Volumetric 3D Research Articles

Volumetric 3D printing for rapid production of medicines

3D printing (3DP), or additive manufacturing, has been actively investigated as one of the enabling technologies for the impending era of personalized medicines. However, existing 3DP technologies do not afford the speeds required for on-demand production of medicines in fast-paced clinical settings. Volumetric printing is a novel 3DP technology that offers rapid printing speed and overcomes the geometric and surface quality limitations of layer-based vat photopolymerization techniques. Unlike previous vat photopolymerization 3DP technologies, volumetric printing cures the entire desired 3D geometry simultaneously by exploiting the threshold behavior in the photopolymerization process that arise due to oxygen-induced polymerization inhibition. In this work, for the first time, a volumetric printer was used to fabricate drug-loaded 3D printed tablets (Printlets™) within seconds. Six resin formulations were evaluated using this printer, each composed of poly(ethylene glycol) diacrylate (PEGDA) as the crosslinking monomer, lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) as the photoinitiator, and paracetamol as the model drug. Water or PEG300 were included as diluents in varying concentrations to facilitate drug release. Paracetamol-loaded Printlets were successfully fabricated within 17 s. Drug release rates could be tuned by altering the monomer-to-diluent ratio of the photosensitive resin, with a lower ratio releasing drug faster. The present work confirms the suitability of volumetric 3DP for printing drug products in a matter of seconds. Upon further optimization, this novel technology can enable rapid, on-demand fabrication of medicines and medical devices.

Stiffness control in dual color tomographic volumetric 3D printing

Tomographic volumetric printing (TVP) physically reverses tomography to offer fast and auxiliary-free 3D printing. Here we show that wavelength-sensitive photoresins can be cured using visible (bar{lambda }=455 nm) and UV (bar{lambda }=365 nm) sources simultaneously in a TVP setup to generate internal mechanical property gradients with high precision. We develop solutions of mixed acrylate and epoxy monomers and utilize the orthogonal chemistry between free radical and cationic polymerization to realize fully 3D stiffness control. The radial resolution of stiffness control is 300 µm or better and an average modulus gradient of 5 MPa/µm is achieved. We further show that the reactive transport of radical inhibitors defines a workpiece’s shape and limits the achievable stiffness contrast to a range from 127 MPa to 201 MPa according to standard tensile tests after post-processing. Our result presents a strategy for controlling the stiffness of material spatially in light-based volumetric additive manufacturing.

Compressed Lateral and anteroposterior Anatomical Systematic Sequences \xabCLASS\xbb: compressed MRI sequences with assessed anatomical femoral and tibial ACL's footprints, a feasibility study

PurposeThis study's main objective is to assess the feasibility of processing the MRI information with identified ACL-footprints into 2D-images similar to a conventional anteroposterior and lateral X-Ray image of the knee. The secondary aim is to conduct specific measurements to assess the reliability and reproducibility. This study is a proof of concept of this technique.MethodsFive anonymised MRIs of a right knee were analysed. A orthopaedic knee surgeon performed the footprints identification. An ad-hoc software allowed a volumetric 3D image projection on a 2D anteroposterior and lateral view. The previously defined anatomical femoral and tibial footprints were precisely identified on these views. Several parameters were measured (e.g. coronal and sagittal ratio of tibial footprint, sagittal ratio of femoral footprint, femoral intercondylar notch roof angle, proximal tibial slope and others). The intraclass correlation coefficient (ICCs), including 95% confidence intervals (CIs), has been calculated to assess intraobserver reproducibility and interobserver reliability.ResultsFive MRI scans of a right knee have been assessed (three females, two males, mean age of 30.8 years old). Five 2D-"CLASS" have been created. The measured parameters showed a "substantial" to "almost perfect" reproducibility and an "almost perfect" reliability.ConclusionThis study confirmed the possibility of generating "CLASS" with the localised centroid of the femoral and tibial ACL footprints from a 3D volumetric model. "CLASS" also showed that these footprints were easily identified on standard anteroposterior and lateral X-Ray views of the same patient, thus allowing an individual identification of the anatomical femoral and tibial ACL's footprints.Level of evidenceLevel IV diagnostic study

