Age Distribution Research Articles

Soft-tissue sarcoma in Japan: National Cancer Registry-based analysis from 2016 to 2019.

No previous reports have characterized national profiles of soft-tissue sarcoma overall. We examined the nationwide statistics for soft-tissue sarcoma in Japan using data from the population-based National Cancer Registry. We identified 23 522 soft-tissue-sarcoma patients who were entered in the National Cancer Registry during 2016-19 using International Classification of Diseases-Oncology, Third Edition codes for cancer topography and morphology. We extracted data on patient demographics, tumor details (reason for diagnosis, tumor location, histology, extent of disease), hospital volume/type, treatment, and prognosis for each patient. Soft-tissue sarcoma showed a slight male preponderance. Approximately 5500-6000 new cases were diagnosed as soft-tissue sarcoma per year, with the age-adjusted incidence of soft-tissue sarcoma being 3.22/100000/year. The age distribution showed a single peak in the 70-79 age range, and sex-stratified data showed it was higher in men. The most common histologic subtype was liposarcoma. The most frequent tumor locations were the soft tissue and skin, followed by the retroperitoneum. Extent of disease was categorized as: "localized" (31.3%), "regional" (38.9%), or "distant" (10.5%). We found significant associations between overall survival and sex, age, tumor location, facility type, hospital volume, reason for diagnosis, extent of disease, and surgical treatment. This is the first study to outline the epidemiology, clinical features, treatment, prognosis, and significant factors affecting prognosis of soft-tissue sarcoma in Japan using the National Cancer Registry. Documenting our data regarding elderly patients' outcomes is essential so other countries showing similar population-aging trends can learn from our experiences. Prognostic studies, Level III.

Prognostic Value of Prolonged QT Interval in Patients with Acute Ischemic Stroke

Abstract Background Early predictors of mortality and poor functional outcome are crucial for planning the level of care and optimizing resource utilization. Nonetheless, rapid and noninvasive methods for assessing the prognosis of patients with acute hemorrhagic stroke in the emergency department (ED) are currently lacking. Aim of the Work The aim of this work is to assess and evaluate the QT- prolongation in patients with acute stroke without known cardiac disease and to correlate between prolonged QT interval and different neurological outcomes. Patients and Methods This was a case control study. Data from patients with acute ischemic stroke (stroke patients) who were admitted to the neurological intensive care unit were collected for the period from June 2021 to December 2021 at the First Affiliated Ahmad Maher teaching hospital, and patients in other departments were enrolled as controls. Results This study had several limitations. First, the study was performed in a single center, which may reduce its generalizability. In addition, we were unable to determine non-fatal long-term outcomes, such as major adverse cerebro-cardiovascular events (MACCE). Second, the mechanism underlying QTc interval prolongation remains tentative because ECG was performed at single time points, not overtime. Furthermore, major cardiac and non-cardiac comorbidities were defined as the previous history and/or ECG results at admission, thus possibly underestimating subclinical conditions. In addition, the contribution of each cardiac and non-cardiac condition to QTc interval prolongation is not equally the same. We also could not absolutely exclude patients with coronary artery disease who shared similar risk factors because we did not conduct echocardiography or coronary angiography, and this may have affected the QTc interval changes in ECG. Conclusion Prolonged QTc interval was associated with the increased risk of long-term mortality, in parallel with the increasing trend of the prevalence of cardiovascular risk profiles and stroke severity, across sex differences, such as different distributions of age, comorbidities, morality, and QTc intervals in AIS patients. Acute ischemic stroke patients may have a longer QT interval and a higher incidence of electrocardiogram abnormalities. In clinical practice, careful attention should be paid to acute ischemic stroke patients to prevent malignant arrhythmia.

Characteristics and urbanization of agricultural migrants in the Yangtze River Delta based on new-type urbanization perspective

ABSTRACT Investigating the characteristics of the agricultural floating population stands as a fundamental prerequisite for fostering human urbanization and constitutes a pivotal aspect within the framework of people-centered New-type urbanization. Drawing upon data from the 2017 China Migrants Dynamic Survey (CMDS), this study delves into the age distribution, educational attainment, and other mobility traits of the agricultural migrant populace residing in the urban agglomeration of the Yangtze River Delta, alongside examining the patterns concerning their places of origin and settlement convergence. Furthermore, utilizing questionnaire data sourced from the CMDS, this paper proceeds to evaluate the urbanization level of the agricultural floating population. The findings of this research are threefold: Firstly, the age composition of the agricultural migrant cohort predominantly comprises youthful and middle-aged laborers, characterized by limited educational attainment and chiefly inter-provincial mobility. Secondly, within urban agglomerations, the agricultural migrant influx predominantly originates from Anhui Province, while beyond these urban centers, migrants predominantly hail from provinces noted for substantial labor outflows. Thirdly, a notable proportion, one-third to be precise, of the surveyed agricultural migrants express a willingness to settle in urban locales, thereby underscoring the imperative to enhance their integration into urban societal fabric and elevate their level of civic engagement.

