Anthropometric Measurements In Adults Research Articles

Association of Overnight Fasting and Meal Irregularity with Nutrient Quality and Anthropometric Measures in Adults

Background: Timing, frequency, and regularity as chrono-nutrition are emerging fields in nutritional epidemiology. The authors investigated the association of irregularity in energy intake, frequency, and overnight fasting with nutrient quality and health. Methods: Iranian adults who attended the health center of Tehran participated in this cross-sectional study. Dietary intake was derived from 3-day 24-h dietary recalls of 850 participants. Weight, height, and blood pressure of the participants were measured, and frequency, irregularity, and overnight fasting were recorded from 24-h dietary recall. Then, intra-class correlation coefficient (ICC) was used to obtain the consistency of time regarding three main meals. Following that, energy density was measured and nutrient density was calculated using the nutrient rich food (NRF 9.3) index. Obesity was defined as body mass index (BMI) >30 kg/m2, and blood pressure was measured. Results: The highest consistency regarding the time of meal was observed at breakfast. Frequency was positively related to the intake of fruit, energy, carbohydrate, and NRF 9.3 index (P<0.05). Overnight fasting was negatively associated with fruit, vegetable, grain, energy intake, and NRF 9.3 index (P<0.05). Moreover, irregularity in energy intake showed a negative and significant association with fruits, vegetables, and NRF9.3 (P<0.05). Frequency was significantly associated with weight and diastolic blood pressure (DBP) after adjustment with covariates (P<0.05) and overnight fasting was negatively related to body weight (P=0.009). Moreover, irregularity in energy intake showed a significant association with systolic blood pressure (SBP) (P=0.03). Conclusions: Frequency and regularity may have a potential positive association with dietary intake which is not associated with BMI. Nutrient density is higher among the participants with a higher number of eating occasions, more regular eaters, and shorter overnight fasting.

Disease-associated comorbidities, medication records and anthropometric measures in adults with Duchenne muscular dystrophy

We investigated the comorbidities, associated factors, and the relationship between anthropometric measures and respiratory function and functional abilities in adults with Duchenne muscular dystrophy (DMD). This was a single-centre cross-sectional study in genetically diagnosed adults with DMD (>16 years old). Univariate and multivariate analyses identified factors associated with dysphagia, constipation, Body Mass Index (BMI), and weight. Regression analysis explored associations between BMI, weight, and respiratory/motor abilities. We included 112 individuals (23.4 ± 5.2 years old), glucocorticoid-treated 66.1 %. The comorbidities frequency was 61.6 % scoliosis (61.0 % of them had spinal surgery), 36.6 % dysphagia, 36.6 % constipation, and 27.8 % urinary conditions. The use of glucocorticoids delayed the time to spinal surgery. The univariate analysis revealed associations between dysphagia and constipation with age, lack of glucocorticoid treatment, and lower respiratory and motor function. In the multivariate analysis, impaired cough ability remained as the factor consistently linked to both conditions. Constipation associated with lower BMI and weight. BMI and weight positively correlated with respiratory parameters, but they did not associate with functional abilities. Glucocorticoids reduce the frequency of comorbidities in adults with DMD. The ability to cough can help identifying dysphagia and constipation. Lower BMI and weight in individuals with DMD with compromised respiratory function may suggest a higher calories requirement.

Associations of Early-Life and Adult Anthropometric Measures with the Expression of Stem Cell Markers CD44, CD24, and ALDH1A1 in Women with Benign Breast Biopsies.

