Absence Of Urinary Tract Infection Research Articles

Evaluation of uroflowmetry in different groups of patients after transurethral resection of prostatic adenoma

One hundred patients after transurethral prostatectomy (TURP) were examined. The patients' age, presence or absence of urinary tract infection, time after TURP, and the size of adenoma were taken into consideration in the assessment of uroflowmetry. It was found that with the passage of time all parameters have improved. Comparison of the results of uroflowmetry performed in patients with large or small adenomas showed that TURP was successful in both groups. Infection was found to affect the volume of the bladder, but it had no significant influence on other uroflowmetry parameters or on residual urine. The age of the operated patients seemed to have no influence on the results of flowmetry after TURP.

Autoimmune responses to Tamm-Horsfall protein in the pathogenesis of chronic pyelonephritis.

Although the role of bacterial infection as the major determinant in the development of acute pyelonephritis has been well documented for years, the nature of the renal scarring typical of chronic "atrophic" pyelonephritis has been a matter of controversy for at least three decades. In the past, recurrent bacterial infection of the kidney was thought to be responsible for the pathologic entity of "chronic pyelonephritis." However, more recent studies suggest that recurrent bacteriuria, in the absence of some form of obstructive uropathy, rarely produces chronic pyelonephritis. The close association between vesicoureteral reflex and chronic pyelonephritis has also been firmly established and has been observed to occur frequently in the absence of urinary tract infection. However, the mechanism by which vesicoureteral reflux injures the kidney has not been firmly established. A number of observations have suggested that some normal component of urine, particularly Tamm-Horsfall protein, might serve as an antigenic determinant involved in the immunopathogenesis of renal scarring in vesicoureteral reflux. The present studies were designed to investigate the immunopathogenic role of Tamm-Horsfall protein in a rabbit model of tubulointerstitial nephritis, and in a swine model of reflux nephropathy. The immune responses to Tamm-Horsfall protein in patients with recurrent nephrolithiasis were also examined, as were the antigenic similarities between Tamm-Horsfall protein and protein-containing components of uropathic bacteria. The results of these studies indicate that autoimmune responses to Tamm-Horsfall protein may occur after exposure to Tamm-Horsfall protein by intravenous challenge in rabbits, and by urinary reflux in pigs, as well as in recurrent nephrolithiasis in man.(ABSTRACT TRUNCATED AT 250 WORDS)