Adiantum Philippense Research Articles

Phytochemical screening and evaluation of antibacterial, antipyretic, hypoglycemic, and anxiolytic effects of Adiantum philippense leaf extracts

Adiantum philippense (AP) is a source of various important phytochemicals and has been traditionally used to cure many diseases, including dysentery, ulcers, fevers, cooling, and elephantiasis. This study aimed to evaluate the anti-bacterial, anti-pyretic, analgesic, and anxiolytic effects of AP using a number of in vitro and in vivo test protocols. For this, dried leaves were extracted by the Soxhlet extractor using ethanol. The crude ethanol extract was then fractionated by treating with chloroform and n-hexane. A preliminary phytochemical screening was done for its crude extracts. The antibacterial activity of ethanol, chloroform, and n-hexane extracts of AP was tested against 10 pathogenic bacteria at concentrations of 500 µg/disc. The ethanol extract showed significant activity against Gram (+ve) and Gram (-ve) bacteria. In mice, the chloroform extracts showed significant (p <0.05) antipyretic and hypoglycemic effects, while the ethanol extract exerted significant anxiolytic effects on mice. The results obtained from this study indicate that AP leaf extracts contain important phytochemical groups and exert antibacterial, antipyretic, hypoglycemic, and anxiolytic effects. Further studies are required to isolate the bioactive compounds responsible for these claimed biological activities.

In-vitro Neuro-2a cytotoxicity analysis and molecular docking investigation on potential anti-amyloid agents from Adiantumlunulatum

In neurodegenerative diseases, amyloid formation by some proteins cause neuronal damage and loss. To prevent this neuronal damage and loss certain pharmaceuticals are available. Many of these pharmaceuticals act on the neurodegenerative disease symptoms but not on the root cause. This study helps to detect more effective agents which directly act on the root cause and reduce the risk of neurodegenerative diseases. To identify new anti-amyloid agents, the folk medicinally important plant Adiantum lunulatum was collected, authenticated, dried, extracted with ethanol and analyzed by GC-MS method. The screening of the identified phytochemicals was done using the webservers swissADME and ProTox-II. In-vitro MTT assay using Neuro-2a cell lines was carried out to determine the cytotoxicity of the extract. The interactions of these phytochemicals with the amyloid forming peptides and proteins were predicted using the molecular docking tools such as AutoDock Vina and BIOVIA discovery studio visualizer 2020. Through GC-MS analysis, 18 different volatile phytochemicals were identified from the ethanol extract. From this, 7 phytochemicals were selected based on the computational non-toxicity prediction. In-vitro cytotoxicity analysis of the ethanol extract using Neuro-2a cell lines detected the IC50 value of 0.09 mg/ml. Of these, the phytochemical P1 (trans, trans-9, 12-Octadecadienoic acid, propyl ester) interacts with tau, and huntingtin proteins, P2 (2-Pentadecanone, 6, 10, 14-trimethyl-) interacts with prion protein. The phytochemicals P1, P3 (Ethyl oleate), P4 (Octadecanoic acid, ethyl ester), and P5 (Phytol) interact with acetylcholinesterase. P2, P4, P5 and P6 (Henicosanal), interact with BACE-1. The phytochemical P3 interacts with γ- Secretase. The interaction of P2 and P5 with BACE-1 and P3 with γ- Secretase show better inhibition in inhibitory constant (Ki) analysis. These phytochemicals have been predicted to show significant potential against the formation or breakdown of peptide/protein amyloids, and further in-vitro studies are necessary to develop them into anti-amyloid agents.