Relationship between the Injury Location and Swallowing Difficulty among Stroke Patients, A Retrospective Cohort Study

Post-stroke dysphagia (PSD), a neurological or mechanical disorder that hinders food transport from the oral cavity to the stomach. It has been widely associated with severe complications with higher mortality and morbidity rates. Traditional therapies for the treatment of dysphagia mainly focused on compensatory methods and behavioural rehabilitation approaches. The retrospective cohort study aimed to determine the association and correlation between developments of dysphagia in relation to the location of the stroke and to identify the swallowing recovery period following the stroke. A retrospective cohort study investigated swallowing difficulties in 64 stroke patients at an ambulatory care centre over a year. Data collection involved reviewing medical records and imaging reports, with analyses conducted using SPSS software, ANOVA and chi-square methods to assess associations between injury location and swallowing difficulty. Hemorrhagic stroke was more prevalent (65.6%) than ischemic stroke (34.4%). A significant association was found between gender and stroke type, with males exhibiting a higher prevalence of ischemic strokes (71.4%) compared to females (29.8%). Age differences between stroke types, gender and affected swallowing phases and stroke type and affected swallowing phase revealed no significant associations. Distinct differences were noted in swallowing difficulties across stroke types. Furthermore, recovery time varied depending on the intervention method, with speech therapy linked to shorter recovery periods. The study underscores the importance of considering gender and stroke-type-specific differences in stroke prevalence, age distribution, and swallowing difficulties. These findings contribute valuable insights to understanding stroke characteristics and their implications for clinical management and rehabilitation strategies.

Mapping evidence on the distribution of uterine fibroids in sub-Saharan Africa: A scoping review protocol.

Uterine fibroids are the most common pelvic benign tumours found in reproductive-aged women and may affect up to 70% of all women by menopause. Uterine fibroids place a heavy burden on women and society resulting in poor quality of life, impaired self-image, and impaired social, sexual, emotional, and physical well-being of affected individuals. This study aims to map the evidence on the burden of uterine fibroids in Sub-Saharan Africa; uterine fibroids' burden by age, uterine fibroids' geographic burden, uterine fibroids' cost estimation and reported experiences among women diagnosed with uterine fibroids. Articles will be selected from countries within Sub-Saharan Africa. This scoping review will be guided by the Arksey & O'Malley framework, enhanced by Levac et al (2010). The following electronic databases will be searched; PubMed, EBSCOhost (Cumulated Index to Nursing and Allied Health Literature and Health Source), Medical Literature Analysis and Retrieval System Online, Cochrane Library, Scopus, Web of Science, Africa Journal Online, and Google Scholar. The Population Concept and Context (PCC) framework will be used and the PRISMA flow diagram will also be used to show the literature search and selection of studies. Descriptive data analysis will be used; results will be presented in themes, narrative summaries, tables, and charts. The study anticipates finding relevant literature on the distribution of uterine fibroids, the burden of uterine fibroids in terms of geographic distribution, age distribution, and cost approximation related to the disease. This will assist in identifying research gaps to guide future research contribute to the body of scientific knowledge and develop preventative strategies for the disease.

