Acute Threat Research Articles

The strongman presidency and the two logics of presidential power

AbstractThe strongman presidency presents an acute threat to democracy. Two logics underpin its emergence, both of which implicate the administrative state. Under the first, presidents have sought to deploy the vast resources of the administrative state in pursuit of power and legacy. This logic is symmetric, shaping the behavior of Republican and Democratic presidents alike. The second logic, however, sets them apart. Because most of the administrative state is the embodiment of progressive values, Democratic presidents have approached presidential power in ways that are largely compatible with its well‐being, whereas Republican presidents have laid claim to increasingly extreme powers in order to retrench and sabotage it. Layered on the first, this asymmetric logic is the main driver of the strongman presidency—and, ultimately, a major threat to American democracy.

Neural patterns of threat response in adolescents predict vulnerability for and resilience against internalizing symptoms during COVID-19 waves

Defensive stress reactions, such as freezing and active fight-or-flight, are relevant for coping with threat. Action-preparatory activity supporting these reactions, including the amygdala, has been posited as a potential marker for stress-resilience. We considered the successive COVID-19 lockdowns as two pervasive stressors, to prospectively investigate the predictive value of neural threat-responses towards symptom development. Five years prior to the COVID-19 pandemic, 17-year-old adolescents (n = 64, Baseline-17) performed the fMRI-adapted Go/Nogo Under Threat (GUNT) task, where threat-anticipatory freezing reactions and transition to action are evoked to avoid a shock. A majority (n = 44) made themselves available for follow-up assessments before COVID (Baseline-20, age 20), during the first COVID-19 lockdown in the Netherlands (LD1, age 22.5), and during a second lockdown (LD2, age 23). The GUNT task quantified neural (thalamic, subcortical, amygdala) and physiological (bradycardia) markers of threat-anticipatory freezing and transition to action (mediated by anterior cingulate cortex). Threat-anticipatory amygdala responses (Baseline-17) were linked to stressor resilience, as quantified by self-reported anxiety symptoms between LD1 and LD2. However, stronger amygdala responses to low threat cues (Baseline-17) were associated with stronger anxiety symptoms. These effects occurred over and above early-life stress, COVID-19 stress burden, and overall symptom changes between age 17 and 20. These findings suggest that amygdala responses to acute threat provide a marker for resilience against real-life stressors, with adequate threat discrimination signaling resilience and stronger amygdala responses to low threat predicting vulnerability. The findings support the notion that neural responses to threat are instrumental for adaptive coping with pervasive stress.

Community assembly processes of soil bacteria and fungi along a chronosequence of rice paddies cultivated on saline‐sodic land

AbstractSaline‐alkali soils cover an area of more than 900 million ha and pose an acute threat to global food security. Rice cultivation is an effective method of saline‐sodic soil amelioration in the Songnen Plain in northeastern China. However, the changes in soil microbial communities that follow rice cultivation are largely unknown. In this study, soil bacterial and fungal communities were investigated using high‐throughput sequencing along a chronosequence of rice paddies cultivated in saline‐sodic soils. The results showed that soil fungi and bacteria become more diverse and abundant after rice cultivation compared with uncultivated saline‐sodic soil, in combination with the decreased pH and increased soil organic matter, indicating the amelioration of saline‐sodic soil. The processes of microbial succession following rice cultivation can be divided into two stages: shorter than and longer than 10 years. Moreover, soil fungi and bacteria exhibited distinct variation patterns as they were dominated by different influential factors. The results indicated that bacteria were more strongly dominated by soil properties than fungi, while the latter were more dependent on vegetation. As rice cultivation continued, fungi exhibited better adaptation and faster succession than bacteria in response to environmental shifts after rice cultivation. Therefore, measures that can enhance plant–microbe interactions may be a viable approach for promoting saline‐sodic soil amelioration. This study provided novel insights into the microbial assembly processes following rice cultivation on saline‐sodic lands.

An expert-based system to predict population survival rate from health data.