Floristic Composition of Nandihalli, in Ballari district

Abstract: The current study based on the broad survey on the floristic composition of Jnana sarovara campus Nandihalli, postgraduate centre of VSKUB. This research enumerates total 204 plants species belonging to 156 genera 61 families. Among the collected plant families dominant are Fabaceae with 23 species (11.2%) stands first followed by Euphorbiacae with 17(8.3%), Poaceae 15(7.3%), Apocynaceae 11(5.3%) and Lamiaceae 8(3.9%). Dominant plants species were Parthenium hysterophorus, Lantana camara, Rostellularia procumbens, Senna uniflora, Dactoyloctenium aegyptium. Also documneted the pteridophytes plant species like Adiantum Philippense, Perkinsonia Aculata, Madhuca Longidolia. Among the species this shows IUCN RED LIST, PG Center, Nandihalli. As per research paper most of collected species belongs to , LC 82 (40%) , EN 2 (0.9%), DD 1(0.4%). The survey reveales that, the Herbs 102 speies (50%) are dominant followed by the shrubs 50(24.5%), trees 37(18.1%), and climbers 15 (7.3%). Majority of the documented plant species were used against several diseases, either alone or in combination with other plants. Herbal medicine offers safe, gentle and effective treatment. It does not just treat the isolated signs and symptoms of disease but treats the whole of us – physically, mentally because the healing cannot be fully achieved unless all are addressed .

A Review of Antiulcer Activity of Some Medicinal Plants

Peptic ulcer is a gastrointestinal disorder and with increased prevalence. Peptic ulcer is breaking of endothelial lining of stomach and exposing underlying tissues. Peptic ulcer occurs due to high secretion of acid and reduced defensive factors in stomach and duodenum. It is imbalance between aggressive and defensive factors. Non-steroidal anti-inflammatory drugs and Helicobacter pylori infection also increases the risk of peptic ulcer. Indiscriminate use of synthetic drugs leads to adverse effects and concomitant use of antibiotics potentiates drug-drug interaction thus search of drugs from natural sources especially herbs is need of hour. several herbal medicines have been evaluated for its antiulcer efficacy using several ulcer inducing models in laboratory animals. Present study aims at review of gastroprotective and ulcer healing potential medicinal herbs and compilation of data. This article is only restricted to antiulcer efficacy of the medicinal plants. This review presents information about the anti-ulcer efficacy of medicinal plants and various antiulcer models used to screen them. Keywords: Peptic ulcer, Gastric ulcer, Gastroprotective activity, Phyllanthus urinaria, Adiantum lunulatum, Ulcer healing activity

Phytochemical Screening and α-Glucosidase Inhibitor Activity of Aerial Parts of Maidenhair Fern: &lt;i&gt;Adiantum lunulatum&lt;/i&gt;

Background: Medicinal plants and herbs are used extensively in traditional medicine to treat and manage a wide range of conditions, including diabetes mellitus and its after-effects. As diabetes mellitus is increasing rapidly and is mostly caused by changes in lifestyle, the use of traditional medicines for its treatment and management has increased. Fern extracts have demonstrated tremendous potential in the management of diabetes, cancer, cardiovascular problems and neurological disorders. A prominent class of type 2 antidiabetic drugs and α-glucosidase inhibitors work by lowering postprandial hyperglycemia. Aim: The purpose of this in vitro investigation was to assess any possible inhibitory effects of aerial portions of the Maidenhair Fern (Adiantum lunulatum Burm). Methods: Using extracts of Adiantum lunulatum derived from methanolic and chloroform solvents, the research team performed phytochemical screenings to ascertain if the extracts could stop α-glucosidase. Results: Minimising the postprandial plasma glucose spikes is achieved by delaying the absorption of carbs and glucose by inhibiting the activity of α-glucosidase. The chloroform extract of Adiantum lunulatum exhibited an IC50 value of 705.02 ± 2.122 μg/ml and the methanol extract exhibited an IC50 value of 526.12 ± 1.155 μg/ml. Acarbose was used as a positive control with an IC50 value of 314.11 ± 1.021 μg/ml. The methanol extract exhibited more potent alpha-glucosidase inhibitory activity than other extracts. The phytochemical screening of the extracts showed the presence of polyphenols and flavonoids. The microscopic study of the rachis of the fronds was carried out which showed the presence of a single layer of epidermic, sclerenchyma, stele and exarch xylem which helps in authentication. Conclusion: These findings can pave the way for the development of novel medicinal compounds derived from the Maidenhair Fern and bring more standardisation to the use of traditional herbal therapies for the treatment of diabetes mellitus.

