Addictive Behaviors Research Articles

Opioid Use and Gut Dysbiosis in Cancer Pain Patients.

Opioids are commonly used for the management of severe chronic cancer pain. Their well-known pharmacological effects on the gastrointestinal system, particularly opioid-induced constipation (OIC), are the most common limiting factors in the optimization of analgesia, and have led to the wide use of laxatives and/or peripherally acting mu-opioid receptor antagonists (PAMORAs). A growing interest has been recently recorded in the possible effects of opioid treatment on the gut microbiota. Preclinical and clinical data, as presented in this review, showed that alterations of the gut microbiota play a role in modulating opioid-mediated analgesia and tolerability, including constipation. Moreover, due to the bidirectional crosstalk between gut bacteria and the central nervous system, gut dysbiosis may be crucial in modulating opioid reward and addictive behavior. The microbiota may also modulate pain regulation and tolerance, by activating microglial cells and inducing the release of inflammatory cytokines and chemokines, which sustain neuroinflammation. In the subset of cancer patients, the clinical meaning of opioid-induced gut dysbiosis, particularly its possible interference with the efficacy of chemotherapy and immunotherapy, is still unclear. Gut dysbiosis could be a new target for treatment in cancer patients. Restoring the physiological amount of specific gut bacteria may represent a promising therapeutic option for managing gastrointestinal symptoms and optimizing analgesia for cancer patients using opioids.

Intergenerational Methods for Processing Art to Understand Challenging Topics (The IMPACT Study): Addiction

ABSTRACT Little is known about generational differences and similarities in beliefs about addiction. Science Gallery Atlanta (SGA) integrates science and art to approach challenging topics, like addiction, with empathy. Intergenerational communication about addiction could positively impact older and younger adults. This study investigated perceptions of addiction among older (60+ years) and younger (18–26 years) adults through intergenerational dialogue on addiction-focused art, offered through SGA’s HOOKED exhibition. This exploratory pilot study recruited ten randomized older-younger dyads who received a mediated tour of HOOKED. Addiction attitudes were assessed pre- and post-tour with the Belief in a Just World and Addiction Belief Scale questionnaires, concurrent interviews, and focus groups. Qualitative data were recorded, transcribed and analyzed thematically. Thematic analysis revealed younger and older adults were equally concerned with addiction-produced waste and technology addiction. Generational differences emerged regarding social media and drug-induced euphoria. Across age groups, participants scored similarly in their beliefs about justice for others and self. Post-tour, young adults were more likely to view addiction as a disease rather than a choice (p = 0.05). Art-based intergenerational communication may increase empathy. Intergenerational bridging may help young adults see addiction as a disease and older adults understand behavioral addictions. Emergent themes illuminate generational differences and similarities in addiction beliefs.

Smartphone Addiction and Sleep Quality among Medical Students

The availability of smartphones and their multi-functionality make them indispensable devices in day-to-day life, especially among students. When smartphone use goes beyond necessity and turns into addiction, the consequences can affect various aspects of life such as mental health, sleep quality, and academic performance. The focus of this research was assessing the presence of smartphone addiction and its association with sleep quality among medical students of the University of Novi Sad. In this cross-sectional study, using the Smartphone Addiction Assessment Scale (SAS-SV) and the Pittsburgh Sleep Quality Index (PSQI), an online survey method, we included 119 medical students, mean age 21.5 (SD±2.8), from of which 75.6% were female students. The obtained results indicate the absence of smartphone addiction (SAS-SV=25.6; SD ±9.1) and the presence of poorer sleep quality (PSQI=5.9; SD±3.3). The prevalence of smartphone addiction was 21%, while the prevalence of poor sleep quality was around 46%. The established moderate positive, statistically significant, correlation between the scores of the questionnaire indicates that increasing the presence of smartphone addiction can worsen the sleep quality in medical students. The need for further research on this subject, on a wider, more representative sample, was recognized. As the complexity of the study program dictates the characteristic lifestyle of students, timely education and raising awareness of the potential risks of behavioral addictions is considered desirable, even necessary.

