In endovascular treatment, manually operated guidewires and catheters often damage blood vessels. One of the reasons is that the behavior of the device does not match the operator's expectations. We hypothesized that this discrepancy can be quantified by responsiveness. The purpose of this study is to measure this responsiveness experimentally using several vascular phantoms. In particular, we investigated the effect of the distance between the catheter and the guidewire on responsiveness. Under the combination of two devices, we gave the operation of pushing or rotating the guidewire. We investigated the movement of the guidewire when pushing or rotating the guidewire with various distances. In order to investigate the relationship between the distance and the responsiveness, the obtained responsiveness data was statistically analyzed using EZR. The median responsiveness of a certain region was 0.262 with 2D vessel phantom and pushing operation, 0.414 with 3D vessel phantom and pushing operating, and 0.337 with 3D vessel phantom and rotation operation. A significant relationship was found in responsiveness under the condition given a pushing operation within the 3D vascular phantom. The operability deteriorated as the distance between the devices increased. This result suggests that the effect on the guidewire operation of the catheter is limited. Investigating the relationship between vascular shape and optimal device-to-device distance is expected to facilitate the selection of the appropriate operation for a vascular region to be treated.