Absolute Workload Research Articles

Effects of concentric and eccentric exercise regimens on bioenergetic efficiency of lymphocytes in sedentary males.

Eccentric exercise training (EET) increases physical performance while having lower metabolic demand than concentric exercise training (CET). Whether EET influences bioenergetic efficiency in peripheral blood mononuclear cells (PBMCs) remains unclear. This study investigates the effects of EET and CET on PBMC phenotypes and mitochondrial functions in blood. Thirty three sedentary healthy males were randomly assigned to either EET (n=11) or CET (n=11) that performed at progressively increased from 60% to 80% of maximal absolute workload for 30min/day, 5days/week for 6weeks, or a control group (n=11) that did not receive any exercise intervention. A graded exercise stress test (GXT) was performed before and after the intervention. PBMC phenotypes and mitochondrial respiratory capacity were analyzed using flowcytometry and high-resolution respirometry, respectively. In the same absolute workload, EET elicited lower heart rate and rating of perceived exertion than CET. However, EET as CET increased the VO2 level at the ventilatory threshold. Notably, both EET and CET increased central memory (CD45RO+/CD62+/CD3+) T cells and decreased effector memory T cells reexpressing CD45RA (CD45RA+/CD62-/CD3+). Moreover, the two exercise regimens diminished the loss of mitochondrial membrane potential (ΔΨm) caused by GXT, increased maximal/reserve O2 consumption rates (OCR), and bioenergetic health index in intact PBMCs and enhanced complex I-/II-related OCR in PBMCs with a substrate-rich environment. EET improves aerobic fitness with a lower cardiovascular response to exercise than CET. Moreover, EET as CET reduces senescent T-cell distribution in blood and improves PBMC bioenergetic efficiency by stabilizing ΔΨm and increasing capacity of oxidative phosphorylation.

Sex-based differences in the blood pressure responses to muscle metaboreflex activation are consistent between limb and respiratory muscle.

The purpose of this study was to compare sex-based differences in the mean arterial blood pressure (MAP) response to limb and inspiratory metaboreflex activation, during relative and absolute workloads. Healthy males (n = 9) and females (n = 8) completed pulmonary function testing, forearm volume and circumference measurements, and bouts of limb and inspiratory muscle exercise. The exercises performed included bouts of rhythmic handgrip exercise (RHG) and inspiratory pressure threshold loading (PTL) to task failure, performed in a randomized order and separated by 30 minutes of rest. Participants performed both RHG and PTL at predetermined relative (R) and absolute (A) workloads, while cardiopulmonary measurements were recorded continuously. A time-dependent rise in MAP was observed in all participants, regardless of sex, muscle, or workload (P < 0.001). MAP was greater in males than females during all exercise bouts regardless of muscle group or workload (P < 0.001). The change in MAP from baseline was also greater in males (R-RHG: Δ31 ± 12 mmHg; R-PTL: Δ31 ± 9; A-RHG: Δ35 ± 6; and A-PTL: Δ30 ± 7) than females (R-RHG: Δ21 ± 7 mmHg; R-PTL: Δ13 ± 7; A-RHG: Δ21 ± 7; and A-PTL: Δ14 ± 3) (P < 0.001). Results from this study show that when the forearm and diaphragm perform the same relative or absolute work, the blood pressure response is statistically similar, and both responses are greater in males than females. The findings from the present study suggest that the sex-based difference in the response to metaboreflex activation is similar between the limb and respiratory musculature.NEW & NOTEWORTHY With rhythmic handgrip exercise and inspiratory pressure threshold loading there was a time-dependent rise in the blood pressure that was significantly lower in females than males. The blunted blood pressure response in females was present whether handgrip or inspiratory workload was relative or absolute. An attenuated cardiovascular response to high levels of limb or respiratory muscle work may have implications for whole body exercise in health and disease.

Modulators of Energy Expenditure Accuracy in Adults with Overweight or Obesity: E-MECHANIC Secondary Analyses.