According to the stem cell hypothesis, breast carcinogenesis may be related to the breast stem cell pool size. However, little is known about associations of breast cancer risk factors, such as anthropometric measures, with the expression of stem cell markers in noncancerous breast tissue. The analysis included 414 women with biopsy-confirmed benign breast disease in the Nurses' Health Study and Nurses' Health Study II. Birthweight, weight at age 18, current weight, and current height were reported via self-administered questionnaires. IHC staining of stem cell markers (CD44, CD24, and aldehyde dehydrogenase family 1 member A1) in histopathologically normal epithelial and stromal breast tissue was quantified using an automated computational image analysis system. Linear regression was used to examine the associations of early-life and adult anthropometric measures with log-transformed stem cell marker expression, adjusting for potential confounders. Birthweight [≥10.0 vs. <5.5 lbs: β (95% confidence interval) = 4.29 (1.02, 7.56); P trend = 0.001 in the stroma] and adult height [≥67.0 vs. <63.0 inch: 0.86 (0.14, 1.58); P trend = 0.02 in the epithelium and stroma combined] were positively associated with CD44 expression. Childhood body fatness was inversely associated (P trend = 0.03) whereas adult height was positively associated with CD24 expression in combined stroma and epithelium (P trend = 0.03). Our data suggest that anthropometric measures, such as birthweight, adult height, and childhood body fatness, may be associated with the stem cell expression among women with benign breast disease. Anthropometric measures, such as birthweight, height, and childhood body fatness, may have long-term impacts on stem cell population in the breast.

Evaluation of relationship of intuitive eating and eating awareness with body mass index and anthropometric measurements in adults

Evaluation of relationship of intuitive eating and eating awareness with body mass index and anthropometric measurements in adults

Effects of Hesperidin Supplementation on Anthropometric Indices in Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Background: Although some studies have reported that flavonoids can be associated with anti-obesity effects, the putative effects of hesperidin, as a subgroup of flavonoids, on anthropometric parameters are inconclusive. Therefore, this systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to determine the effect of hesperidin supplementation on anthropometric measures in adults. Methods: A comprehensive literature search was performed until February 2022 in electronic databases such as PubMed, Scopus, Web of Science, and Google Scholar. The pooled results were obtained by a random-effects model. Results: A total of nine RCTs enrolling 493 participants were identified. Seven studies had illustrated the effect of hesperidin on weight, eight on body mass index (BMI), five on waist circumference (WC), two on waist to hip ratio (WHR), and two on hip circumference (HC). The results of the pooled analysis showed no significant changes in body weight (0.01 kg, 95% CI: -0.22, 0.24), BMI (-0.02 kg/m2, 95% CI: -0.16, 0.13), and WC (-0.48 cm, 95% CI: -1.52, 0.55) after hesperidin supplementation compared to the control group (P &gt; 0.05). Qualitative assessment of other anthropometric indices also showed no beneficial effect of hesperidin in reducing WHR and HC values; however, these findings are not conclusive because of the limited number of studies. Conclusion: The present study provides no evidence that hesperidin supplementation is effective in improving anthropometric measures. More high-quality RCTs especially among overweight and obese individuals are needed to strengthen the evidence.

Effects of probiotic/synbiotic supplementation on body weight in patients with diabetes: a systematic review and meta-analyses of randomized-controlled trials

ObjectiveThe aim of the present study was to assess the effect of probiotic/synbiotic supplementation on anthropometric measures in adults with diabetes, independent of body weight.MethodsPubMed, Scopus, Web of Sciences and the Cochrane Library were searched for randomized controlled trials (RCTs) up until December 14, 2022. The effect sizes were pooled using an inverse-variance random-effects model. The methodological quality of studies as well as the quality of evidence was assessed using standard tools.ResultsThirty-two RCTs met the established inclusion criteria. Overall, compared with the respective control groups, probiotic/synbiotic supplementation resulted in a significant reduction in body weight (weighted mean difference [WMD]: -0.50 kg; 95% CI: -0.83, -0.17; I2 = 79.8%, n = 27 studies]), body mass index (WMD: -0.24 kg/m2; 95% CI: -0.39, -0.09; I2 = 85.7%, n = 30 studies), and waist circumference (WMD: -0.90 cm; 95% CI: -1.13, -0.52; I2 = 0%, n = 11 studies). However, hip circumference and waist to hip ratio were not significantly improved.ConclusionsOur analysis revealed that probiotic/synbiotic supplementation may assist with weight management in patients with diabetes, especially when consumed at higher doses, in younger adults, and in participants with obesity. However, more studies are needed to elucidate the anti-obesity effects of specific strains of probiotics/synbiotics.