Toward 3D-Printed Inverse-Designed Metaoptics

Optical metasurfaces have been heralded as the platform to integrate multiple functionalities in a compact form-factor, potentially replacing bulky components. A central stepping stone towards realizing this promise is the demonstration of multifunctionality under several constraints (e.g. at multiple incident wavelengths and/or angles) in a single device -- an achievement being hampered by design limitations inherent to single-layer planar geometries. Here, we propose a general framework for the inverse design of volumetric 3D metaoptics via topology optimization, showing that even few-wavelength thick devices can achieve high-efficiency multifunctionality. We embody our framework in multiple closely-spaced patterned layers of a low-index polymer. We experimentally demonstrate our approach with an inverse-designed 3d-printed light concentrator working at five different non-paraxial angles of incidence. Our framework paves the way towards realizing multifunctional ultra-compact 3D nanophotonic devices.

3D Volumetric Imaging System Based on a Carbon-Based Light-Induced Ultrasound Transmitter

3D Volumetric Imaging System Based on a Carbon-Based Light-Induced Ultrasound Transmitter

Object-Space Optimization of Tomographic Reconstructions for Additive Manufacturing.

Volumetric 3D printing motivated by computed axial lithography enables rapid printing of homogeneous parts but requires a high dimensionality gradient-descent optimization to calculate image sets. Here we introduce a new, simpler approach to image-computation that algebraically optimizes a model of the printed object, significantly improving print accuracy of complex parts under imperfect material and optical precision by improving optical dose contrast between the target and surrounding regions. Quality metrics for volumetric printing are defined and shown to be significantly improved by the new algorithm. The approach is extended beyond binary printing to grayscale control of conversion to enable functionally graded materials. The flexibility of the technique is digitally demonstrated with realistic projector point spread functions, printing around occluding structures, printing with restricted angular range, and incorporation of materials chemistry such as inhibition. Finally, simulations show that the method facilitates new printing modalities such as printing into flat, rather than cylindrical packages to extend the applications of volumetric printing.

Abstract 11582: Prognostic Implications of Anatomical Aortic Valve Area in Patients with Bicuspid Aortic Stenosis by Three-Dimensional Transesophageal Echocardiography

Background: Three-dimensional (3D) transesophageal echocardiography (TEE) provides high-resolution images of aortic valve area (AVA) in patients with bicuspid aortic stenosis (AS). However, the correlation with pressure gradient compared with conventional echocardiographic indices and prognostic implications of 3D TEE derived valve area (AVA 3DTEE ) has not been evaluated. Therefore, we assessed the disease severity and the prognostic value of AVA 3DTEE in patients with bicuspid AS. Methods: We retrospectively analyzed 105 patients with at least mild bicuspid AS (peak aortic velocity >2.5m/sec) and LVEF ≥50% (mean transaortic pressure gradient 46±17 mm Hg) underwent transthoracic echocardiography, two-dimensional (2D) and 3D TEE between 2012 and 2019. AVA was measured using (i) the continuity equation (CE) obtained with transthoracic echocardiography, (ii) planimetric 2D TEE, and (iii) volumetric 3D TEE. Cardiac events were defined as surgical or transcatheter aortic valve replacement and/or aortic replacement, heart failure admission, or cardiac death. Results: AVA 3DTEE was larger than AVA CE (mean difference 0.21±0.03, P <0.001), and smaller than AVA 2DTEE (mean difference 0.11±0.02, P <0.001). AVA 3DTEE had an excellent correlation with mean transaortic pressure gradient (r=0.91, P <0.001), whereas AVA 2DTEE and AVA CE showed lower correlations (r=0.81 and r=0.59, both P <0.001). AVA 3DTEE significantly reduced the proportion of inconsistent AS grading, compared with AVA CE (6% versus 17%, P <0.001). During a follow-up period (median, 853 days; range 513 to 1287 days), 101 surgical or transcatheter aortic valve replacement and/or aortic replacement, 6 heart failure admission, or 1 cardiac death occurred. AVA 3DTEE ≤1cm 2 was an independent predictor of cardiac events (adjusted hazard ratio (HR) 2.40, (1.41 to 4.09), P =0.001) and AVA 3DTEE of 1 cm 2 was the optimal cutoff value for predicting cardiovascular events with sensitivity of 71% and specificity of 100%. Conclusions: AVA measured by 3D TEE has a good correlation with mean transaortic pressure gradient and improved the hitherto inconsistent AS grading. AVA 3DTEE ≤1cm 2 is an important predictor for cardiac events of patients with bicuspid AS.