Opioids, stress and addiction: From stress-induced analgesia to opioid heterodimers with extraordinary analgesic efficacy and without the side effects of traditional opioids

The Special Issue on Stress and Addiction is concerned with interrelationships between environmental stimuli such as stress and endogenous opioid systems that lead to addiction and other behaviors. Stress can have a profound effect on pain that is mediated in part through endogenous opioids. Here we briefly summarize investigation pertaining to the involvement of endogenous opioids in stress-induced analgesia, and their mediation by hypothalamo-pituitary-adrenal systems. Subsequent studies of the contribution of opioid receptor subtypes mediating supraspinal pain-inhibitory systems are examined using selective agonists and antagonists largely developed by Dr. Philip Portoghese. Because of the ongoing opioid epidemic yet the need to discover effective analgesics, we conclude with a discussion of several approaches to manage pain effectively without such serious side effects as tolerance and addiction, associated with traditional opioid use. These include opioid analgesic synergy, biased opioid agonism, and targeting of opioid receptor heteromers with bivalent ligands.

Correction: Treatment of Behavioral Addictions and Substance Use Disorders: a Focus on the Effects of Theta-Burst Stimulation Over the Pre-SMA

Correction: Treatment of Behavioral Addictions and Substance Use Disorders: a Focus on the Effects of Theta-Burst Stimulation Over the Pre-SMA

“We’re going to tie you to the chair”: the perception of perpetrators and the risk of violence in old age

This article analyses the experiences and perceptions of a sample of people over 60 about the most frequent type of violence in old age, the risk factors, the offenders and the reactions to abuse. A mixed study was carried out with the sequential application of 677 questionnaires and 45 interviews. The results show that older people are mainly victims of psychological abuse and financial exploitation; the type of abuse varies according to the type of aggressor; and that machismo, ageism, mental health problems, addictive behaviours and social isolation are risk factors for violence. Health and justice professionals are perceived as those to whom victims should turn and confide.

Culturally Relevant Music Remedies for At-Risk Students

This article presents a comprehensive review of the existing literature on the impact of social media on mental health. With the rapid growth and widespread adoption of social media platforms, concerns regarding their potential influence on individuals' psychological well-being have emerged. Drawing from a diverse range of studies, this review explores the various dimensions through which social media can affect mental health, including self-esteem, body image, loneliness, depression, anxiety, and addictive behaviors. The findings reveal both positive and negative outcomes, highlighting the complex relationship between social media use and mental health. Additionally, this article discusses the underlying mechanisms and potential moderating factors that contribute to these effects. Understanding the nuances of this relationship is crucial for developing effective strategies to promote positive mental health in the digital age.

Conditional deletion of the AMPA-GluA1 and NMDA-GluN1 receptor subunit genes in midbrain D1 neurons does not alter cocaine reward in mice

Synaptic plasticity in the mesolimbic dopamine (DA) system contributes to the neural adaptations underlying addictive behaviors and relapse. However, the specific behavioral relevance of glutamatergic excitatory drive onto dopamine D1 receptor (D1R)-expressing neurons in mediating the reinforcing effect of cocaine remains unclear. Here, we investigated how midbrain AMPAR and NMDAR function modulate cocaine reward-related behavior using mutant mouse lines lacking the glutamate receptor genes Gria1 or Grin1 in D1R-expressing neurons (GluA1D1CreERT2 or GluN1D1CreERT2, respectively). We found that conditional genetic deletion of either GluA1 or GluN1 within this neuronal sub-population did not impact the ability of acute cocaine injection to increase intracranial self-stimulation (ICSS) ratio or reduced brain reward threshold compared to littermate controls. Additionally, our data demonstrate that deletion of GluA1 and GluN1 receptor subunits within D1R-expressing neurons did not affect cocaine reinforcement in an operant self-administration paradigm, as mutant mice showed comparable cocaine responses and intake to controls. Given the pivotal role of glutamate receptors in mediating relapse behavior, we further explored the impact of genetic deletion of AMPAR and NMDAR onto D1R-expressing neurons on cue-induced reinstatement following extinction. Surprisingly, deletion of AMPAR and NMDAR onto these neurons did not impair cue-induced reinstatement of cocaine-seeking behavior. These findings suggest that glutamatergic activity via NMDAR and AMPAR in D1R-expressing neurons may not exclusively mediate the reinforcing effects of cocaine and cue-induced reinstatement.

