Tc-99m MDP Uptake Research Articles

Imaging of primary Ewing sarcoma with 13N-L-glutamate.

Eleven patients with untreated primary Ewing sarcoma were studied with intravenously administered 13N-labeled L-glutamate. Seven were repeatedly scanned during chemotherapy using this agent and 99mTc-methylene diphosphonate (99mTc-MDP). The untreated primary tumor was distinctly visualized with 13N-L-glutamate in all cases; the distribution of 13N label in the tumor sometimes differed from that of 99mTc. A kinetic study showed rapid uptake of 13N by tumor tissue. Repeat scans following therapy indicated that 13N-L-glutamate and 99mTc-MDP uptake showed changes consistent with histological findings following subsequent surgery. 13N uptake often decreased more markedly than 99mTc uptake during chemotherapy, but metastatic lesions were not visualized with 13N-L-glutamate. Tumor imaging with this labeled amino acid may be of value in assessing the response of primary Ewing sarcoma to chemotherapy.

Uptake and localization of 99mTc-methylene diphosphonate in mouse osteosarcoma.

The localization of 99mTc-methylene diphosphonate (99mTc-MDP) in mouse osteosarcoma was studied using a skeletal scintigraphic method and macro- and microautoradiographic methods. On the skeletal scintigraph, the tumor showed a high uptake of 99mTc-MDP and its concentration was about 20 times as high as the value seen in the muscular tissue. The macroautoradiography showed high activity in the tumor bone region and little activity in the nonossified region. On the microautoradiography, the activity of 99mTc-MDP was localized in the mineralized matrix of tumor bone and was almost nil in the nonmineralized matrix (osteoid) and the tumor cells. These findings indicate that the mineralization of the tumor bone matrix plays an important role in 99mTc-MDP uptake in osteosarcoma.

Primary neuroblastoma uptake of 99mtechnetium methylene diphosphonate.

Forty patients, ages three days to 12 years, with neuroblastomas had bone scans with 99mtechnetium methylene diphosphonate (99mTc-MDP) as part of their pretreatment examination. Twenty-four (60%) had primary tumor uptake and 16 (40%) did not. No difference was seen between the two groups in the incidence of tumor calcification or necrosis. No relationship between the level of urinary vanillylmandelic acid (VMA) and the presence of primary tumor uptake of 99mTc-MDP was found. The possible causes for the localization of 99mTc-MDP are discussed.

Radionuclides in orthopaedic surgery.

