Acceptable Limits Research Articles

Investigation of natural radioactivity in soil of selected hospitals in Imo State, Nigeria

We measured the terrestrial activity contents, radiation doses; hazard indices and excessive lifetime cancer risk (ELCR) from primordial radionuclides (226Ra, 232Th and 40K) in 50 soil samples collected from the five selected hospitals within Imo State, Nigeria. Radioactivity measurements were carried out by the method of gamma-ray spectrometry with thallium doped sodium iodide [NaI(Tl)] detector. The mean activity values obtained for the radionuclides 226Ra, 232Th and 40K (respectively) in Federal Medical Centre, Owerri (FMC); General Hospital, Umuguma, Owerri West, (GHW); Neuroscience Hospital, Ohaji Egbema (NHO); St. Joseph Hospital, Okigwe (SJH); Imo State University Teaching Hospital, Orlu (IMSUTH) are: 20.56±4.73, 14.96±3.42 and 105.65±31.40 Bqkg-1; 11.77±3.03, 17.45±4.20 and 63.67±18.44 Bqkg-1; 17.97±4.65,10.02±2.18 and 190.43±42.83 Bqkg-1; 11.36±3.71, 17.39±4.46 and 76.29±25.08 Bqkg-1; and 11.84±3.64, 4.89±2.25 and 165.18±58.41 Bqkg-1 respectively. These values were below the worldwide average values: 32 Bqkg-1 for 226Ra, 45 Bqkg-1 for 232Th, and 412 Bqkg-1 for 40K as documented by UNSCEAR (2000). 40K recorded the highest mean activity compared to 226Ra and 232Th in the studied soil samples. Radium equivalent activity (Raeq), absorbed gamma dose rate (Dr), annual effective dose equivalent (AEDE), external hazard index (Hex), gamma representative index (Ιϒr) and annual gonadal dose equivalent (AGDE), were calculated to quantify the radiation risk to the public from exposure to 226Ra, 232Th and 40K in the studied samples. In addition, excess lifetime cancer risk (ELCR) was also accessed. The mean computed values of the excess lifetime cancer risk for FMC, GHW, NHO, SJH and IMSUTH are 0.08±0.03, 0.09±0.15, 0.10±0.2, 0.10±0.03 and 0.07±0.02 respectively. The mean values of these hazard parameters were within the acceptable safety limits provided for human safety and environmental protection.

Assessment of refining efficiency during the refining cycle in a foundry degassing unit in industrial conditions.

The article focuses on the issue of improving the efficiency of a Foundry Degassing Unit (FDU) via operational testing of aluminium alloys during casting at MOTOR JIKOV Slévárna a.s.. As part of the research, the efficiency of the refining process in the FDU was assessed. The main emphasis was placed on determining the moment of the greatest decrease in the hydrogen content in the melt and whether it is possible to shorten the refining cycle. The values of the Dichte Index were determined, on the basis of which the degassing curve was plotted and the progress of the melt degassing was assessed. To ensure the required quality of castings, the maximum allowable value of the Dichte Index ranged from 3 to 4%. During the process, the temperature drop during the refining cycle was also determined. The total temperature drop from pouring the melt into the ladle to the end of refining ranged from 26 to 32°C, which is within the acceptable limits of the foundry. Based on the knowledge resulting from the operational experiments, recommendations were formulated to optimize the refining technology at the FDU for the MOTOR JIKOV Slévárna a.s. foundry.

Evaluation of Peri-Implant Parameters and Functional Outcome of Immediately Placed and Loaded Mandibular Overdentures: A 5-year Follow-up Study.

