Event Abstract Back to Event Apical papilla stem cells and polyurethane based scaffolds, a new approach for the development of constructs in tissue engineering Raul E. Solis-Correa1, Luis M. Rodriguez-Lorenzo1, 2, Jose Cano-Brown3, Ana K. Hernandez-Gonzalez3 and Raul Rosales-Ibanez4 1 ICTP-CSIC, Polymeric Nanomaterials and Biomaterials, Spain 2 CIBER-BBN, Polymeric Biomaterials group, Spain 3 UNAM, FES-Iztacala, Mexico 4 UASLP, Estomatologia, Mexico Introduction: Scaffold based tissue engineering aims to regenerate damaged tissues by culturing cells ex vivo on scaffolds that should provide with an adequate framework for biological interactions. This proposal involves the use of apical papilla stem cells in chitosan and lysine polyurethane based scaffolds that offer the potential for growth factors incorporation and delivery for a faster development of constructs. Experimental: Scaffolds containing Chitosan/PU/lysine with 100/0/0 to 50/50/80 component ratios have been manufactured by freeze drying. Porosity has been characterized by density measurements and SEM. Apical papilla stem cells were isolated from impacted third molars of young healthy donors. CD44, Stro-1 positive and CD45 negative have been used as phenotype markers. Live and dead assays have been used for viability tests and MTT for proliferation at 7, 14 and 21 days Results: Scaffolds with a three modal pore size distribution have been obtained. Interconnected pores with 80 micrometers interconnection sizes can be appreciated. A significant increase in cell viability and proliferation could be observed in lysine containing scaffolds. This study confirms that lysine may act as a favorable substrate for cell adhesion and proliferation. Conclusion: The combination of lysine-polyurethane scaffolds and apical papilla stem cells offer a promising alternative for the development of a new family of constructs for tissue regeneration Funding Project: MAT2014-51918-C2-1-R DGCYT, Spain; Funding Grant: PAPIIT/IN221315, Mexico Keywords: Cell Proliferation, material design, 3D scaffold, Cell modulation Conference: 10th World Biomaterials Congress, Montréal, Canada, 17 May - 22 May, 2016. Presentation Type: Poster Topic: Biomaterials in mesenchymal and hematopoietic stem cell biology Citation: Solis-Correa RE, Rodriguez-Lorenzo LM, Cano-Brown J, Hernandez-Gonzalez AK and Rosales-Ibanez R (2016). Apical papilla stem cells and polyurethane based scaffolds, a new approach for the development of constructs in tissue engineering. Front. Bioeng. Biotechnol. Conference Abstract: 10th World Biomaterials Congress. doi: 10.3389/conf.FBIOE.2016.01.02580 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 27 Mar 2016; Published Online: 30 Mar 2016. Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Raul E Solis-Correa Luis M Rodriguez-Lorenzo Jose Cano-Brown Ana K Hernandez-Gonzalez Raul Rosales-Ibanez Google Raul E Solis-Correa Luis M Rodriguez-Lorenzo Jose Cano-Brown Ana K Hernandez-Gonzalez Raul Rosales-Ibanez Google Scholar Raul E Solis-Correa Luis M Rodriguez-Lorenzo Jose Cano-Brown Ana K Hernandez-Gonzalez Raul Rosales-Ibanez PubMed Raul E Solis-Correa Luis M Rodriguez-Lorenzo Jose Cano-Brown Ana K Hernandez-Gonzalez Raul Rosales-Ibanez Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.