To identify latent profiles of insomnia, fatigue, recovery, psychological distress and burnout among hospital nurses; examine variations in personal and work-related characteristics across profiles; investigate associations between profiles and outcomes such as patient care quality, nursing work satisfaction and workplace satisfaction; and assess the moderating role of organisational support on these relationships. A cross-sectional descriptive study. This study analysed survey data from 2488 hospital nurses using latent profile analysis, multinomial logistic regression and hierarchical multiple linear regression. Four well-being profiles emerged: low, average, above-average and high well-being. Profiles differed significantly in personal and work-related characteristics. Nurses in the high well-being profile were associated with better patient safety, care quality and satisfaction. Organisational support moderated the negative associations between low well-being profiles and nursing work and workplace satisfaction. Tailored interventions addressing factors associated with low well-being and enhancing organisational support may be beneficial for improving nurse well-being, delivering high-quality care and supporting nurse retention in sustainable healthcare environments. Healthcare organisations should prioritise nurse well-being through targeted interventions, adequate staffing, recovery opportunities and stress management resources to support a resilient and sustainable workforce. The findings revealed the diversity of well-being patterns among hospital nurses and provided insights for identifying subgroups at higher risk of impaired patient safety, reduced care quality and dissatisfaction with nursing work and the workplace. Greater organisational support was associated with weaker negative relationships between poor well-being and nurse outcomes. STROBE guidelines. No direct patient or public contribution.
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