To evaluate the peri-implant parameters of immediately placed and loaded mandibular overdentures over a 5-year follow-up period. All subjects who had been advised and planned for two-implant mandibular overdenture treatment were included in this study. The peri-implant parameters -including plaque index (PI), bleeding index (BI) and peri-implant pocket depth (PIPD) as well as marginal bone loss (MBL) - were assessed. In addition, prosthodontic parameters including abutment-, implant- and denture-related complications were assessed. Patients were evaluated at follow-up visits, scheduled at 1, 12, 24, 36, 48, and 60 months. The data distribution was analysed with the Shapiro-Wilk test. Data within follow-up categories were compared using ANOVA and the Tukey-Kramer test. A p-value < 0.05 was considered statistically significant. Among the 32 participants, 19 were males and 13 were females, with a mean age of 60.5 ± 7.33. The mean plaque index (PI), bleeding index (BI) and peri-implant pocket depth (PIPD) varied over time. However, no statistically significant difference was observed in the plaque index, bleeding index and peri-implant pocket depth over time (p > 0.05). The mean value at baseline was found to be -0.9 ± 0.3. The values increased over time, with the highest value observed at 60 months 2.6 ± 0.7, which was statistically significant (p < 0.001). Immediately placed and loaded mandibular implant overdentures using two un-splinted implants with locator attachments showed acceptable PI, BI and PIPD at the 5-year follow-up. Statistically significantly greater marginal bone loss was observed from baseline to follow-up, but it was within acceptable limits. A moderate number of restorative and abutment complications were observed during the follow-up of IODs.

Post-Harvest Management of Immature (Green and Semi-Green) Soybeans: Effect of Drying and Storage Conditions (Temperature, Light, and Aeration) on Color and Oil Quality

Soybean downgrading due to immature (green and semi-green) color at harvest, caused by frost conditions, poses a significant loss to producers and processors. After harvest, drying and storage are important for preserving the quality of the harvested produce. This study investigated the impact of drying on color change in harvested immature soybeans and the effect of the soybean moisture content, storage environment (temperature, light, and aeration), and storage period on color change and oil quality of immature soybeans. Soybeans were harvested at three different maturity stages: R6 (green) and R7 (semi-green) in pods and R8 (fully matured) in seed. The soybeans in pods were dried, shelled, and conditioned to moisture contents of 12% and 17% (wet basis) prior to storage in 12 storage chamber (box) environments. The chambers were built to have four environments of “light” and “no light” with and without aeration and were stored at temperatures of either 4 °C or 23.5 °C for 24 weeks. Samples were taken every 2 weeks for 2 months and then bimonthly in storage. Soybean color change during drying and their chlorophyll, color, peroxide value (PV), and free fatty acid (FFA) status in storage were determined. Visual observation showed that R6 (green) soybean color faded after 48 h drying, which was supported with a colorimeter reading as the “a” value increased from −8.89 to −3.83 and −8.89 to −1.71 with 37 °C and 27 °C drying temperatures, respectively. The ANOVA analysis showed that light had the greatest contribution (~81%) to the color change compared to the other three storage environment factors of temperature (~9.1%), aeration (~8%), and moisture content (~1.5%) with &lt;10% separate effects. During storage, the R6 green and R7 semi-green soybean color continued to fade with color a-values that exceeded the initial values of the R8 matured (control) by 353% and 350%, respectively, by the end of the storage period. Low amounts of peroxide and free fatty acids (FFA) were recorded throughout the storage period. Only the FFA of 17% M.C. soybeans stored at 23.5 °C exceeded acceptable limits at the end of the storage period. Exposing immature (green and semi-green) soybeans to light resulted in the fading of the green color. Seed producers in regions prone to frost can extend harvest time by allowing immature soybeans to field-dry.

