Accidental Reactions Research Articles

Using NHS Data to Monitor Trends in the Occurrence of Severe, Food-Induced Allergic Reactions Work Package 2

People with food allergies may experience food allergic reactions due to accidental exposure. These reactions are commonly categorised as non-severe, fatal food anaphylaxis and near-fatal food anaphylaxis. Non-severe allergic reactions to food are more common with an incidence of up to 1,000 times greater than fatal food-related anaphylaxis. However, obtaining accurate data relating to the circumstances under which these reactions occurred is challenging under the current diagnosis coding system used in the National Health Service (NHS). This project addressed two key questions: 1. What are the trends in the occurrence of food hypersensitivity (FHS) reactions and their consequences in terms of healthcare encounters (both to hospital and primary care)? 2. What are the circumstances surrounding severe, life-threatening reactions to food? Approach • A UK arm of NORA was established using the same online platform as the existing European Registry. • Participation of healthcare professionals and/or patients to enter relevant information was co-ordinated by BSACI in conjunction with the Paediatric Emergency Research in the United Kingdom Ireland (PERUKI) network. • Different versions of the questionnaire were developed to increase response rates: (1) a comprehensive form mapped to existing NORA data fields for completion by Healthcare Professionals in the non-acute setting; (2) a shorter form with key data fields to increase data reporting in more pressured, acute healthcare settings; and (3) a form for completion by patients or their parent/guardian. Key Results The launch of the UK anaphylaxis registry faced delays and was impacted by significant pressures on NHS services due to the COVID-19 pandemic. This led to a lower than anticipated uptake of the Registry by clinics and Accident & Emergency departments. As a result, only a minority of accidental reactions (less than 5%) were captured in the registry, almost all in children and young people under age 18 years. Some indicative results of this analysis are the following: • 213 cases reported to be due to a food trigger and of these, 208 occurred in children/young people aged 18 years or under. • Common food triggers were peanut, tree nuts (especially cashew), cow’s milk/dairy and hen’s egg. • 47% of reactions occurred after consumption of prepacked food products and in at least 59% of these cases, the allergen was declared as an actual ingredient. Further work would be needed to understand how to optimise reporting of data, for example by reducing the time burden for completion by clinicians and patients.

Accidental allergic reactions to immediate-type food allergens in Japanese children: A single-center study.

Few studies have assessed the nature of accidental allergic reactions (AAR). We assessed the prevalence and risk factors for AAR in Japanese children. This study included children with immediate-type hen's egg (HE), cow's milk (CM), wheat, or peanut allergy who developed allergic reactions within at least 2 years and were followed up regularly at a single national allergy center in Japan. From January to December 2020, low-dose reactivity was defined as allergic reactions to ≤250, ≤102, ≤53, or ≤ 133 mg of HE, CM, wheat, or peanut protein, respectively. The annualized AAR rate showed the number of reactions per patient per year (95% confidence interval). AAR risk factors were analyzed using multiple logistic regression. Of the 1096 participants, 609, 457, 138, and 90 had HE, CM, wheat, and peanut allergies, respectively. The median (interquartile range) age was 5.0 (2.3-8.6) years, 39% had completely eliminated allergenic food, and 24% had low-dose reactivity. The annualized AAR rate was 0.130 (0.109-0.153) in all sub-cohorts. Moderate and severe symptoms occurred in 50% and 0.7%, respectively, of children who experienced AAR. Multiple logistic regression revealed that low-dose reactivity was a significant risk factor for AAR in the overall and CM cohorts, respectively (p < .001 and p = .036). In this single-center study in Japan, the annualized AAR rate was relatively low during the COVID-19 pandemic; however, half of the participants with AAR had moderate to severe symptoms. Especially in the case of low-dose reactivity, children would require careful AAR risk management.

Frequency and Severity of Cow’s Milk Allergy Reactions in Children: A Prospective Audit