Efficacy of Quercetin and Kaempferol from Methanolic Extracts of Adiantum lunulatum Burm. F. and Polystichum acrostichoides as Antidiabetic Activity

In present investigation, the aerial parts of two fern species viz. Polystichum acrostichoides (PA) and Adiantum lunulatum (AL) were used to evaluate the potent antidiabetic activity. Methanol solvent was used for extraction by soxhlation method followed by LC-MS analysis to identify the presence of compounds in both the extracts. Further, isolation of the major compounds was carried out and characterized by IR, mass and NMR techniques. Thereafter, in vitro α-amylase inhibitory activity for both the extracts was determined by comparing with acarbose as standard. Thereafter, α-glucosidase inhibition activity followed by glucose uptake was studied using L6 cell line study. Practical yield for both the fern extracts was calculated and observed A. lunulatum extract showed more yield (7 g) than P. acrostichoides (3 g). Based on the analytical data, isolated compound was identified as quercetin and kaempferol from the A. lunulatum and P. acrostichoides extracts, respectively. A. lunulatum extract even showed better dose dependent α-amylase inhibition and α-glucosidase inhibition activity than P. acrostichoides furthermore, L6 cell line study showed increased glucose uptake by A. lunulatum extract than P. acrostichoides extract when compared with standard insulin. Based on the findings, it appears that the both A. lunulatum and P. acrostichoides have the potential to be used as antidiabetic drugs due to presence of major isolated flavonoids i.e. quercetin and kaempferol as among the bioactive compounds. Antidiabetic efficacy was dosage dependent and A. lunulatum extract was more effective in inhibiting glucose uptake than P. acrostichoides extract.

Assessing the effect of solvent extraction on the antioxidant activity of Polystichum acrostichoides and Adiantum lunulatum aerial parts: A comparative study

Introduction and Aim: Free radicals have been established detrimental effects on human health, mostly because of oxidative stress. Antioxidants are essential in reducing these effects and protecting cells from oxidative damage. As a result, there is rising interest in finding natural antioxidants. In this work, Polystichum acrostichoides and Adiantum lunulatum aerial parts, both widely utilized in medical systems for their therapeutic effects and as sources of free radicals, were examined to see how solvent extraction affected their antioxidant activity.&#x0D; &#x0D; Materials and Methods: In both plants' methanolic and hexane extracts, the amounts of phenolic and flavonoid compounds were measured. Utilizing the ABTS, DPPH, and hydroxyl radical scavenging tests, the antioxidant activity of the extracts was evaluated.&#x0D; &#x0D; Results: In both plant species, the methanolic extracts had higher phenolic and flavonoid contents than the hexane extracts. Notably, the ABTS, DPPH, and hydroxyl radical scavenging assays revealed that the methanol extract had the best antioxidant potency. On the other hand, there was no apparent antioxidant action in the hexane extracts.&#x0D; &#x0D; Conclusion: The results suggest that the aerial parts of Polystichum acrostichoides and Adiantum lunulatum could be effective sources of antioxidants. In the ABTS, DPPH, and hydroxyl radical scavenging experiments, the methanolic extracts had reduced IC50 values, which indicated that they had considerable antioxidant activity. These results demonstrate the potential of these ferns in the creation of innovative treatments for a range of oxidative stress-related diseases.

