Application Of Correlation Spectroscopy Research Articles

4-(ethyl-p-chlorophenylglycinylamino)-7-chloroquinoline: Synthesis and in vivo antimalaria evaluation

4-amino-7-chloroquinoline derivative was synthesized and characterized using both1D and 2D nuclear magnetic resonance (NMR) techniques, with the application of correlation spectroscopy (COSY), nuclear overhauser enhancement spectroscopy (NOESY), heteronuclear multiple bond correlation (HMBC), heteronuclear single quantum coherence (HSQC), liquid chromatography-mass spectroscopy (LC-MS) and infra-red (IR) spectroscopy. The in vivo antimalaria activity of the compound against Plasmodium berghei berghei (Pbb) was assessed within 5 days (D5) of treatment. The antimalaria effect of JH7E evaluated at D30 shows a mean inhibition of parasitemia 46.32, 60.40 and 85.71% recorded on Pbb effected mice at 25, 50 and 100 mgKg-1body weight dosages respectively as compared to 97.04 and 94.40% curative rate obtained for artemisinin and chloroquine (Standard drugs) used as positive control. The results of the investigation showed that JH7E is a possible lead candidate for the development of antimalarial drug, because of its strong antimalarial activity against Pbb. Key words: 4-amino-7-chloroquinoline, antimalaria, Plasmodium bergei bergei. Spectroscopy.

4-(ethyl-p-chlorophenylglycinylamino)-7-chloroquinoline: Synthesis and in vivo antimalaria evaluation

4-amino-7-chloroquinoline derivative was synthesized and characterized using both1D and 2D nuclear magnetic resonance (NMR) techniques, with the application of correlation spectroscopy (COSY), nuclear overhauser enhancement spectroscopy (NOESY), heteronuclear multiple bond correlation (HMBC), heteronuclear single quantum coherence (HSQC), liquid chromatography-mass spectroscopy (LC-MS) and infra-red (IR) spectroscopy. The in vivo antimalaria activity of the compound against Plasmodium berghei berghei (Pbb) was assessed within 5 days (D5) of treatment. The antimalaria effect of JH7E evaluated at D30 shows a mean inhibition of parasitemia 46.32, 60.40 and 85.71% recorded on Pbb effected mice at 25, 50 and 100 mgKg-1body weight dosages respectively as compared to 97.04 and 94.40% curative rate obtained for artemisinin and chloroquine (Standard drugs) used as positive control. The results of the investigation showed that JH7E is a possible lead candidate for the development of antimalarial drug, because of its strong antimalarial activity against Pbb. Key words: 4-amino-7-chloroquinoline, antimalaria, Plasmodium bergei bergei. Spectroscopy.

Novel polyene from Vernonia urticifolia (Asteraceae)

Phytochemical investigation of Vernonia urticifolia resulted in isolation of urticifolene, a new polyene metabolite together with lutein and sitosterol, which were fully characterized using NMR spectroscopy with the application of correlation spectroscopy (COSY), Nuclear overhauser enhancement spectroscopy (NOESY), heteronuclear multiple bond spectroscopy (HMBC) and heteronuclear single quantum coherence (HSQC). The biological assay determination showed that Lutein inhibited the growth of Enterococcus faecium at low concentration (MIC) of 8 μgmL-1, while urticifolene inhibited the growth ofEnterococcus faecium and Pseudomonas aeruginosa at low concentration (MIC) of 16 and 32 μgmL-1, respectively. In contrast to the related polyenes, nystatin and amphotericin B, which exhibit no antibacterial activity, urticifolene exhibited inhibitory property against all the bacteria investigated. Key words: Urticifolene, lutein, antibacterial activity, Vernonia urticifolia, Asteraceae.

The application of correlation spectroscopy to the study of dispersion from tall stacks

The application of correlation spectroscopy to the study of dispersion from tall stacks

The application of correlation spectroscopy to the study of dispersion from tall stacks

The application of correlation spectroscopy to the study of dispersion from tall stacks