Layered double hydroxides (LDHs) are widely used in photocatalytic degradation of antibiotic pollutants under ultraviolet (UV)-light, but their efficiency under visible light is hampered by large band gaps and layer agglomeration. Herein, we have successfully developed bimetallic NiCo LDHs-MXenes heterostructures (LDHs-MXenes) for enhanced degradation of tetracycline (TC) pollutants under visible light. As-prepared LDHs-MXenes photocatalysts (20 mg) show exceptional performance, achieving ∼ 97.4 % TC degradation efficiency (20 mg L−1, 100 mL) within just 50 min under a 300 W Xe lamp. This significant enhancement underscores the synergistic effects derived from the combination of LDHs and MXenes nanosheets.