Chemical and Pharmacological Potential of Adiantum philippense Linn and Further Molecular Simulation Study of Its Compounds Against COX-2: An Unexplored Medicinal Fern

Chemical and Pharmacological Potential of Adiantum philippense Linn and Further Molecular Simulation Study of Its Compounds Against COX-2: An Unexplored Medicinal Fern

Ethnopharmacological properties of the fern Adiantum lunulatum: A Review

Adiantum lunulatum (Hamsapadhi) is a cosmopolitan tropical fern that is traditionally employed in folklore medicine to address various maladies. The fern is a reservoir for major plant secondary metabolites like tannins, saponins, alkaloids, phenolics flavonoids, etc. Accredited the presence of phytochemicals the fern portrays pharmacological properties like antimicrobial, antifertility, hepatoprotective, anti-ulcerative, antipyretic, gastroprotective properties, etc. Despite numerous evidences of pharmacological applications in traditional medicines, there are very few in vitro and in vivo studies on the fern to corroborate its pharmacological properties and to appraise it as a prospective therapeutic agent, thus necessitating more research in this fern. The current review circumscribes the phytochemistry of the fern and its concomitant pharmacological properties.

GC-MS Screening of Adiantum lunulatum Burm. F Phytochemicals and Interaction with COX-2, TRPV1, and TRPC3 Proteins-bioinformatics Approach

Background:The Adiantum lunulatum is a medicinally important pteridophyte used to treat inflammatory-related diseases. The phytochemical profile of this plant is poorly investigated.Objective:Here, we screened the nonpolar phytochemicals and their interactions with cyclooxygenase 2 (COX-2) enzyme (inflammation), transient receptor potential cation channel V member 1 (TRPV1), and transient receptor potential channel 3 (TRPC3) receptors (pain).Methods:The identification and molecular docking analysis used gas chromatography-mass spectrometry (GC-MS), AutoDock Vina, and BIOVIA discovery studio visualizer 2020. The online computer tools Swiss ADME and admetSAR predicted these compounds' bioavailability and toxicity.Results:GC-MS analysis detected the 12 different compounds. Five compounds with high similarity to mass spectrum were selected for molecular docking. This includes 2, 4 di-tert-butylphenol; n-hexadecanoic acid (palmitic acid); 2 pentadecanone, 6, 10, 14-trimethyl-; Quinoline 1, 2 dihydro 2, 2, 4 trimethyl and 3, 7, 11, 15-tetramethyl hexadec 2-en-1-yl acetate. These compounds showed interaction with the binding pocket of COX-2, TRPV1, and TRPC3 proteins. This interaction with enzyme and receptor activity causes a reduction in inflammatory pathogenesis.Conclusion:This study enhances our fundamental knowledge of biologically important volatile phytochemicals in Adiantum lunulatum dichloromethane extract and its possible effects in reducing inflammatory responses.

Pharmacognostical Study of Leaf of Hamsapadi (Adiantum Lunulatum)

Pharmacognostical evaluation of leaves of Adiantum lunulatum is done for identification in field and for differentiation from other species of Adiantum. Methods: A detailed literary work of drug studied and its pharmacognostical, phytochemical and analytical study including powder microscopy and taste determination of leaves with suitable instruments. Results: Macroscopic evaluation reveals the pinnacles are half moon shaped, alternate, sub-opposite or opposite in apical portion of the frond, having lobes with minor incisions. In microscopic structure the two surfaces of pinna are covered by epidermis and epidermal cells are wavy in outline. The opening and closing of stomata will be regulated by guard cells, whereas there is absence of stomata on epidermis. The vascular cells are lined by an endodermal tissue. Transverse section of petiole showed that it is externally covered by an epidermis lined by cuticle on its outer wall which renders the petiole to be shining. Below the epidermis is a fairly thick hypodermis made up Sclerenchyma cells of 4-5 layers in thickness. They are dead cells compact in arrangement and look dark in colour. Powder microscopy of leaves reveals shows few Tracheids of the veins and the Parenchyma cells of the leaves. The Sori are very prominent structures occurring at the leaf margin, they are visible characteristically under the microscope. The Sori contain number of Sporangia each Sporangium is lined by cells with U shaped thickening having their outer wall thin in nature. Conclusion: This study will help in Authentication of Hamspadi plant.

