Mastitis remains one of the most economically important diseases in dairy farming. The aim of this review was to discuss the main ideas, practical benefits, economic impacts, rules and regulations, and environmental aspects of selective dry cow therapy (SDCT) as a means for managing udder health and antibiotic use. Interest is increasing in antimicrobial resistance, environmental pollution, and stronger regulations on antibiotic use in food production, so SDCT has become even more relevant in modern dairy herd management. This method involves selectively treating only cows or quarters at a high risk of intramammary infections at dry-off, mainly based on somatic cell count, clinical history of mastitis, or bacterial culture results. Evidence shows that when used correctly, SDCT can significantly reduce antibiotic use without compromising udder health, particularly if used with internal teat sealants. Economic analyses have indicated that SDCT can cut antibiotic-related costs by up to 50% while keeping mastitis under control, if protocols are followed properly. Global policies, such as the European Green Deal and One Health initiatives, encourage targeted antibiotic use to improve both animal health and environmental conservation in dairy farming. However, challenges still remain in implementation, including the risk of under-treatment, the need for accurate diagnostic tools, and ensuring farmer compliance with selection protocols. Advanced developments in precision dairy farming, such as automated testing and AI-assisted decision-making, have improved the feasibility and success of SDCT in different herd management systems.

Deep metagenomic insights into the formation characteristics of the resistome in Pristine Saline Lakes.

Zoliflodacin versus ceftriaxone plus azithromycin for treatment of uncomplicated urogenital gonorrhoea: an international, randomised, controlled, open-label, phase 3, non-inferiority clinical trial

Antimicrobial resistance poses a significant threat to medicine, exemplified by methicillin-resistant Staphylococcus aureus (MRSA), which is resistant to nearly all antibiotics. We designed chimeric antisense oligonucleotides (ASOs) targeting the conserved flavin mononucleotide (FMN) riboswitch, a regulator of essential bacterial metabolic pathways. Three chemically modified ASOs were optimized for stability, binding affinity, and RNase H recruitment, and conjugated to the pVEC cell-penetrating peptide for uptake. Antibacterial activity was tested against MRSA ATCC 6538, with growth monitored by optical density. pVEC-ASO-3 showed the most potent effect, with MIC50 and MIC90 values of 1.25 and 7.5 nM, respectively. No inhibition was observed in Escherichia coli, which lacks the FMN riboswitch, confirming specificity. Cytotoxicity testing in human A549 cells revealed 95% viability at the highest concentration. These results demonstrate that riboswitch-targeted ASOs can selectively inhibit MRSA growth with minimal toxicity, supporting their potential as a new class of antibacterial agents against drug-resistant pathogens.

Targeting drug-resistant E. coli with quinoline-thiazolidinone derivatives: A new avenue for combating antibacterial resistance from molecular design to mechanistic action.

Global policy responses to antimicrobial resistance, 2021-22: a systematic governance analysis of 161 countries and territories.

Breaking barriers in antimicrobial therapy: resistance mechanisms and novel antimicrobial strategies.

An international Delphi survey on priorities in antimicrobial resistant infections therapeutic research: A preliminary study of MePRAM project.

Antimicrobial resistance, genomic, and public health insights into Enterococcus spp. from Australian cattle.

Genomics uncover resistant and virulent Klebsiella on foods: a potential risk to human health.

Antimicrobial resistance and environmental-lifestyle exposures: A canonical analysis of national mortality indicators.

Determining the contribution of stream morphometry and microbial extracellular polymeric substances in the spread patterns of antimicrobial resistance.

Comparative analysis of antibiotic-administered vs. antibiotic-free farming in meat production: Implications for health, environment, and antibiotic resistance.

Microbiological Profile of Bacterial Infections in Patients With Cirrhosis Over Time: A 20-year Territory-wide Study.

Global Trends in Antimicrobial Resistance Among Cirrhosis Patients With Bacteremia: A Systematic Review and Meta-analysis.

Pneumococcal meningitis in Mexico. Serotype distribution and antimicrobial resistance before and after the introduction of pneumococcal conjugate vaccines in pediatric patients. Results from the GIVEBPVac group.

Occurrences of antibiotics and antimicrobial resistance in combined and separate sewage overflow effluents of Shanghai, China.

Predicting norovirus contamination and antimicrobial resistance in coastal waters from community and hospital-derived sources.

Short-chain PFAS in coastal sediments: PFBS-driven antimicrobial resistance and pathogen risks.

In-depth characterization of microbiome and resistome of carcasses and processing environments in a swine slaughterhouse.