Problematic Gaming and Gambling: A Systematic Review of Task-Specific EEG Protocols.

Even though gaming and gambling bear similar problematic behavioral aspects, there are no recognizable neurophysiological biomarkers or features characterizing and/or distinguishing these conditions. A systematic review of the literature with a focus on methods was performed in PubMed, Scopus, Web of Science (Web of Science Core Collection), EBSCOhost Research Databases (APA PsycINFO; APA PsycArticles; OpenDissertations; ERIC) databases. Following search terms were used to search the databases: ERP, "event related potential*", EP, "evoked potential*", SS, "steady state", EEG, electroencephal*; gam*. Data about the participants (total number, gender, age), main aim of the study and information about the experimental setup (experimental task description, stimuli used, ERPs measured (latency windows and placement of the electrodes), process evaluated) was extracted. A total of 24 studies were revised (problematic gaming - 16, pathological gambling - 8). The experimental protocols could be grouped into 3 main target domains (Cue-reactivity, General Information processing and Reward Processes & Risk Assessment). Sample-related limitations (small sample sizes, gender differences, differences between the groups regarding potential confounding variables) and heterogeneity regarding the experimental tasks, implementation and interpretation reviewed. Gambling-related research is highly focused on the investigation of the reward-related processes, whereas gaming-related research is mostly focused on the altered aspects of more general information processing. A vast heterogeneity regarding the ERP experimental paradigms being usedand lack of clear guidelines and standardized procedures prevents identification of measures capable to reliably discriminate or characterize the population susceptible to addictive behavior or being able to diagnose and monitor these disorders.

Loneliness, Number of Facebook Friends, and Facebook Addiction among University Students

Facebook addiction gets huge attention among researchers as a new form of behavioral addiction. The present study aimed to assess the role of loneliness and the number of friends on Facebook as risk factors of Facebook addiction. Necessary information was collected from a sample of 234 students who were selected through non-probability sampling techniques using a structured questionnaire that contained the UCLA Loneliness scale, Bergen Facebook addiction scale, questions regarding the number of Facebook friends and personal information. Results showed male Facebook users had higher number of Facebook friends than female users. Results also explored that loneliness, the number of Facebook friends, and being female were significant predictors of Facebook addiction. These findings would help respective authorities take proper initiative for reducing loneliness and Facebook addiction and ensuring sound mental health for making students as future leaders of the country's development. The Chittagong Univ. J. B. Sci.,Vol. 10(1 &2):139-148, 2020

A comprehensive measure assessing different types of problematic use of the internet among Chinese adolescents: The Assessment of Criteria for Specific Internet-use Disorders (ACSID-11)