Development of Gender-Specific Equations for Estimating Body Weight and Height Based on Anthropometric Measurements in Adults from Shiraz, Iran

Background: In various situations, such as determining nutrition requirements, medication dosage, mechanical ventilation, and resuscitation, height, weight, and BMI are considered. Anthropometric body measurements differ among populations of different genders and ethnicities. Objectives: This study aimed to develop gender-specific equations for estimating body weight and height based on anthropometric measurements in Iranian adults. Methods: This cross-sectional study was conducted in Shiraz, Iran, over six months. Healthy volunteers aged 18-80 were included. Exclusion criteria were limb(s) amputation or immobilization and pregnancy. Participants were randomly divided into modeling (n = 400) and validation (n = 78) groups. We used the modeling group to generate regression equations based on gender and the validation group to test them. Results: Demi-span, age, knee height, and arm span could predict height with reasonable accuracy. Calf, waist, neck, and wrist circumferences entered our regression for predicting weight. Waist and calf circumferences entered the regression for BMI prediction in both genders. Arm circumference in men and neck circumference in women is strongly correlated with BMI. Conclusions: Many different equations have been suggested to predict height, weight, and BMI. Linear and circumferential body measures are usually used to predict height and weight. The suggested equations in this study are simple, and the anthropometric measurements require only a cloth tape measure and have good predictive ability. Complimentary studies are necessary to evaluate the precision of these formulas in other samples from other regions of Iran and in immobilized patients.

Diets differing in carbohydrate cellularity and amount similarly reduced visceral fat in people with obesity - a randomized controlled trial (CARBFUNC)

Visceral adipose tissue (VAT) volume is associated with common lifestyle diseases. Dietary quality, including food matrix and degree of carbohydrate cellularity, as well as the carbohydrate/fat ratio, may influence VAT volume. We aimed to determine the effects of isocaloric diets differing in either "cellularity", a novel marker of dietary carbohydrate quality, or carbohydrate amount on visceral fat volume and anthropometric measures in adults with obesity. In a randomized controlled trial of 193 people with obesity/central adiposity, we compared changes in VAT volume after 6 and 12 months, measured by abdominal computed tomography, on three isocaloric eating patterns based on "acellular" carbohydrate sources (e.g., flour-based whole-grain products; comparator arm), "cellular" carbohydrate sources (minimally processed foods with intact cellular structures such as fruits, potatoes/tubers, and rice), or low-carbohydrate high-fat (LCHF) principles. Outcomes were compared by an intention-to-treat (ITT) analysis using constrained linear mixed-effects modelling (cLMM) providing baseline-adjusted change scores and proper missing data handling without imputation. 78 and 57 participants completed 6 and 12 months, respectively, with similar intakes of energy (females: 1820-2060kcal, males: 2480-2550kcal) and protein (16-17 energy percent, E%) throughout the intervention, and only modest reductions in energy from baseline. Reported dietary intakes were 42-44, 41-42, and 11-15E% carbohydrate and 36-38, 37-38, and 66-70E% fat in the acellular, cellular and LCHF groups, respectively. There were no significant between-group differences in VAT volume after 6 months (cellular vs. acellular [95% CI]:-55cm³ [-545, 436]; LCHF vs. acellular [95% CI]:-225cm³ [-703, 253]) or after 12 months (cellular vs. acellular [95% CI]:-122cm³ [-757, 514]; LCHF vs. acellular [95% CI]:-317cm³ [-943, 309]). VAT volume decreased significantly within all groups by 14-18% and 12-17% after 6 and 12 months, respectively. Waist circumference was reduced to a significantly greater degree in the LCHF vs. acellular group at 6 months (LCHF vs. acellular [95% CI]:-2.78cm [-5.54,-0.017]). Despite modest energy restriction, the three isocaloric eating patterns, differing in carbohydrate cellularity and amount, decreased visceral fat volume significantly and to a similar clinically relevant degree. NCT03401970. https://clinicaltrials.gov/ct2/show/NCT03401970.