O-103

Abstract In the mid-1970s, when women born immediately after the Second World War were at full reproductive age, the demographic transition in Europe could be considered concluded. Birth and death rates were around 10 per thousand (a quarter compared to a century earlier), fertility was around two children per woman, and the differences in fertility between countries were modest. It seemed like the end of a path towards a new demographic stability. In reality, for subsequent cohorts, things continue to change: fertility in many countries declines, while differences between countries grow. The fertility of women born around 1980 in Europe is not far from two children for France and Northern Europe, around 1.6 children in Central and Eastern Europe, around 1.4 children in Southern Europe. Although these differences may seem minimal, the medium-long term consequences on age distributions are enormous. It would be wrong, however, to say that no similar patterns of fertility exist after the end of the demographic transition. First of all, as already mentioned, there are strong similarities between countries and regions of the same geographical area: Italian fertility patterns, for example, are similar to those of other countries on the northern shore of the Mediterranean, such as Spain, Portugal, Greece and the Balkan states. Furthermore, all European countries share a progressive increase in the age at birth, both of the first and subsequent children, while late fertility (35+ years of age) increases greatly. The differences between countries are far from irrelevant. However, the variability between countries has been progressively decreasing for thirty years now. These changes in reproductive behaviours are intertwined with other important changes in Europe's natural demography. The most important is undoubtedly aging, determined by the lengthening of the average lifespan, especially by the spectacular increase in survival beyond fifty years of age. This phenomenon has also been very diversified among European states, less accentuated in particular in Eastern Europe and Russia. The imbalances in the age structure of the population generated by the joint effect of low birth rates and high survival of the elderly are attenuated by consistent and growing immigration flows from poor countries, where – contrary to what happened in Europe – the working age population grows. These population movements are accompanied by those within Europe, in particular from Eastern and Balkan countries to the other part of the continent. The future prospects of European demography are traced starting from this global description, underlining in particular what can reasonably be predicted about reproductive behaviour.

Benign epileptiform variants in EEG: A comprehensive study of 3000 patients

BackgroundThe analysis of EEG demands expertise and keen observation to distinguish epileptiform discharges from benign epileptiform variants (BEVs), a frequent source of erroneous interpretation. The prevalence of BEVs varies based on geographical, racial, and ethnic characteristics. However, most data on BEVs originates from Western populations, and additional studies on different cohorts would enrich the existing literature. MethodsWe reviewed EEGs from our institutional database to study the prevalence of benign epileptiform variants and analyzed their frequency, topography, and other characteristics. Additionally, we investigated the co-existence of epileptiform discharges with BEVs. ResultsWe identified 296 patients with BEVs after reviewing 3000 EEGs (9.9%). The most common BEV was small sharp spikes (SSS), observed in 114 patients (3.8%). Wicket waves, 6 Hz spike and slow wave, 14 and 6 Hz positive bursts, and Rhythmic Temporal Theta of Drowsiness (RTTD) were identified in 67 (2.2%), 40 (1.3%), 39 (1.3%), and 35 (1.16%) patients, respectively and one patient with Subclinical Rhythmic EEG Discharges in Adults (SREDA). Additionally, we observed the co-existence of epileptiform discharges with BEVs, most commonly with SSS (27.8%). ConclusionsThe present study is a large study with 3000 EEGs to describe the BEV characteristics. BEVs were seen in 9.9% of patients, BSSS being the most common. There were minor differences in frequency, gender or age distribution compared to existing literature. We demonstrated the co-existence of epileptiform discharges. Morphological characteristics remain the cornerstone in recognising BEVs. EEG readers need to be aware of features of BEVs to avoid wrongly interpretation.

P-143 Comparison of clinical outcomes between overnight warmed and embryo transfer day warmed blastocysts in frozen embryo transfer cycles

Abstract Study question Is there any difference between clinical outcomes of overnight warmed (ONW) and embryo transfer day warmed (ETDW) blastocysts in frozen embryo transfer (FET) cycles? Summary answer ETDW blastocysts had better clinical outcomes compared to ONW blastocysts in FET cycles. What is known already Some studies reported that the resumption of mitosis in thawed cleavage-stage embryos resulted in significantly better clinical outcomes in FET cycles. Unnecessary transfer of non-functioning embryos can be avoided by incubating thawed embryos overnight to deselect embryos that developed abnormally or failed to undergo additional cleavage. The synchronisation between a viable embryo and a receptive endometrium is vital for successful implantation to take place. The optimal implantation rates occur with embryo-endometrial developmental asynchrony of ± 1.5 days or less. The implantation rates are progressively reduced when embryo-endometrial development asynchrony is greater than 3 days. Study design, size, duration This was a retrospective study involving 2368 FET cycles in KKIVF Centre, KK Women’s and Children’s Hospital, Singapore from Jan 2021 to Dec 2022. The transfer of embryos or blastocysts derived from thawed oocytes, cleavage-stage embryos, double blastocysts and cultured blastocysts from thawed cleavage-stage embryos were excluded. Only single vitrified-warmed blastocyst transfers (n = 1445) were included in this study. Participants/materials, setting, methods Cryopreserved blastocysts were routinely warmed one day before embryo transfer (ET) using Vit Kit - Warm (FUJIFILM Irvine Scientific®) and incubated overnight (ONW group). However, when ETs fell on Monday or post public holiday, vitrified blastocysts were warmed on ET day (ETDW group). Regardless of blastocyst age, surviving blastocysts were transferred into day 5 endometrium. Statistical analysis was performed using t-test or Chi-square test. Differences with P < 0.05 were considered as significant. Main results and the role of chance No statistical significant difference was observed in terms of maternal age distribution at the time of oocyte retrieval between ONW and ETDW groups (34.26 ± 3.29 vs. 34.49 ± 3.22, P = 0.221). Overall, clinical pregnancy rates (CPR) and live birth rates (LBR) were significantly higher in the ETDW group (CPR: 47.47% vs. 40.47%, P < 0.01; LBR: 34.99% vs. 28.78%, P < 0.05). Clinical outcomes were comparable in both ONW and ETDW groups for vitrified-warmed day 5 blastocyst transfers (CPR: 51.27% vs. 58.44%, P = 0.11; LBR: 37.06% vs. 44.81%, P = 0.07). CPR (45.02% vs. 25.71%, P < 0.0001) and LBR (32.03% vs. 17.45%, P < 0.0001) were significantly increased when vitrified day 6 blastocysts were warmed and transferred on the actual day of ET. 18.42% CPR and 13.16% LBR were achieved when vitrified-warmed day 7 blastocysts were transferred on the ET day itself. However, transfer of vitrified-warmed day 7 blastocysts in the ONW group did not result in any pregnancy. Limitations, reasons for caution Study subjects were not stratified according to patient’s age band and blastocyst quality. Age itself is an independent determinant of blastocyst quality which can affect clinical outcomes. Wider implications of the findings Warming of a vitrified blastocyst on ET day is preferred regardless of blastocyst age. However, to facilitate seamless operation in laboratory, overnight warming for vitrified day 5 blastocysts is feasible without compromising clinical outcomes. Trial registration number Not applicable

