Alumina Sulfuric Acid Research Articles

Rabbit muscle pyruvate kinase activators: Synthesis, molecular docking and theoretical studies of N-substituted sulfonamide derivatives

Pyruvate kinase (PK) activators have potential therapeutic applications in diseases such as sickle cell anemia. In this study, N-Substituted sulfonamide derivatives of 1,4-dihydropyridines were synthesized and evaluated as PK activators in vitro and using molecular docking studies. The compounds were synthesized by reacting dicarbonyl compounds with ammonium acetate, 5-nitrobenzaldehyde, and alumina sulfuric acid (ASA), followed by reduction and sulfonylation. The structures of the compounds were analyzed using spectroscopic techniques. DFT calculations provided insights into the electronic properties. Molecular docking of the compounds into the active site of PK showed favorable binding interactions. ADME evaluation indicated suitable solubility, BBB permeation, and lack of CYP450 inhibition. Overall, this study demonstrates the potential of new hybrid 1,4-dihydropyridine substituted sulfonamides as PK activators for further development. According to AC50 values, the compound (DTSF7, 0.97μM) is about 100-fold higher affective than the clinically used sulfonamide compound (AC50 = 90μM) for PK.

Solvent free one pot syntheses of highly substituted propargyl ethers and propargyl amines from propargyl alcohols catalyzed by recyclable alumina-sulfuric acid

A study to develop an efficient protocol for the solvent-free synthesis of a wide variety of highly substituted propargyl ethers and amines using alumina-sulfuric acid as a recyclable heterogeneous solid acid catalyst has been presented. This mild protocol tolerates a good number of acid-sensitive moieties and can be applicable to a diverse range of alcohols and amines accommodating a variety of substitution patterns. Moreover, the entire process is highly atom-efficient leaving the most innocuous material, namely water, as the sole by-product.

Silica–sulfuric acid and alumina–sulfuric acid: versatile supported Brønsted acid catalysts

–SO3H functionalized silica and alumina have emerged as efficient and eco-compatible heterogeneous solid acid catalysts for the construction of various important molecular skeletons.

Synthesis and molecular docking studies of imines as α-glucosidase and α-amylase inhibitors.

Imine functionality is found in many compounds with important biological activity. Thus, the development of novel synthetic approaches for imines is important. In this work, it is propose an easy, eco-friendly and straightforward synthesis pathway of aryl imines under microwave irradiation catalyzed by Alumina-sulfuric acid. In addition, the in vitro enzymatic inhibition, antioxidant activity and molecular docking studies were performed. The aryl imines were isolated with yields in the range of 37-94%. All aryl imines synthesized were evaluated for in vitro inhibitory potential against α-glucosidase and α-amylase enzymes and the results exhibited that the most of the compounds displayed inhibitory activity against both enzymes. The (E)-1-(4-nitrophenyl)-N-(pyridin-2-yl)methanimine (3d) was 1.15-fold more active than acarbose against α-amylase whilst the (E)-1-phenyl-N-(pyridin-2-yl)methanimine (3c) displayed similar activity that acarbose against α-glucosidase. The molecular docking studies in α-glucosidase and α-amylase reveal that aryl imines mainly establish an H-bond with the R2-subtituent and hydrophobic interactions with the R1-subtituent. The docking analysis reveals these synthetic aryl imines 3d-i interact in same active site than acarbose drug in both enzymes.

Hydroarylation of Alkynes and Alkenes Catalyzed by Alumina-Sulfuric Acid

Hydroarylation of Alkynes and Alkenes Catalyzed by Alumina-Sulfuric Acid

Hydroarylation of alkynes and alkenes through alumina-sulfuric acid catalyzed regioselective C[sbnd]C bond formation

A highly atom-efficient synthetic protocol for hydroarylation of terminal-aryl alkynes and styrene through the regioselective CC bond formation via the electrophilic addition of naphthols and substituted phenols has been developed using alumina-sulfuric acid as a heterogeneous supported solid acid catalyst. This methodology shows excellent regioselectivity and affords the desired product in good to excellent yield. The heterogeneous catalyst can also be recycled efficiently without much loss of activity.