American College of Sports Medicine (ACSM) metabolic equations are used to estimate energy expenditure (EE) of physical activity and prescribe aerobic exercise to meet EE requirements. Limited evidence supports their accuracy in sedentary adults with overweight or obesity during controlled exercise interventions. The purpose of this study was to compare EE estimated by the ACSM walking equation versus EE measured by indirect calorimetry during a 24-week aerobic exercise intervention, and identify potential modulators for their accuracy. Data from the exercising groups (8 or 20 kcal·kg body weight-1·week-1) of the E-MECHANIC study were utilized in this ancillary analysis (N = 103). Every 2 weeks for the initial 8 weeks and monthly thereafter, EE was measured via indirect calorimetry during absolute (2 mph, 0% grade) and relative (65-85% VO2peak) workload exercise. Resting metabolic rate, VO2peak, and body composition were assessed at baseline and follow-up. An EE offset factor (EOF) was calculated to express measured EE as a percentage of the estimated EE at each workload (EOF < 100% represents an overestimation of ACSM estimated EE). The accuracy of the equation decreased with increasing exercise workload (0.44%, 9.2%, and 20.3% overestimation at absolute, relative, and maximal workloads, respectively, at baseline) and overestimation of EE was greater after the exercise intervention. Furthermore, race, sex, age, fat mass, and VO2peak were identified as modulators for equation accuracy. Greater overestimation of EE was observed in Black compared to white females, particularly at lower exercise workloads. These findings support future efforts to improve the accuracy of metabolic equations, especially in diverse populations. Researchers should account for exercise efficiency adaptations when using metabolic equations to prescribe exercise precisely.

Lower Oxygen Cost Of Absolute Workload Submaximal Exercise During Acute High Altitude Exposure

Lower Oxygen Cost Of Absolute Workload Submaximal Exercise During Acute High Altitude Exposure

Workloads in Collegiate Women's Lacrosse Athletes During a Division II National Championship Season.

Sutton, PJ, Mumford, PW, and Sunderland, KL. Workloads in collegiate women's lacrosse athletes during a Division II national championship season. J Strength Cond Res 38(9): 1651-1657, 2024-A comprehensive examination of the external and internal workloads in collegiate women's lacrosse athletes has yet to be reported. Thus, the primary purpose of this study was to determine the absolute and relative external and internal training and game workloads of National Collegiate Athletic Association (NCAA) Division II women's lacrosse athletes throughout an entire season. Data from 19 Division II women's lacrosse athletes were analyzed, encompassing each training session and game across an entire competitive season (February-May). External workloads were assessed using a wearable global positioning system, whereas internal workloads were determined through heart rate (HR) variables and session rating of perceived exertion. Game days were associated with significantly ( p < 0.05) greater absolute external and internal workloads. However, when comparing workloads relative to session duration, relative workloads between training and games were no longer significant ( p > 0.05) for total distance, high-speed running (≥15 km·h -1 ), HR-derived training impulse, or caloric expenditure. Nonetheless, relative sprint distance (>19 km·h -1 ) was significantly lower during games, whereas high-intensity accelerations (>2 m·s -2 ) and decelerations (<-2 m·s -2 ) were significantly greater during training compared with games ( p < 0.05). Practical applications of these findings suggest that coaches can better prepare athletes for game day conditions by adjusting training plans to replicate the duration and intensity of games. Overall, this comprehensive examination of internal and external workloads provides valuable data for coaches and practitioners to support performance comparisons, rehabilitation protocols, and workload analyses in collegiate women's lacrosse athletes.

Association of central blood pressure with an exaggerated blood pressure response to exercise among elite athletes