Analysis of the impact of COVID-19 variants and vaccination on the time-varying reproduction number: statistical methods.

The COVID-19 pandemic has profoundly impacted global health systems, requiring the monitoring of infection waves and strategies to control transmission. Estimating the time-varying reproduction number is crucial for understanding the epidemic and guiding interventions. Probability distributions of serial interval are estimated for Pre-Delta and Delta periods. We conducted a comparative analysis of time-varying reproduction numbers, taking into account population immunity and variant differences. We incorporated the regional heterogeneity and age distribution of the population, as well as the evolving variants and vaccination rates over time. COVID-19 transmission dynamics were analyzed with variants and vaccination. The reproduction number is computed with and without considering variant-based immunity. In addition, values of reproduction number significantly differed by variants, emphasizing immunity's importance. Enhanced vaccination efforts and stringent control measures were effective in reducing the transmission of the Delta variant. Conversely, Pre-Delta variant appeared less influenced by immunity levels, due to lower vaccination rates. Furthermore, during the Pre-Delta period, there was a significant difference between the region-specific and the non-region-specific reproduction numbers, with particularly distinct pattern differences observed in Gangwon, Gyeongbuk, and Jeju in Korea. This research elucidates the dynamics of COVID-19 transmission concerning the dominance of the Delta variant, the efficacy of vaccinations, and the influence of immunity levels. It highlights the necessity for targeted interventions and extensive vaccination coverage. This study makes a significant contribution to the understanding of disease transmission mechanisms and informs public health strategies.

Extracranial Head and Neck Schwannomas: A Single Centre Retrospective Experience of 97 Cases.

Schwannomas are rare benign neurogenic tumours. About 25-45% of extracranial schwannomas are found in the head and neck region. In the head and neck, they can arise from various cranial, peripheral and autonomic nerves. Due to this, they have varied clinical presentations. This retrospective cohort includes 97 patients diagnosed with extra cranial head and neck schwannoma, and operated in the Otolaryngology and Head & Neck Surgery department, from 2013 to 2022. The parameters observed were the age and gender distribution, location, nerve of origin, size, pressure symptoms, cranial palsies, post-operative symptoms, recurrence and complications. The data were collected from the institute's electronic records. The median age of the study population was 36years; among them, 51 were men and 46 were women. The most common tumour location was parapharynx. The patients had varied head and neck symptoms, of which 23.7% had nerve paresis at presentation. Transcervical surgical approaches was most used. New onset cranial nerve paresis immediately post-surgery was noted in 22.7%. Recurrence was noted in 2% of cases. Extra cranial schwannomas are uncommon neoplasms and have varied presentations. Comprehensive evaluation with appropriate imaging should be done in all cases. Though benign, patients can present with nerve paresis. Recurrence is uncommon after complete resection.