Emergency Prevention Control as a Means of Power Quality Improvement in a Shipboard Hybrid Electric Power System

The problems associated with the greenhouse effect have increased the desire to limit carbon dioxide (CO2) emissions into the atmosphere, including emissions produced by shipboard electrical power systems. This has led to a further search for solutions in this area, such as shipboard hybrid electric power systems (SHEPSs). These systems do not yet have a wide application compared with traditional shipboard electrical power systems for several reasons, including the lack of studies establishing the fault tolerance of such systems. Therefore, in this work, problems related to generated power quality deterioration under large disturbances are studied. To achieve the fault-free operation of SHEPS, an emergency prevention control (EPC) system based on controlled parameter forecasting, along with a system structure and operation algorithm, is developed. The goals of improving electrical power quality are achieved by increasing the control efficiency of the power system’s generating sources. To validate the feasibility of the proposed control system, a computer simulation was carried out after developing a mathematical model of the SHEPS under study. The results of the study show that the use of the proposed EPC system will improve power quality when the controlled parameters are within acceptable limits. At the same time, further research is needed, as the problem of false control action as a consequence of EPC system hardware or software faults remains unstudied.

Concept and Life Cycle Assessment of a Tiny House Made from Root Section Structures of a Decommissioned Large-Scale Wind Turbine Blade as a Repurposed Application

With the green energy transition, the wind industry has grown rapidly in recent decades. Wind turbine blades (WTBs) are primarily manufactured from glass fibers and thermoset matrix composites. Considering their lifetime from 20 to 25 years, significant amounts of wind turbine components will eventually enter the global waste stream. Currently, recycling is not sufficiently optimized and commercially available. Other strategies, such as repurpose, are becoming relevant to divert components from waste streams. This research explores a pathway to sustainable repurposing of decommissioned WTBs. The concept of a tiny house constructed from the root section of a 5 MW/61.5 m WTB is presented (“5 MW house”). The deformations and stresses of the repurposed composite structures were investigated using a finite element analysis based on the three load cases, defined by (1) a combination of snow load and payload, (2) a combination of wind load and payload, and (3) a thermal stress analysis of a critical temperature distribution of the 5 MW house. Furthermore, a life cycle assessment (LCA) was conducted to evaluate the environmental impacts of the proposed concept. The numerical analysis results showed that the 5 MW house can withstand the applied loads, and that the deformations are within acceptable limits. A reduction of up to 97% in environmental impacts for most impact categories was calculated, compared to a wooden tiny house, whereas climate change, ozone depletion, and eutrophication potential were up to 3.7 times higher, mainly due to the weight and composition of the 5 MW house. The authors believe that the proposed concept may be a high-volume repurposed solution for large-scale WTB root sections.

Insightful t-SNE guided exploration spotlighting Palbociclib and Ribociclib analogues as novel WEE1 kinase inhibitory candidates

In the era of targeted therapeutics, protein kinases like WEE1 have become pivotal drug targets, especially for cancer therapy. Utilizing a multi-faceted approach, our study adds fresh insights to this endeavour. We employed the t-SNE algorithm, combined with ECFP4 fingerprints, to analyse the molecular similarity between FDA-approved drugs and known clinical trial inhibitors. Our t-SNE analysis identified the closest clusters to known inhibitors and selected 11 FDA-approved drugs for further study. Using the DrugSpaceX platform, we generated analogues for these 11 FDA-approved drugs. These analogues were refined according to Lipinski’s Rule of Five and Synthetic Accessibility scores, yielding 68,640 analogues for additional scrutiny. Among these, derivatives of Palbociclib and Ribociclib stood out as the most promising WEE1 inhibitors, based on docking scores and interaction patterns. Molecular dynamics simulations validated the stability of these protein-ligand interactions, particularly for DE50607359, a top-ranked Palbociclib analogue, which also met most pharmacokinetic parameters within acceptable limits. Our study uncovers new candidates for WEE1 inhibition not previously reported. With our multi-layered computational strategy, we provide a solid foundation for future experimental validation and targeted drug development in cancer therapeutics. Communicated by Ramaswamy H. Sarma

Persistent organic pollutants and trace metals in selected marine organisms from the Akanda National Park, Gabon (Central Africa)

Akanda National Park (ANP) is composed of mangrove ecosystems bordering Libreville, Gabon's capital. The contamination of aquatic resources from the ANP by persistent organic pollutants (POPs) and trace metals (TMs) was never evaluated. To provide a basis for their monitoring in the ANP, five species (two fish, two mollusks, and one crustacean) were analyzed from three sampling sites in 2017. Contamination levels for POPs and TMs were below maximum acceptable limits for seafood, including Cd and Pb. No DDT was found in any sample. Inter-specific differences were more obvious than the differences among sites, although the results may be biased by an unbalanced sampling design. The oyster Crassostrea gasar was the most contaminated species, making this species a good candidate to assess environmental contamination in the area. The studied species also contained essential elements, such as Fe, Zn and Mn at interesting levels in a nutritional point of view.