Timely detection and understanding of causes for population decline are essential for effective wildlife management and conservation. Assessing trends in population size has been the standard approach, but we propose that monitoring population health could prove more effective. We collated data from 7 bottlenose dolphin (Tursiops truncatus) populations in the southeastern United States to develop a method for estimating survival probability based on a suite of health measures identified by experts as indices for inflammatory, metabolic, pulmonary, and neuroendocrine systems. We used logistic regression to implement the veterinary expert system for outcome prediction (VESOP) within a Bayesian analysis framework. We fitted parameters with records from 5 of the sites that had a robust network of responders to marine mammal strandings and frequent photographic identification surveys that documented definitive survival outcomes. We also conducted capture-mark-recapture (CMR) analyses of photographic identification data to obtain separate estimates of population survival rates for comparison with VESOP survival estimates. The VESOP analyses showed that multiple measures of health, particularly markers of inflammation, were predictive of 1- and 2-year individual survival. The highest mortality risk 1year following health assessment related to low alkaline phosphatase (odds ratio [OR]=10.2 [95% CI: 3.41-26.8]), whereas 2-year mortality was most influenced by elevated globulin (OR=9.60 [95% CI: 3.88-22.4]); both are markers of inflammation. The VESOP model predicted population-level survival rates that correlated with estimated survival rates from CMR analyses for the same populations (1-year Pearson's r=0.99, p=1.52×10-5 ; 2-year r=0.94, p=0.001). Although our proposed approach will not detect acute mortality threats that are largely independent of animal health, such as harmful algal blooms, it can be used to detect chronic health conditions that increase mortality risk. Random sampling of the population is important and advancement in remote sampling methods could facilitate more random selection of subjects, obtainment of larger sample sizes, and extension of the approach to other wildlife species.

Infarct-Related Artery as aDonor of Collaterals in ST-Segment-Elevation Myocardial Infarction With Concomitant Chronic Total Occlusion: Challenge of the Double-Jeopardy Thesis.

BACKGROUND In ST-segment-elevation myocardial infarction (STEMI), a concomitant chronic total occlusion (CTO) in a non-infarct-related artery (NIRA) is associated with adverse outcome. In the case of the infarct-related artery (IRA) as a donor vessel for collaterals to the CTO, the IRA occlusion may lead to an acute threat to both the immediate IRA and the collaterally supplied CTO area, which has been described as a double-jeopardy effect. METHODS AND RESULTS We investigated the role of preformed intercoronary collaterals to the CTO originating from either the IRA or NIRA. Data were obtained from 2 hospitals participating in the prospective FITT-STEMI (Feedback Intervention and Treatment Times in ST-Segment Elevation Myocardial Infarction) study. From a total cohort of 2102 patients with acute STEMI, 93 patients had single-vessel CTO in an NIRA and well-developed intercoronary collaterals to the CTO. In-hospital mortality differed significantly with respect to the origin of the collaterals. Mortality was 15.2% with collaterals originating from the NIRA, 29.4% with a collateral origin from the IRA proximal to the acute STEMI occlusion, and 3.3% with a collateral origin from the IRA distal to the acute occlusion (P=0.044). A multivariate regression model confirmed that a proximal collateral origin had a significant higher mortality compared with a branching in the distal position from the acute STEMI occlusion (P=0.027; odds ratio=20.8 [95% CI, 1.4-304.1]). CONCLUSIONS In STEMI with CTO in an NIRA, a CTO collateralization from the IRA distal to the acute occlusion is associated with a better prognosis. This finding challenges the double-jeopardy assumption as the main cause of adverse outcome in STEMI with CTO in an NIRA. REGISTRATION URL: https://www.clinicaltrials.gov; Unique identifier: NCT00794001.

