prefrontal cortex and the dorsomedial striatum in aspects of attentional function in the rat. It has been reported previously that disconnection of the same corticostriatal circuit produced marked deficits in performance of a serial, choice reaction-time task while sparing the acquisition of an appetitive Pavlovian approach behaviour in an autoshaping task (Christakou et al., 2001). Here, we hypothesized that unilateral disruption of the same circuit would lead to hemispatial inattention, contrasting with the global attention deficit following complete disconnection of the system. Combined unilateral lesions of the medial prefrontal cortex (mPFC) and the medial caudate-putamen (mCPu) within the same hemisphere produced a severe and long-lasting contralesional neglect syndrome while sparing the acquisition of autoshaping. These results provide further evidence for the involvement of the medial prefrontal-dorsomedial striatal circuit in aspects of attentional function, as well as insight into the nature of neglect deficits following lesions at different levels within corticostriatal circuitry.

Attentional abilities and functional outcomes following stroke.

Although stroke affects cognitive functioning as well as motor functioning, research on cognitive consequences has lagged behind that focused on motor function. The evidence that is accruing suggests that cognitive function is importantly related to successful rehabilitation. The present study examined two aspects of attentional functioning (divided attention and switching attention) in older adult stroke survivors and healthy older adults. In addition, the authors investigated the relation between attention and functional outcomes following stroke. Results revealed stroke-related deficits in both of the types of attention as well as significant associations between attentional functioning and both physical and social outcome measures. Poorer attentional performance was associated with a more negative impact of stroke on daily functioning. These findings suggest an important role for attention in post-stroke function and provide information that can contribute to improving outcomes following stroke.

Effects of (+/-)-4-[[2-(1-methyl-2-pyrrolidinyl)ethyl]thio]phenol hydrochloride (SIB-1553A), a selective ligand for nicotinic acetylcholine receptors, in tests of visual attention and distractibility in rats and monkeys.

Nicotine, a nonselective ligand for nicotinic acetylcholine receptors (nAChRs), has been shown to improve attention and reduce distractibility in humans. Although the numerous side effects induced by nicotine prevent its use as a therapeutic agent, it is hypothesized that subtype-selective nAChR ligands may offer a potential therapeutic benefit to humans with attention deficits. In this study, we evaluated the attention-enhancing properties of (+/-)-4-[[2-(1-methyl-2-pyrrolidinyl)ethyl]thio]phenol hydrochloride (SIB-1553A), a ligand selective for neuronal nAChRs with predominant activity at the human beta 4 subtype. SIB-1553A was evaluated in a test of attention (i.e., five-choice serial reaction time task or SRTT) and distractibility (i.e., delayed matching to sample task with distractor or DMTS-D) in adult rats and monkeys, respectively. SIB-1553A did not improve SRTT performance in normal rats, but reversed deficits induced by the N-methyl-D-aspartate (NMDA) antagonist dizocilpine. In the DMTS-D, SIB-1553A improved accuracy across several doses at the short delay intervals, which were affected most by distracting stimuli in adult monkeys. Subsequent testing with optimal doses for each monkey was also associated with significant improvements in DMTS-D accuracy at short delays, indicating the reproducibility of the drug effect. In both species, SIB-1553A had no significant effects on latencies for sample or choice selection and was not associated with adverse effects at efficacious doses. Although it remains to be further demonstrated, SIB-1553A may act through combined nicotinic and non-nicotinic mechanisms. Collectively, the present data suggest that in specific conditions SIB-1553A may improve certain aspects of attentional function in young adult rats and nonhuman primates without adverse side effects.

Attention modulation of neural tuning through peak and base rate.

This study investigates the influence of attention modulation on neural tuning functions. It has been shown in experiments that attention modulation alters neural tuning curves. Attention has been considered at least to serve to resolve limiting capacities and to increase the sensitivity to attended stimulus, while the exact functions of attention are still under debate. Inspired by recent experimental results on attention modulation, we investigate the influence of changes in the height and base rate of the tuning curve on the encoding accuracy, using the Fisher information. Under an assumption of stimulus-conditional independence of neural responses, we derive explicit conditions that determine when the height and base rate should be increased or decreased to improve encoding accuracy. Notably, a decrease in the tuning height and base rate can improve the encoding accuracy in some cases. Our theoretical results can predict the effective size of attention modulation on the neural population with respect to encoding accuracy. We discuss how our method can be used quantitatively to evaluate different aspects of attention function.

