With the rapid development of information technology, database principles, as one of the core courses of computer science and technology majors, the quality of its teaching is directly related to the cultivation of students' practical work ability and innovation ability. However, the traditional teaching mode has problems such as emphasizing theory over practice, single assessment method and neglecting ability cultivation, which is difficult to meet the current social demand for high-quality technical talents. Therefore, this paper introduces the OBE (Outcome-Based Education) education concept into the teaching of "Principles of Database" course, and puts forward a series of teaching reform measures based on the OBE concept, including the formulation of specific teaching objectives, optimization of teaching content, innovative teaching methods, diversified course evaluation and assessment mechanism, etc., to realize the training of students' ability and innovation through the construction of student-centered and output-oriented teaching mode, and to realize the training of students' ability and innovation. By constructing a student-centered and output-oriented teaching mode, it realizes the enhancement of students' independent learning and innovation and practice ability, so as to make students become excellent talents of the new century with innovative consciousness and ability.