The creative class has become an important force in promoting sustainable urban development. Existing research has explored many factors for the agglomeration of the creative class, but there is still a lack of comparative studies from a heterogeneity perspective and on the design of cross-cultural adaptability factors, especially comparative studies across different regions in Chinese cities. This paper focuses on 27 central district cities in the Yangtze River Delta region of China, based on panel data from 2012 to 2019, and uses the location entropy method to measure the agglomeration degree of the creative class in different cities. Considering the cultural background of China, a model of influencing factors including five dimensions: economic foundation, living environment, cultural and educational environment, innovation environment, and ecological environment is constructed. The study finds: (1) The agglomeration degree of the creative class in the central urban cluster of the Yangtze River Delta is significantly higher than the peripheral level, forming an agglomeration distribution pattern led by Shanghai, with Nanjing, Hefei, Hangzhou, Suzhou, Ningbo, and other important node cities. The agglomeration degree of the creative class generally shows an upward trend. (2) The economic foundation, living environment, cultural and educational environment, innovation environment, and ecological environment all have a significant positive impact on the agglomeration of the creative class, among which the impact of the living environment, cultural and educational environment, and innovation environment is larger, while the economic foundation and ecological environment are relatively smaller. (3) There are differences in the influencing factors of the creative class agglomeration at the provincial levels of Jiangsu, Zhejiang, and Anhui in the Yangtze River Delta. Compared with the more core provinces of Jiangsu and Zhejiang, the cultural and educational environment and ecological environment have a more significant impact, while the relatively peripheral Anhui province is more dependent on the city’s openness and innovation environment factors. This study reveals the spatial distribution rules and influencing factors of the creative class in the central cities of the Yangtze River Delta, providing insights for coordinated and sustainable regional development.
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