BackgroundProblematic use of the internet (PUI) is prevalent, particularly among adolescents and young adults. Given the limited measures to assess specific types of PUI, which encompasses a broad spectrum of activities such as online gaming, social media use, pornography use, shopping, gambling, and web-streaming, Muller et al. (2022) developed the Assessment of Criteria for Specific Internet-use Disorders (ACSID-11) to comprehensively assess different types of PUI (i.e., gaming, shopping, social media use, gambling, and pornography use). The present study aimed to validate the Chinese ACSID-11 among adolescents incorporating cross-cultural adaptations. MethodsUsing forward-backward translation method, a culturally adapted version of the ACSID-11 was prepared. Then, a cross-sectional online survey was administered between September 8 and September 26, 2023. Adolescents, using a convenience sample (N = 11,492; mean age = 16.42 years [SD ± 0.91]; 59.1% male), were recruited from six schools to complete the translated ACSID-11, Internet Gaming Disorder Scale-Short Form (IGDS9-SF), Bergen Social Media Addiction Scale (BSMAS), and Smartphone Application Based Addiction Scale (SABAS) via an online platform. Pearson correlation coefficients assessed convergent/discriminant validity. Factor structure and measurement invariance were examined through confirmatory factor analysis (CFA) and multi-group CFA. Cronbach's alpha and McDonald's omega tested internal consistency. ResultsAssociations between the ACSID-11 components and other scales supported convergent validity (i.e., ACSID-11 gaming scale with IGDS9-SF [0.37 ≤ r ≤ 0.41]; social networks use scale with BSMAS [0.24 ≤ r ≤ 0.31]) and discriminant validity (i.e., online gambling scale with BSMAS [0.16 ≤ r ≤ 0.19] and with SABAS [0.11 ≤ r ≤ 0.13]). A four-factor solution indicated good fit with comparative fit index (CFI) ranging from 0.982 to 0.958. The ACSID-11 was measurement invariant across sexes (∆CFI = -0.001 to 0.000) and different levels of related addictive behaviors (∆CFI = -0.001 to 0.000). Both Cronbach's alpha and McDonald's omega (0.63 to 0.97) were acceptable for both frequency and intensity of responses. ConclusionsThe ACSID-11 is an appropriate scale to assess different kinds of PUI among Chinese adolescents and students. Psychometric assessment of the measure in other cultures and among clinical samples is recommended.

Concurrent behavioral modeling and multimodal neuroimaging reveals how feedback affects the performance of decision making in internet gaming disorder

Internet gaming disorder (IGD) prompts inquiry into how feedback from prior gaming rounds influences subsequent risk-taking behavior and potential neural mechanisms. Forty-two participants, including 15 with IGD and 27 health controls (HCs), underwent a sequential risk-taking task. Hierarchy Bayesian modeling was adopted to measure risky propensity, behavioral consistence, and affection by emotion ratings from last trial. Concurrent electroencephalogram and functional near-infrared spectroscopy (EEG-fNIRS) recordings were performed to demonstrate when, where and how the previous-round feedback affects the decision making to the next round. We discovered that the IGD illustrated heightened risk-taking propensity as compared to the HCs, indicating by the computational modeling (p = 0.028). EEG results also showed significant time window differences in univariate and multivariate pattern analysis between the IGD and HCs after the loss of the game. Further, reduced brain activation in the prefrontal cortex during the task was detected in IGD as compared to that of the control group. The findings underscore the importance of understanding the aberrant decision-making processes in IGD and suggest potential implications for future interventions and treatments aimed at addressing this behavioral addiction.

Translation, transcultural adaptation, and convergent validity of the Arabic version of the Mukbang addiction scale