Estimasi Populasi dan Habitat Rusa Timor (Rusa timorensis Blainville1882) dalam Kawasan Taman Wisata Alam Menipo

Knowing the population and habitat conditions of Timor Deer (Rusa timorensis), which is a protected animal, is very important to ensure the survival of this species. One of the most important habitats for Timor Deer is Menipo Nature Park, which must be well managed to support the welfare and sustainability of the species. Good management includes protection of natural habitats, regular population monitoring, and sustainable conservation efforts so that Timor Deer can survive in their natural environment. The purpose of this study was to estimate the population and habitat conditions of Timor deer in Menipo. The method used is a combination of point and path, while the habitat is described descriptively. From the results of research on the 571 ha habitat area, the population of timor deer was estimated to be 399 individuals with a population range of 366 to 432 individuals at the 95% confidence interval with a population density of 1.14 individuals per hectare. The population structure showed an inverted pyramid, indicating less than optimal conditions in terms of population age distribution. The sex ratio was 2:5 for juveniles, 2:3 for adults, and 1:1 for the old age group. This sex ratio is not good for the timor deer population as 1:5 is good. The most common type of grass for deer is timor grass (Ischaemum timorensis). Other grass species are Microlaena stipoides, Paspalum scrobiculatum, Imperata cylindrical, and Desmodium capitulum shrub. However, some areas of this habitat are covered by alien invasive species, Cromolaena odorata, which needs to be eradicated to maintain food availability. Mangrove parts eaten by Timor deer (Rusa timorensis) include young leaves, young stems, and exfoliated bark. Mangrove species commonly found as food for deer include Rhizophora mucronata, Bruguiera parviflora, and Sonneratia alba. Keywords: habitat, Menipo, population, timor deer, Rusa timorensis

Age-related task progression in two Australian Tetragonula stingless bees

Stingless bees are a widespread group of highly social bees found in tropical regions throughout much of the world. Despite an impressive diversity, relatively little is known about worker behaviour and division of labour. In this study, we investigate the progression of colony tasks over the lifespan of worker bees in colonies of the two most commonly kept Australian species: Tetragonula carbonaria and T. hockingsi. We marked cohorts of 25–100 newly emerged female bees with a paint dot and released them back into colonies housed in observation hives before recording twice weekly behaviours of marked bees within the nest. Foragers were observed through a clear plastic entrance tube. We replicated this with 5–6 marked cohorts across three colonies for each species. We found the two species were similar to each other in the frequency and age distribution of behaviours. Young worker bees were mostly found cleaning, filling or constructing brood cells and collecting honey from food pots. Middle aged bees were more likely to build or maintain food pots or supporting structures, with guarding and foraging occupying the oldest bees. There was, however, significant overlap in timing of tasks. Moreover, fast cohorts progressed to foraging in less than half the time of the slowest cohorts. Despite subtle differences between our Tetragonula species and other stingless bees, it adds to the evidence that progression from safe to risky jobs with age is an ancestral feature shared across stingless bees, and has similarities to honeybees despite an independent evolutionary origin.

Clinical epidemiology of Epstein-Barr virus-associated Lymphoproliferative Disorders (EBV-LPDs) in hospitalized children: A six-year multi-institutional study in China

BackgroundEpstein-Barr virus-associated lymphoproliferative disorders (EBV-LPDs) are a group of disorders involving lymphoid tissues or lymphocytes. The epidemiology and economic burden of hospitalized children with EBV-LPDs in China have not been well studied. This study aimed to reveal the epidemic characteristics and disease burden of EBV-LPDs among the Chinese hospitalized children, providing strategies for the prevention and management.MethodsThis study was based on the FUTang Updating medical REcords (FUTURE) database of China and collected the medical records from 27 tertiary children’s hospitals between January 2016 and December 2021 in China, counting five types of EBV-LPDs, namely EBV-positive T-cell lymphoproliferative disease, NK/T cell lymphoma, extranodal NK/T-cell lymphoma (nasal type), systemic EBV-positive T-cell lymphoproliferative disease of childhood and posttransplant lymphoproliferative disorders. We conducted a retrospective syhthesis and analysis of the epidemiological characteristics, expenses, length of stay (LOS), as well as complications among hospitalized children diagnosed with five types of EBV-LPDs and compared parameters using appropriate statistical tests.ResultsThe study described 153 children aged 0–18 years hospitalized with EBV-LPDs from 2016 to 2021 in the FUTURE database. The male-to-female ratio was 1.10:1, and more than half of the age distribution was in the 6–12 y group. Among EBV-LPDs cases, EBV+ T-LPD accounted for the largest proportion (65.36%). Complications were presented in 93 children with EBV-LPDs, mainly hemophagocytic lymphohistiocytosis (HLH). The median LOS of NKTL was 26.5 days [interquartile range (IQR) = 3–42], which was the longest among EBV-LPDs. The median hospitalization cost of PTLD was 10 785.74 United States dollars (IQR = 7 329.38–16 531.18), which was the heaviest among EBV-LPDs.ConclusionsCompared with the total number of hospitalized children in China during the same period and in the same age group, the proportion of EBV-LPD is very low. EBV-LPD can develop in all age groups, but it is more common in school-age children. Among 5 EBV-LPDs, the disease with the highest proportion is EBV+ T-LPD. The overall disease burden of EBV-LPD was heavy, especially the economic burden. HLH was one of the most common complications, which could directly affect the burden of patients because of prolonged hospitalization. These data are taken from a very large database, illustrating the epidemiological and economic burden of EBV-LPDs hospitalized children in China, which enriched the existing epidemiological and disease burden content of EBV-LPDs.