Effectiveness of wastewater treatment plant at the removal of nutrients, pathogenic bacteria, and antibiotic-resistant bacteria in wastewater from hospital source.

This study is aimed at assessing the effectiveness of hospital's wastewater treatment plant (WWTP) in removing nutrients, pathogenic bacteria, and addressing antibiotic resistance using a case study of a tertiary hospital in Ibadan, Nigeria. During the dry and wet seasons in the month of July and December, respectively, samples were collected, and analyzed using standard guidelines to examine significant physicochemical parameters of the WTTP; to evaluate the removal efficiency of biological oxygen demand (BOD) and chemical oxygen demand (COD), and to examine the prevalence of pathogenic and antibiotic-resistant bacteria. The results of this study showed that during the dry season, certain parameters exceeded acceptable limits, including temperature, total suspended solids (TSS), total dissolved solids (TDS), phosphate, and nitrate. Although there were reductions in BOD (1555mg/L to 482mg/L) and COD levels (3160mg/L to 972mg/L), they remained above acceptable limits by World Health Organization. In the wet season, the level of COD (20mg/L) in the effluent was within acceptable limit, while the BOD (160mg/L) was above the acceptable limit. The WWTP effectively removed nutrients and reduced the microbial load, as evident from the absence of fecal coliforms in the effluent in both seasons. In respect to BOD removal efficiency, the level of purification of wastewater by the WWTP was 69% during the dry season, while the removal efficiency of COD was 83.54% which showed the efficiency of the WWTP at the removal of COD. However, antibiotic resistance was still present. The study concludes that while the WWTP effectively addressed nutrients and microbial load, additional measures such as tertiary treatment methods like chlorination and UV radiation are necessary to tackle antibiotic resistance. This is crucial to prevent the release of antibiotic-resistant bacteria into the environment, safeguarding human health, animals, plants, and overall environmental well-being.

Analysis of a Fuzzy Based Intrusion Detection System in Wireless Ad Hoc Networks

Technology and its growth is considerably enormous. This massive growth allows the opening of new fields of application in the domain of wireless networking and mobile ad-hoc networks (MANET) is one of its kinds. Mobile ad hoc network is widely used from collaborative computing to time critical applications in indoor and outdoor environment. Mobility of ad hoc network makes very attractive in all areas of mobile applications. Nodes participating in mobile ad hoc networks are autonomous, self-configurable and act as a router as well. These types of networks are dynamic in nature and have sort life time. Dynamic nature and limitations of the wireless transmission medium make MANET unsecured and vulnerable to various attacks. It is very tough to implement security for this networks and it opens up doors for further research work on this area. There is a great scope for designing a system to identify attacks and take countermeasures to minimize it and keep the performance of the network within acceptable limits. Intrusion detection system is one of its kinds and considered as security mechanism for MANET. This thesis explores different types of intrusion detection system like misuse detection and anomaly detection for mobile ad hoc networks. Anomaly detection techniques for ad hoc networks depend on the characterization of normal behavior pattern of wireless nodes. This research work focuses on wireless node behavior based detection technique. Most of anomaly intrusion detection systems are focusing on upper layer traffic to a profile normal behavior of wireless node. This research work focus on media access control (MAC) layer and network layer of wireless node. It is inefficient to use a large feature set of MAC layer and network layer due to energy limitation in ad-hoc network. A minimal feature set from MAC layer and network layer were proposed. This research work proposed an anomaly intrusion detection system for mobile ad hoc network using fuzzy logic and weighted average method. The network performance of mobile ad hoc network with intrusion detection system was analyzed using various network parameters. Further the performance of the performance of the intrusion detection system was analyzed using detection rate and false alarms. Results show good improvement in detection rate and other performance metrics

Effects of first-line nucleot(s)ide analogues on lipid profiles in patients with chronic hepatitis B: a network meta-analysis.