Milk ranks as the second most common allergen, following peanuts. Recent studies from Spain and theUSA reports an annual frequency of accidental allergic reactions (AAR) ranging from 34% to 40%. AAR severity is influenced by food allergens and the presence of atopic diseases such as asthma, eczema, hay-fever, and recurrent wheezing. This study aimed to determine the frequency of accidental allergic reactions in children with cow’s milk protein allergy between September 2011 to September 2012. The study design employed is missing. A structured questionnaire was used and the guardians of the patients were guided in answering by the research assistants (Students). The questionnaire was conducted on 62 patients (35 males, 27 females) with a median age of 67 months. The inquiries were about the number and locations of accidental reactions, their severity, other food allergies, and risk factors such as asthma, hay-fever, recurrent wheezing, and eczema. Symptoms were classified as mild, moderate, or severe, and previous and current skin prick test results were recorded. Between 2011 and 2012, the frequency of AAR was found to be 57% (inclusive of adults). Among the children, 37 (60%) experienced 51 accidental reactions in the past year, with 43% classified as mild, 19% as moderate, and 38% as severe. The majority of reactions (60%) occurred at home, and treatment primarily involved the use of Chlorphenamine [Piriton©] (79%). Three anaphylactic reactions occurred and were identified leading to hospitalization and administration of epinephrine. Oral exposure was the primary route (89%), with milk-containing products being the most common allergen sources (51%). The main cause of AAR was attributed to mislabeling and misreading of labels, especially in newly implemented recipes and non-packaged cereal products like homemade croissants sold in cafes and restaurants. Other causes included high levels of peanut traces and hazelnuts in cookies and chocolates. In conclusion, accidental allergic reactions are prevalent in children and are often caused by contamination, mislabeling, recipe changes by companies, misinterpretation by caregivers, and direct milk intake. Risk factors for AAR severity include hay fever, peanut allergy, multiple atopic diseases, and wheal size.

Introduction to food allergy

Food allergy is a common chronic disorder that affects infants, children, adolescents, and adults. The prevalence of food allergy has increased in recent decades throughout the world, not limited to Western countries. Since there is no treatment, this focuses on avoiding allergens, in addition to educating patients and caregivers in the emergency treatment of acute reactions, for example: application of epinephrine. Studies suggest that accidental reactions occur in about 45% of children with food allergies each year, although most reactions are mild or moderate in severity. Hospital admissions for food anaphylaxis vary from 4 to 20 per 100,000 inhabitants; Deaths are rare, with an estimated incidence of 0.03 to 0.3 per million people with food allergy. Death from food anaphylaxis is rare and appears to have remained stable, possibly due to increases in food allergen labeling, diagnostic services, rates of intramuscular epinephrine prescription, and awareness of food allergies. Omalizumab is a drug approved for several disorders (chronic hives or difficult asthma) and may help reduce symptoms associated with food allergy. The relative importance of alternative technologies, management strategies and policies for food allergy varies from one region to another, due to differences in the epidemiology, education, socioeconomic well-being, and cultural preferences of the population.

Socializing practices of Irish children and adolescents with food allergy: Aprospective study.

Food is an integral part of social activities; because of fear of accidental reaction, children with food allergy (FA) are at risk of exclusion or oversupervision at these events. The extent of adaptive exclusion behaviors is poorly defined. Families attending our service are encouraged to socialize and taught to minimize risk and avoid accidental reactions. The aim of this study was to establish the social practices and eating-out habits of children and adolescents with FA who are already attending an allergy clinic. Irish children, aged 2 to 16 years, with confirmed FA were recruited as part of a parallel prospective observational study titled Recording Accidental Allergic Reactions in Children and Teenagers (ReAACT). Information on social activities and eating out habits was collected prospectively. A total of 531 children were enrolled. The majority attended age-appropriate social activities; 97% of the 5- to 12-year-olds went to birthday parties and 85% visited friends' houses. More nonparticipators had previous anaphylaxis (relative risk [RR]= 1.44; 95% CI= 0.97-2.14; P= .06) and peanut allergy (RR= 1.19; 95% CI= 0.99-1.42; P= .06). Among adolescents, 94% visited friends' homes, but only 12% had been away from home alone. Overall, 523 participants (98.5 %) visited food establishments, whereas 4.6% did not eat out in any food establishment; these participants were significantly more likely to be adolescents (RR= 3.27; 95% CI= 1.65-7.48; P= .0001). Overall, Irish children with FA are "living with allergy." There was a trend toward decreased participation among adolescents. Future interventions should target this group specifically.