CRYPTOGAM DIVERSITY AND ECONOMIC UTILITY OF NILAMBUR, MALAPPURAM, KERALA

The present study resulted in recording of 22 species of Pteridophytes belonging to 14 families from Nilambur. Plants were collected from 35 sites of the study area Selaginellaceae, Pteridaceae and Thelypteridaceae are the common families in this area. Selaginellaceae consist of 3 species. Pteridaceae are with 5 species and Thelypteridaceae with 2 species. Selaginella, Pteris and Christella are the dominant genera of the area. Selaginella, Pityrogramma, Pteris, Athyrium, Christella and Tectaria are more common in the study area. Alsophila gigantea, Adiantum philippense, Anisocampium cummingianum, Macrothelypteris torresiana, Bolbitis terminans and Drynaria quercifolia were the rate species of the study area. The distribution pattern varies from site to site. Keywords: Nilambur, Pteridophytes, Survey

The diversity of Pteridophytes in pepe watershed Surakarta polluted by household waste

Pepe River is one of the Bengawan Solo with a reasonably high level of water pollution due to the habit of the surroundings in throwing garbage into the river. Plants that can survive in polluted land conditions have a high tolerance level, called pioneer plants. One of them is ferns (Pteridophyta). This study aims to identify the type, abundance, Important Value Index (IVI), and index Diversity of pteridophytes plant diversity in the Pepe Watershed. The method used in this research is descriptive quantitative using the quadrat sampling technique method with a 1x1 meter plot. The sampling technique is using purposive sampling. Data analysis was conducted qualitatively and quantitatively. Analysis of diversity index data (H’) by Shannon-Wiener. Based on the results of the study found eight species of ferns from 5 families. There are Pteris vittata, Pteris biaurita L., Adiantum lunulatum Burm.fil., Adiantum latifolium Lam., Adiantum hispidulum Sw, Marsilea crenata C. Presl, Microlepia speluncae (L.) T. Moore, and Asplenium scandicinum Kaulf. This diversity is included in the medium category with H'= 1.44. The fern with the highest abundance was Pteris vittata with 176 individuals, a density of 5.87 individuals/m2, a frequency of 0.53, and an IVI of 109.3%. Set side by set, the lowest abundance was Microlepia speluncae with eight individuals, a density of 0.27 individuals/m2, a frequency of 0.03, and IVI of 5.6%. Based on this, ferns can survive in polluted river areas. Information on the diversity of ferns found on critical land, especially rivers, is expected to provide initial information in overcoming other similar critical lands.

The Effect of the plant Adiantum philippense Extracts on Biofilms Formation and Adhesion to Shigella flexneri: A Predictive Modelling Approach

In the quest for novel bioactive metabolites, which can also be used as therapeutic agents, Adiantum philippense (A. philippense), an ethnomedically important fern, has become a fascinating herb. In this study, the predictive mathematical modelling of A. philippense crude extract was tested against Shigella flexneri, a common food pathogen for its phytochemical constituents, antagonistic ability, and effect on bacterial adhesion and biofilm formation was calculated. Various kinetics models such as Von Bertalanffy, Baranyi-Roberts, modified Schnute, Modified Richards, Modified Gompertz, Modified Logistics and latest Huang were used to get values for the above kinetic constants or parameters. modified Gompertz of the entire model was found to be the best model with the highest adjusted R2 value and lowest RMSE value. The accuracy and bias factors values were close to unity (1.0). The maximum specific growth rate (mmax (h-1) for S. flexneri treatment with A. philippense extract was significantly much lower (p&lt;0.05) with a value of 0.292 (95% confidence interval of 0.254 to 0.331) compared to control with a value of 0.540 (95% confidence interval of 0.481 to 0.599) indicating potential biofilm inhibition.

