Exploiting vegetarian and vegan cheeses with hibiscus extract: Functional and nutritional perspectives

NADES-based extraction of betalains from Terminalia catappa: impact on bioaccessibility, antioxidant capacity, and antimicrobial efficacy.

Green synthesis of ZnO nanoparticles using Datura stramonium leaf extracts and investigate the antibacterial activity against selected bacterial strains.

Insight into simultaneous destabilization of oleosomes during aqueous enzymatic extraction of Idesia polycarpa fruit oil by short-chain alcohol with talc.

The aim of the present study was to thoroughly examine the mechanism of action underlying the therapeutic efficacy of Psoralea corylifolia in the management of vitiligo, using a comprehensive approach integrating bioinformatics prediction with empirical validation. Network pharmacology and the GEO database were employed to construct a P. corylifolia‑vitiligo‑target network, screen the active ingredients of P. corylifolia and its core targets for vitiligo therapy, analyze target enrichment pathways, verify component‑key target binding using molecular docking and validate using ultra‑high‑performance liquid chromatography‑triple/time‑of‑flight mass spectrometry (UPLC‑Q‑TOF/MS), zebrafish and cellular experiments. The active ingredients of P. corylifolia used to treat diseases may include isobavachin, bavachin and stigmasterol, among others and the core targets may include AKT1, TNF, ESR1 and BCL2. The outcomes of the enrichment analysis predominantly pertained to signaling pathways, including apoptosis, protein phosphorylation, enzyme binding and pathways implicated in cancer and the PI3K‑Akt signaling pathway. Molecular docking results indicated that core components exhibited low binding energies with key targets. UPLC‑Q‑TOF/MS analysis revealed that the main components of the aqueous and ethanol extracts of P. corylifolia included: Angelicin, psoralidin, stigmasterol, bavachin and bakuchiol. Experiments involving zebrafish and B16 melanocytes showed that the aqueous and ethanol extracts of P. corylifolia were able to increase melanin production. Within a certain range, greater concentrations resulted in greater melanin synthesis. The therapeutic effect of P. corylifolia in vitiligo treatment may be due to the active ingredients isobavachin, bavachin and stigmasterol, which act on Akt1, TNF and other targets and modulate apoptosis, protein phosphorylation and PI3K/Akt signaling pathways.

Techno-economic analysis for production of red beet food colourant

Activating NK cell immunity against prostate cancer with Hedysarum polybotrys Hand.-Mazz.: A multi-omics integration of computational prediction and experimental validation on PI3K/AKT and PD-1/PD-L1 axes.

UPLC-QTOF-MS profiling combined with GNPS and evaluation of antioxidant activity in aqueous extracts from Metapanax delavayi leaves

Fungal contamination of chili crops by aflatoxin-producing Aspergillus species poses serious health and trade challenges worldwide. We investigated the antifungal efficacy of aqueous, ethanolic, and n-hexane extracts from 10 medicinal plants ( Caesalpinia bonduc , Melia azedarach , Portulaca oleracea , Sonchus oleraceus , Cressa cretica , Cymbopogon citratus , Acacia nilotica , Cassia fistula , Rhazya stricta , and Bambusa vulgaris ) against Aspergillus flavus and Aspergillus parasiticus infecting chili varieties Sanam and Longi. Plant extracts were tested at concentrations ranging from 10% to 50% using the poisoned food technique on potato dextrose agar, and their protective effects were evaluated further through spore suspension assays and pathogenicity tests on chili fruit. Our results showed dose-dependent inhibition of mycelial growth, with aqueous extracts of P. oleracea and B. vulgaris achieving more than 50% inhibition at 10%. At higher concentrations (40%–50%), extracts of C. fistula , C. bonduc , and S. oleraceus displayed the strongest antifungal activity, reaching up to 74% inhibition. Ethanolic and n-hexane extracts of M. azedarach, R. stricta, and C. citratus also demonstrated significant activity, with inhibition exceeding 70% in some cases. Pathogenicity assays revealed that untreated chili fruit developed large lesions (up to ∼21 mm in Sanam and ∼9 mm in Longi), whereas treatment with 20% to 30% extracts reduced lesion diameters markedly to <2 mm, with C. fistula , C. citratus , and B. vulgaris providing near-complete suppression of infection. These findings highlight the potential of selected plant extracts, particularly aqueous and ethanolic formulations, as natural antifungal agents for managing aflatoxin-producing fungi in chili crops.