How Common Are Allergic Reactions During Commercial Flights? A Systematic Review and Meta-Analysis

Global passenger demand for air travel has increased by over 7% annually since 2006, with a strong recovery following the COVID-19 pandemic. Prior to COVID-19, individuals with food allergies reported significant concern and anxiety over the risk of reactions when travelling by air. However, published data of in-flight medical events (IMEs) due to allergic reactions are limited. To undertake a systematic review with meta-analysis to estimate the incidence of in-flight medical emergencies (IMEs) due to allergic reactions on commercial flights. We searched MEDLINE, Embase, PsycINFO, TRANSPORT databases and the Cochrane Register of Controlled Trials for relevant studies reporting IMEs of allergic etiology, published since 1980. Data were extracted in duplicate for meta-analysis, and risk of bias assessed. PROSPERO CRD42022384341. 17 studies met the inclusion criteria. At meta-analysis, a pooled estimate of 2.2% (95%CI 1.6%-3.1%) of IMEs are coded as being due to allergic reactions. This may be higher in children (3.1%, 95%CI 1.5%-6.7%). The incidence of allergic IMEs at meta-analysis was 0.7 events per million passengers (95%CI 0.4 to 1.1). Reassuringly, the rate of allergic IMEs has been stable over the past 30 years, despite increasing passenger numbers and food allergy prevalence. Allergic reactions coded as IMEs during commercial air travel are uncommon, occurring at an incidence around 10-100 times lower than that reported for accidental allergic reactions to food occurring in the community. Despite increasing passenger numbers and food allergy prevalence, the rate of allergic IMEs has not changed over the past 3 decades.

Factors influencing accidental food allergic reactions in schools and preschools

BackgroundChildren spend a large proportion of their childhood in schools. In Ireland, there is no government policy on the management of food allergy (FA) in schools or preschool childcare settings (CCS). There is limited data worldwide on rate of accidental allergic reactions (AARs) within these settings.AimThe aim of this paper is to report the management of FA and the incidence of AARs in Irish school or preschool CCS.MethodsA prospective observational study was established, enrolling children aged 2 to 16 years with confirmed FA. Participants were contacted at three monthly intervals for 1 year to report AARs to food. Data pertaining to schools and preschool CCS is reported here.ResultsA total of 521 children (402 attending school and 119 attending preschool CCS) were enrolled. The annualised incidence of AARs in school was 4.5% (95% CI 2.6–7.0) and in preschool CCS 5% (95% CI 1.8–11.1); 6 of 7 of the nut reactions occurred in schools banning nuts. Half (3/6) of the preschool reactions were to cow’s milk; 174/521 (33%) children did not provide their individualised allergy action plan (AAP). Four out of 18 (22%) AARs in school were anaphylaxis and none were administered adrenaline by school staff.ConclusionThe incidence of AARs in this Irish cohort was found to be equivalent to the international experience. However, many of the recorded reactions identified in this study were likely avoidable. Preparation for AARs needs optimising. The ineffectiveness of “nut bans” remains unrecognised. Promoting milk and egg allergy resolution in infancy would likely reduce preschool- and school-based reaction numbers.

Accidental allergic reactions to food in adolescents and adults: An overview of the factors involved and implications for prevention.

Accidental allergic reactions to food are one of the major problems in adult patients diagnosed with food allergy. Such reactions occur frequently, are often severe and are associated with higher medical and non-medical costs. The aim of this Perspective is to provide insight into the different factors involved in the occurrence of accidental allergic reactions and to present an overview of practical implications for effective preventive measures. Several factors affect the occurrence of accidental reactions. These factors are related to the patient, health care, or food. The most important patient-related factors are age, social barriers to disclosing their allergy and non-adherence to the elimination diet. With regards to healthcare, the degree to which clinical practice is tailored to the individual patient is an important factor. The major food-related factor is the absence of adequate precautionary allergen labeling (PAL) guidelines. Since many factors are involved in accidental allergic reactions, different preventive strategies are needed. It is highly recommended that health care be tailored to the individual patient, with regard to education about the elimination diet, support on behavioral and psychosocial aspects, usage of shared decision-making and taking into account health literacy. In addition, it is crucial that steps are taken to improve policies and guidelines for PAL.

Delay in peanut allergy diagnosis in the United States

Most commonly, food allergy (FA) symptoms present within the first few years of life. However, these initial concerns may not coincide with the time of an official diagnosis by an experienced healthcare provider (HCP). Potential delays in diagnosis (DD) can result in unwarranted changes in lifestyle or continued accidental exposures and reactions. The purpose of this retrospective study is to determine the delay in FA diagnosis from first reaction and evaluate the factors that may affect this time period in peanut-allergic children.

Going on vacation increases risk of severe accidental allergic reaction in children and adolescents

Short holiday breaks with family, away from routine and familiar surroundings are an important part of childhood 1. To date, studies of the risks for allergic people, while on holiday, examine accidental allergic reactions (AARs) aboard airplanes or avoidance strategies of nut allergic adults 2-4. There is limited, published data, on the risk of vacation related accidental allergic reactions (VAARs), in food allergic children, who commonly have multiple allergies 5. Their use of restaurants versus self- catering has not been defined.