Nitration of Phenolic Compounds with Magnesium nitrate and acetic acid

Nitration of aromatic compounds is an indispensible reaction for organic chemists. Various metal nitrates are being used now-a-days as an eco-friendly nitrating agent instead of harsh strong acids, namely, nitric and sulfuric acids. A mixture of calcium nitrate and acetic acid, as well as a mixture of magnesium nitrate and alumina sulfuric acid, are reported to be used as nitrating agent. Inferring from these ideas, a mixture of magnesium nitrate and acetic acid (glacial or about 80% aqueous) is introduced for the first time as a fairly efficient nitrating agent for phenolic compounds successfully.

A Convenient Method for One-Pot Synthesis of β-Acetamido Ketones using Nano-Alumina Sulfuric Acid (Nano-ASA) Reusable Catalyst

We describe an efficient method for the synthesis of β- acetamido ketones through the condensation of an aryl (aromatic) aldehyde, an acetophenone, acetyl chloride, and acetonitrile in the presence of natural alumina, alumina sulfuric acid (ASA), nano-γ- alumina, nano alumina sulfuric acid (nano-ASA) at room temperature. High efficiency, easy availability and reusability are some advantages of nano alumina sulfuric acid (nano-ASA) catalyst.

ChemInform Abstract: Alumina Sulfuric Acid (ASA), Tungstate Sulfuric Acid (TSA), Molybdate Sulfuric Acid (MSA) and Xanthan Sulfuric Acid (XSA) as Solid and Heterogeneous Catalysts in Green Organic Synthesis: A Review

AbstractReview: 63 refs.

Alumina sulfuric acid (ASA), tungstate sulfuric acid (TSA), molybdate sulfuric acid (MSA) and xanthan sulfuric acid (XSA) as solid and heterogeneous catalysts in green organic synthesis: a review

In this comprehensive review, we report on the sulfonic acid functionalized solid acids such as alumina sulfuric acid (ASA), tungstate sulfuric acid (TSA), molybdate sulfuric acid (MSA) and xanthan sulfuric acid (XSA) as green and heterogeneous catalysts in a wide range of organic transformations. Recently, the use of sulfonic acid functionalized solid acids as catalyst in organic synthesis has become an efficient and green strategy for the selective construction of organic motifs. The sustainable advantage of sulfonic acid functionalized solid acids is that it can be recovered and reused several times without loss of their efficiency. In this review, we attempt to give an overview of the use of ASA, TSA, MSA, XSA as catalysts in the synthesis of various organic compounds having industrial as well as pharmaceutical applications.

Application of various types of alumina and nano-γ-alumina sulfuric acid in the synthesis of α-aminonitriles derivatives: comparative study

An efficient and green protocol for the synthesis of α - aminonitrile derivatives by one-pot reaction of different aldehydes with amines and trimethylsilyl cyanide has been developed using natural alumina, alumina sulfuric acid (ASA), nano-g-alumina, nano-g-alumina sulfuric acid (nano-g-ASA) under microwave irradiation and solvent-free conditions. The advantages of methods are short reaction times, high yields, milder conditions and easy work up. The catalysts can be recovered for the subsequent reactions and reused without any appreciable loss of efficiency. KEY WORDS : Nano-g-alumina, Nano-g-alumina sulfuric acid, Green synthesis, Microwave irradiation, α-aminonitriles derivatives Bull. Chem. Soc. Ethiop. 2014 , 28(3), 441-450. DOI: http://dx.doi.org/10.4314/bcse.v28i3.13

Eco-friendly synthesis of 2-aryl-1-arylmethyl-1H-benzimidazoles using alumina-sulfuric acid as a heterogeneous reusable catalyst

A cost-effective and eco-friendly synthesis of 2-aryl-1-arylmethyl-1H-benzimidazoles has been developed through the condensation of different aldehydes with o-phenylenediamine using alumina-sulfuric acid as a recyclable heterogeneous solid acid catalyst. Morphological properties of the catalyst have been investigated. Effect of different solvents and comparison of alumina-sulfuric acid with different acid catalysts have also been studied. A plausible mechanistic pathway has been proposed on the basis of the isotope labelling experiments where catalytic behaviour of alumina-sulfuric acid has been explained.

