Semiannual computer printouts of reproductive disorders diagnosed in high producing Israeli dairy herds were evaluated for a comparison of fertility indices of diseased and normal cows in low (LFH) and normal fertility herds (NFH). In 16,910 cows, conception rates to first AI in cows with reproductive disorder were >50% below those in normal cows (P<0.001). For both groups of cows, conception rates were lower in LFH (P<0.0001). A comparison of fertility indices between LFH (5, 171 cows) and NFH (14,573 cows) revealed, in addition a higher overall conception rate and a lower percentage of cows still open on Day 150 post partum (problem cows, (P<0.0001), as well as a higher pregnancy rate for NFH (P<0.001), for cows with reproductive disorder and for normal cows in these herds. In herds with predominantly uterine-related reproductive disorder, a high incidence of postpartum anestrus was seen infrequently; while in herds with a high incidence of postpartum anestrus, postbreeding anestrus was equally high (P<0.05 − 0.001). In general reproductive disorder have been shown to have long-term negative effects on fertility indices in both LFH and NFH, but with more serious consequences in LFH. Since a sizeable percentage of normal cows can be identified, reproducing normally under identical management conditions, cows in both kinds of herds with reproductive disorder must be less resistant to environmental stress. Thus, while cows with reproductive disorders maintained their general health and their high level of productivity, they responded either immediately with uterine disturbances or they refused to cycle properly, and they conceived later. A case can be made that all reproductive disorders represent disease entities influenced by management factors.