Health-related quality of life in food and venom induced anaphylaxis and role of influencing factors.

The impact on health-related quality of life (HRQL) plays a key role for patients suffering from allergies and anaphylaxis. In this narrative review we review the HRQL in allergic patients suffering from food and venom allergy, both being the most frequent elicitors of severe allergic, potential life-threatening reactions and provide an overview on the current knowledge and identified gaps. The data show that for food and venom allergy standardized assessment tools to measure HRQL are available and have been successfully applied. Our analysis shows that multiple factors can modulate HRQL in these patient groups. These include sociodemographic data like patients' age and sex, fear of accidental reactions but also external factors like the social environment and the appreciation of the seriousness of the condition by others. External factors may have a significant impact on HRQL and should be considered in patient-related outcome assessments to avoid biased measurements possibly affecting the results. The assessment of the quality of life in the context of specific immunotherapy should consider lifestyle factors and ideally, the individual change in HRQL should be measured. Although there are many data indicating a negative impact on HRQL in food allergic children and their caregivers, limited data are existing from adults with food allergy and venom allergic patients from all age groups. Also, the use of standardized questionnaires should be extended to allow for a better comparability of results between studies. Therefore, translation to additional languages is necessary. Taken together, the eliciting allergen, the severity of the allergic disease but moreover multiple external factors impact the outcome in HRQL and should be considered in HRQL assessment.

A practical focus on oral immunotherapy to tree nuts.

Tree nut (TN) allergy is common, with a global prevalence of up to 4.9%. TN allergy is persistent in most patients, and accidental reactions are common. There is considerable clinical cross-reactivity between cashew and pistachio, and between walnut and pecan. A diagnosis of TN allergy is based on a history of clinical reaction on ingestion, along with confirmed sensitization through either skin-prick or serum immunoglobulin E (IgE) testing. Component testing and food challenges may be required in patients with birch pollinosis to distinguish between IgE-mediated allergy to a heat-stable protein and pollen food allergy syndrome. There is available evidence that TN oral immunotherapy (OIT) is reasonably safe and effective. There are numerous nonpharmaceutical food products to facilitate TN-OIT dosing. TN OIT should be offered as a treatment option for patients with TN allergy.

Food allergy: Symptoms and diagnosis.

Food allergy is common and has increased in prevalence over time. Although there are many types of reactions to foods, immunoglobulin E (IgE) mediated food allergy is acute in onset and resolves quickly, and is reproducible in nature. Anaphylaxis is the most severe form of IgE-mediated food allergy and has a range of clinical manifestations. First-line food allergy diagnostic testing is sensitive but not specific and should only be done in the context of a convincing history of a reaction. Oral food challenge is the criterion standard in diagnosis but carries the risk of a reaction. The only therapy for anaphylaxis is immediate intramuscular epinephrine. Traditional management of food allergy consists of avoidance management, with strict avoidance, reading labels, and carrying an epinephrine autoinjector at all times. Although effective, accidental reactions do occur, and this management strategy has a profound impact on quality of life.

White paper peanut allergy

AbstractThe current management of a primary IgE-mediated peanut allergy consists of the two basic pillars “exposure prophylaxis” with avoidance of the allergen and “emergency therapy” with short-term treatment of an acute allergic reaction after accidental ingestion. Accidental reactions are common despite attempted avoidance. The severity of an allergic or even anaphylactic reaction after accidental ingestion is difficult to assess prior to reaction. In addition, reaction thresholds may vary depending on the accompanying augmentation factor. Therefore, every peanut allergic patient should receive individual dietary counseling as well as instructions for the use of the emergency kit and a structured patient education program (anaphylaxis group training), if necessary. For the first time, since fall 2021 a causal treatment option with a drug for oral immunotherapy will now be available for 4‑ to 17-year-old peanut-allergic children and adolescents. The oral immunotherapy with peanut protein as defatted powder of Arachis hypogaea L., semen (peanuts) leads to desensitization with a good efficacy record and an acceptable safety profile. Other treatment options with different therapeutic approaches are also under development and will probably expand the range for treatment in the coming years.

Personalized management for unmet needs with food allergy.