3D Display for 3D Telepresence: A Review

Over the years, people have tried to advance 3D display technology and researchers as well as developers have created different innovations in recent decades. there are many other different types of 3D display technology that can be classified into stereoscopic, auto stereoscopic, holographic and volumetric 3D displays. This paper, however, discusses the 3D display technology that have been implemented in the telepresence system, which can be divided into two main devices, projectors and head mounted display (HMD). From these two devices, the 3D display technology using projector devices are on-stage hologram, auto stereoscopic display, and holographic projection; while for HMD can be divided into MR headset and VR HMD. This paper provides a review on these 3D display for telepresence. Finally, we make a comparison based on the features of the 3D display technologies such as life-size capability, viewable from different perspectives, headset-free experience number of viewers per device, level of ease of setup and the nausea of discomfort level. To choose the best 3D display technology for a telepresence system, we must first identify the number of users who will be projected and who will be viewed. The goal and activity of using telepresence technology will also define the appropriate type of 3D display.

NIMG-33. VOLUMETRIC TUMOR MEASUREMENTS ARE SUPERIOR TO 2D BIDIRECTIONAL MEASUREMENTS IN THE EVALUATION OF IDH INHIBITION IN DIFFUSE GLIOMAS: EVIDENCE FROM A PROSPECTIVE PHASE I TRIAL OF IVOSIDENIB

Abstract Since IDH mutant (mIDH) low-grade gliomas (LGGs) progress slowly and patients have a relatively long survival, testing of new therapies in clinical trials based solely on survival can take more than 20 years. Guidance on therapeutic evaluation using LGG RANO criteria recommends serial bidirectional (2D) measurements on a single slice; however, questions remain as to the best approach for evaluating LGGs in clinical trials including use of volumetric (3D) measurements, which would theoretically allow for more accurate measurements of irregular shaped lesions and allow readers to better assess areas of change within these tumors. A total of 21 (out of 24) non-enhancing, recurrent mIDH LGGs with imaging pre- and post-treatment enrolled in a phase I, multicenter, open-label study to assess the safety and tolerability of oral ivosidenib (NCT02073994) were included in this exploratory ad hoc analysis. 2D bidirectional and 3D volumetric measurements were centrally evaluated by one of 3 radiologists at an imaging CRO using a paired read and forced adjudication paradigm. The effects of 2D vs. 3D measurements on progression-free survival (PFS), growth rate measurement variability, and reader concordance and adjudication rates were then quantified. 3D volumetric measurements had significantly longer estimates of PFS (P=0.0181), more stable (P=0.0063) and considerably lower measures of tumor growth rate (P=0.0037), the highest inter-reader agreement (weighted Kappa=0.7057), and significantly lower reader discordance rates (P=0.0002) with comparable recommended LGG RANO 2D approaches. In summary, 3D volumetric measurements are better for determining response assessment in LGGs due to longer PFS and more stable measures of tumor growth rates (i.e. less “yo-yo-ing” of measurements over time causing fewer erroneous calls of progression and more accurate growth rates), highest inter-reader agreement, and lowest reader discordance rates. Future studies will focus on validating this in a larger cohort and determining whether these measurements better reflect clinical benefit.

