Coagulation-flocculation process is one of the first step of wastewater treatment. Coagulant aid as flocculant material is an essential for it's treatment successfully as an important factor for the next step processes. Although, flocculant fron unnatural polymer have potentially to cause environmental contamination and may affect to human health due to its persistent in environment and difficulties to degraded. This paper examines some of the natural flocculants that have been developed and their potential used to wastewater treatment. A type of natural flocculant that is widely developed to treat wastewater is cassava starch. Plant seed extracts such as fromPlantago ovatawere able to remove turbidity was > 90% at pH 6-8. Flour ofMoringa oleiferaLam seeds are used to treat various types of wastewater with the ability to remove color and turbidity was > 90%.Tamarindus indicapods seed, able to remove golden yellow was 60% and was 25% for direct fast scarlet. The latest development was used durio seed to treat leachate that showed high potential as natural flocculant. Natural flocculant application for water and wastewater treatment is able to decrease of energy using to production and commercialization of it.