PurposeThe systolic blood pressure/workload (SBP/MET) slope was recently reported to be a reliable parameter to identify an exaggerated blood pressure response (eBPR) in the normal population and in athletes. However, it is unclear whether an eBPR correlates with central blood pressure (CBP) and vascular function in elite athletes.MethodsWe examined 618 healthy male elite athletes (age 25.8 ± 5.1 years) of mixed sports with a standardized maximum exercise test. CBP and vascular function were measured non-invasively with a validated oscillometric device. The SBP/MET slope was calculated and the threshold for an eBPR was set at > 6.2 mmHg/MET. Two groups were defined according to ≤ 6.2 and > 6.2 mmHg/MET, and associations of CBP and vascular function with the SBP/MET slope were compared for each group.ResultsAthletes with an eBPR (n = 180, 29%) displayed a significantly higher systolic CBP (102.9 ± 7.5 vs. 100 ± 7.7 mmHg, p = 0.001) but a lower absolute (295 ± 58 vs. 384 ± 68 W, p < 0.001) and relative workload (3.14 ± 0.54 vs. 4.27 ± 1.1 W/kg, p < 0.001) compared with athletes with a normal SBP/MET slope (n = 438, 71%). Systolic CBP was positively associated with the SBP/MET slope (r = 0.243, p < 0.001). In multiple logistic regression analyses, systolic CBP (odds ratio [OR] 1.099, 95% confidence interval [CI] 1.045–1.155, p < 0.001) and left atrial volume index (LAVI) (OR 1.282, CI 1.095–1.501, p = 0.002) were independent predictors of an eBPR.ConclusionSystolic CBP and LAVI were independent predictors of an eBPR. An eBPR was further associated with a lower performance level, highlighting the influence of vascular function on the BPR and performance of male elite athletes.

Physical Activity and Cardiac Morphologic Adaptations.

Chronic and intense exercise programs lead to cardiac adaptations, followed by increased left ventricular wall thickness and cavity diameter, at times meeting the criteria for left ventricular hypertrophy (LVH), commonly referred to as "athlete's heart". Recent studies have also reported that extremely vigorous exercise practices have been associated with heightened left ventricular trabeculation extent, fulfilling noncompaction cardiomyopathy criteria, as part of exercise-induced structural adaptation. These changes are specific to the exercise type, intensity, duration, and volume and workload demands imposed on the myocardium. They are considered physiologic adaptations not associated with a negative prognosis. Conversely, hypertrophic cardiac adaptations resulting from chronic elevations in blood pressure (BP) or chronic volume overload due to valvular regurgitation, lead to compromised cardiac function, increased cardiovascular events, and even death. In younger athletes, hypertrophic cardiomyopathy (HCM) is the usual cause of non-traumatic, exercise-triggered sudden cardiac death. Thus, an extended cardiac examination should be performed, to differentiate between HCM and non-pathological exercise-related LVH or athlete's heart. The exercise-related cardiac structural and functional adaptations are normal physiologic responses designed to accommodate the increased workload imposed by exercise. Thus, we propose that such adaptations are defined as "eutrophic" hypertrophy and that LVH is reserved for pathologic cardiac adaptations. Systolic BP during daily activities may be the strongest predictor of cardiac adaptations. The metabolic demand of most daily activities is approximately 3-5 metabolic equivalents (METs) (1 MET = 3.5 mL of kg of body weight per minute). This is similar to the metabolic demand of treadmill exercise at the first stage of the Bruce protocol. Some evidence supports that an exercise systolic BP response 150 mmHg at the end of that stage is a strong predictor of left ventricular hypertrophy, as this BP reflects the hemodynamic burden of most daily physical tasks. Aerobic training of moderate intensity lowers resting and exercise systolic BP at absolute workloads, leading to a lower hemodynamic burden during daily activities, and ultimately reducing the stimulus for LVH. This mechanism explains the significant LVH regression addressed by aerobic exercise intervention clinical studies.

Human skeletal muscle mitochondrial responses to single-leg intermittent or continuous cycle exercise training matched for absolute intensity and total work.

There is renewed interest in the potential for interval (INT) training to increase skeletal muscle mitochondrial content including whether the response differs from continuous (CONT) training. Comparisons of INT and CONT exercise are impacted by the manner in which protocols are "matched", particularly with respect to exercise intensity, as well as inter-individual differences in training responses. We employed single-leg cycling to facilitate a within-participant design and test the hypothesis that short-term INT training would elicit a greater increase in mitochondrial content than work- and intensity-matched CONT training. Ten young healthy adults (five males and five females) completed 12 training sessions over 4 weeks with each leg. Legs were randomly assigned to complete either 30 min of CONT exercise at a challenging sustainable workload (~50% single-leg peak power output; Wpeak) or INT exercise that involved 10 × 3-min bouts at the same absolute workload. INT bouts were interspersed with 1min of recovery at 10% Wpeak and each CONT session ended with 10min at 10% Wpeak. Absolute and mean intensity, total training time, and volume were thus matched between legs but the pattern of exercise differed. Contrary to our hypothesis, biomarkers of mitochondrial content including citrate synthase maximal activity, mitochondrial protein content and subsarcolemmal mitochondrial volume increased after CONT (p < 0.05) but not INT training. Both training modes increased single-leg Wpeak (p < 0.01) and time to exhaustion at 70% of single-leg Wpeak (p < 0.01). In a work- and intensity-matched comparison, short-term CONT training increased skeletal muscle mitochondrial content whereas INT training did not.