Evaluation of the Relationship between Probiotic and Prebiotic Food Consumption and Depression Status and Anthropometric Measurements in Adults

Bu çalışmada yetişkin bireylerde prebiyotik ve probiyotik içeren besin tüketimi ile depresyon durumu ve antropometrik ölçümler arasındaki ilişki değerlendirilmiştir. Çalışmaya 19-65 yaş arası 385 yetişkin birey dahil edilmiş ve prebiyotik ve probiyotik içeren besin tüketimleri ile besin desteği kullanımları sıklık formu aracılığıyla değerlendirilmiştir. Depresyon düzeylerinin değerlendirilmesinde Beck Depresyon Ölçeği (BDS) kullanılmıştır. Bireylerin yaş ortalaması 22,4±6,4 yıldır. Bireylerin beden kitle indeksi (BKİ) ortalaması 22,0±3,9 kg/m2, bel/boy oranı 0,44±0,1’dır. Çalışmaya katılan bireylerin %95,1’i probiyotik ve %89,9’u ise prebiyotik kavramını bildiğini ifade etmiştir. Bireylerin %94,5’i probiyotiklerin ve %89,1’i ise prebiyotiklerin sağlık açısından yararlı olduğunu düşünmektedir. Bireylerin probiyotik içeren besin tüketim sıklıklarına göre BDS puanları arasında istatistiksel olarak anlamlı bir fark saptanmamıştır (P&gt;0,05). Prebiyotik içeren besinlerden domates, badem ve ceviz tüketim sıklıklarına göre bireylerin BDS puanları arasında istatistiksel olarak anlamlı fark saptanmıştır (P

The effects of hesperidin supplementation or orange juice consumption on anthropometric measures in adults: A meta-analysis of randomized controlled clinical trials.

The current evidence-base regarding the effect of hesperidin (a flavanone found in citrus fruits) on body composition is equivocal. We conducted a meta-analysis on the effect of orange juice and/or hesperidin supplementation on anthropometric measures in randomized controlled trials (RCTs). A systematic search of PubMed and Scopus was performed up to February 2020. The overall estimates and their 95% confidence intervals (CIs) were calculated using a random-effects model. Eleven eligible RCTs, with 512 individuals, were included in this study. The meta-analysis showed that orange juice and/or hesperidin had no significant effect on body weight [weighted mean difference (WMD)=-0.31kg; 95% CI,-1.44 to 0.82, P=0.592], body mass index [WMD=0.11kg/m2; 95% CI,-0.33 to 0.56, P=0.617], fat mass [WMD=0.14kg; 95% CI,-0.95 to 1.22, P=0.807], percentage body fat [WMD=-0.70%; 95% CI,-2.58 to 1.18, P=0.463] and waist circumference [WMD=0.07cm; 95% CI,-1.16 to 1.30, P=0.588]. The present study revealed that there is no significant beneficial effect of orange juice and/or hesperidin supplementation on anthropometric measures. The authors advocate that more high-quality clinical trials are needed to better discern the potential efficacy of orange juice and/or hesperidin.

Is Probiotic Supplementation Useful for the Management of Body Weight and Other Anthropometric Measures in Adults Affected by Overweight and Obesity with Metabolic Related Diseases? A Systematic Review and Meta-Analysis.

The aim of this systematic review and meta-analysis is to assess the effectiveness of probiotics in inducing body weight loss in patients with overweight or obesity with related metabolic diseases. The research was carried out on PubMed and Scopus, focusing on studies reporting the effect on anthropometric measures (weight, body mass Index (BMI), waist circumference (WC), and hip circumference (HC) after administration of various probiotic strains compared to placebo. Twenty randomized controlled trials, that included 1411 patients, were considered. The meta-analyzed mean differences (MD) for random effects showed no significant decrease in body weight after probiotic supplementation (−0.26 kg [−075, 0.23], p = 0.30), while a significant BMI decrease was found (−0.73 kg/m2 [−1.31, −0.16], p = 0.01). For WC and HC, the meta-analyzed MD for random effects showed a significant decrease (WC: −0.71 cm [−1.24; −0.19], p = 0.008 and HC: −0.73 cm [−1.16; −0.30], p = 0.0008). The risk of bias was also evaluated considering a high risk and a low risk according to PRISMA criteria. In conclusion, the results of this meta-analysis highlight a positive trend of probiotics supplementation on the amelioration of anthropometric measures of overweight and obese patients with related metabolic diseases. However, further research is needed before recommending the use of probiotics as a therapeutic strategy for these patients. The focus of the future research should be to evaluate the efficacy of different probiotic strains, the quantities to be administered, and the duration of the intervention.