Alterations in brain morphology by MRI in adults with neurofibromatosis 1

ObjectiveNeurofibromatosis 1 (NF1) is a rare autosomal dominant disease that causes the dysregulated growth of Schwann cells. Most reported studies of brain morphology in NF1 patients have included only children, and clinical implications of the observed changes later in life remain unclear. In this study, we used MRI to characterize brain morphology in adults with NF1.MethodsPlanar (2D) MRI measurements of 29 intracranial structures were compared in 389 adults with NF1 and 112 age- and sex-matched unaffected control subjects. The 2D measurements were correlated with volumetric (3D) brain measurements in 99 of the adults with NF1 to help interpret the 2D findings. A subset (n = 70) of these NF1 patients also received psychometric testing for attention deficits and IQ and was assessed for clinical severity of NF1 features and neurological problems. Correlation analysis was performed between the MRI measurements and clinical and psychometric features of these patients.ResultsFour of nine corpus callosum measurements were significantly greater in adults with NF1 than in sex- and age-matched controls. All seven brainstem measurements were significantly greater in adults with NF1 than in controls. Increased corpus callosum and brainstem 2D morphology were correlated with increased total white matter volume among the NF1 patients. No robust correlations were observed between the 2D size of these structures and clinical or neuropsychometric assessments.ConclusionOur findings are consistent with the hypothesis that dysregulation of brain myelin production is an important manifestation of NF1 in adults.

Comparative performance analysis of 2D and 3D gamma metrics for patient specific QA in VMAT using Octavius 4D with 2D-Array 1500.

Gamma pass percentage (GPP) is the predominant metric used for Patient Specific Quality Assurance (PSQA) in radiation therapy. The dimensionality of the measurement geometry in PSQA has evolved from 2D planar to 3D planar, and presently to state-of-the-art 3D volumetric geometry. We aim to critically examine the performance of the three-dimensional gammas vis-à-vis the older gamma metrics of lower dimensionality to determine their mutual fungibility in PSQA, using clinically approved Volumetric Arc Therapy (VMAT) plans. Gamma pass percentages derived from PSQA for VMAT plans using Octavius 4D phantom with 2D-Array 1500 and its proprietary software were recorded. 2D planar, 3D planar, and 3D volumetric gamma pass percentages were retrospectively extracted for multiple treatment plans at three sites, using three acceptance limits, and for two modes of normalization. The differences in mean pass percentages, and the pairwise correlation between geometries were calculated within limits of statistical significance. A significant increase in mean pass rates was observed from 2D planar to 3D planar geometries. The difference was less pronounced from 3D planar to 3D volumetric. 2D planar v/s 3D planar showed a significant degree of correlation among themselves, which was not seen against most of the 3D volumetric pass rates. The mean gamma pass rates show conclusive evidence of the benefits of shifting from 2D planar to higher dimensions measurement geometries, but the benefits of using 3D volumetric compared to 3D planar is not always unequivocal. The correlations show mixed results regarding the interdependence of pass percentages at different geometries.

VP46.19: Volumetric assessment of cervical cerclage indemnity using the Omniview technique

Ultrasound evaluation of the indemnity of uterine cerclage. A prospective clinical study, in Santo Domingo, Dominican Republic, was conducted that included five singleton pregnancies, between 16–36 weeks of gestation, diagnosed with cervical insufficiency and treated with cervical cerclage. Ultrasound follow-up examination was performed using the 3D volumetric technique Omniview, with a single line tracing the sagittal plane of the cervix, crossing both ultrasound reference points of the cerclage, with a thickness of 2 mm. Subsequently, tissue rendering was used, with a 50/50% mixture, 3D Contrast: 60, and 3D brightness: 57. The entire uterine cerclage suture was visualised, including its knot, using the 3D transvaginal ultrasound rendered and captured with the Omniview technique at 16, 28, 34, and 36 weeks of gestation. The volumetric 3D transvaginal ultrasound Omniview technique allows for the evaluation of the integrity of the suture and cerclage knot on different gestational ages. This allows the physician to suggest the use of alternative pharmacological therapies for the prevention of preterm labour if rupture or dehiscence of the cerclage is evidenced. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.

Characterization and verification of astigmatic interferometric particle imaging for volumetric droplet 3D position and size measurement

Sprays generated by atomization processes have been used in a wide range of fields. The size and spatial distribution of volumetric droplets in a spray are critical parameters in industrial applications. Astigmatic interferometric particle imaging (AIPI), an extension of the traditional interferometric particle imaging (IPI), is developed to simultaneously measure the size and 3D position of volumetric droplets in a sparse spray. Based on the generalized Huygens–Fresnel integral and the transfer matrix, the size and depth position of droplet can be respectively extracted from the fringe spacing and orientation of interferogram in AIPI. An AIPI setup is established to characterize droplets in a sparse spray generated by a nozzle with the AIPI calibration procedure adopted. The measured parameters by AIPI are compared with those obtained synchronously by digital inline holography, which is regarded as a standard measurement technique. Results show that the average deviation values of droplet size and depth position are respectively 3.8% and 6.8%. AIPI has been demonstrated with high accuracy in simultaneous 3D positions and size measurements.