Recent studies have found that lipid levels in patients with chronic hepatitis B (CHB) may change during antiviral therapy. To assess the effects of first-line nucleot(s)ide analogues (NAs) on lipid profiles in patients with CHB using network meta-analysis. Seven electronic databases (PubMed, Embase, Cochrane Library, and four Chinese databases) were searched for cohort studies on the effect of NA on lipids in patients with CHB up to August 1, 2023. The changes of serum total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) were taken as outcomes. The mean difference (MD) of continuous variables and 95% confidence intervals (CI) were calculated using RevMan 5.4 and Stata 16.0 software, and network meta-analysis was based on a frequentist framework. A total of 4194 patients were included in the study, including patients with CHB treated with entecavir (ETV), tenofovir disoproxil fumarate (TDF), and tenofovir alafenamide (TAF), as well as patients not receiving antiviral therapy [patients with inactive CHB who were not receiving antiviral therapy (referred as inactive CHB patients) and non-HBV-infected patients]. TDF reduced TC levels compared to the non-antiviral group (TDF vs. inactive CHB patients: MD = - 17.27, 95% CI (- 30.03, - 4.47); TDF vs. non-HBV-infected individuals: MD = - 17.10, 95% CI (- 20.13, - 14.07)). TC changes in the TAF and ETV groups were not statistically different from the non-antiviral group (TAF vs. inactive CHB patients: MD = - 2.69, 95% CI (- 14.42, 9.04); TAF vs. non-HBV-infected individuals: MD = - 2.52, 95% CI (- 8.47, 3.43); ETV vs. inactive CHB patients: MD = - 4.24, 95% CI (- 17.12, 8.64); ETV vs. non-HBV-infected individuals: MD = - 4.07, 95% CI (- 9.90, 1.75)). The ranking of the effects for lowering TC is as follows: CHB patients treated with nucleotide analogues [with varying efficacy: TDF (SUCRA = 99.9) > ETV (SUCRA = 59.3) > TAF (SUCRA = 43.6)] > inactive CHB patients (SUCRA = 27.3) > non-HBV-infected individuals (SUCRA = 19.9). As for secondary outcomes, among the three antiviral drugs, TDF had the most significant effect on lowering TG, LDL-C, and HDL-C, but none of the three drugs was statistically different from the non-antiviral group. Subgroup analysis showed that the lipid-lowering effect of TDF was more pronounced in the elderly (≥ 50years). TDF was effective in lipid reduction, particularly pronounced in the older population. TAF and ETV had a neutral effect to TC, TG, LDL-C, and HDL-C. Despite a relative increase in lipids observed in patients transitioning from TDF to TAF or ETV, these changes remained within acceptable limits.

Characterization of soil trace metal pollution, source identification, and health risk assessment in the middle reaches of the Guihe River Basin.

