A combination of salinomycin or its C20 triphenylphosphonium-conjugated derivative with carboplatin leads to autophagy in ovarian cancer cells - An in vitro study.

Novel synthesis of Ag:WO3/TiO2 nanocomposites for photocatalytic reduction of Cr(VI) and anticancer activities

Structure-activity relationship and anticancer mechanism of febuxostat-1,2,3-triazole hybrids inducing DNA damage and apoptosis.

Naphthalimide-derived new zinc salen complexes in picric acid recognition and anticancer activity

Integrating experimental and computational approaches to explore the anticancer potential of a pyridine-based reduced Schiff base.

Ethnopharmacological insights into native medicinal plants for cancer management by indigenous and local communities of Africa: A systematic review.

A staurosporine-derived fluorescent probe with AIE and photoinduced Z-E isomerization for lysosome-targeted imaging and anticancer activity

Copper(I) complexes with extended aromatic ligands: biomolecular interactions and anticancer activity

Identification of quinazolinone and quinoline alkaloids from Peganum harmala L. inducing mitochondria-mediated apoptosis in liver cancer.

Aloesin improves metabolic associated fatty liver disease and obesity by targeting TGFBR1.

Trends and multidisciplinary research of torch ginger [Etlingera elatior (Jack) R.M.Sm.]: A systematic review.

Preparation of hydrogel-conjugated drug-loaded exosome nanomaterials and preliminary in vitro anticancer activity study against hepatocellular carcinoma

Nanoengineering approach as a tool for enhancing the anticancer activity of alkynyl Au(I) complexes with cyclic P2N2 ligands

pH-responsive polymeric-peptide complex enhances tumor immunogenic cell death by membrane disruption.

Targeting PFKFB3-dependent endothelial-mesenchymal transition by luteolin attenuates doxorubicin-induced cardiotoxicity.

The online version contains supplementary material available at 10.1007/s13205-026-04755-6.

Dual potential of tetrandrine: Antiangiogenic efficacy and safety liabilities revealed through in silico, in vitro, and zebrafish models.

Isolation, structure elucidation, and absolute configuration of 5,6-dioxygenated aaptamine derivatives from the marine sponge Aaptos sp.

Colorectal cancer remains a major health concern and the second leading cause of cancer deaths, underscoring the urgent need for advanced early diagnostic methods to improve survival outcomes. In this study, we designed and synthesized a new series of hybrid compounds that incorporate Lonidamine and various N-heterocycles, such as pyridine, 4-quinoline, 4,7-chloroquinoline, and acridine. Synthesized compounds were characterized by various spectral techniques, including NMR (1H and 13C), mass spectra, and HPLC. The cytotoxicity studies of the conjugates were conducted using the colorectal cancer cell line (HCT116), and compound (22a) exhibited potent antiproliferative activity, with the lowest IC50 value of 2.59 ± 0.33 µM, indicating that it is the most potent among the screened compounds. The compound effectively induces apoptosis, as demonstrated by Hoechst/PI double staining in HCT116 cells. The treatment group showed reduced migratory capabilities, highlighting the compound's strong antiproliferative activity and antimigratory propensity against HCT116 cells. Additionally, physicochemical features and ADMET profiles have been investigated to gain a better understanding of their pharmacokinetic and toxicological characteristics. The results demonstrated satisfactory pharmacokinetic behavior and acceptable toxicity profiles, with (22a) emerging as a promising candidate due to its superior bioavailability, enhanced stability, and potent anticancer activity. Molecular docking, dynamics simulations, and DFT studies were used to better understand the SAR and mechanisms of action of potential cancer drugs. This study indicates the promising potential of compound (22a) as a prospective candidate agent for colorectal cancer treatment. Further comprehensive investigations are needed to explore its therapeutic efficacy in greater detail.

Discovery, crystal structure, anticancer property of the first-row transition metal complexes of norcantharidin (NCTD) as potential inducer of mitochondrial damage.