Impact of early life famine exposure on adulthood anthropometry among survivors of the 1983\u20131985 Ethiopian\xa0Great famine: a historical cohort study

BackgroundNutritional insult in early life brings adaptive changes in body structure and functioning that could remain throughout the affected individual’s life course. The long term impact of early life famine exposure on adulthood anthropometric measurements has been recorded in previous studies. However, the results were contradictory. Hence, we extend this study to examine the impact of famine exposure during early life on adulthood’s anthropometry among survivors of the 1983–85 Ethiopian great famine.MethodsA total of 1384 adult men and women survived from 1983 to 85 Ethiopian great famine were included in the study. Famine exposure status was classified into five groups: early life-exposed, prenatal-exposed, postnatal-exposed, adolescence-exposed, and non-exposed based on self-reported age and birthdate of the participants. Prenatal, post-natal, and adolescence exposed groups were considered as early life exposed. Following a standard procedure, anthropometric measurements were taken. A linear regression analysis was used to analyze the impact of famine exposure on adult anthropometric measurements adjusted for all possible covariates. The effect of famine exposure on overweight, general obesity, and abdominal obesity was examined using multinomial and binary logistic regression analysis.ResultCompared to non-exposed groups, adult height was lower by 1.83 cm (β = − 1.83; 95% CI: − 3.05, − 0.58), 1.35 cm (β = − 1.35; 95% CI: − 2.56, − 0.14) and 2.07 cm (β = − 2.07 cm; 95% CI: − 3.31, − 0.80) among early life, prenatal and post-natal exposed groups, respectively. Likewise, famine exposure during early life (β = 0.02; 95% CI: 0.01, 0.03), prenatal (β = 0.03; 95% CI: 0.02, 0.03) and post-natal life (β = 0.02; 95% CI: 0.02, 0.03) was positively associated with increased waist to height ratio. However, none of the above exposures resulted in a significant association with body mass index (P > 0. 05). Additionally, exposure to famine during early stage of life was not associated with increased risk of overweight, general obesity and abdominal obesity in adults.ConclusionDecreased adult height and increased waist-to-height ratio were associated with early life exposure to famine, particularly prenatal and post-natal exposure. These results therefore underscore the significance of avoiding undernutrition in early life, which tends to be important for achieving once potential adult height and to minimize the increased risk of anthropometric markers of abdominal obesity such as waist to height ratio in later life.

Obesity and kidney disease in care

Nursing and Residential CareVol. 19, No. 7 EditorialObesity and kidney disease in careLinda NazarkoLinda NazarkoSearch for more papers by this authorLinda NazarkoPublished Online:20 Jun 2017https://doi.org/10.12968/nrec.2017.19.7.370AboutSectionsView articleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareShare onFacebookTwitterLinked InEmail View article References Kovesdy CP, Furth SL, Zoccali C; World Kidney Day Steering Committee (2017) Obesity and kidney disease: hidden consequences of the epidemic. J Neprol 30(1): 1–10. https://doi.org/https://doi.org/10.1007/s40620-017-0377-y Google ScholarLittlejohn NK, Grobe JL (2015) Opposing tissue-specific roles of angiotensin in the pathogenesis of obesity, and implications for obesity-related hypertension. Am J Physiol Regul Integr Comp Physiol 309(12): R1463–73. https://doi.org/https://doi.org/10.1152/ajpregu.00224.2015 Crossref, Google ScholarMoody A (2013) Adult anthropometric measures overweight and obesity. http://bit.ly/2s2L0E1 (accessed 26 May 2017) Google ScholarPublic Health England (2016) Modern life responsible for ‘worrying’ health in middle aged. http://bit.ly/2hNG4ON (accessed 26 May 2017) Google ScholarRull G (2016) Renal replacement therapy and transplantation. http://bit.ly/2rowsCr (accessed 26 May 2017) Google ScholarThink Kidneys (2017) Care homes. http://bit.ly/2qqlPdu (accessed 26 May 2017) Google ScholarWorld Health Organization (2016) Obesity and overweight. http://bit.ly/18pCdAN (accessed 26 May 2017) Google Scholar FiguresReferencesRelatedDetails 2 July 2017Volume 19Issue 7ISSN (print): 1465-9301ISSN (online): 2052-2932 Metrics History Published online 20 June 2017 Published in print 2 July 2017 Information© MA Healthcare LimitedPDF download