Galaxy archaeology for wet mergers: Globular cluster age distributions in the Milky Way and nearby galaxies

Context. Identifying past wet merger activity in galaxies has been a longstanding issue in extragalactic formation history studies. Gaia’s 6D kinematic measurements in our Milky Way (MW) have vastly extended the possibilities for Galactic archaeology, leading to the discovery of a multitude of early mergers in the MW’s past. As recent work has established a link between younger globular clusters (GCs; less than about 10–11 Gyr old) and wet galaxy merger events, the MW provides an ideal laboratory for testing which GC properties can be used to trace extragalactic galaxy formation histories. Aims. To test the hypothesis that GCs trace wet mergers, we relate the measured GC age distributions of the MW and three nearby galaxies, M 31, NGC 1407, and NGC 3115, to their merger histories and interpret the connection with wet mergers through an empirical model for GC formation. Methods. The GC ages of observed galaxies are taken from a variety of studies to analyze their age distributions side-by-side with the model. For the MW, we additionally cross-match the GCs with their associated progenitor host galaxies to disentangle the connection to the GC age distribution. For the modeled GCs, we take galaxies with similar GC age distributions as observed to compare their accretion histories with those inferred through observations. Results. We find that the MW GC age distribution is bimodal, mainly caused by younger GCs (10–11 Gyr old associated with Gaia-Sausage/Enceladus (GSE) and in part by unassociated high-energy GCs. The GSE GC age distribution also appears to be bimodal. We propose that the older GSE GCs (12–13 Gyr old) were accreted together with GSE, while the younger ones formed as a result of the merger. For the nearby galaxies, we find that clear peaks in the GC age distributions coincide with active early gas-rich merger phases. Even small signatures in the GC age distributions agree well with the expected wet formation histories of the galaxies inferred through other observed tracers. From the models, we predict that the involved cold gas mass can be estimated from the number of GCs found in the formation burst. Conclusions. Multimodal GC age distributions can trace massive wet mergers as a result of GCs being formed through them. From the laboratory of our own MW and nearby galaxies we conclude that the ages of younger GC populations of galaxies can be used to infer the wet merger history of a galaxy.

Assessing Urinary 8-OHdG: A Comparative Analysis between Benign Breast Diseases and Healthy Participants

Background: Benign breast problems account for a considerable share of diagnoses for breast diseases, which is a major global health concern. The study investigates the correlation between urinary 8-OHdG levels and benign breast illnesses, aiming to identify oxidative stress variations, aid in developing targeted therapies and personalized healthcare plans. Methods: This comparative study evaluated urinary 8-OHdG levels in patients with clinically suspected breast lump cases at Bangabandhu Sheikh Mujib Medical University, Dhaka. The sample included 30 healthy individuals and 30 patients with benign breast disorders. Important variables included oestrogen replacement medication, alcohol intake, age of menarche, menopause, obesity, and urinary 8-OHdG levels. Results: The study analysed 60 participants with benign breast diseases, revealing significant differences in age distribution, menarche age, BMI categories, demographic and reproductive factors, and urine 8-OHdG levels. Multiple logistic regression analysis revealed significant associations between urinary 8-OHdG concentrations and factors like age, OCP consumption history, marital status, age of menarche, breast feeding history, menopausal status, family history of breast cancer, and histopathological grading. However, body mass index and number of parities did not show significant associations with urinary 8-OHdG concentrations.