Indocalamus latifolius (IL), a traditional Chinese food packaging material, possesses bioactive compounds with antioxidant and anti-inflammatory properties. This study investigated IL's aqueous extract (ILAE) protective effects against acute alcohol intoxication (AAI) and chronic alcoholic gastric injury (AGI). In the AAI model, ILAE enhanced ADH and ALDH activities, reduced intoxication rate, shortened sobering time. In the chronic AGI model, ILAE alleviated gastric injury, increased SOD and PGE2, and decreased MDA, TNF-α, IL-6, IL-8, TGF-β1, and MPO levels. Network pharmacology predicts that the PI3K-Akt pathways is the main protective mechanisms. Molecular docking confirmed strong binding affinities between stigmasterol and key target proteins. Furthermore, ILAE downregulated PI3K, AKT, and NF-κB protein expression in ethanol-induced GES-1 cells. These findings suggest that ILAE protects against AAI and AGI by activating the PI3K/AKT pathway regulate oxidative stress and inflammation. Collectively, ILAE shows promise as a functional food component for preventing alcohol-related disorders.

Inonotus obliquus (Ach. ex Pers.) Pilát aqueous extract alleviates acute cold exposure/rewarming-induced myocardial injury by regulating mitochondrial dynamics via liver kinase B1/adenosine monophosphate-activated protein kinase/peroxisome proliferator-activated receptor gamma coactivator-1 alpha signaling pathway activation.

Nanoemulsion of coriander oil and Asparagus racemosus extract enhances immunity in Nile tilapia (Oreochromis niloticus).

Extraction, structural characterization, and liposome encapsulation of alcohol dehydrogenase from pig liver: Potential applications in alcohol detoxification.

Anthocephalus cadamba leaf extract mediated synthesis of copper oxide nanoparticles and evaluation of their methylene blue dye degradation, antioxidant and anti-inflammatory properties

Green inhibition of microbiologically influenced corrosion on 316L stainless steel by Artemisia annua extract

Integrated in silico, in vitro, and machine learning pipeline for extraction of antioxidant peptides and lipids from fish viscera.

A novel strategy for cooked sheep liver preservation: Integrating high-barrier polymer packaging with Cistanche deserticola aqueous extract treatment

Neurodegenerative diseases, such as Alzheimer's disease (AD), are characterized by oxidative imbalance, leading to memory deficits and cognitive impairments. Aluminium chloride (AlCl3), a neurotoxin found in certain foods and medications, disrupts neurotransmitter systems, thereby exacerbating cognitive decline. Current drug development strategies aim to counter these effects through cholinesterase inhibition, activation of GABAergic transmission, the use of antioxidants, and the promotion of neuroprotection. This work was conducted to assess the neuroprotective properties of the aqueous extract of Linzia gerberiformis (L. gerberiformis) leaves against AlCl3 induced cognitive impairment in mice. AlCl3 (70 mg/kg) was administered orally in mice to induced memory loss a core feature of Alzheimer Disease. Mice were pretreated with aqueous extract of L. gerberiformis leaves (75, 150 and 300 mg/kg) for six weeks, and memory integrity was assessed using the object location test (OLT) and the T-Maze test. One hour after completion of the T-Maze, the mice were sacrificed, the hippocampus and prefrontal cortex were then collected to assess the cholinergic (acetylcholinesterase (AChE) and acetylcholine (ACh)), GABAergic systems and oxidative stress (nitric oxide (NO), malondialdehyde (MDA) SOD, Catalase (CAT), reduced glutathione (GSH)). The aqueous extract of L. gerberiformis leaves demonstrated significant effects (P < 0.01 and P < 0.05) at doses of 75 and 150 mg/kg in improving short-term learning memory, as well as a significant enhancement (P < 0.05) of long-term spatial memory on day 3 at the dose of 75 mg/kg. AlCl3 (70 mg/kg) induced increase in AChE (P < 0.05; P < 0.01), NO (P < 0.05; P < 0.001), and MDA (P < 0.05; P < 0.01), while decreasing ACh (P < 0.01), GABA (P < 0.05; P < 0.01), SOD (P < 0.01; P < 0.001), CAT (P < 0.05), and GSH (P < 0.01) in the hippocampus and prefrontal cortex. Pretreatment with aqueous extract of L. gerberiformis leaves significantly restored these parameters (P < 0.01; P < 0.001) for Ach at the doses 75 and 150 mg/kg and GABA (P < 0.05) at all doses. Significant improvement was also observed for SOD (P < 0.05 and P < 0.01), GSH, and MDA (P < 0.05 and P < 0.01), as well as for NO (P < 0.05 and P < 0.01) in both the hippocampus and prefrontal cortex. The present study established that the aqueous extract of L. gerberiformis leaves ameliorated AlCl3-induced neurotoxicity by modulating the activation of the cholinergic, GABAergic and antioxidant pathways.

In silico docking and in vivo assessment of Mondia whitei fruit extract in attenuating CdCl2-Induced neurodegeneration in rat.

Retraction notice to "Anti-inflammatory, anti-diabetic, and biocompatibility properties of aqueous extract of Tamarindus indica L. fruit coat analyses by in-vitro and in-vivo approaches" [Environ. Res. 251 (2024) 118702