Novel Volumetric and Morphological Parameters Derived from Three-dimensional Virtual Modeling to Improve Comprehension of Tumor’s Anatomy in Patients with Renal Cancer

BackgroundThree-dimensional (3D) models improve the comprehension of renal anatomy. ObjectiveTo evaluate the impact of novel 3D-derived parameters, to predict surgical outcomes after robot-assisted partial nephrectomy (RAPN). Design, setting, and participantsSixty-nine patients with cT1-T2 renal mass scheduled for RAPN were included. Three-dimensional virtual modeling was achieved from computed tomography. The following volumetric and morphological 3D parameters were calculated: VT (volume of the tumor); VT/VK (ratio between tumor volume and kidney volume); CSA3D (ie, contact surface area); UCS3D (contact to the urinary collecting system); Tumor-Artery3D: tumor’s blood supply by tertiary segmental arteries (score = 1), secondary segmental artery (score = 2), or primary segmental/main renal artery (scoren = 3); ST (tumor’s sphericity); ConvT (tumor’s convexity); and Endophyticity3D (ratio between the CSA3D and the global tumor surface). InterventionRAPN with a 3D model. Outcome measurements and statistical analysisThree-dimensional parameters were compared between patients with and without complications. Univariate logistic regression was used to predict overall complications and type of clamping; linear regression was used to predict operative time, warm ischemia time, and estimated blood loss. Results and limitationsOverall, 11 (15%) individuals experienced overall complications (7.2% had Clavien ≥3 complications). Patients with urinary collecting system (UCS) involvement at 3D model (UCS3D = 2), tumor with blood supply by primary or secondary segmentary arteries (Tumor-Artery3D = 1 and 2), and high Endophyticity3D values had significantly higher rates of overall complications (all p ≤ 0.03). At univariate analysis, UCS3D, Tumor-Artery3D, and Endophyticity3D are significantly associated with overall complications; CSA3D and Endophyticity3D were associated with warm ischemia time; and CSA3D was associated with selective clamping (all p ≤ 0.03). Sample size and the lack of interobserver variability are the main limits. ConclusionsThree-dimensional modeling provides novel volumetric and morphological parameters to predict surgical outcomes after RAPN. Patient summaryNovel morphological and volumetric parameters can be derived from a three-dimensional model to describe surgical complexity of renal mass and to predict surgical outcomes after robot-assisted partial nephrectomy.

4: Bone Tissue Engineering in the Growing Skull: A Short-term Study Using Dipyridamole-loaded 3D-printed Beta-tricalcium Phosphate Scaffolds to Repair Critically Sized Calvarial Defects in a Translational Animal Model

Purpose:The repair of bony defects remains a challenge to reconstructive surgeons due to limitations of current bone replacement techniques. Previous studies have shown that dipyridamole-loaded 3D-printed bioceramic (DIPY-3DPBC) scaffolds composed of 100% beta-tricalcium phosphate regenerate bone across critically sized defects in multiple in vivo models. However, a critical step to translating this bone tissue engineering construct to bedside is its successful application in a pre-clinical translational model that mimics biologic similarities to humans. Pigs are considered to be an excellent species for bone tissue engineering studies due to their similarities to humans both in bone biology and wound healing. In this short-term study, our group implanted DIPY-3DPBC scaffolds in an effort to repair critically sized bony defects in a translational, skeletally immature, growing craniofacial pig model. The purpose was to evaluate the performance of these 3D-printed constructs in terms of bone growth and scaffold absorption.Methods:Unilateral calvarial defects were created in six-week-old Göttingen minipigs (n=12). Four defects were left empty to serve as negative controls, four defects were filled with a 1000μM DIPY-3DPBC scaffold with a closed scaffold design (contains a solid barrier on the ectocortical side of the scaffold to prevent soft tissue infiltration), and four defects were filled with a 1000μM DIPY-3DPBC scaffold with an open design (no solid barrier on the ectocortical side). Animals were euthanized at 12-weeks post-operatively. Calvaria were subjected to micro-computed tomography (CT) for volumetric (3D) analysis. 3D reconstruction was performed using Amira software to quantitatively assess percent bone volume occupying the defect space (bone volume/total volume x 100%) and percent scaffold volume occupying the defect space (scaffold volume/total volume x 100%). A generalized linear mixed model (GLMM) was used to determine significance between groups. Results are presented using means with corresponding 95% confidence intervals and p-values.Results:Significantly higher mean (± 95% CI) percent bone volume was observed in calvarial defects treated with the scaffolds compared to negative controls (42.6% ± 8.6% vs 4.6% ± 12.1%, p≤0.001). Defects that were filled with closed cap scaffolds had a significantly greater mean percent bone volume compared to defects filled with the open scaffolds (52.9% ± 12.1% vs 32.3% ± 12.1%, p=0.024). No significant difference was detected between percent scaffold volume between closed and open scaffolds (4.4% ± 1.6% vs 3.7% ± 1.6%, p=0.493).Conclusions:The results from this work indicate an effective bone tissue engineering scaffold design that is able to regenerate bone across critically sized calvarial defects in a short-term skeletally immature, growing translational pig model.