Young Adult and Usual Adult Body Mass Index and Multiple Myeloma Risk: A Pooled Analysis in the International Multiple Myeloma Consortium (IMMC).

Background: Multiple myeloma risk increases with higher adult body mass index (BMI). Emerging evidence also supports an association of young adult BMI with multiple myeloma. We undertook a pooled analysis of eight case-control studies to further evaluate anthropometric multiple myeloma risk factors, including young adult BMI.Methods: We conducted multivariable logistic regression analysis of usual adult anthropometric measures of 2,318 multiple myeloma cases and 9,609 controls, and of young adult BMI (age 25 or 30 years) for 1,164 cases and 3,629 controls.Results: In the pooled sample, multiple myeloma risk was positively associated with usual adult BMI; risk increased 9% per 5-kg/m2 increase in BMI [OR, 1.09; 95% confidence interval (CI), 1.04-1.14; P = 0.007]. We observed significant heterogeneity by study design (P = 0.04), noting the BMI-multiple myeloma association only for population-based studies (Ptrend = 0.0003). Young adult BMI was also positively associated with multiple myeloma (per 5-kg/m2; OR, 1.2; 95% CI, 1.1-1.3; P = 0.0002). Furthermore, we observed strong evidence of interaction between younger and usual adult BMI (Pinteraction <0.0001); we noted statistically significant associations with multiple myeloma for persons overweight (25-<30 kg/m2) or obese (30+ kg/m2) in both younger and usual adulthood (vs. individuals consistently <25 kg/m2), but not for those overweight or obese at only one time period.Conclusions: BMI-associated increases in multiple myeloma risk were highest for individuals who were overweight or obese throughout adulthood.Impact: These findings provide the strongest evidence to date that earlier and later adult BMI may increase multiple myeloma risk and suggest that healthy BMI maintenance throughout life may confer an added benefit of multiple myeloma prevention. Cancer Epidemiol Biomarkers Prev; 26(6); 876-85. ©2017 AACR.

Effect of pomegranate extract on blood pressure and anthropometry in adults: a double-blind placebo-controlled randomised clinical trial.

Pomegranate (Punica granatum), a polyphenol-rich fruit, has been suggested to reduce cardiovascular risk due to its antioxidant properties. Hypertension and obesity are the most preventable cardiovascular risk factors. Few studies on blood pressure and/or body-weight status have been conducted in human subjects. Previous investigations have tended to focus on pomegranate juice. The aim of the present study was to investigate the effect of pomegranate extract (PE) on blood pressure and anthropometric measures in adults with no symptomatic disease. A total of fifty-five participants enrolled in a randomised double-blinded placebo-controlled clinical trial where they were assigned to either PE capsules or placebo capsules for 8 weeks. Blood pressure, body weight, waist circumference, waist:hip ratio (WHR) and body composition (lean body mass, body fat) were measured at baseline, week 4 and week 8. Results showed a significant decrease in diastolic blood pressure after 8 weeks (by 2·79 (sd 5·32)mmHg; P<0·05), while the decrease in systolic blood pressure did not reach statistical significance (2·57 (sd 7·4)mmHg; P>0·05). Body fat percentage, lean body mass, waist circumference and WHR did not significantly differ between groups at the end of the intervention. Results suggest that PE may reduce blood pressure and possibly prevent hypertension in the normotensive population. Further large trials are required to elucidate this effect.