Russophonia as an Epistemic Challenge

This is a contribution to the discussion forum "Conceptualizing Society after the Modern Territorial State and Nation." Marco Puleri offers a new look at the actually existing, rather than hypothetically anticipated, form of postnational collective belonging in the post-Soviet space: the "archipelago" of Russian-speaking communities in different countries. This choice might seem counterintuitive, given the acute threat to national cultures and statehood coming from the ideological and political program of the "Russian world" promoted by the Russian Federation, which claims sovereignty over everything russkii. Puleri argues that the only means to neutralize this threat without assuming an anti-Russian but equally repressive and nationalist stance is to develop a new epistemic approach to Russian language and culture. He notes that Russophone communities in post-Soviet societies have proved their political loyalty to their countries and that the Russian language is a double-edged strategic linguistic weapon. Using Ukrainian Russian-language literature as an example, Puleri demonstrates the possibility of disconnecting the Russian language from Russia or even the Russian way of life and completely reorienting it to local cultural scenarios. The hybridization and "diasporization" of Russian language and culture open the way to its reconceptualization as World Russians – similar to World Englishes. This perspective necessitates the transformation of Russian studies into a transnational discipline – Russophone studies, limited neither to Russia nor to ethnic Russians.

Niche diversity effects on personality measurement – evidence from large national samples during the COVID-19 pandemic

We report systematic variability in the psychometric properties of a brief personality inventory during the early stages of the COVID-19 pandemic. Drawing upon recent discussions about the universality vs cultural relativism of personality measures, we review and comparatively test theories predicting systematic variability in personality measurement across cultures using an established brief personality measure applied to population samples in 16 nations during the first wave of the COVID-19 pandemic (N = 35,052). We found systematic variation in factor replicability and effective dimensionality. In line with previous theorizing, factors replicated better in contexts with greater niche diversity. Examining possible drivers underlying this association, the investigation of the individual components in the niche construction index suggested that life expectancy and to a lesser degree economic complexity are associated with greater personality structure differentiation. Population-level indicators of acute threat due to COVID-19 did not show credible effects. These patterns suggest that a) investigation of personality structure in population samples can provide useful insights into personality dynamics, b) socioecological factors have a systematic impact on survey responses, but c) we also need better theorizing and research about both personality and culture to understand how niche construction dynamics operate.

GLOBALIZATION CHALLENGES TO UKRAINE’S ECONOMIC SECURITY AND POLICY PRIORITIES TO COUNTER THEM

Increased attention to the issue of ensuring Ukraine’s economic security in the conditions of the intensifying influence of globalization factors, challenges and threats. It is indicated that new globalization challenges determine the need for the formation of new tools and means of ensuring Ukraine’s economic security. The purpose of the study is to identify the globalization challenges to the economic security of Ukraine and justify the policy priorities for countering them. Main directions of the negative impact of globalization threats are determined and, based on them, strategic vectors of the state policy of ensuring the economic security of the national economy are identified. A complex of regulatory tasks and tools has been developed, which serve as guidelines for the formation of an effective and effective system for strengthening the economic security of Ukraine at the current stage of its socio-economic development. The priority areas of counteraction to globalization threats to the economic security of Ukraine are outlined, which define the diversification of foreign economic ties and relations, ensuring the stability of the functioning and independence of the financial system, improving the parameters of the social security system, engaging the “drivers” of economic development, strengthening energy independence and increasing the level of energy efficiency and energy saving , forming a system and ensuring a higher level of functional capacity of critical infrastructure elements, strengthening the functional and structural integration of spatial and territorial economic complexes. The applied value of the research results lies in the further development of the applied provisions of state policy strategizing to ensure the economic security of the state. The scientific novelty of the research results lies in the improvement and clarification of strategic priorities for strengthening the economic security of the state in the conditions of critically acute globalization risks, challenges and threats.

Iwokrama in Guyana, South America, and Indigenous Shared Governance of Rainforest During a Pandemic: Use It or Lose It?

Iwokrama International Centre for Rainforest Conservation and Development, located in Guyana, was established in 1996. It was intended to conserve rainforest in this often overlooked—yet ecologically invaluable—corner of South America, which forms the edge of the Amazon biome. It was also founded to serve as a model of shared governance with Indigenous populations and to function as a test site for sustainable rainforest use. This case summarizes its history and takes us to the period of 2020–2021, when the COVID-19 pandemic shut down tourism and logging. The end of this legal (if controversial) economic activity in the region and the skyrocketing price of gold created the perfect storm for illegal—and much more damaging—exploitation. Specifically, mining and associated harmful human activity expanded into Iwokrama’s territory. In addition to these immediate and acute threats, the leadership of Iwokrama was confronted with an existential question about their path forward. Readers of this case are invited to consider options for the institution, both in terms of process (especially the inclusion of Indigenous preferences), regulation (what activities to permit and promote within the region), and action. Readers of this case can expect to learn about the context of this region and organization and will acquire familiarity with various perspectives and multidimensional dilemmas related to Indigenous shared governance, sustainable natural resource use, and conservation. This will enable readers to better evaluate, articulate, and advocate for positions in comparable contexts elsewhere.