Volumetric coronary endothelial function assessment: a feasibility study exploiting stack-of-stars 3D cine MRI and image-based respiratory self-gating.

Abnormal coronary endothelial function (CEF), manifesting as depressed vasoreactive responses to endothelial-specific stressors, occurs early in atherosclerosis, independently predicts cardiovascular events, and responds to cardioprotective interventions. CEF is spatially heterogeneous along a coronary artery in patients with atherosclerosis, and thus recently developed and tested non-invasive 2D MRI techniques to measure CEF may not capture the extent of changes in CEF in a given coronary artery. The purpose of this study was to develop and test the first volumetric coronary 3D MRI cine method for assessing CEF along the proximal and mid-coronary arteries with isotropic spatial resolution and in free-breathing. This approach, called 3D-Stars, combines a 6 min continuous, untriggered golden-angle stack-of-stars acquisition with a novel image-based respiratory self-gating method and cardiac and respiratory motion-resolved reconstruction. The proposed respiratory self-gating method agreed well with respiratory bellows and center-of-k-space methods. In healthy subjects, 3D-Stars vessel sharpness was non-significantly different from that by conventional 2D radial in proximal segments, albeit lower in mid-portions. Importantly, 3D-Stars detected normal vasodilatation of the right coronary artery in response to endothelial-dependent isometric handgrip stress in healthy subjects. Coronary artery cross-sectional areas measured using 3D-Stars were similar to those from 2D radial MRI when similar thresholding was used. In conclusion, 3D-Stars offers good image quality and shows feasibility for non-invasively studying vasoreactivity-related lumen area changes along the proximal coronary artery in 3D during free-breathing.

A single-camera, 3D scanning velocimetry system for quantifying active particle aggregations

A three-dimensional (3D) scanning velocimetry system is developed to quantify the 3D configurations of particles and their surrounding volumetric, three-component velocity fields. The approach uses a translating laser sheet to rapidly scan through a volume of interest and sequentially illuminate slices of the flow containing both tracers seeded in the fluid and particles comprising the aggregation of interest. These image slices are captured by a single high-speed camera, encoding information about the third spatial dimension within the image time-series. Where previous implementations of scanning systems have been developed for either volumetric flow quantification or 3D object reconstruction, we evaluate the feasibility of accomplishing these tasks concurrently with a single-camera, which can streamline data collection and analysis. The capability of the system was characterized using a study of induced vertical migrations of millimeter-scale brine shrimp (Artemia salina). Identification and reconstruction of individual swimmer bodies and 3D trajectories within the migrating aggregation were achieved up to the maximum number density studied presently, $8 \, \times\,10^5$ animals per $\textrm{m}^3$. This number density is comparable to the densities of previous depth-averaged 2D measurements of similar migrations. Corresponding velocity measurements of the flow indicate that the technique is capable of resolving the 3D velocity field in and around the swimming aggregation. At these animal number densities, instances of coherent flow induced by the migrations were observed. The accuracy of these flow measurements was confirmed in separate studies of a free jet at $Re_D = 50$.