Green synthesis of iron oxide nanoparticles and their ameliorative effect on arsenic stress relief in Oryza sativa seedlings

Nanotechnology has immense potential in the field of agriculture. This study utilized an eco-friendly method to synthesize iron oxide nanoparticles (FeO-NPs) using leaf extract of Adiantum lunulatum. The synthesized FeO-NPs were characterized by UV–visible spectroscopy, FTIR, zeta potential, XRD, EDX and TEM analysis. The nanoparticles were quasi-spherical, with a mean particle size of 5 ± 1 nm (range: 3–10 nm). The 100 mg/L dose of FeO-NPs was further applied in the rice growth medium to check the effect of FeO-NPs on the growth of rice seedlings against arsenic (As) stress. FeO-NPs significantly improved seed germination by 9.8% and 15.4%, respectively, of seeds germinated under 50 μm AsIII and 50 μm AsV stress when compared to seed germinated in only 50 μm AsIII and 50 μm AsV. The phytotoxic effect of AsIII on seed germination, seedling growth, chlorophyll content was more severe than AsV. However, IONP fertigation helps the rice plants to overcome the detrimental effect caused by As exposure. FeO-NPs increased the growth and vigour of the seedlings under As stress. The uptake and translocation of As by seedlings were decreased with IONP fertigation under As stress. The reduced accumulation of As in seedlings treated with FeO-NPs caused a significant (p ≤ 0.05) reduction in oxidative stress and antioxidants activities. All these findings indicated that the synthesis of FeO-NPs using Adiantum lunulatum leaf extract not only produces safe and non-toxic FeO-NPs but these FeO-NPs can be also efficiently improve the rice seedling growth under As stressed condition.

Total Free Proline Estimated in Some Selected Species of Pteridophytic Flora of Rajasthan

Proline, a well-known amino acid, has been estimated in ten different pteridophytes, including Adiantum capillus-veneris L., Adiantum caudatum L., Adiantum incisum Forssk., Adiantum philippense L., and Actiniopteris radiata (Sw.) link. Christenh. in various organs such as the root, rhizome, and leaves Hemionitis anceps (Blanf.) Christenh., Hemionitis bicolor (Roxb.) Christenh., Hemionitis formosana Christenh (Hayata). Result of study is indicate that the maximum total proline in entire plant was recorded 43.54 mg/gdw and leaves have been recorded 24.10 mg/gdw in Pteris vittata subsp. vittata and the minimum value was recorded 3.60 mg/gdw in root of Adiantum caudatum L.

Diversity of Pteridophytes in Nipani Taluk, Karnataka, India

Considering diverse ecological and topographical conditions, Nipani Taluk is close to the Eastern ranges of Western Ghats. Adi Hill and Stavanidhi Ranges are the extended branches of the Western Ghats. An attempt was undertaken to enumerate the ferns from Nipani Taluk to fill the gap of a valid document of the ferns from the study area. During the study, 14 species from 9 different genera of 6 different families were recorded. The distribution of some species is found to be unique from Adi Hill and Stavanidhi Ranges. The study revealed that the number of species from family Pteridaceae was the highest, common to both the ranges followed by family Ophioglossaceae, Marsileaceae, Lomariopsidaceae, Salviniaceae and Polypodiaceae. Adiantum philippense L. was dominantly found in both the studied areas, while Adiantum incisum Forssk. and Actiniopteris radiata (Sw.) Link are less dominant. Whereas Microsorum membranaceum (D. Don) Ching is least populated and found very rarely at both the study area.

Antimicrobial metabolite profiling of Nigrospora sphaerica from Adiantum philippense L.

BackgroundEndophyte bestows beneficial aspects to its inhabiting host, along with a contribution to diverse structural attributes with biological potential. In this regard, antimicrobial profiling of fungal endophytes from medicinal plant Adiantum philippense revealed bioactive Nigrospora sphaerica from the leaf segment. Chemical and biological profiling through TLC–bioautography and hyphenated spectroscopic techniques confirmed the presence of phomalactone as an antimicrobial metabolite. ResultsThe chemical investigation of the broth extract by bioassay-guided fractionation confirmed phomalactone as a bioactive antimicrobial secondary metabolite. The antimicrobial activity of phomalactone was found to be highest against Escherichia coli by disc diffusion assay. The MIC was found to be significant against both Escherichia coli and Xanthomonas campestris in the case of bacteria and dermatophyte Candida albicans at 150 μg/ml, respectively. ConclusionsOverall, the results highlighted the antimicrobial potential of phomalactone from the endophyte Nigrospora sphaerica exhibiting a broad spectrum of antimicrobial activity against human and phytopathogenic bacteria and fungi. This work is the first report regarding the antibacterial activity of phomalactone.

