The purpose of this study is to specifically identify the stress factors of multicultural youth and analyze the relationship between stress, health, and life satisfaction, and provide implications for stress management and life satisfaction. The study population was 2,022 participants (5th graders) of the Multicultural Adolescent Panel Survey (2nd cohort) conducted by the National Youth Policy Institute, and was analyzed using a structural regression model. First, personal factors had the greatest impact on stress, followed by academic and family factors. Second, stress had a negative effect on both health assessment and life satisfaction, and the effect size was the same. Third, self-rated health assessment had a positive effect on life satisfaction. It is noteworthy that personal factors had a higher impact on stress than academic and family factors, suggesting that it is important to increase the positive self-concept and self-esteem of multicultural adolescents. It also reaffirms the importance of managing stress in order to improve health assessment and life satisfaction.urpose