IntroductionThe present study evaluated the psychometric properties of the Arabic translation of the Mukbang Addiction Scale (MAS) among Arabic-speaking adults from the general population. Specifically, it aimed to assess the factorial structure through a confirmatory factor analysis, determine the composite reliability through Cronbach alpha and McDonald’s omega scores, assess gender invariance, and evaluate the convergent validity by examining its correlation to eating addiction and psychological distress.MethodsA total of 370 individuals with a mean age of 21.94 ± 2.29 years participated in this study, which was conducted using an online platform. The participants were surveyed on demographic information, mukbang addiction, food addiction, and psychological distress. Translation was conducted using the forward and backward technique.ResultsThe findings demonstrated excellent internal consistency of the Arabic MAS (McDonald’s omega coefficient = 0.93). Confirmatory factor analyses validated the one-factor structure of the scale, while establishing measurement invariance across sex at the configural, metric, and scalar levels. No sex differences were observed in the Mukbang addiction levels. Lastly, the MAS scores were significantly and positively correlated with food addiction and psychological distress, supporting their convergent validity.ConclusionThe current research provides evidence supporting the reliability and validity of the Arabic version of the MAS as a self-report method for assessing addictive Mukbang watching. While further validations are needed to corroborate the present findings, this measure can be effectively utilized across different fields, including schools, mental health centers, and researchers aiming to understand this global phenomenon.Plain English SummaryMukbang refers to individuals or hosts consuming large quantities of food while interacting with their audiences through recorded video or a live stream. The Mukbang phenomenon has gained substantial popularity among young individuals over the past years, rising concerns about its potential impact on their eating habits and health, especially when overconsumed. Overconsumption of mukbang content, or Mukbang addiction, aligns with the core features of addiction, including compulsive engagement, tolerance, and withdrawal symptoms, making it comparable to other addictive behaviors. Mukbang addiction can lead to detrimental effects on mental and physical health, including neglect of balanced nutrition, disordered eating habits, obesity, feelings of guilt, shame, poor self-esteem, distorted self-images, body dissatisfaction, heightened anxiety or depression, and social isolation. Given these significant impacts, valid and reliable tools are crucial to enable an accurate assessment of Mukbang addiction. This study proposes to translate, adapt and examine the psychometric properties of the Mukbang Addiction Scale (MAS) in a sample of Arabic-speaking individuals from the general population. Findings showed that the six MAS items loaded on a single factor with strong internal consistency and good convergent validity, preliminarily indicating its potential validity and reliability for assessing addictive mukbang-watching among Arabic-speaking individuals.

Behavioral addictions beyond classic addictions and their future perspectives

Behavioral addictions beyond classic addictions and their future perspectives

Genes associated with cortical thickness alterations in behavioral addiction.

Behavioral addiction (BA) is a conceptually new addictive phenotype characterized by compulsive reward-seeking behaviors despite adverse consequences. Currently, its underlying neurogenetic mechanism remains unclear. Here, this study aimed to investigate the association between cortical thickness (CTh) and genetic phenotypes in BA. We conducted a systematic search in five databases and extracted gene expression data from the Allen Human Brain Atlas. Meta-analysis of 10 studies (343 addicted individuals and 355 controls) revealed that the BA group showed thinner CTh in the precuneus, postcentral gyrus, orbital-frontal cortex, and dorsolateral prefrontal cortex (P < 0.005). Meta-regression showed that the CTh in the precuneus and postcentral gyrus were negatively associated with the addiction severity (P < 0.0005). More importantly, the CTh phenotype of BA was spatially correlated with the expression of 12 genes (false discovery rate [FDR] < 0.05), and the dopamine D2 receptor had the highest correlation (rho = 0.55). Gene enrichment analysis further revealed that the 12 genes were involved in the biological processes of behavior regulation and response to stimulus (FDR < 0.05). In conclusion, our findings demonstrated the thinner CTh in cognitive control-related brain areas in BA, which could be associated with the expression of genes involving dopamine metabolism and behavior regulation.