The natural environment, as well as human production and survival, is intrinsically dependent on soil. This study comprehensively assessed the pollution status, health risks, and sources of trace metals in the middle reaches of the River Gui Basin (MRGB) utilizing the geoaccumulation index, potential ecological risk index (PERI), and human health risk evaluation method. The findings of this study provide the following key insights: (1) only Cu and Pb levels in the MRGB soils did not exceed the background values established for soils in Weifang City (WFC). (2) The geoaccumulation status in most areas of the MRGB ranged from non-polluted to mildly polluted, with the overall ecological risk classification ranging from mild to moderate. (3) The cumulative non-carcinogenic risk for humans in the MRGB remained within acceptable limits, whereas the carcinogenic risk indices fell within tolerable levels. Oral ingestion emerged as the primary exposure pathway for both non-carcinogenic and carcinogenic health risks. (4) Cu, Zn, Ni, and Cr concentrations in MRGB soils primarily stemmed from natural sources associated with parent rocks, with Zn exhibiting additional influence from anthropogenic factors. In contrast, Pb, Cd, Hg, and As concentrations were predominantly driven by anthropogenic sources. Although the soils in the MRGB typically exhibited mild-to-moderate contamination levels, the contamination levels of Hg and Cd were notably more severe. As and Cr were significant health hazards. Most soil contamination sources are attributed to anthropogenic factors, warranting heightened attention from the relevant authorities.

Prediction of Cotton Shell from Sodecoton Behavior in Thermal Conversion and Theoretical Energy Potential

This work focuses on the evaluation of the energy potential of cotton shells from SODECOTON and to predict suitable thermal conversion conditions. To achieve this goal, structural and proximate analyses were performed, while ultimate analysis, flue gas and higher heating value were calculated from models. This study reveals that cotton shells highly contain cellulose, volatile matter, lignin and carbon, which make it suitable for bioethanol, bio-oil/syngas and biochar production via biochemical and thermochemical technologies as well as fuel briquette. Heating value from cotton shell ranging from 17 MJ/kg to 19 MJ/kg, is set in the interval to be used as fuel. From the results, the value of flue gas is within acceptable limits and the pollutant emissions are less than the values of regulated threshold set. The energy potential released is around 1.30 GJ per year, 1.58 × 107 Nm3/year, 1.62 × 104 m3/year, 15.21 × E6 L and 26 × E6 L for annual combustion energy, syngas, methane, bioethanol and bio oil, respectively. Amongst them combustion via fuel briquette is suitable for less developing country such as Cameroon thus, it could supply 40% of cooking energy consumption in Garoua center town and can improve environmental sustainability in company.

Characterization of soy curd residue and full-fat soy flour as protein-based food ingredients

The study investigated the soy curd residue and full-fat soy flour as potential protein-based food ingredients. Standard protocols were used to determine proximate parameters, functional properties, markers of oxidative stability under shelf storage, colour (CIE L* a* b*), and microbial quality of the flours. Commercial Afayak soybean varieties were used to prepare soy curd residue flour and two differently treated soy flours, namely full-fat soy flour and cold-water extracted full-fat soy flour. Findings from the study indicate that processing treatment and storage time significantly (p&lt;0.001) affected the parameters measured. Cold-water extraction of full-fat soy flour resulted in a significantly (p&lt;0.001) higher protein content denoting 1.0, and 1.2-fold than full-fat soy flour and soy curd residue, respectively. Full-fat soy flour showed the highest peroxide, acid, and p-anisidine (p &lt; 0.001) under processing and storage conditions. Soy curd residue was the most oxidatively stable among the samples; however, it was noted that cold-water extraction of full-fat soy had better oxidative stability than full-fat Soy flour. After 12 weeks of storage, peroxide and acid values were below the acceptable limit of 10 mEq/Kg and 0.6 mg/KOH/g, respectively. The study supports the hypothesis that the proximate composition, physicochemical properties, and oxidative stability of soy-based flours are affected by the sample processing method and storage time. The study concludes that the samples characterized in this study are oxidatively stable, protein and energy-rich and may be ideal ingredients for food product development with desirable functional properties.