Sex differences in the acute effect of stair-climbing on postprandial blood glucose levels: A randomized controlled trial

Backgrounds and aimsSingle, short stair climbing and descending (SCD) bouts of low to moderate intensity effectively lower postprandial blood glucose but previous reports have found conflicting results on interactions by sex during exercise. We hypothesize that SCD at a self-selected intensity will be equally effective at lowering postprandial blood glucose in males and females. Methods and Results: Thirty subjects (age: 23.8 (3.0) years) performed 0, 1, 3, and 10 min of SCD following consumption of a mixed meal. SCD was performed at a self-selected comfortable pace and all bouts ended at minute 28. Postprandial blood glucose was measured every 15 min for 1 h and analyzed as glucose over time, area under the curve (AUC), and incremental AUC (iAUC) using mixed-design ANOVAs with repeated measures. Although there was no interaction between sex and condition or time (p = .129 to .541) for glucose over time, AUC, or iAUC, there was a main effect for sex for glucose over time (p = .004) and AUC (p = .006), but not iAUC (p = .125). Females had higher blood glucose throughout each trial (22% (13 to 31%), p = .004) but both males' and females’ postprandial blood glucose was lowered following 10 min of SCD relative to the seated control condition. Conclusions: Males and females benefited equally from single, short SCD bouts of low to moderate intensity despite females having higher blood glucose at all time points. Previous findings of sex differences in the attenuating effect of exercise on postprandial blood glucose are likely due to the use of absolute workloads leading to varying relative intensities.

Distributed Triangle Approximately Counting Algorithms in Simple Graph Stream

Recently, the counting algorithm of local topology structures, such as triangles, has been widely used in social network analysis, recommendation systems, user portraits and other fields. At present, the problem of counting global and local triangles in a graph stream has been widely studied, and numerous triangle counting steaming algorithms have emerged. To improve the throughput and scalability of streaming algorithms, many researches of distributed streaming algorithms on multiple machines are studied. In this article, we first propose a framework of distributed streaming algorithm based on the Master-Worker-Aggregator architecture. The two core parts of this framework are an edge distribution strategy, which plays a key role to affect the performance, including the communication overhead and workload balance, and aggregation method, which is critical to obtain the unbiased estimations of the global and local triangle counts in a graph stream. Then, we extend the state-of-the-art centralized algorithm TRIÈST into four distributed algorithms under our framework. Compared to their competitors, experimental results show that DVHT-i is excellent in accuracy and speed, performing better than the best existing distributed streaming algorithm. DEHT-b is the fastest algorithm and has the least communication overhead. What’s more, it almost achieves absolute workload balance.

Contextual Variation in External and Internal Workloads across the Competitive Season of a Collegiate Women's Soccer Team.

As sports technology has continued to develop, monitoring athlete workloads, performance, and recovery has demonstrated boundless benefits for athlete and team success. Specifically, technologies such as global positioning systems (GPS) and heart rate (HR) monitors have granted the opportunity to delve deeper into performance contributors, and how variations may exist based upon context. A team of NCAA Division I women’s soccer athletes were monitored during games throughout one competitive season. Individual athlete, positional groups, and team external and internal workloads were explored for differences based upon game location, opponent ranking, game result, and the final score differential. Game location and opponent ranking were found to have no effect on team-wide absolute or relative external workloads, whereas game result and score differential did. Internal workloads across the team tended to only vary by game half, independent of game context; however, the HR of defenders was determined to be higher during losses as compared to wins (p = 0.0256). Notably, the games that resulted in losses also represented the games with the fewest number of substitutions. These findings suggest high value in monitoring performance and workloads that are characteristic of varying, often multifaceted, contexts. It is hoped that this information can lead to more informed approaches to vital game-time and coaching decisions.

