AIM: to study the role of fine suspended particles in the atmospheric air in the formation of allergic, non-allergic and mixed phenotypes of bronchial asthma in adults.
 METHODS: The analysis of atmospheric air pollution by fine particles in Kazan was carried out according to the database of social and hygienic monitoring of the Center for Hygiene and Epidemiology in the Republic of Tatarstan for 20142020. To study the relationship between the level of atmospheric air pollution with fine particles and bronchial asthma in adults (1865 years old), a retrospective analysis of the incidence of bronchial asthma (ICD-10 codes J45.0, J45.1, J45.8) was carried out during the same period among the population of Kazan. The regional medical information system "Electronic Health of the Republic of Tatarstan" was used. Statistical modeling was carried out using the method of mixed models based on the Poisson distribution or the negative binomial distribution.
 RESULTS: The average annual absolute risk of bronchial asthma in the adult population of Kazan was 0.51 per 100 people aged 1865 years, an increase of 0.09 per 100 people (17.6%) per year (p=0.039). An increase in the annual maximum concentrations of PM2,5 by 10 g increased the absolute risk of non-allergic bronchial asthma by 0.066 per 100 people aged 1865 years (p=0.043). Similar dependences, but without statistical significance at the level of p 0.05, were found for such exposure parameters as the mass concentration of РМ10 and the mass of particles deposited in the tracheobronchial and alveolar sections of the lungs. For allergic and mixed asthma, no statistically significant relationships with mass concentrations and deposited doses of suspended particles were found.
 CONCLUSION: Air pollution with fine suspended particles increases the risk of developing a non-allergic phenotype of adult bronchial asthma, which may be associated with specific pathogenetic mechanisms, including the reaction of the epithelium to the deposition of fine particles.
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