The Journal of Bone and Joint Surgery. British volumeVol. 62-B, No. 2 ArticlesFree AccessRadionuclides in orthopaedic surgeryS HughesS HughesSearch for more papers by this authorPublished Online:1 May 1980https://doi.org/10.1302/0301-620X.62B2.6988434AboutSectionsPDF/EPUB ToolsAdd to FavouritesDownload CitationsTrack CitationsPermissions ShareShare onFacebookTwitterLinked InRedditEmail FiguresReferencesRelatedDetailsCited ByDisorders of Tendons and Fascia and Adolescent and Adult Pes PlanusSeptic ArthritisDisorders of Tendons and FasciaUse of scintigraphy for assessment of fracture healing and early diagnosis of osteomyelitis following fracture repair in rabbitsAmerican Journal of Veterinary Research, Vol. 64, No. 6Fracture stiffness measurement in tibial shaft fractures: a non-invasive methodClinical Biomechanics, Vol. 10, No. 8[ 99m Tc]diphosphonate uptake and hemodynamics in arthritis of the immature dog knee18 February 2005 | Journal of Orthopaedic Research, Vol. 9, No. 2Dynamic bone imaging in the investigation of local bone pathology — When is it useful?Clinical Radiology, Vol. 43, No. 2Dynamic Versus Static Joint Scintimetry in Juvenile Arthritis: An Experimental Study in DogsPostoperative nuklearmedizinische VerlaufskontrollenThree-phase [ 99m Tc]diphosphonate scintimetry in septic and nonseptic arthritis of the immature knee: An experimental investigation in dogs18 February 2005 | Journal of Orthopaedic Research, Vol. 7, No. 4Development of an equine nuclear medicine facility for gamma camera imagingEquine Veterinary Journal, Vol. 21, No. 2^sup 99m^Tc-DPD Uptake in Juvenile Hemarthrosis Scintimetry and Autoradiography of the Knee in DogsOrthopedics, Vol. 12, No. 3OsteonecrosisScintigraphy with Tc, Ga and In in painful total hip prosthesesInternational Orthopaedics, Vol. 12, No. 2Sequential scintimetry in prediction of healing rate after femoral neck fractureArchives of Orthopaedic and Traumatic Surgery, Vol. 106, No. 3Radionuclide imaging in internal derangements of the knee23 April 2016 | The American Journal of Sports Medicine, Vol. 15, No. 2Effects of Age on Cell Size and Ion Uptake in Canine Cortical BoneMayo Clinic Proceedings, Vol. 62, No. 1Static and sequential dynamic scintigraphy of the tibia following fractureInjury, Vol. 17, No. 2The use of radionuclide bone scintigraphy to determine local spread of oral squamous cell carcinoma to mandibleJournal of Maxillofacial Surgery, Vol. 1499m Tc-DPD uptake in juvenile arthritis: Scintimetry and autoradiography of the knee in dogs8 July 2009 | Acta Orthopaedica Scandinavica, Vol. 57, No. 4Diagnosis of Acute Bone InfectionEarly detection of developing osteoarthritis by scintigraphy: An experimental study on rabbitsEuropean Journal of Nuclear Medicine, Vol. 9, No. 9The Use of Bone Scanning for the Diagnosis and Management of Musculoskeletal TraumaSurgical Clinics of North America, Vol. 63, No. 3THE ROLE OF BONE SCANS IN THE ASSESSMENT OF PROGNOSIS OF SCAPHOID FRACTURESANZ Journal of Surgery, Vol. 53, No. 2Acute Haematogenous Osteitis—A Ten Year Review25 June 2016 | Scottish Medical Journal, Vol. 28, No. 2Painful Heel Syndrome: Rationale of Diagnosis and Treatment5 November 2016 | Foot & Ankle, Vol. 3, No. 5Mandibular reconstruction by “simple” bone graftBritish Journal of Plastic Surgery, Vol. 36, No. 1Scintigraphy in the evaluation of potential fracture healing: a clinical study of tibial fracturesThe British Journal of Radiology, Vol. 55, No. 658Book reviewPhlebography of the Lower Limb. By ThomasM. Lea, pp. 220, 1982 (Churchill Livingstone, Edinburgh), £21.00. ISBN 0–443–018411–3The British Journal of Radiology, Vol. 55, No. 658Relationship of 99mTc-MDP uptake to regional osseous circulation in skeletally immature and mature dogsSkeletal Radiology, Vol. 8, No. 2Klinische Methoden Vol. 62-B, No. 2 Metrics Downloaded 118 times History Published online 1 May 1980 Published in print 1 May 1980 InformationCopyright © 1980, The British Editorial Society of Bone and Joint Surgery: All rights reservedPDF download

Localization of 99mTc-Methylene Diphosphonate in Skin Lesions of Pseudoxanthoma Elasticum

Increased uptake of 99mTc-methylene diphosphonate (MDP) is demonstrated in a patient with pseudoxanthoma elasticum (PXE) at the affected site. PXE is a hereditary disease with variable expression. Calification of dermal elastic fibers is a characteristic feature of affected skin. Recently, apatite crystals were identified in the affected skin of the patients with PXE. The mechanism of uptake of 99mTc-MDP is probably related to chemisorption of the tracer onto hydroxyapatite crystals in the affected dermis.

Radionuclide Imaging of Septic Joints and Their Differentiation from Periarticular Osteomyelitis and Cellulitis in Pediatrics

Thirty-eight children who had septic arthritis, juxtaarticular osteomyelitis, cellulitis or a combination thereof were studied on consecutive days with 99mTc-methylene diphosphonate (99mTc-MDP) and 67Ga-citrate (67Ga) imaging, respectively, in an attempt to make a definitive diagnosis. The 99mTc-MDP uptake reflects the bone response to the septic process, whereas 67Ga seems to be concentrated at the site of infection by the inflammatory components. By utilizing the information from both modalities the septic focus was disclosed in all cases, and in the majority of patients the precise location of the infection, i.e., bone, synovium, or adjacent soft tissue was possible. The relatively poor resolution of the gamma camera vis a vis radiography was the limiting factor, particularly with infants, in determining the exact site of the septic process. Early in the evolution of the disease radionuclide imaging is considerably more sensitive than radiography.