Genome Size in the Arenaria ciliata Species Complex (Caryophyllaceae), with Special Focus on A. ciliata subsp. bernensis, a Narrow Endemic of the Swiss Northern Alps.

The genus Arenaria (Caryophyllaceae) comprises approximately 300 species worldwide; however, to date, just six of these taxa have been investigated in terms of their genome size. The main subject of the present study is the A. ciliata species complex, with special focus on A. ciliata subsp. bernensis, an endemic plant occurring in the Swiss Northern Alps. Altogether, 16 populations and 77 individuals of the A. ciliata complex have been sampled and their genome sizes were estimated using flow cytometry, including A. ciliata subsp. bernensis, A. ciliata s.str., A. multicaulis, and A. gothica. The Arenaria ciliata subsp. bernensis shows the highest 2c-value of 6.91 pg of DNA, while A. gothica showed 2c = 3.69 pg, A. ciliata s.str. 2c = 1.71 pg, and A. multicaulis 2c = 1.57 pg. These results confirm the very high ploidy level of A. ciliata subsp. bernensis (2n = 20x = 200) compared to other taxa in the complex, as detected by our chromosome counting and previously documented by earlier work. The genome size and, thus, also the ploidy level, is stable across the whole distribution area of this taxon. The present study delivers additional support for the taxonomic distinctiveness of the high alpine endemic A. ciliata subsp. bernensis, which strongly aligns with other differences in morphology, phylogeny, phenology, ecology, and plant communities, described previously. In affirming these differences, further support now exists to re-consider the species status of this taxon. Upgrading to full species rank would significantly improve the conservation prospects for this taxon, as, because of its precise ecological adaptation to alpine summit habitats, the A. ciliata subsp. bernensis faces acute threats from accelerated climate warming.

Bolaamphiphile Analogues of 12-bis-THA Cl2 Are Potent Antimicrobial Therapeutics with Distinct Mechanisms of Action against Bacterial, Mycobacterial, and Fungal Pathogens.

12-Bis-THA Cl2 [12,12'-(dodecane-1,12-diyl)-bis-(9-amino-1,2,3,4-tetrahydroacridinium) chloride] is a cationic bolalipid adapted from dequalinium chloride (DQC), a bactericidal anti-infective indicated for bacterial vaginosis (BV). Here, we used a structure-activity-relationship study to show that the factors that determine effective killing of bacterial, fungal, and mycobacterial pathogens differ, to generate new analogues with a broader spectrum of activity, and to identify synergistic relationships, most notably with aminoglycosides against Acinetobacter baumannii and Pseudomonas aeruginosa, where the bactericidal killing rate was substantially increased. Like DQC, 12-bis-THA Cl2 and its analogues accumulate within bacteria and fungi. More hydrophobic analogues with larger headgroups show reduced potential for DNA binding but increased and broader spectrum antibacterial activity. In contrast, analogues with less bulky headgroups and stronger DNA binding affinity were more active against Candida spp. Shortening the interconnecting chain, from the most lipophilic twelve-carbon chain to six, improved the selectivity index against Mycobacterium tuberculosis in vitro, but only the longer chain analogue was therapeutic in a Galleria mellonella infection model, with the shorter chain analogue exacerbating the infection. In vivo therapy of Escherichia coli ATCC 25922 and epidemic methicillin-resistant Staphylococcus aureus 15 (EMRSA-15) infections in Galleria mellonella was also achieved with longer-chain analogues, as was therapy for an A. baumannii 17978 burn wound infection with a synergistic combination of bolaamphiphile and gentamicin. The present study shows how this class of bolalipids may be adapted further to enable a wider range of potential applications. IMPORTANCE While we face an acute threat from antibiotic resistant bacteria and a lack of new classes of antibiotic, there are many effective antimicrobials which have limited application due to concerns regarding their toxicity and which could be more useful if such risks are reduced or eliminated. We modified a bolalipid antiseptic used in throat lozenges to see if it could be made more effective against some of the highest-priority bacteria and less toxic. We found that structural modifications that rendered the lipid more toxic against human cells made it less toxic in infection models and we could effectively treat caterpillars infected with either Mycobacterium tuberculosis, methicillin resistant Staphylococcus aureus, or Acinetobacter baumannii. The study provides a rationale for further adaptation toward diversifying the range of indications in which this class of antimicrobial may be used.