Averting Burnout in Pediatricians: Understanding the Intersection of Workload and Meaning of Work.

Averting Burnout in Pediatricians: Understanding the Intersection of Workload and Meaning of Work.

Examining Internal and External Physical Workloads Between Training and Competitive Matches Within Collegiate Division I Men's Soccer.

Anderson, T, Adams, WM, Martin, KJ, and Wideman, L. Examining internal and external physical workloads between training and competitive matches within collegiate Division I men's soccer. J Strength Cond Res 35(12): 3440-3447, 2021-A direct analysis comparing differences in the demands of competition relative to in-season training in Division I collegiate soccer players has yet to be reported. Thus, the primary purpose of this study was to compare the absolute and relative internal and external workloads measured during training with competitive matches. Twenty-six male college soccer players were monitored over 2 consecutive seasons using a GPS and heart rate (HR) telemetry system. Differences between outdoor training sessions and competitive matches were analyzed for internal and external absolute and relative training workloads. Differences in training workloads between the 3 days before a match were also analyzed. Absolute time in HR zone 4 (80-89% of HRmax) and 5 (90-100% of HRmax); accelerations in zone 1 (0.50-0.99 m·s-2), zone 2 (1.00-1.99 m·s-2), and zone 3 (2.00-2.99 m·s-2); all negative acceleration zones; training load; and estimated energy expenditure were greater in competition than training (p < 0.05). By contrast, when comparing training and competition values using metrics relative to session duration, relative workload in trainings were greater than competition for HR zone 1 (50-59% of HRmax), zone 2 (60-69% of HRmax), zone 3 (70-79% of HRmax), and zone 4 (80-89% of HRmax) and all acceleration and negative acceleration zones. In addition, absolute training workloads were generally greatest 3 days prior (p < 0.01), but not different 2 days before the competitive match. Absolute physical workloads of competition are significantly greater than those achieved during training; however, these differences and impact on the physical condition of players are mitigated by the greater relative workloads achieved during training. These results provide meaningful metrics that may lead to insights into proper conditioning and in-season workload management for Division I collegiate soccer programs.

The effect of leg preference on mechanical efficiency during single-leg extension exercise.

To investigate how leg preference affects net efficiency (ηnet), we examined central and peripheral hemodynamics, muscle fiber type, activation and force of preferred (PL) and nonpreferred (NPL) leg. Our hypothesis was that PL greater efficiency could be explained by adaptations and interactions between central, peripheral factors, and force. Fifteen young participants performed single-leg extension exercise at absolute (35 W) and relative [50% peak power-output (Wpeak)] workloads with PL and NPL. Oxygen uptake, photoplethysmography, Doppler ultrasound, near-infrared-spectroscopy deoxyhemoglobin [HHb], integrated electromyography (iEMG), maximal isometric force (MVC), rate of force development (RFD50-100), and muscle biopsies of both vastus lateralis were studied to assess central and peripheral determinants of ηnet. During exercise executed at 35 W, ηnet was 17.5 ± 5.1% and 11.9 ± 2.1% (P < 0.01) in PL and NPL respectively, whereas during exercise at the 50% of Wpeak was in PL = 18.1 ± 5.1% and in NPL = 12.5 ± 1.9 (P < 0.01). The only parameter correlated with ηnet was iEMG, which showed an inverse correlation for absolute (r = -0.83 and -0.69 for PL and NPL) and relative workloads (r = -0.92 and -0.79 for PL and NPL). MVC and RFD50-100 were higher in PL than in NPL but not correlated to ηnet. This study identified a critical role of leg preference in the efficiency during single-leg extension exercise. The whole spectrum of the central and peripheral, circulatory, and muscular determinants of ηnet did not explain the difference between PL and NPL efficiency. Therefore, the lower muscle activation exhibited by the PL is likely the primary determinant of this physiological phenomenon.NEW & NOTEWORTHY This study examined the impact of leg preference on efficiency during single-leg exercise. The results revealed lower efficiency of the nonpreferred leg during exercises performed at absolute and relative workloads. Central (cardiac output) and peripheral (fiber typing) determinants of efficiency did not explain the difference between the legs. However, the lower muscle activation of the preferred leg that was inversely correlated with efficiency is likely the primary determinant of this physiological feature.