Distinct Changes in Cortical Acetylcholine and Noradrenaline Efflux during Contingent and Noncontingent Performance of a Visual Attentional Task

Optimization of cognitive processing may depend on specific and distinct functions of the cortical cholinergic and noradrenergic systems. This investigation dissociates functions of cortical acetylcholine (ACh) and noradrenaline (NA) in arousal and visual attention by simultaneously measuring ACh and NA efflux in the rat prefrontal cortex during sustained attentional performance. The five-choice serial reaction time task was used to provide a continuous assessment of visuospatial attention. Previous studies using this task have established a critical role for the cortical cholinergic system in the detection of visual targets. However, selective lesions of the locus coeruleus noradrenergic system impair performance only when additional attentional demands are placed on the subject by distractors or temporally unpredictable targets. To test the hypothesis that the cortical noradrenergic system is particularly sensitive to novel task contingencies, we also assessed NA and ACh efflux in rats that been trained previously on the task but for whom the instrumental contingency coupling responding with stimulus detection and reward was abolished. Cortical ACh efflux showed a robust and task-related increase during established contingent performance. This response was significantly attenuated in noncontingent subjects, although it still exceeded pretask values. In contrast, NA efflux only increased transiently in contingent subjects after task onset but showed sustained elevations in noncontingent subjects on the first day when contingencies were changed. These data also implicate cortical ACh in aspects of attentional functioning but highlight a specific involvement of the cortical noradrenergic system in detecting shifts in the predictive relationship between instrumental action and reinforcement.

Developmental changes in attentional performance in urban children from eight to thirteen years

In an earlier study of an epidemiological sample of 435 urban 8-year-old children, factor analytically-derived components of attention, as assessed by neuropsychological tests, were identified and were found to be significantly related to adaptive functioning. In this study we followed that cohort longitudinally and assessed developmental changes in specific aspects of attentional function into early adolescence. Significant reductions in omission errors and improvements in reaction times were found from ages 8 to 13 years on different versions of the Continuous Performance Task, a measure of sustained attention, with the effects varying by task difficulty level and subjects' gender. Significant improvements across age also were found on measures of the ability to focus attention and execute a response, shift attentional focus, and encode information in memory. In general, the most rapid changes in attention occurred between ages 8 to 10 years with more gradual changes occurring between ages 10 to 13. The results highlight the importance of developmental epidemiological approaches for assessing and predicting the normal evolution of attentional function in school-aged children.

Subtypes of children with attention disabilities

Abstract Subtypes of children with attentional problems were investigated using cluster analysis. Subjects were 9-year-old-elementary school children (N = 443). The test battery administered to these children comprised a comprehensive set of common attention tests, covering different aspects of attentional functioning, and a test of reading comprehension. Cluster analysis of these data yielded eight stable and reproducible clusters. The test profiles of two subgroups were indicative of distinct attentional problems. One group appeared deficient in speed of processing, the other in attentional control. A third subgroup showed a reading deficit. Two additional clusters had very poor and excellent performance on the whole battery, respectively. Finally, three clusters were found with minor variations approximating average performance. The internal validity, that is, the adequacy and stability of the cluster solution, appeared to be reasonably good, as indicated by a variety of measures. The long-term stability over an 18-month period was also checked and found to be satisfactory.

Attention deficits in adolescents with ADHD and other clinical groups

Abstract Adolescents with a childhood diagnosis of ADHD were compared to adolescents with other psychiatric disorders and to a control group on aspects of attentional functioning. IQ was covaried in the analyses. The ADHD group performed significantly more poorly than did comparison groups except on the Stroop test, where all clinical groups showed reduced resistance to interference. On the Paced Auditory Serial Addition Test and the Letter Cancellation Task the adolescents with ADHD were markedly poorer and could not develop appropriate strategies to cope with the task demands. It is argued that the concept of the Supervisory Attentional System (SAS; Shallice, 1991) has heuristic value in understanding the persisting attentional problems of individuals with ADHD.

Anxiety and attention

Normal individuals high and low in anxiety differ from each other in their attentional functioning in various ways. More specifically, they differ with respect to the content, capacity, distractibility and selectivity of attention. Any complete theoretical account of anxiety and attention will have to account for all four differences, although it is likely that these various aspects of attentional functioning are dynamically interrelated. Anxious patients with generalized anxiety disorder appear to differ from normal controls in similar ways, and there is evidence that some aspects at least of non-normal attentional functioning in anxious patients may reflect a vulnerability factor rather than merely an anxious mood state.