Hepatoprotective and antioxidant effect of Adiantum lunulatum Burm. F. leaf in alcohol-induced rat model.

Background Adiantum lunulatum Burm. F. leaf (AL) and its related species have been used traditionally for the treatment of various diseases. Objective The present study evaluated the hepatoprotective, and antioxidant activities of ethanolic extract of AL. Methodology and Result The hepatoprotective effect of AL was evaluated against ethanol-induced hepatotoxicity in rats. Administration of ethanol (2 g/kg) showed a significant biochemical and histological deterioration in the liver of experimental animals. Pretreatment with ethanolic extract of AL (250 and 500 mg/kg b.wt. p.o) significantly reduced the elevated levels of serum enzymes like serum glutamic-oxaloacetic transaminase (AST), serum glutamic-pyruvic transaminase (ALT), alkaline phosphatase (ALP), total protein, total bilirubin and reversed the hepatic damage in the liver which evidenced the hepatoprotective activity. The superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) level notably increased due to doses of AL. Conclusion The results of the present study demonstrate that the ethanolic extract of AL possesses hepatoprotective and antioxidant activities. Graphical Abstract.

Effect of Adiantum philippense Extract on Biofilm Formation, Adhesion With Its Antibacterial Activities Against Foodborne Pathogens, and Characterization of Bioactive Metabolites: An in vitro-in silico Approach.

Adiantum philippense (A. philippense), an ethnomedicinally important fern, has become an interesting herb in the search for novel bioactive metabolites, which can also be used as therapeutic agents. Primarily, in this study, A. philippense crude extract was screened for its phytochemical constituents, antagonistic potential, and effect on bacterial adhesion and biofilm formation against common food pathogens. Phytochemical profiling of A. philippense was carried out by using High Resolution-Liquid Chromatography and Mass Spectroscopy (HR-LCMS) followed by antibacterial activity via agar cup/well diffusion, broth microdilution susceptibility methods, and growth curve analysis. Antibiofilm potency and efficacy were assessed on the development, formation, and texture of biofilms through light microscopy, fluorescent microscopy, scanning electron microscopy, and the assessment of exopolysaccharide production. Correspondingly, a checkerboard test was performed to evaluate the combinatorial effect of A. philippense and chloramphenicol. Lastly, molecular docking studies of identified phytochemicals with adhesin proteins of tested food pathogens, which helps the bacteria in surface attachment and leads to biofilm formation, were assessed. A. philippense crude extract was found to be active against all tested food pathogens, displaying the rapid time-dependent kinetics of bacterial killing. A. philippense crude extract also impedes the biofilm matrix by reducing the total content of exopolysaccharide, and, likewise, the microscopic images revealed a great extent of disruption in the architecture of biofilms. A synergy was observed between A. philippense crude extract and chloramphenicol for E. coli, S. aureus, and P. aeruginosa, whereas an additive effect was observed for S. flexneri. Various bioactive phytochemicals were categorized from A. philippense crude extract using HR-LCMS. The molecular docking of these identified phytochemicals was interrelated with the active site residues of adhesin proteins, IcsA, Sortase A, OprD, EspA, and FimH from S. flexneri, S. aureus, P. aeruginosa, and E. coli, respectively. Thus, our findings represent the bioactivity and potency of A. philippense crude extract against food pathogens not only in their planktonic forms but also against/in biofilms for the first time. We have also correlated these findings with the possible mechanism of biofilm inhibition via targeting adhesin proteins, which could be explored further to design new bioactive compounds against biofilm producing foodborne bacterial pathogens.