The adaptive immune system in early life: The shift makes it count.

Respiratory infectious diseases encountered early in life may result in life-threatening disease in neonates, which is primarily explained by the relatively naive neonatal immune system. Whereas vaccines are not readily available for all infectious diseases, vaccinations have greatly reduced childhood mortality. However, repeated vaccinations are required to reach protective immunity in infants and not all vaccinations are effective at young age. Moreover, protective adaptive immunity elicited by vaccination wanes more rapidly at young age compared to adulthood. The infant adaptive immune system has previously been considered immature but this paradigm has changed during the past years. Recent evidence shows that the early life adaptive immune system is equipped with a strong innate-like effector function to eliminate acute pathogenic threats. These strong innate-like effector capacities are in turn kept in check by a tolerogenic counterpart of the adaptive system that may have evolved to maintain balance and to reduce collateral damage. In this review, we provide insight into these aspects of the early life's adaptive immune system by addressing recent literature. Moreover, we speculate that this shift from innate-like and tolerogenic adaptive immune features towards formation of immune memory may underlie different efficacy of infant vaccination in these different phases of immune development. Therefore, presence of innate-like and tolerogenic features of the adaptive immune system may be used as a biomarker to improve vaccination strategies against respiratory and other infections in early life.

Population distribution within the human climate niche

Climate change may pose an acute threat to humanity due to physical and biological constraints on regional habitability. A recent study proposed that the human climate niche is a narrow segment of the Earth’s temperature range, with a mode of habitation around 13°C. Here, the human climate niche is recharacterized using a novel graphical technique, the size-intensity chart. Several measures of population distribution were compiled to test the idea that humans live preferentially in the temperate range (10–20°C) rather than the warm range (20–30°C). The temperate range has a higher average population density (people/km2), which suggests that it is more suitable for humans than the warm range. However, other population measures suggest the opposite. The warm range has a greater overall population; and regions with high population densities cover a greater land area and are home to more people in the warm range. Population density also depends on annual precipitation R; size intensity charts show that population density increases sharply with precipitation for 40 < R < 80 cm/yr. The warm temperature range has a greater surface area with desert conditions of R < 10 cm/yr, but sparse habitation in dry regions does not explain the lower average population density of the warm range. Overall, human habitation patterns do not show a consistent preference for temperate over warm lands, and that precipitation may mediate, but not limit this relationship.

The effect of inherently threatening contexts on visuocortical engagement to conditioned threat.

Fear and anxiety are crucial for adaptive responding in life-threatening situations. Whereas fear is a phasic response to an acute threat accompanied by selective attention, anxiety is characterized by a sustained feeling of apprehension and hypervigilance during situations of potential threat. In the current literature, fear and anxiety are usually considered mutually exclusive, with partially separated neural underpinnings. However, there is accumulating evidence that challenges this distinction between fear and anxiety, and simultaneous activation of fear and anxiety networks has been reported. Therefore, the current study experimentally tested potential interactions between fear and anxiety. Fifty-two healthy participants completed a differential fear conditioning paradigm followed by a test phase in which the conditioned stimuli were presented in front of threatening or neutral contextual images. To capture defense system activation, we recorded subjective (threat, US-expectancy), physiological (skin conductance, heart rate) and visuocortical (steady-state visual evoked potentials) responses to the conditioned stimuli as a function of contextual threat. Results demonstrated successful fear conditioning in all measures. In addition, threat and US-expectancy ratings, cardiac deceleration, and visuocortical activity were enhanced for fear cues presented in threatening compared with neutral contexts. These results are in line with an additive or interactive rather than an exclusive model of fear and anxiety, indicating facilitated defensive behavior to imminent danger in situations of potential threat.