Patients with food allergies are at risk of experiencing accidental allergic symptoms in real life. Low thresholds may be a risk factor for accidental allergic reactions. Therefore, the evaluation of this threshold is required for the management of food allergies. We have suggested a management approach to identify the threshold dose and the consumable dose, considering patient age and the severity of food allergies. A younger age is a risk factor for accidental allergic reactions, and school-age children are likely to have a lower quality of life (QOL) than younger children. Additionally, patients with a low threshold may have difficulty in acquiring tolerance. We performed a stepwise oral food challenge (OFC) to evaluate the threshold and consumable doses for patients with food allergies. Performing a low-dose OFC for the first step would identify the dose that could be consumed at home safely and avoid the complete elimination of allergic foods. Identifying the threshold dose would be effective in managing the risk of accidental ingestion. For patients who react to low-dose OFC, low-dose oral immunotherapy (OIT) would be expected to prevent the experience of allergic reactions by accidental ingestion and consume medium doses safely. For food allergy patients and their caregivers, identifying the consumable dose would help manage the diet and eliminate their anxiety. Low-dose OFC and low-dose OIT are effective and well tolerated, which would improve their QOL. Considering the severity of food allergy and age, determining a safe threshold with no reactions would meet the unmet needs of patients with food allergy.

Accidental Reactions to Foods: Frequency, Causes, and Severity.

Purpose of ReviewIn this review, we present the epidemiology of food allergy and allergic reactions to foods using studies that have been published over the past decade. We review these allergic reactions — how they differ by food trigger, geographic region, demographic distribution, setting, and severity.Recent FindingsThe rising prevalence of food allergy and persistent accidental allergic reactions to foods in various settings remains a worldwide concern. Differences in global prevalence, food triggers for reactions, and severity of accidental reactions may be explained by diversity in diets and food labeling legislation. A number of studies are highlighted that describe the unique challenges and risk factors that contribute to accidental reactions in restaurants and schools, as well as the efforts that have been made to improve safety and outcomes in these settings.SummaryFood allergy prevalence has demonstrated significant variations between regions and age groups. Despite best efforts by individuals, physicians, and legislative bodies to improve safety for food allergic individuals, accidental reactions to foods still occur and can result in fatalities.

Exploring barriers to commercial peanut oral immunotherapy treatment during COVID-19

Among children in the United States, the prevalence of peanut allergy has continued to rise and contributes substantially to the mortality and morbidity associated with food allergies.1-3 Although the standard of care for peanut allergy is strict allergen avoidance in addition to early use of rescue medications, accidental ingestions often occur and can result in severe allergic reactions across the life span.4,5 Despite significant patient and caregiver motivation to reduce the risk for these accidental reactions, treatment options for peanut allergy have not been widely accessible until recently.

Sesame allergy is more prevalent among Middle Eastern/North African patients in an urban healthcare system

Sesame allergy is the ninth most common food allergy in the United States, and reports suggest that the prevalence is increasing.1 Sesame allergy develops in early infancy and is seldom outgrown.2 In Canadian children, sesame allergy had a higher annual rate of accidental reactions than peanut (15.9% vs 12.4%, respectively).3 Sesame-induced anaphylaxis accounts for 43% of all food-induced anaphylaxis cases in Israeli children,4 but little is known about the prevalence of sesame allergy among the Americans of Middle Eastern or North African descent (MENA) currently residing in the United States.

Oral Immunotherapy

Food allergy affects approximately 7% of the Canadian population and is a lifelong diagnosis for many patients. While fatal anaphylaxis is rare, accidental exposures are common, with many accidental reactions being moderate- to-severe. The fear of severe or fatal anaphylaxis is of major concern and food allergy represents a significant burden on the life of food-allergic families. Until recently, the standard of care for food allergy management in North America included avoidance of the allergenic food and epinephrine autoinjector carriage. However, additional proactive therapeutic options are becoming increasingly more commonplace. Oral immunotherapy (OIT) has been investigated through real worl evidence and in phase II and III clinical trials. Canadian experience with OIT is increasing with the publication of guidelines to support this clinical activity. OIT is an elective, non-curative procedure which carries a risk of allergic reaction. Comprehensive and effective education for families to ensure informed consent is essential as part of the shared decision making (SDM) process and is key to successful OIT implementation.

Peanut allergen reaction thresholds during controlled food challenges in 2 Canadian randomized studies (Canada-ARM1 and PISCES)

Food allergy affects millions worldwide.1 Vigilance by affected individuals and families is necessary to prevent accidental ingestions, allergic reactions, and anaphylaxis. Understanding the minimum amount of food allergen that elicits a reaction—thresholds—in susceptible individuals is paramount to inform safe practice, food manufacturing, and public health policy.1 Thresholds can also inform how to optimize food challenge schedules, advise patients about the potential for accidental reactions, and the design of desensitization approaches.