The so-called osteoid-osteoma, described by Jaffe (1) in 1935 and, more extensively, by Jaffe and Lichtenstein (2) in 1940, is a solitary, benign neoplasm involving spongy or cortical bone. It has been recognized in the extremities, more often the lower, and in the vertebral column, but not yet in the ribs, sacrum, innominate bones, and skull bones. This lesion may be misinterpreted, clinically and roentgenographically, as chronic osteomyelitis or bone abscess. The diagnosis should be considered in an adolescent or young adult with localized pain, with or without localized swelling, of at least several months' duration, unassociated with local heat or bouts of fever, and with normal clinical laboratory findings. The histologic features of osteoid-osteoma are distinctive and unlike those of any other classified lesion of bone. Local excision of the tumor results in immediate and complete recovery. Case Report A 16-year-old colored male complained of increasing pain and swelling of the right ankle of four months' duration. There was no definite history of trauma. Examination of the right foot revealed slight swelling and tenderness on the anterior surface in the ankle region. The temperature, pulse, and respiratory rate were normal, as were repeated blood counts and urinalyses. The blood Wassermann and Kahn tests and an intradermal tuberculin test were also negative. A lateral roentgenogram of the right foot was reported by the radiologist as “negative.” It revealed an oval, sharply defined, radiolucent area near the upper surface of the neck of the astragalus, its superior portion elevating the overlying intact cortical bone like a blister. There was some increase in density of the surrounding cancellous bone, but no periosteal or adjacent soft-tissue reaction (Fig. 1). The lesion was exposed through an anterolateral incision and was excised, together with the overlying cortex and adjacent sclerotic cancellous bone. The wound was closed without drainage and healed per primam. Smears, culture, and guinea-pig inoculation of material taken from the lesion were negative. The patient experienced immediate relief of pain, although some swelling of the right ankle region has persisted. Histopathologic Features: Grossly, the tumor was soft and reddish brown in color. Microscopically, it was composed predominantly of trabeculae and patches of osteoid tissue, lined by osteoblasts and set in a substratum of highly vascular osteogenic connective tissue that was sprinkled with numerous osteoclasts. A few of the osteoid trabeculae were undergoing early calcification and transformation into atypical bone (Figs. 2 and 3). The tumor tissue was sharply delimited from the compact trabeculae of the adjacent bone. Discussion The roentgenographic picture in osteoid-osteoma demonstrates two features—the neoplasm proper and the reaction of the surrounding bone.
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