Diagnosis of COVID-19 using 3D CT scans and vaccination for COVID-19

PurposeFor the first time in a decade, a new form of pneumonia virus, coronavirus, COVID-19, appeared in Wuhan, China. To date, it has affected millions of people, killed thousands and resulted in thousands of deaths around the world. To stop the spread of this virus, isolate the infected people. Computed tomography (CT) imaging is very accurate in revealing the details of the lungs and allows oncologists to detect COVID. However, the analysis of CT scans, which can include hundreds of images, may cause delays in hospitals. The use of artificial intelligence (AI) in radiology could help to COVID-19-positive cancer in this manner is the main purpose of the work.Design/methodology/approachCT scans are a medical imaging procedure that gives a three-dimensional (3D) representation of the lungs for clinical purposes. The volumetric 3D data sets can be regarded as axial, coronal and transverse data sets. By using AI, we can diagnose the virus presence.FindingsThe paper discusses the use of an AI for COVID-19, and CT classification issue and vaccination details of COVID-19 have been detailed in this paper.Originality/valueOriginality of the work is, all the data can be collected genuinely and did research work doneown methodology.

A comparative analysis of Acuros XB and the analytical anisotropic algorithm for volumetric modulation arc therapy

BackgroundThis study aimed to verify the dosimetric impact of Acuros XB (AXB) (AXB, Varian Medical Systems Palo Alto CA, USA), a two model-based algorithm, in comparison with Anisotropic Analytical Algorithm (AAA ) calculations for prostate, head and neck and lung cancer treatment by volumetric modulated arc therapy (VMAT ), without primary modification to AA. At present, the well-known and validated AA algorithm is clinically used in our department for VMAT treatments of different pathologies. AXB could replace it without extra measurements. The treatment result and accuracy of the dose delivered depend on the dose calculation algorithm.Materials and methodNinety-five complex VMAT plans for different pathologies were generated using the Eclipse version 15.0.4 treatment planning system (TPS). The dose distributions were calculated using AA and AXB (dose-to-water, AXBw and dose-to-medium, AXBm), with the same plan parameters for all VMAT plans. The dosimetric parameters were calculated for each planning target volume (PTV) and involved organs at risk (OA R). The patient specific quality assurance of all VMAT plans has been verified by Octavius®-4D phantom for different algorithms.ResultsThe relative differences among AA, AXBw and AXBm, with respect to prostate, head and neck were less than 1% for PTV D95%. However, PTV D95% calculated by AA tended to be overestimated, with a relative dose difference of 3.23% in the case of lung treatment. The absolute mean values of the relative differences were 1.1 ± 1.2% and 2.0 ± 1.2%, when comparing between AXBw and AA, AXBm and AA, respectively. The gamma pass rate was observed to exceed 97.4% and 99.4% for the measured and calculated doses in most cases of the volumetric 3D analysis for AA and AXBm, respectively.ConclusionThis study suggests that the dose calculated to medium using AXBm algorithm is better than AAA and it could be used clinically. Switching the dose calculation algorithm from AA to AXB does not require extra measurements.

Learning Optimal Wavefront Shaping for Multi-Channel Imaging.

Fast acquisition of depth information is crucial for accurate 3D tracking of moving objects. Snapshot depth sensing can be achieved by wavefront coding, in which the point-spread function (PSF) is engineered to vary distinctively with scene depth by altering the detection optics. In low-light applications, such as 3D localization microscopy, the prevailing approach is to condense signal photons into a single imaging channel with phase-only wavefront modulation to achieve a high pixel-wise signal to noise ratio. Here we show that this paradigm is generally suboptimal and can be significantly improved upon by employing multi-channel wavefront coding, even in low-light applications. We demonstrate our multi-channel optimization scheme on 3D localization microscopy in densely labelled live cells where detectability is limited by overlap of modulated PSFs. At extreme densities, we show that a split-signal system, with end-to-end learned phase masks, doubles the detection rate and reaches improved precision compared to the current state-of-the-art, single-channel design. We implement our method using a bifurcated optical system, experimentally validating our approach by snapshot volumetric imaging and 3D tracking of fluorescently labelled subcellular elements in dense environments.