Magnitude of Change in Middle Cerebral Artery Cross‐Sectional Area is Associated with Cardiorespiratory Fitness

Cardiorespiratory fitness has beneficial effects on the systemic vasculature; however, its influence on the function of the large cerebral vessels is unclear. Recent studies using high field magnetic resonance imaging (MRI) suggest that the middle cerebral artery (MCA) may vasodilate during a vasoactive stimulus such as hypercapnia, but the influence of cardiorespiratory fitness on MCA dilation is unknown. The purpose of this study was to evaluate the association between cardiorespiratory fitness and MCA cross-sectional area (CSA) before and during hypercapnia. We hypothesized that cardiorespiratory fitness would be positively associated with the percent change in MCA CSA from baseline to hypercapnia. A total of 16 healthy, physically-active adults (age = 54 ± 17 y, men = 8, women = 8) participated in this pilot study. Left MCA CSA was assessed with a 4D flow MRI scan on a 3T MRI scanner at baseline and during hypercapnia (6% CO2). End-tidal carbon dioxide and mean arterial pressure were continuously monitored with an anesthesia monitor. CSA analysis was performed offline. On a separate study visit, cardiorespiratory fitness was assessed by a VO2max test on a cycle ergometer. The average absolute VO2max was 2.5 ± 0.9 L/min, the average relative VO2max was 37 ± 8 ml/kg/min and the average maximal workload attained during the VO2max test was 231 ± 77 watts. The MCA CSA was 0.068 ± 0.011 cm2 at baseline and 0.069 ± 0.013 cm2 during hypercapnia. The average percent change in the MCA CSA from baseline to hypercapnia was 2 ± 4 %. The percent change in MCA CSA was positively associated with absolute VO2max (r = 0.52, p = 0.04) and maximal workload (r = 0.58, p = 0.02), but not significantly associated with relative VO2max (r = 0.32, p = 0.22). Because age and body size may impact these results, we also investigated the associations between MCA CSA percent change and cardiorespiratory fitness or workload when adjusted for age and body surface area. With these adjustments, these associations were no longer significant (absolute VO2max: r = 0.16, p = 0.58; workload: r = 0.33, p = 0.25). The results were similar when delta MCA CSA was assessed. In conclusion, absolute cardiorespiratory fitness levels and maximal workload were positively associated with change in MCA CSA during hypercapnia; however, these associations were no longer significant after adjusting for age and body surface area. These results suggest that cardiorespiratory fitness may influence the vasoreactivity of large intracranial vessels in response to vasoactive stimuli. In addition, age and body size may also need to be considered.

Influence of a Patent Foramen Ovale on Heart Rate‐Core Temperature Relationship at Rest and During Exercise in Young, Healthy Men

During both passive and active heat stress, there is a relationship between increases in core temperature (Tcore) and the heart rate (HR) response. As Tcore rises, HR increases as a result of sympathetic nervous system stimulation and due to the direct effects of temperature on the sinoatrial node. Young, healthy men with a patent foramen ovale (PFO+) have a higher Tcore at rest and during exercise so they may have altered thermoregulatory (Tcore) and cardiovascular (HR) coupling compared to those without a PFO (PFO-). We aimed to test two hypotheses: 1) That there is a relationship between inter-individual values for HR and Tcore at rest and during exercise and 2) The presence of a PFO alters the HR-Tcore inter-individual relationship at rest and during exercise. Thirty male subjects free of cardiometabolic and respiratory diseases (ages 19-36) participated in the study (15 PFO+/15 PFO-) and performed a graded exercise protocol that included cycling at exercise intensities of 50% (154 ± 22 W) and 90% (277 ± 40 W) of VO2max. HR and Tcore (esophageal probe) were measured at rest and continuously during the exercise test. Linear regression analyses were performed to determine the relationships between Tcore and HR at rest and at 50% and 90% of VO2max as a main group and in both PFO- and PFO+ subgroups. Absolute workload was not different at 50% and 90% VO2max between PFO+ and PFO- groups (p > 0.05). A positive relationship between Tcore and HR was seen at rest (r = 0.45, p < 0.05), 50% (r = 0.50, p < 0.05), and 90% (r = 0.44, p < 0.05) VO2max for combined group data. PFO+ subjects had higher resting HR (66 ± 8 vs 58 ± 9 bpm, p < 0.05) and Tcore (36.67 ± 0.23 vs 36.41 ± 0.28°C, p < 0.05) vs PFO- subjects; no group differences were seen during exercise (p > 0.05 for both intensities). A positive relationship existed between individual values for resting Tcore and HR in PFO+ (r = 0.66, p < 0.05) but not in PFO- subjects. In PFO+ subjects, there was no relationship between the two variables during exercise. In PFO- subjects, there was a positive relationship between Tcore and HR at 50% (r = 0.65, p < 0.05) and 90% (r = 0.54, p < 0.05) VO2max. Our data are consistent with the idea that there are differences in thermoregulatory and/or cardiovascular coupling between PFO+ and PFO- subjects at rest and during exercise. A possible explanation is that PFO+ subjects may have higher levels of inflammatory markers (interleukins, TNFα, etc), leading to elevated core temperatures at rest, thus contributing to the greater variability in the HR-Tcore responses during exercise.

