Forest fires significantly disrupt global ecosystems. Many forecasting techniques predict fire activity and allocate prevention resources, but various factors are missing from the assessments, and multi-criteria decision approaches alone are insufficient. This work introduced a novel methodology combining artificial neural networks (ANN) with the analytical hierarchy process (AHP), fuzzy AHP multi-criteria methods, and spatial data to detect potential forest fire vulnerability areas using twenty variables. The results from AHP or fuzzy AHP, were processed using a multilayer perceptron with a backpropagation algorithm. The final ANN model has two objectives: first, to create a forest fire vulnerability with four classes (low, moderate, high, and very high), and second, to classify burned area sizes in regions highly or very highly vulnerable to fire. Evaluation metrics were also applied for validation. The fire model was tested using both literature review data and in situ observations. Comparative analysis showed that the burned area size model performed better than other machine learning methods, achieving an accuracy score of 89%. Meanwhile, the fire vulnerability model scored 82%. The study addresses the problem of prediction and provides an algorithm for classifying fire risk based on historical data in the Czech Republic, offering a master model for future forest management. Therefore, the ANN model, once trained, validated, and tested, does not require resetting and is effective for estimating forest fire vulnerability. Moreover, it produces results quickly, providing rapid insights into complex forest ecosystems, saving time and enhancing understanding for decision-makers.