Kinematic origin of white dwarfs in the solar neighborhood

Context. White dwarfs are considered to be efficient cosmochronometers. Thanks to the recent space-borne mission Gaia, a nearly complete sample up to about 100 parsecs from the Sun has been compiled. However, the Galaxy, as a dynamic system, implies that these objects may have very diverse origins. It is therefore of paramount importance to characterize the origins of white dwarfs from the different Galactic structure components found in our solar neighborhood. Aims. We aim to compute the Galactic orbits for white dwarfs of the thin and thick disk, as well as the halo components observed in our solar neighborhood. On the basis of these determinations, we analyze the most probable regions of the Galaxy where they could have formed, along with the distribution of their orbital parameters and the observational biases introduced when constructing the local sample. Methods. We used a detailed Galactic orbit integration package, in conjunction with a detailed population synthesis code specifically designed to replicate the different Galactic components of the white dwarf population. Synthetic stars were generated based on the current observational sample and their orbital integration allowed for the reconstruction of the population’s history. Results. Our kinematic analysis of the white dwarf population reveals the ephemeral nature of the concept of the solar neighborhood, as the majority of thin-disk, thick-disk, and halo white dwarfs will have left our 100 pc neighborhood in approximately 3.30 Myr, 1.05 Myr, and 0.6 Myr, respectively. Moreover, the spatial distribution of the integrated thin-disk orbits suggests that 68% of these stars were formed at less than 1 kpc from the Sun, while most of the thick-disk members have undergone radial disk migration. Halo members are those stars that typically belong to the “inner halo”, given that their orbits mostly planar and do not extend beyond R = 20 − 25 kpc. Despite the observational bias, which mostly affects the oldest stars in the thick disk and halo, we show that the wider distribution of orbital parameters is well represented by the sample. Conclusions. The solar neighborhood is a transitory concept, whereby its current population of white dwarfs originates from larger regions of the Galaxy. This fact must be taken into account when analyzing the overall properties of such a population, such as its age distribution, metallicities, and formation history. Even so, the kinematic properties observed by recent missions such as Gaia are representative of the total population up to a distance of approximately 500 pc.

Prevalence and risk factors of hyperuricemia among freshmen at Beijing Sport University from 2021 to 2022

To investigate the prevalence of hyperuricemia among freshmen enrolled in Beijing Sport University and to explore the influencing factors of hyperuricemia in the college population. The study period was from September 2021 to February 2022.3372 freshmen of the class of 2021 from Beijing Sport University in Beijing were selected as the study subjects, and two blood uric acid tests were performed on non-same days to calculate the prevalence of the population and to explore the risk factors of hyperuricemia in the college student population using a case-control method.246 people were selected from the hyperuricemia patients of the population to be included in the case group by convenience sampling, and 211 people were selected from the non-hyperuricemia persons of the population to be included in the control group. They were included in the control group, underwent physical and laboratory examinations, and were retrospectively surveyed with questionnaires that included general information such as age, gender, specialty, place of birth, and diet related to hyperuricemia, awareness of hyperuricemia disease, physical activity level, and sleep. Statistical analysis was performed using chi-square analysis, one-way Logistic regression analysis, and multi-factor logistic regression analysis. The number of patients actually diagnosed with hyperuricemia by two blood uric acid tests on non-same days was 479, with a population prevalence rate of 14.21%. Among them, the number of males in the diseased population was 391(22.39%), and the number of females in the diseased population was 88(5.41%). A total of 457 subjects were enrolled in the case-control study, among them, 246 in the case group(218 males and 28 females, average age 19.74 years), 211 in the control group(177 males and 34 females, average age 19.93 years), and 247 in the case group, 211 in the control group, and 2 groups of subjects were included. A total of 211 subjects, and there was no significant difference between the 2 groups in terms of gender composition and age distribution. One-way logistic regression analysis showed that central obesity(OR=31.52, 95%CI 7.59-130.86), obesity(OR=2.59, 95%CI 1.20-5.58), overweight(OR=1.67, 95%CI 1.08-2.59), frequent consumption of fresh vegetables(OR=0.66, 95%CI 0.43-0.99), and drinking 1500-2000 mL of water per day(OR=0.63, 95%CI 0.41-0.95) were associated with hyperuricemia, and multifactorial Logistic regression analyses were performed to analyze the above factors, and finally central obesity(OR=32.05, 95%CI 7.65-134.20), BMI obesity(OR=3.22, 95%CI 1.44-7.20), and daily water intake of 1500-2000 mL(OR=0.60, 95%CI 0.37-0.95) were included in the model at the level of P=0.05. The current high prevalence of hyperuricemia in the college student population, which is more prevalent in male college students. Obesity and central obesity are risk factors for hyperuricemia in young college students, and daily water intake of 1500-2000 mL is a protective factor.