TRAUMA, ADDICTION, AND THE PATH TO RECOVERY AFTER THE KAHRAMANMARAŞ EARTHQUAKES

The 2023 Kahramanmaraş earthquakes in Turkey, characterized by their suddenness and severity, have highlighted the acute need to understand and address the psychological aftermath of such natural disasters. This article examines the intersection of trauma and addiction that frequently follows such catastrophic events. It delves into the widespread psychological distress and the documented rise in post-traumatic stress disorder, anxiety, depression, and addictive behaviors among the affected populations. The review synthesizes findings from global earthquake studies, including those from Japan, Nepal, Italy, Iran, Pakistan, Haiti and China, to draw parallels and learn from previous experiences in managing post-disaster mental health challenges. The article proposes a multi-pronged approach to intervention that includes immediate responses such as Psychological First Aid and longer-term strategies like sustained psychological counseling and community-based support. It acknowledges the complexity of integrating cultural nuances into these interventions and highlights the importance of ethical considerations, political coordination, and the need for training mental health professionals in trauma-informed care. Challenges such as resource limitations, infrastructural damage, cultural barriers, and the need for long-term sustainability of mental health programs are discussed. Furthermore, the article stresses the importance of supporting the mental health of professionals and volunteers working in disaster zones, who are at risk of burnout and secondary trauma. Innovative and adaptable interventions, supported by rapid and responsive research, are advocated to improve mental health outcomes. This comprehensive review contributes to the discourse on disaster response, emphasizing that addressing both trauma and addiction is essential for the holistic recovery of affected individuals and communities.

Experiences and Cognitive Characteristics of Non-Suicidal Self-Injury in Adolescents With Depression: A Qualitative Study.

To elucidate the underlying motivations, experiential dimensions, and cognitive perceptions in adolescents with depression and non-suicidal self-injury (NSSI). A descriptive qualitative design was used. Participants were 18 Chinese adolescents with depression and NSSI. Conventional content analysis was used for data analysis. Three primary themes and 11 subthemes were identified: Triggers of NSSI (personal, family, school, and social factors); Experiencing Emotional Complexity in NSSI Implementation (mitigating psychological distress, awakening a sense of existential life, generating secondary negative emotions, stimulating reflections on life and death); and Perceptions and Understandings of NSSI are Diverse (NSSI as a form of seeking validation or approval, an addictive behavior, a means to attain a sense of control, and unacceptable behavior). Although nursing staff should provide comprehensive treatment and psychological support, efforts should also be made to strengthen caregiving skills of family members, thereby promoting overall physical and mental health of adolescents. [Journal of Psychosocial Nursing and Mental Health Services, xx(x), xx-xx.].

Preventing Online Addictive Behaviors Promoting Active Online Use: Preliminary Findings in Italian Early Adolescents

&lt;strong&gt;Introduction:&lt;/strong&gt; Information and Communication Technologies (i.e., ICT) are fundamental in everyone’s daily lives, especially for youths who integrate them into their routines as instruments for academic, relational, and entertainment purposes (Oka et al., 2021). Thus, it becomes crucial to differentiate positive or proactive online behaviors, which motivate people to interact directly with others and are positively associated with well-being, from negative or addictive online behaviors, which increase emotional, behavioral, or work-related and academic problems (Alimoradi et al., 2019; Gjoneska et al., 2022; Oka et al., 2021). Social and clinical policies are mostly focused on negative and addictive online behaviors in youths, due to their huge effects on mental health, which also significantly impact social and health costs to deal with these problems (Cañas &amp;amp; Estévez, 2021; Lopez-Fernandez &amp;amp; Kuss, 2020). To our knowledge, promotive policies and interventions in this field are still lacking, because they mostly focus only on the reduction of problematic behaviors rather than promoting individual or contextual protective factors (Cañas &amp;amp; Estévez, 2021; Li et al., 2020). Contrary to this trend, considering the potentiality of ICTs for youths, research is now highlighting the importance of considering both preventive and promotive components in online behaviors. According to the Positive Youth Development perspective (Lerner et al., 2018), which emphasized the importance of focusing on individuals’ resources and protective factors, a preventive-promotive intervention was developed and implemented in an Italian Junior High School, that aimed to contrast negative online behaviors, while promoting positive ones (La Rose et al., 2010). &lt;strong&gt;Aims of this Study:&lt;/strong&gt; Thus, the present study preliminary investigated the effectiveness of this intervention, by analyzing longitudinal mean differences of two negative (i.e., problematic use of social network and smartphones) and two positive (i.e., searching for social support online, offering social support online) internet-related behaviors in youths. &lt;strong&gt;Method and Results:&lt;/strong&gt; 358 youths (35% females; Mage=15.35, S.D.=.63) completed the Bergen Social Media Addiction Scale (Monacis et al., 2017), the Smartphone Addiction Scale (Kwon et al., 2013), and the Active and Passive Use of Social Networking Sites Scale (Remondi et al., 2023) in the pre-and-post intervention assessments. Repeated Analysis of Variances showed that smartphone and SNS addictions significantly decreased from pre-to-post assessments. In addition, offering and searching for social support on SN significantly increased across the two time points. &lt;strong&gt;Discussion:&lt;/strong&gt; Our findings showed that addictive smartphone and SNS use significantly decreased in a short time period, while relational activities engaged with SNS significantly increased across the intervention. These results could suggest the short-term efficacy of the project and could be considered in the implementation of other school-based interventions, and in the implementation of more effective socioeconomic strategies to contrast internet-related addictive behaviors (Andreassen et al., 2017).