The associations between sleep disorders and anthropometric measures in adults from three Colombian cities at different altitudes

BackgroundSleep disorders are common but underdiagnosed conditions, which are associated with obesity. In Colombia, the distribution of sleep disorders remains unclear. We aimed to describe the distribution of sleep disorders, according to demographic, geographic and anthropometric characteristics, in adult Colombian populations. MethodsA multicenter study was conducted with 5474 participants recruited from three Colombian cities at different altitudes. A two-stage cluster sampling method was applied. Participants’ mean age was 40.2 years and 53.8% were female. Collected data included demographic information and anthropometric characteristics of adiposity such as body mass index, neck circumference and waist circumference, as well as participants’ scores on five scales used to assess sleep disorders. Disorders included sleepiness, obstructive sleep apnea (OSA), insomnia, poor sleep quality and restless legs syndrome; the scales were the Epworth Sleepiness Scale, Berlin questionnaire, STOP-Bang questionnaire, Pittsburgh Sleep Quality Index and diagnostic criteria for the restless legs syndrome set out by the International Restless Legs Syndrome Study Group. ResultsNearly two-thirds of the population reported at least one sleep disorder according to their results on the five scales (59.6% [95%CI 57.4; 61.81)]. This proportion was similar by sex. Prevalence of overweight was 34.8% and of obesity was 14.4%. Sleep disorders were more frequent among those aged 65 years or more (91.11 [95%CI 86.1; 94.43]), those who were obese (83.71% [95%CI 78.94; 87.56]) and those who resided in the cities at the lowest altitude (72.4% [95%CI 70.2; 74.5]). Waist circumference showed a stronger association with sleep disorders among women than among men. ConclusionsSleep disorders are common in Colombia, irrespective of sex and geographical location. They are associated with obesity. Abdominal obesity could explain the high frequency of sleep disorders among women.We believe that this part of the study will substantially contribute to the understanding of sleep disorders. Further research is needed to identify key factors behind the high prevalence rates of sleep disorders and obesity in Colombia.

Validation of self-reported figural drawing scales against anthropometric measurements in adults.

The aim of the present study was to validate figural drawing scales depicting extremely lean to extremely obese subjects to obtain proxies for BMI and waist circumference in postal surveys. Reported figural scales and anthropometric data from a large population-based postal survey were validated with measured anthropometric data from the same individuals by means of receiver-operating characteristic curves and a BMI prediction model. Adult participants in a Scandinavian cohort study first recruited in 1990 and followed up twice since. Individuals aged 38-66 years with complete data for BMI (n 1580) and waist circumference (n 1017). Median BMI and waist circumference increased exponentially with increasing figural scales. Receiver-operating characteristic curve analyses showed a high predictive ability to identify individuals with BMI > 25·0 kg/m2 in both sexes. The optimal figural scales for identifying overweight or obese individuals with a correct detection rate were 4 and 5 in women, and 5 and 6 in men, respectively. The prediction model explained 74 % of the variance among women and 62 % among men. Predicted BMI differed only marginally from objectively measured BMI. Figural drawing scales explained a large part of the anthropometric variance in this population and showed a high predictive ability for identifying overweight/obese subjects. These figural scales can be used with confidence as proxies of BMI and waist circumference in settings where objective measures are not feasible.