SUSTAINABLE GREEN ANALYTICAL CHEMISTRY: SPECTROPHOTOMETRIC METHOD DEVELOPMENT OF DAPAGLIFLOZIN AND OMEPRAZOLE BY USING ECO-FRIENDLY SOLVENT

The present research’s aim was to develop analytical method utilizing ecologically suitable solvent which enhances solubility of analyte, sensitivity of the method etc. An analytical method was developed for the estimation of dapagliflozin (DGZ) and omeprazole (OPZ) by using aqueous 0.1 N HCl on the UV-VIS spectrophotometer. Wavelengths 223 nm and 282.5 nm were set to measure absorbance of DGZ and OPZ respectively. The results of different spectral characteristic techniques were examined to select the parameters and the design was validated against the ICH Q 2 R1 regulatory guidelines. The linearity of the drug was determined at a concentration of 1 to 50μg/ml and 1 to 32μg/ml for DGZ and OPZ respectively. The accuracy was found within acceptable limit with standard deviation 1.1874 to 6.4984 for DGZ and 0.1401 to 0.9843 for OPZ; and the assay study data was found 99.77 % for DGZ and 97.92 % for OPZ. The stability study of the method was performed out by minute variation in the wavelength, scan speed. The developed method is rigid, robust and efficient for the estimation of DGZ and OPZ from their respective dosage form. The effort was made to develop green or eco-friendly analytical method utilizing hydrotropic solvent for water insoluble drug dapagliflozin and omeprazole. KEYWORDS: Green method, Dapagliflozin, Omeprazole, analytical method, eco-friendly solvent, UV spectroscopy.

Monitoring the quality and safety of sausage products

The role of quality control in providing consumers with high-quality food is shown. The objects of the study were encoded samples of sausage products. In total, 76 samples of boiled and boiled-smoked sausages presented on the consumer market of Kuzbass were analyzed. Quality monitoring was carried out in the period from 2019 to 2022. When conducting research, we used generally accepted methods for testing sausages in accordance with the requirements of current regulatory documents. Gravimetric, extraction, titrimetric, capillary electrophoresis, spectrophotometric, organoleptic test methods were used. A non-compliance with the requirements of TR CU 022/2011 was found in 4.3% of the samples in terms of the availability of the marking for reading. A discrepancy in terms of the mass fraction of moisture was revealed in 1% of sausages, in 3.5% an overestimated content of sodium chloride by 0.1-0.3%, in one sample a starch content of up to 2.0% was detected. In addition to the normalized indicators, the iron content, the residual activity of acid phosphatase, the mass fraction of glutamic acid and its salts (E620-E625) were determined. its salts is within acceptable limits. The content of iron in the analyzed samples is from 7 to 13 mg/kg of the product.The results obtained can be used in the preparation of a daily diet, taking into account the permissible norms for the consumption of sausages.

Metal levels in Sander lucioperca (Linnaeus, 1758) and their health risk assessment for consumers

AbstractThe current study was conducted to determine the residues of Zn, Fe, Cu, Cd, Hg, Pb, and As in the edible tissues of Sander lucioperca. Total of 20 fish individuals collected from Lake Balık, Samsun were analysed by using ICPMS (Inductively Coupled Plasma Mass Spectrophotometer). All metal values in the muscle of S. lucioperca were quite low. Fe is the highest concentration (4.07 mg/kg), whereas Cd had the lowest Cd (0.007 mg/kg). Therefore, it can be said that the bioaccumulation of metals in pike‐perch did not go over the acceptable limits established for these metals by national and international organisations. The hazard quotients (HQs) for individual elements and the hazard index (HI) were all &lt;1 in S. lucioperca, showing no danger by these chemicals when consumed by infants, children, and adults. The RIs for Pb were between 1.45 × 10−7 and 4.30 × 10−7, indicating their insignificant carcinogenic risks, whereas for As these values were between 2.78 × 10−5 and 1.06 × 10−4, indicating their tolerable or acceptable carcinogenic risks.

Does a self-reported sleep duration reflect actigraphy reported sleep duration in female football players?

