Anthropometric variation and sex differences were investigated among the Yanadi tribe, who live in different regions and show differences in population structure variables and form regional breeding populations. In case of within population variation in anthropometric characters, both males and females show greater variation in a few specific characters (e.g., HB, LL) and almost no variation in FB, but least variation in HL and NB in males and in ZB, LB in females and show sex differences. Overall, females showed greater variation in more number of characters than males. In case of between population variation a few traits show clinal trend between male-female comparisons. Each character shows a specific pattern (e.g., HB, ZB, EL, GB) which vary according to the spatial distribution of the regional populations. The curves also indicate least average differences corresponding to within regional homogeneity among males and females (e.g., HB, ECD, EB) and increasing differences with males and females of other regions. A comparison of anthropometric profiles of the five populations show significant sex differences in IY subpopulation. The three mainland subpopulations show wide morphological differentiation with two coastal subpopulations, who also differ in subsistence pattern and geographically isolated. A comparison of anthropometric profiles between males and females across five populations show positive association between P1, HF and P2 populations, whereas significant negative association with CY and HF. The correllelographs based on the male-female comparisons also indicate greater morphological similarity between sexes in cases of within regional population. They also show clinal changes of either decreasing or increasing trends of morphological variation between populations in association with spatial distribution and population structure differences. The results obtained are in agreement with the expectations from the population structure of the tribe.