Seroprevalence of Dengue and Hepatitis B infections among young adults attending a secondary health care facility at Olabisi Onabanjo University, Ogun State, Nigeria

Hepatitis B and Dengue virus infections carry significant public health implications due to their potential to cause illness and death. This study focused on examining the prevalence of these infections among young adults seeking care at a secondary health facility at Olabisi Onabanjo University. Ninety samples obtained from study participants underwent screening using Enzyme-linked Immunosorbent Assay (ELISA) for both HBsAg and Dengue IgM. The participants, predominantly female, were aged between 15 and 30 years. The analysis revealed a 13.3% prevalence of Dengue IgM, a 4.5% prevalence of HBsAg, and a 4.4% prevalence for both infections. Regarding age distribution, the highest prevalence occurred among participants aged 15-20 years for both single infections and the co-occurrence of Hepatitis B and Dengue viral infections. Examining gender distribution, female participants exhibited higher seropositivity across all infection categories. Although not statistically significant, these findings lay the groundwork for a comprehensive surveillance study on the Hepatitis B and Dengue viral infections in young adults. This study provides valuable insights into the prevalence patterns of Hepatitis B and Dengue virus, offering a basis for further research and public health interventions in this population.

PROFILE OF DYSPHAGIA IN ACUTE STROKE PATIENTS

Background: Stroke has been a leading cause of mortality and disability since 2013, and its incidence continues to rise. Dysphagia is a common complication following stroke, contributing to increased rates of aspiration, pneumonia, and prolonged hospital stays for stroke patients. Objective: This study aims to investigate the profile and distribution of acute stroke patients experiencing dysphagia who are admitted to RSUD dr. Saiful Anwar in East Java. Methods: The assessment was conducted on acute stroke patients with compos mentis consciousness in the Stroke Unit from July to September 2023, using the GUSS (Gugging Swallowing Screen) questionnaire. The assessment categories included no dysphagia (20), mild dysphagia (15-19), moderate dysphagia (10-14), and severe dysphagia (0-9). Results: Data collected during the period from July to September 2023 yielded a total of 35 samples. Based on gender, there were 22 male patients (62.9%) and 13 female patients (37.1%). Regarding age distribution, 15 patients fell into the productive age range (20 to 59 years), while 20 patients were over 60 years old. The majority of cases were ischemic strokes, with 25 patients, and 10 patients had hemorrhagic strokes. Dysphagia assessment using the GUSS method on the 35 samples revealed 2 samples with GUSS scores of 12 and 14 (moderate) and 1 sample with a score of 18 (mild). Conclusion: The profile and distribution of acute stroke patients experiencing dysphagia were identified, including gender, age, type of stroke, and GUSS scores in acute stroke patients in the stroke unit with Compos Mentis consciousness.

Patient Demographic Factors Affect Response Rates to Patient-Reported Outcome Measures for Total Hip Arthroplasty Patients

BackgroundThe Hip Disability and Osteoarthritis Outcome Score (HOOS JR) is a widely used patient-reported outcome measures questionnaire for total hip arthroplasty (THA). However, not all patients choose to complete HOOS JR, and thus, a subset of the THA population may be underrepresented. This study aims to investigate the association between patient demographic factors and HOOS JR response rates. MethodsThis was a retrospective cohort study of adult, English-speaking patients who underwent primary THA by a fellowship-trained arthroplasty surgeon between 2017 and 2023 at a single, high-volume academic institution. The HOOS JR completion status—complete or incomplete—was recorded for each patient within 90 days of surgery. Standard statistical analyses were performed to assess completion against multiple patient demographic factors. ResultsOf the 2,908 total patients, 2,112 (72.6%) had complete and 796 (27.4%) had incomplete HOOS JR questionnaires. Multivariate analysis yielded statistical significance (P < .05) for the distribution of patient age, race, insurance, marital status, and income quartile with respect to questionnaire completion. Patient sex or religion did not affect response rates. Failure to complete HOOS JR (all P < .001) was associated with patients aged 18 to 39 (59.8%), who identified as Black (36.4%) or “other” race (39.6%), were never married (38%), and were in the lower half income quartiles (43.9%, 35.9%) when compared to the overall incomplete rate. ConclusionsMultiple patient demographic factors may affect the HOOS JR response rate. Overall, our analyses suggest that older patients who identify as White and are of higher socioeconomic status are more likely to participate in the questionnaire. Efforts should focus on capturing patient groups less likely to participate to elucidate more generalizable trends in arthroplasty outcomes.