Abstract #604: Detection of Cardiovascular Risk Factors by Anthropometric Measures in Adults Living in an Urban Setting in Sri Lanka

Abstract #604: Detection of Cardiovascular Risk Factors by Anthropometric Measures in Adults Living in an Urban Setting in Sri Lanka

Developmental programming of growth: Genetic variant in GH2 gene encoding placental growth hormone contributes to adult height determination

IntroductionGiven the physiological role of placental growth hormone (PGH) during intrauterine development and growth, genetic variation in the coding Growth hormone 2 (GH2) gene may modulate developmental programming of adult stature. Two major GH2 variants were described worldwide, determined by single polymorphism (rs2006123; c.171 + 50C > A). We sought to study whether GH2 variants may contribute to adult anthropometric measurements. MethodsGenotyping of GH2 SNP rs2006123 by RFLP, testing its genetic association with adult height and Body Mass Index (BMI) by linear regression analysis, and combining the results of three individual study samples in meta-analysis. Study samplesHYPEST (Estonia), n = 1464 (506 men/958 women), CADCZ (Czech), n = 871 (518/353); UFA (Bashkortostan), n = 954 (655/299); meta-analysis, n = 3289 (1679/1610). ResultsMeta-analysis across HYPEST, CADCZ and UFA samples (n = 3289) resulted in significant association of GH2 rs2006123 with height (recessive model: AA-homozygote effect: beta (SE) = 1.26 (0.46), P = 5.90 × 10−3; additive model: A-allele effect: beta (SE) = 0.45 (0.18), P = 1.40 × 10−2). Among men (n = 1679), the association of the A-allele with taller stature remained significant after multiple-testing correction (additive effect: beta = 0.86 (0.28), P = 1.83 × 10−3). No association was detected with BMI. Notably, rs2006123 was in strong LD (r2 ≥ 0.87) with SNPs significantly associated with height (rs2665838, rs7209435, rs11658329) and mapped near GH2 in three independent meta-analyses of GWA studies. ConclusionsThis is the first study demonstrating a link between a placental gene variant and programming of growth potential in adulthood. The detected association between PGH encoding GH2 and adult height promotes further research on the role of placental genes in prenatal programming of human metabolism.

Prospective investigation of pituitary functions in patients with acute infectious meningitis: is acute meningitis induced pituitary dysfunction associated with autoimmunity?

Previous case reports and retrospective studies suggest that pituitary dysfunction may occur after acute bacterial or viral meningitis. In this prospective study we assessed the pituitary functions, lipid profile and anthropometric measures in adults with acute bacterial or viral meningitis. Moreover, in order to investigate whether autoimmune mechanisms could play a role in the pathogenesis of acute meningitis-induced hypopituitarism we also investigated the anti-pituitary antibodies (APA) and anti-hypothalamus antibodies (AHA) prospectively. Sixteen patients (10 males, 6 females; mean ± SD age 40.9 ± 15.9) with acute infectious meningitis were included and the patients were evaluated in the acute phase, and at 6 and 12 months after the acute meningitis. In the acute phase 18.7% of the patients had GH deficiency, 12.5% had ACTH and FSH/LH deficiencies. At 12 months after acute meningitis 6 of 14 patients (42.8%) had GH deficiency, 1 of 14 patients (7.1%) had ACTH and FSH/LH deficiencies. Two of 14 patients (14.3%) had combined hormone deficiencies and four patients (28.6%) had isolated hormone deficiencies at 12 months. Four of 9 (44.4%) hormone deficiencies at 6 months were recovered at 12 months, and 3 of 8 (37.5%) hormone deficiencies at 12 months were new-onset hormone deficiencies. At 12 months there were significant negative correlations between IGF-I level vs. LDL-C, and IGF-I level vs. total cholesterol. The frequency of AHA and APA positivity was substantially high, ranging from 35 to 50% of the patients throughout the 12 months period. However there were no significant correlations between AHA or APA positivity and hypopituitarism. The risk of hypopituitarism, GH deficiency in particular, is substantially high in the acute phase, after 6 and 12 months of the acute infectious meningitis. Moreover we found that 6th month after meningitis is too early to make a decision for pituitary dysfunction and these patients should be screened for at least 12 months. In addition, the occurrence of AHA and APA positivity due to acute infectious meningitis was demonstrated for the first time. Further longer-term prospective investigations need to be carried out on a larger cohort of patients to understand the role of autoimmunity in the pathogenesis of late hypopituitarism after acute infectious meningitis.