NEW SYNTHETIC METHODS FOR THE PREPARATION OF 5-ARYLOXYTETRAZOLES WITH USING MG(HSO4)2 AND AL2O3-SO3H AS EFFICIENT AND GREEN HETEROGENEOUS CATALYSTS UNDER SOLVENT-FREE CONDITIONS

ABSTRACT An eco-friendly procedure for the preparation of 5-Aryloxytetrazoles under solvent-free conditions in the presents of magnesium hydrogen sulfate Mg(HSO 4 ) 2 and alumina sulfuric acid (Al 2 O 3 -SO 3 H) as heterogeneous catalysts was developed. e-mail: ferydoonkhamooshi@yahoo.com INTRODUCTION The tetrazole ring system has attracted considerable attention in recent years, 1-7 especially (specially) among medicinal chemists, as a potential surrogate for cis -peptide linkage and carboxylic acids. 3 Indeed, the number of patent claims and publications related to medicinal uses of tetrazoles continue to grow rapidly and cover a wide range of applications: Tetrazoles have been found to exhibit antihypertensive, ant (anti) allergic and antibiotic activities, and they are currently used, for example, as activator, anticonvulsants also in cancer and AIDS treatment. 1-5 Furthermore tetrazoles derivatives have been patented for muscle relaxation, anti-inflammatory, anti-arthritic, analgesic, ulcer therapeutic and coccidiostatic properties. Tetrazoles are also applied in agriculture, as plant growth regulators, herbicides and fungicides, photography and photo imaging stabilizers and rocket propellants explosives.

Easy Access to Coumarin Derivatives Using Alumina Sulfuric Acid as an Efficient and Reusable Catalyst under Solvent‐Free Conditions

A new and efficient condition for the use of alumina sulfuric acid (ASA) as a heterogeneous catalyst in the Pechmann condensation reaction in solvent‐free condition for the formation of coumarins has been reported.

Alumina-sulfuric acid catalyzed eco-friendly synthesis of xanthenediones

Abstract Alumina-sulfuric acid has been developed as a cost-effective, recyclable, heterogeneous solid acid catalyst for the eco-friendly synthesis of 9-aryl-1,8-dioxododecahydroxanthenes and 9-aryl-3,3,6,6-tetramethyl-1,8-dioxooctahydroxanthenes through the condensation of cyclic 1,3-diketones with different aryl and heteroaryl aldehydes.

Solvent-free chemoselective protection of aldehydes on the surface of alumina-sulfuric acid

Chemoselective protection of alkyl and aryl aldehydes has been accomplished through the formation of dioxolane on the surface of alumina-sulfuric acid under solvent-free conditions where dialkyl ketones, aryl alkyl ketones, and diaryl ketones remain intact.

Al(HSO4)3 and Al2O3-SO3H as Efficient Catalysts for Modified Preparation of 3,4-Dihydropyrimidin-2 (1H)-ones/thiones

An environmentally friendly procedure for the preparation of dihydropyrimidinone derivatives or their sulfur analogues under thermal solvent-free conditions in the presence of aluminium hydrogen sulfate [Al(HSO4)3] and alumina sulfuric acid (Al2O3-SO3H) as heterogeneous catalysts was developed.

ChemInform Abstract: Chemoselective Dithioacetalization and Oxathioacetalization of Carbonyl Compounds Using Alumina Sulfuric Acid as Catalyst.

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

An efficient one pot synthesis of 1,4-dihydropyridines using alumina sulfuric acid (ASA) catalyst

An efficient synthetic method for 1,4-dihydropyridines has been developed using 3 or 4 component condensation reactions of aldehydes, 1,3-dicarbonyl compounds, and ammonium acetate in the presence of alumina sulfuric acid catalyst in minimum methanol at reflux temperature. This procedure offers several advantages including high yields, an environmentally friendly procedure, short reaction times, and a simple work-up procedure.

An Efficient Synthesis of Multi-Substituted 3,4-Dihydropyrimidin-2(1H)-ones/thiones Under Solvent-Free Microwave Irradiation Using Alumina Sulfuric Acid

A new and efficient method for the synthesis of multi-substituted dihydropyrimidinone derivatives or their sulfur analogs has been developed under solvent-free microwave irradiation conditions in the presence of alumina sulfuric acid (Al2O3-SO3H) as an environmentally friendly heterogeneous recyclable catalyst, in high yields and short reaction time.