Proteomics reveals antiviral host response and NETosis during acute COVID-19 in high-risk patients

SARS-CoV-2 remains an acute threat to human health, endangering hospital capacities worldwide. Previous studies have aimed at informing pathophysiologic understanding and identification of disease indicators for risk assessment, monitoring, and therapeutic guidance. While findings start to emerge in the general population, observations in high-risk patients with complex pre-existing conditions are limited.We addressed the gap of existing knowledge with regard to a differentiated understanding of disease dynamics in SARS-CoV-2 infection while specifically considering disease stage and severity. We biomedically characterized quantitative proteomics in a hospitalized cohort of COVID-19 patients with mild to severe symptoms suffering from different (co)-morbidities in comparison to both healthy individuals and patients with non-COVID related inflammation. Deep clinical phenotyping enabled the identification of individual disease trajectories in COVID-19 patients.By the use of the individualized disease phase assignment, proteome analysis revealed a severity dependent general type-2-centered host response side-by-side with a disease specific antiviral immune reaction in early disease. The identification of phenomena such as neutrophil extracellular trap (NET) formation and a pro-coagulatory response characterizing severe disease was successfully validated in a second cohort. Together with the regulation of proteins related to SARS-CoV-2-specific symptoms identified by proteome screening, we not only confirmed results from previous studies but provide novel information for biomarker and therapy development.

Coping strategies of families and their relationships with family quality of life during Covid-19 pandemic.

The COVID-19 pandemic has brought new challenges to almost every aspect of parents’ and their children’s lives, posing an acute threat to the families’ quality of life (FQOL). This study had two aims: (1) to identify changes in family coping-strategy profiles among parents pre- and during the first COVID-19 lockdown and (2) to analyze interactions between the clusters of coping strategies pre-COVID with FQOL during the first lockdown. A sample of 253 parents (58.5% mothers) of children (3 to 18 yr old) completed the Family Pandemic Oriented Personal Evaluation Scales and the FQOL Scale about their family life pre- and during the COVID-19 lockdown. Four family coping-strategy clusters were found. Differences were found between those clusters pre- and during the first COVID-19 lockdown, with a high percentage of families using the positive appraisal strategy more often. Significant interactions were found between the family coping-strategy clusters pre-COVID-19 and the FQOL factors before and during the pandemic. Most families maintained their FQOL levels during the first lockdown. Close and frequent interactions between family members had relationships with positive emotions and significant effects on well-being. Results showed that positive cognitive appraisal was a protective factor against a significant decrease in FQOL during the first COVID-19 lockdown.

Comparing PTSD symptom networks in type I vs. type II trauma survivors

ABSTRACT Background: Network analysis has gained increasing attention as a new framework to study complex associations between symptoms of post-traumatic stress disorder (PTSD). A number of studies have been published to investigate symptom networks on different sets of symptoms in different populations, and the findings have been inconsistent. Objective: We aimed to extend previous research by testing whether differences in PTSD symptom networks can be found in survivors of type I (single event; sudden and unexpected, high levels of acute threat) vs. type II (repeated and/or protracted; anticipated) trauma (with regard to their index trauma). Method: Participants were trauma-exposed individuals with elevated levels of PTSD symptomatology, most of whom (94%) were undergoing assessment in preparation for PTSD treatment in several treatment centres in Germany and Switzerland (n = 286 with type I and n = 187 with type II trauma). We estimated Bayesian Gaussian graphical models for each trauma group and explored group differences in the symptom network. Results: First, for both trauma types, our analyses identified the edges that were repeatedly reported in previous network studies. Second, there was decisive evidence that the two networks were generated from different multivariate normal distributions, i.e. the networks differed on a global level. Third, explorative edge-wise comparisons showed moderate or strong evidence for specific 12 edges. Edges which emerged as especially important in distinguishing the networks were between intrusions and flashbacks, highlighting the stronger positive association in the group of type II trauma survivors compared to type I survivors. Flashbacks showed a similar pattern of results in the associations with detachment and sleep problems (type II > type I). Conclusion: Our findings suggest that trauma type contributes to the heterogeneity in the symptom network. Future research on PTSD symptom networks should include this variable in the analyses to reduce heterogeneity.