Co-occurrence of problematic facebook and video game use: prevalence and association with mental health disorders among adolescents

IntroductionThe rapid proliferation of technology and its impact on adolescents’ lives have raised concerns about addictive behaviors and its potential consequences, including behavioral and mental health problems. This study investigates the prevalence and risk factors associated with the co-occurrence of Problematic Facebook Use and Problematic Video game Use among Tunisian adolescents.MethodologyWe conducted a cross-sectional study in the urban area of Sousse governorate in Tunisia during the 2018/2019 school year. We selected a representative sample of high school students enrolled in public educational institutions in Sousse. Data collection was performed through a self-administered structured questionnaire, which gathered information on sociodemographic characteristics, lifestyle behaviors, and mental health disorders. Problematic Facebook Use was assessed using the validated Arabic version of the Bergen Scale, while Problematic Video Game Use was measured using the 21-point Lemmens Scale, which was translated into Arabic. Statistical analysis was carried out using the SPSS program (version 20).ResultsWe enrolled a total of 1342 high school students in our study, of whom, 63.2% were female with a mean age of 17.5 ± 1.44 years. The prevalence of Problematic Facebook Use and Problematic Video Game Use was 28.3% and 13% respectively. Regarding the co-occurrence of the two problematic behaviors, 31.3% of participants faced a singular addictive behavior, either related to problematic Facebook or video game use, while 5% had both addictive behaviors simultaneously. In a multivariate analysis, risk factors for the co-occurrence of Problematic Facebook and Video Game Use, in decreasing order of significance, included severe depression (AOR = 4.527; p = 0.003), anxiety (AOR = 4.216; p = 0.001), male gender (AOR = 4.130; p < 0.001), problematic internet use (AOR = 3.477; p = 0.006), as well as moderate depression (AOR = 3.048; p = 0.007).ConclusionOur study found that Problematic Facebook and Video Game Use were prevalent among Tunisian adolescents. The co-occurrence of these disorders is strongly linked to male gender, problematic internet use, depression, and anxiety disorders. These findings underscore the urgency of implementing tailored and effective awareness and prevention programs to address these emerging challenges.

Nucleus accumbens sub-regions experience distinct dopamine release responses following acute and chronic morphine exposure.

The social and economic consequences of the opioid epidemic are tragic and far-reaching. Yet, opioids are indisputably necessary in clinical settings where they remain the most useful treatment for severe pain. To combat this crisis, we must improve our understanding of opioid function in the brain, particularly the neural mechanisms that underlie opioid dependence and addictive behaviors. This study uses fiber photometry to examine dopamine changes that occur in response to repeated morphine, and morphine withdrawal, at multiple stages of a longitudinal opioid-dependence paradigm. We reveal key differences in how dopamine levels respond to opioid administration in distinct sub-regions of the ventral striatum and lay a foundation for future opioid research that appreciates our contemporary understanding of the dopamine system.