Effects of resistance training on metabolic and cardiovascular responses to a maximal cardiopulmonary exercise test in Parkinson`s disease.

ABSTRACT:Objective:To evaluate the effects of resistance training on metabolic and cardiovascular responses during maximal cardiopulmonary exercise testing in patients with Parkinson’s disease.Methods:Twenty-four patients with Parkinson’s disease (modified Hoehn and Yahr stages 2 to 3) were randomly assigned to one of two groups: Control or Resistance Training. Patients in the Resistance Training Group completed an exercise program consisting of five resistance exercises (two to four sets of six to 12 repetitions maximum per set) twice a week. Patients in the Control Group maintained their usual lifestyle. Oxygen uptake, systolic blood pressure and heart rate were assessed at rest and during cycle ergometer-based maximal cardiopulmonary exercise testing at baseline and at 12 weeks. Assessments during exercise were conducted at absolute submaximal intensity (slope of the linear regression line between physiological variables and absolute workloads), at relative submaximal intensity (anaerobic threshold and respiratory compensation point) and at maximal intensity (maximal exercise). Muscle strength was also evaluated.Results:Both groups had similar increase in peak oxygen uptake after 12 weeks of training. Heart rate and systolic blood pressure measured at absolute and relative submaximal intensities and at maximal exercise intensity did not change in any of the groups. Muscle strength increased in the Resistance Training but not in the Control Group after 12 weeks.Conclusion:Resistance training increases muscle strength but does not change metabolic and cardiovascular responses during maximal cardiopulmonary exercise testing in patients with Parkinson’s disease without cardiovascular comorbidities.

Skeletal Muscle Deoxygenation and Its Relationship to Aerobic Capacity During Early and Late Stages of Aging.

The aim of this study was to compare muscle O2 dynamics during exercise among elderly (n=10, age: 73±3years), middle-aged (n=9, age: 50±6years), and young (n=10, age: 25±3years) adults. The subjects performed ramp bicycle exercise until exhaustion. Muscle O2 saturation (SmO2) and relative changes from rest in oxygenated hemoglobin/myoglobin (∆oxy-Hb/Mb), deoxygenated hemoglobin/myoglobin (∆deoxy-Hb/Mb), and total hemoglobin concentration (∆total-Hb) were monitored continuously at the vastus lateralis muscle by near-infrared spatial resolved spectroscopy. At given absolute workloads, SmO2 and ∆oxy-Hb/Mb were significantly lower in elderly than the other groups, while ∆deoxy-Hb/Mb, ∆total-Hb, and pulmonary O2 uptake (VO2) were similar among the three groups. In contrast, there were no significant differences in muscle O2 dynamics during submaximal exercise between middle-aged and young subjects. Muscle O2 dynamics may be relatively preserved in early stages of aging, although muscle deoxygenation is enhanced in late stages of aging, probably due to reduced convective O2 supply. Moreover, change in SmO2 was significantly positively correlated with peak VO2 in the elderly, while a significant negative relationship was observed in middle-aged and young subjects. In late stages of aging, diminished peak VO2 may be caused by attenuated convective O2 transport, while reduced peak VO2 can be explained by lowered muscle O2 extraction in early stages of aging.