Classification and assessment of fear and anxiety in personality and psychopathology

We examine fear and anxiety in the context of structural models of personality (the five-factor model, or FFM) and psychopathology (the Hierarchical Taxonomy of Psychopathology, or HiTOP); we also highlight important issues related to their assessment. Anxiety is a sustained, future-oriented response to potential threat. Trait measures of anxiety represent a core facet within the broader domain of neuroticism in the FFM. Anxiety-related symptoms are indicators of the distress subfactor within the internalizing spectrum in HiTOP. In contrast, fear is a brief, present-focused response to an acute threat. We distinguish between two ways of assessing individual differences in fear. The first type assesses phobic responses to specific stimuli. Phobia measures are moderately correlated with measures of neuroticism in the FFM and define the fear subfactor of internalizing in HiTOP. The second type assesses individual differences in harm avoidance versus risk taking. Measures of risk taking (i.e., low fear) are moderately related to disinhibition/low conscientiousness and antagonism/low agreeableness in the FFM and are indicators of the externalizing superspectrum in HiTOP.

Chemiresistive La-doped BaTiO3 microspheres for ambient-temperature formaldehyde gas sensing

Volatile organic compounds pose an acute threat to the environment and human life. Formaldehyde, a well-known volatile organic compound known for its numerous commercial applications, has put forth the requirement for tracking down trace amounts of its presence in order to ensure healthier living. This work emphasizes the novel use of a non-toxic deep eutectic solvent medium (choline chloride and urea) for aiding the solid-state synthesis of pure and La-doped barium titanate. The prepared chemiresistive ceramics were verified for their gas sensing abilities towards a number of volatile organics, among which formaldehyde (100 ppm) showed amplified response of 118 in La-doped BTO modified gold interdigitated electrode. It also produced a rapid response-recovery rate of 12 sec/18 sec witnessing the extreme performance of La-doped BTO ceramic material. Additionally, the chemiresistive sensor was stable to humidity and had extended-shelf life.

Cross-Neutralization of SARS-CoV-2-Specific Antibodies in Convalescent and Immunized Human Sera against the Bat and Pangolin Coronaviruses.

Coronaviruses isolated from bats and pangolins are closely related to SARS-CoV-2, the causative agent of COVID-19. These so-called sarbecoviruses are thought to pose an acute pandemic threat. As SARS-CoV-2 infection and vaccination have become more widespread, it is not known whether neutralizing antibodies to SARS-CoV-2 can cross-neutralize coronaviruses transmitted by bats or pangolins. In this study, we analyzed antibody-mediated neutralization with serum samples from COVID-19 patients (n = 31) and those immunized with inactivated SARS-CoV-2 vaccines (n = 20) against lentivirus-based pseudo-viruses carrying the spike derived from ancestral SARS-CoV-2, bat (RaTG13 or RshSTT182), or pangolin coronaviruses (PCoV-GD). While SARS-CoV-2, PCoV-GD, and RshSTT182 spikes could promote cell-cell fusion in VeroE6 cells, the RaTG13 spike did not. RaTG13, on the other hand, was able to induce cell-cell fusion in cells overexpressing ACE2. Dramatic differences in neutralization activity were observed, with the highest level observed for RaTG13, which was even significantly higher than SARS-CoV-2, PCoV-GD, and RshSTT182 pseudo-viruses. Interestingly, pseudo-viruses containing the chimeric protein in which the receptor-binding domain (RBD) of PCoV-GD spike was replaced by that of RaTG13 could be strongly neutralized, whereas those carrying RaTG13 with the RBD of PCoV-GD were significantly less neutralized. Because the high neutralizing activity against RaTG13 appears to correlate with its low affinity for binding to the human ACE2 receptor, our data presented here might shed light on how pre-existing immunity to SARS-CoV-2 might contribute to protection against related sarbecoviruses with potential spillover to the human host.