You have accessJournal of UrologyBladder Cancer: Invasive IV1 Apr 2015MP67-01 SARCOPENIA AS A PREDICTOR OF CANCER-SPECIFIC AND OVERALL SURVIVAL AFTER RADICAL CYSTECTOMY: IS THERE A GENDER INFLUENCE? Ahmed Harraz, Yasser Osman, Islam Fakhreldin, Osama Mahmoud, Mona El-Deeb, Mahmoud Laymon, Ahmed Mosbah, Hassan Abol-Enein, and Atallah Shaaban Ahmed HarrazAhmed Harraz More articles by this author , Yasser OsmanYasser Osman More articles by this author , Islam FakhreldinIslam Fakhreldin More articles by this author , Osama MahmoudOsama Mahmoud More articles by this author , Mona El-DeebMona El-Deeb More articles by this author , Mahmoud LaymonMahmoud Laymon More articles by this author , Ahmed MosbahAhmed Mosbah More articles by this author , Hassan Abol-EneinHassan Abol-Enein More articles by this author , and Atallah ShaabanAtallah Shaaban More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2015.02.2484AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Sarcopenia is a novel emerging predictor of mortality after cancer surgery. However, published data on the untoward effect of sarcopenia in patients with bladder cancer are few and were derived from studies with a relatively low number of patients. In addition, no previous studies has explored sarcopenia outcome stratified by gender. We evaluated sarcopenia as a predictor for cancer-specific (CSS) and overall survival (OS) in a large series. METHODS A retrospective analysis of electronic database for patients underwent radical cystectomy, between January 2004 and January 2008, for muscle invasive bladder cancer was performed. Only patients with available preoperative computerized tomography scan (CT) and survival data were included. Patients with missed follow-up or those with missing data were excluded. Total psoas area (TPA) score was calculated using preoperative CT and was adjusted for the height (cm2/m2). Cut-off values for men and women were developed using Receiver Operating Characteristic (ROC) curves and were used to investigate the impact of sarcopenia on CSS and OS by univariate and multivariate analyses. RESULTS A total of 460 patients were included in the analysis during the specified period. The mean ± SD adjusted-TPA scores for men and women were 58.8 ± 21.5 and 37 ± 12 cm2/m2, respectively (p < 0.001). An adjusted-TPA scores ≤ 53.5 cm2/m2 and ≤ 37.4 cm2/m2 were identified as cut-off values to define sarcopenia in men and women, respectively. Men with sarcopenia showed significantly worse 5-year CSS than men without sarcopenia (66.7% vs 77.8%; p = 0.01). On multivariate analysis, sarcopenia (Hazards ratio [HR]: 1.7; 95% confidence interval [CI]: 1.1-2.5; p = 0.01) was an independent predictor of 5-year CSS. Similarly, the 5-year OS was significantly worse in men with sarcopenia vs those with no sarcopenia (33.3% vs 40%; p = 0.005). On multivariate analysis, sarcopenia was an independent predictor for 5-year OS (HR: 1.3; 95%CI: 1.1-1.6; p = 0.02). On the other hand, women without sarcopenia did not show neither 5-year CSS benefit (75% vs 80%; p = 0.06) nor 5-year OS benefit (36% vs 55%; p = 0.1). CONCLUSIONS Sarcopenia in men is an independent predictor of cancer-specific and overall survival after radical cystectomy. Further research would confirm sarcopenia as a useful predictor of mortality after radical cystectomy would suggest the development of new nomograms for better cancer outcome prediction. © 2015 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 193Issue 4SApril 2015Page: e849 Advertisement Copyright & Permissions© 2015 by American Urological Association Education and Research, Inc.MetricsAuthor Information Ahmed Harraz More articles by this author Yasser Osman More articles by this author Islam Fakhreldin More articles by this author Osama Mahmoud More articles by this author Mona El-Deeb More articles by this author Mahmoud Laymon More articles by this author Ahmed Mosbah More articles by this author Hassan Abol-Enein More articles by this author Atallah Shaaban More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...