Aerobic exercise capacity is maintained over a 5-year period in mild-to-moderate chronic kidney disease: a longitudinal study

BackgroundAerobic exercise capacity is reduced in non-dialysis chronic kidney disease (CKD), but the magnitude of changes in exercise capacity over time is less known. Our main hypothesis was that aerobic ExCap would decline over 5 years in individuals with mild-to-moderate CKD along with a decline in renal function. A secondary hypothesis was that such a decline in ExCap would be associated with a decline in muscle strength, cardiovascular function and physical activity.MethodsWe performed a 5-year-prospective study on individuals with mild-to-moderate CKD, who were closely monitored at a nephrology clinic. Fiftytwo individuals with CKD stage 2–3 and 54 age- and sex-matched healthy controls were included. Peak workload was assessed through a maximal cycle exercise test. Muscle strength and lean body mass, cardiac function, vascular stiffness, self-reported physical activity level, renal function and haemoglobin level were evaluated. Tests were repeated after 5 years. Statistical analysis of longitudinal data was performed using linear mixed models.ResultsExercise capacity did not change significantly over time in either the CKD group or controls, although the absolute workloads were significantly lower in the CKD group. Only in a CKD subgroup reporting low physical activity at baseline, exercise capacity declined. Renal function decreased in both groups, with a larger decline in CKD (p = 0.05 between groups). Peak heart rate, haemoglobin level, handgrip strength, lean body mass and cardiovascular function did not decrease significantly over time in CKD individuals.ConclusionsOn a group level, aerobic exercise capacity and peak heart rate were maintained over 5 years in patients with well-controlled mild-to-moderate CKD, despite a slight reduction in glomerular filtration rate. In line with the maintained exercise capacity, cardiovascular and muscular function were also preserved. In individuals with mild-to-moderate CKD, physical activity level at baseline seems to have a predictive value for exercise capacity at follow-up.

Is sex a proxy for mechanical variables during an upper limb repetitive movement task? An investigation of the effects of sex and of anthropometric load on muscle fatigue

BackgroundWomen report more work-related pain and neck/shoulder musculoskeletal disorders than men. For the same absolute workload, due to lower strength, females generally work at a higher relative intensity, which could induce more fatigue. However, the arm’s anthropometric load (AL) of men is higher. Therefore, simply lifting their arm could be more fatiguing. Sex as a variable is formed of many constructs, and analyses can become muddied by their differing responses to fatigue. No studies have considered AL, when comparing how fatigue affects men and women. The purpose was to determine if including the arm’s AL in the statistical analysis would impact findings of sex-specific effects of shoulder fatigue on muscle EMG.MethodsFifty-five (29m/26f) participants completed a repetitive pointing task (RPT) at shoulder height until they reported fatigue of 8+ on the BORG CR-10 scale. Muscle activities were measured using surface electrodes placed over the anterior deltoid (AD) and upper trapezius (UT) muscles. Muscle activity amplitude was quantified using root mean square (RMS). First- and last-minute data were used to assess change from no-fatigue (NF) to fatigue-terminal (FT) conditions. AL was calculated using sex-specific body parameter equations. General estimating equations (GEE) were used to determine the effects of sex and fatigue on RMS values, while including AL in the GEE.ResultsThere was no sex difference in time to reach fatigue. A significant main effect of sex on RMS was observed (χ2(1) = 4.17, p = 0.04) when including AL as a covariate. Females displayed a significantly higher percentage change in AD RMS from NF to FT, compared to males (p = 0.03), when AL was included in the GEE. No sex differences in UT were observed.ConclusionsThis sex difference emerged when AL was included as a covariate, suggesting that sex-associated anthropometric differences may contribute to sex differences in the fatigue response. Differences in the impact of AL on AD compared to UT could be explained by differences in their respective mechanical roles or muscle fiber content. Anthropometrics may be useful to include as covariates in future research to separate individual anthropometric differences from sex differences.