ABSTRACT Sleep is often compromised in female athletes, and the monitoring of female athletes' sleep is an important preventative and educational tool. With self-reporting of sleep common practice for athletes as part of a daily wellness assessment, there is a need to understand whether sleep indices are being reported accurately, and thus whether self-report data are useful. This study aimed to compare the agreement between self-reported and actigraphy reported sleep duration in female football players, with the intention of informing best practice for athlete monitoring. Twenty-two female footballers (mean age 19.5 ± 1.3 years) provided a daily self-report across 7 days, whilst also wearing an actigraph across the same testing period. Agreement between the two measures was assessed using Bland-Altman limits of agreement, with acceptable limits of agreement defined as <30 minutes. Results showed evident disagreement between the two methods, with a mean bias of −0.54 (32 min, 95% CI −0.66 to −0.43) and a potential disagreement range of over 2 h (Lower 95% limits of agreement −1.49 to upper 95% limits of agreement 0.40). Coaches using self-reported sleep durations as a monitoring tool for female footballers should interpret the results with caution and be aware of the potential for inaccuracies in this measure. As such, where possible, coaches should consider other methods of sleep monitoring, rather than solely relying on a self-report, to ensure they are operating with optimal practice within situational constraints.

Human health risk assessment of nitrate and heavy metals in urban groundwater in Southeast Nigeria

Groundwater contamination by nitrate and heavy metals is a growing global concern due to its detrimental effects on human health through ingestion and dermal exposure. This study aimed to assess the concentrations of nitrate and heavy metals (Pb, Cu, Cd, and Fe) in groundwater and evaluate the associated health risks among different age groups (females, males, and children) in the Nnewi and Awka regions of southeast Nigeria. Standard methods were followed. Ten groundwater samples were collected from each study locality, and their physicochemical parameters were analyzed. The evaluation of heavy metal levels in groundwater was conducted using the risks of cancer and health hazard index as indicators of public health impact. The results showed that while nitrate levels were within acceptable limits, heavy metal concentrations exceeded permissible levels in all samples. Carcinogenic risk (CR) analysis revealed that approximately 40% of Nnewi samples and 80% of Awka samples exceeded the permitted range of ≤1 × 10 −6–1 × 10 −4. In the Nnewi region, the order of heavy metal toxicity was Cd > Pb > Cu > Fe, while in Awka, it was Pb > Cd > Cu > Fe, resulting in severe non-carcinogenic health hazards for users. Cd and Pb were identified as the most significant contaminants impacting water quality in both regions. Children exhibited greater vulnerability to health risks compared to adults in both areas. These findings contribute to our understanding of localized nitrate and heavy metal contamination, highlight the vulnerability of children, and emphasize the importance of regular monitoring and management practices.

Potential health risk assessment of nitrate in groundwater of Tonk district in Rajasthan, north western India

ABSTRACT Anthropogenic activities like adding synthetic nitrogenous fertilisers in agriculture fields, animal and human waste are the main factors responsible for the increase in nitrate concentration in groundwater of any area. Groundwater is the main source of not only irrigation but also dependency for drinking which has increased on it with decreasing surface sources. Today, increase in such anthropogenic activities has resulted in upsurge of the natural nitrate concentration to the extent of crossing its acceptable limit in drinking water. The Bureau of Indian Standard (BIS, 2012) 1 has prescribed the limit of 45 mg/L, whereas for WHO (2011) 2 the limit of nitrate is 50 mg/L. The goal of this present study is to assess the natural and anthropogenic NO3 concentrations in groundwater in a semi arid area of Rajasthan in Tonk District and its related risks to human health in the different groups of ages, such as children, males, and females. Being immune adults has little less effect on its continuous exposure than children. Even though these risks are non-carcinogenic, incessant exposure can create several health issues. In juveniles, it is known to cause methemoglobinemia, in adults it causes gastric and other stomach issues on prolonged consumption as well as dermal contact. The results show that the oral exposure of nitrate was very high compared to dermal contact. On the basis of non-carcinogenic health risk, the total Hazard Index (HITotal) values of groundwater nitrate were an average of 1.16 for males, 1.37 for females, and 1.58 for children. The nitrate health risk assessment shows that about 39%, 44%, and 51% of the samples constitute the non-carcinogenic health risk to males, females, and children, respectively.