Although the oral pathway is the recommended mode of intake for the majority of medications, it does have some drawbacks i.e., pre-systemic metabolism in the liver, gastrointestinal disturbance, and enzyme degradation. It offers a safe method for administration of medications and easy way to reverse the intake of toxic substances by easy removal of dosage form from oral cavity. This review was designed to critically acknowledge the evaluation parameters, mechanism of cohesion, polymers used in mucoadhesive formulation, main method of preparations (solvent casting & milling), advantages & disadvantages of mucoadhesive patches. This review consists an extensive survey of literature from the Scopus, PubMed, Springer Nature and other international reputed sources. Since the middle of 1980s, the idea of muco-adhesion has acquired extensive interest in drug innovation. Muco-adhesive dosage structures were developed for oral delivery like adhesive unit dosage form, adhesive gels and adhesive patches. The epithelium that forms the internal lining of buccal mucosa is the primary obstruction for the drugs absorption. Muco-adhesion is defined as an interfacial adhesion in which one synthetic mucoadhesive polymer and the other mucin layer (mucosal tissue), are hold together by an attraction force. 'Mucoadhesive’ is defined as an artificial substance being capable of making interaction with mucus membranes and binding them together for extended or delayed periods of time. However, delivering therapeutically for the therapy of both systemic and topical disorders would take a lot more work with these innovative mucoadhesive formulations. In conclusion, it facilitates the target therapy by enriching efficacy or intrinsic activity. Keywords: mucoadhesive patch, solvent-casting, milling, mechanism of muco-adhesion, polymers