Design, synthesis, and comprehensive evaluation of novel azo-linked heterocycles derived from a Sorafenib precursor as potent antioxidant agents: An integrated in vitro and in silico approach

Microenvironment-engineered hydrogels drive osteo-angiogenic coupling to accelerate osteoporotic bone regeneration.

Berberine attenuates methotrexate-induced renal and sciatic nerve toxicity via modulation of the cGAS-STING/NF-κB inflammatory pathway.

The influence of rosmarinic acid on male reproductive health: Biological mechanisms and clinical prospects.

Metabolic syndrome (MetS) is characterized by a cluster of biochemical and physiological abnormalities. Healthy eating, including the consumption of natural products, holds promise for promoting health and preventing disease. Among these, Magnolia officinalis bark extract (MAGBE) is widely used as a dietary supplement due to its potent antioxidant, anti-inflammatory, and neuroprotective properties. In this study, we aimed to investigate the therapeutic potential of MAGBE in a rat model of MetS and to identify its target proteins. One group of 2-month-old male Wistar rats was supplemented with MAGBE (400mg/kg/day, administered intragastrically) for 16weeks alongside a high-carbohydrate diet (containing 32% sucrose) (MetS + MAGBE group). A second group received only the high-carbohydrate diet for the same period (MetS group), while a third group was maintained under standard conditions (Control group). Following confirmation of MetS induction in experimental animals, MAGBE treatment significantly improved elevated systolic and diastolic blood pressure, as well as heart rate. It also provided significant benefits in terms of oxidative stress/antioxidant balance and anti-inflammatory status, along with improved plasma levels of leptin, IL-6, IL-10, TNF-α, and leukotriene B4 (LTB₄), a product of arachidonate 5-lipoxygenase (ALOX5). Furthermore, in silico molecular docking approaches identified several potential protein targets of MAGBE, including the cannabinoid receptors CB₁ and CB₂. These receptors play central roles in regulating appetite and energy balance by modulating metabolic processes, as well as in immune function by suppressing cytokine production. Additionally, our analysis revealed strong interactions between MAGBE and the active site of ALOX5, which catalyzes the conversion of arachidonic acid into proinflammatory molecules such as LTB₄, a key mediator of inflammation and immune response. Overall, our findings highlight the beneficial antioxidant and anti-inflammatory effects of MAGBE in the prevention of MetS-associated disorders, potentially through interactions with receptors such as cannabinoid CB₁/CB₂ and ALOX5.Impact StatementIncreasing evidence supports the rapid rise in the prevalence of metabolic syndrome (MetS) across populations, contributing to the development of various organ dysfunctions and type 2 diabetes. Given the importance of healthy nutrition with natural compounds, we demonstrated the beneficial effects of Magnolia officinalis bark extract (MAGBE) even under a high-carbohydrate diet by analyzing systemic physiological parameters. MAGBE treatment restored heart function as well as plasma biomarkers related to oxidative stress/antioxidant balance and anti-inflammatory status, despite elevated blood glucose and plasma insulin levels. Using in silico molecular docking approaches, we identified several protein targets through which MAGBE may exert its effects, including cannabinoid receptors CB₁ and CB₂, central regulators of appetite, energy balance, and immune response via cytokine suppression, and the active site of ALOX5, which catalyzes the production of leukotriene B₄ (LTB₄), a key proinflammatory mediator in immune responses.

Low-temperature ultrasonic-deep eutectic solvent extraction of ergothioneine from Pleurotus ostreatus: A sustainable new strategy.

Leucaena leucocephala, a well-known invasive species, possesses significant yet underexplored phytochemical potential. This study investigated how its chemical composition contributes to adaptation in arid environments and provides opportunities for valorization. Methanolic extracts from the plant parts (roots, leaves, pods, seeds, and flowers) collected in Algeria were assessed for their phenolic, flavonoid, and tannin content, as well as for their antioxidant, anti-inflammatory, antibacterial, and photoprotective activities. Seeds exhibited the highest phenolic content (197.26 ± 1.90 μg GAE/mg), while roots were richest in tannins and flavonoids. Notably, strong antioxidant activity was recorded in seeds and leaves (IC50: 3.54 ± 0.05 and 3.61 ± 0.05 μg/mL). Roots displayed a high SPF value of 26.40, and both seed and flower extracts showed significant antibacterial effects against Escherichia coli and Staphylococcus aureus. Correlation analyses highlighted a strong positive relationship between tannins and SPF (R2 = 0.92) and a negative correlation between phenolics and DPPH° activity (R2 = -0.84). LC-MS analysis identified 13 key polyphenols, with pods and leaves being particularly rich in compounds like vanillin and gallic acid. These findings underscore L. leucocephala's potential for sustainable use in health and cosmetic industries.

Unraveling the distinctive contributions of various saccharomyces cerevisiae strains to flavor complexity, antioxidant potency, and quality differentiation in cherry wine

Influence of drying temperature on the metabolites profile and potential antioxidant pathways of Passiflora edulis peel: Integrating untargeted metabolomics with network pharmacology analyses, molecular docking, and molecular dynamics simulation.

Optimizing supercritical CO2 extraction of phytochemicals from grape peels using response surface technology: Modeling, characterization, and antioxidant potential

Formulation and characterization of concentrated black cumin seed oil-fortified yogurt for modulating glucose indices

Upcycling of seaweed waste from agar production of red seaweed, Gracilaria tenuistipitata as a source of bioactive and antioxidant potentialities

Phytochemical investigation of Artemisia persica: Isolation and characterization of new monoterpenoids.

Characterization of nutrient-rich Browntop millet (Urochloa ramosa (L) T.Q. Nguyen) hydroalcoholic extract, and assessment of the impact of malting on antioxidant potential, and anti-proliferative efficacy against breast- and colorectal cancer cell lines

The valorization of agricultural co-products represents a promising strategy to reduce food waste while creating new functional ingredients for the food industry. This study aims to evaluate the potential of discarded black quinoa grains (commonly referred as ''destrío'' grains in Spain) as a novel source of functional flour, using particle size-milling to evaluate its influence on the nutritional and techno-functional properties. Four flours with different particle sizes were produced and characterized in terms of chemical composition, mineral profile, physicochemical properties and antioxidant capacity. Particle size reduction significantly modified the distribution of nutrients and bioactive compounds, increasing protein, ash, moisture, and several key minerals, as well as antioxidant potential. Finer flours exhibited higher water activity, darker coloration, and greater redness and yellowness while medium-size particles displayed the highest oil-holding capacity. Overall, black quinoa flour obtained from ''destrío'' grains emerges as a valuable-added ingredient with promising applications in the development of sustainable food formulations, thus contributing to circular economy principles and improving the eco-efficiency of the agro-food sector.

A comprehensive evaluation of Neolamarckia cadamba leaves: Nutritional, elemental, and polyphenolic profiles with antioxidant properties

Biogenic silver nanoparticles synthesis from Guilandina bonduc L. seed kernel extract with antibacterial, antioxidant and anticancer potential against ovarian Cancer cells

Partial NaCl replacement with KCl enhances microbial dynamics and antioxidant potential in fermented Nabali Baladi olives

Optimization of LED-based phototreatments for enhancing antioxidant potential and marketable traits in microgreens

Targeting 7-ketocholesterol-driven metabolic dysfunction in obesity: Therapeutic potential of Bifidobacterium and dietary antioxidants.