Background: Psychological stress has an obvious effect on vital signs of patients with covid-19 The body responses to psychological stress includes tachypnea, pulse rate, blood pressure, and temperature. which will lead to increasing the respiratory rate and increase the length of hospitalization therefore, this study was endeavored to examine the causal relationship between hospitalization-related Psychological stress and change vital signs among the targeted subjects. Aims (s): Examining the impact of psychological stress on the vital signs prognosis of hospitalized adult patients with Covid-2019 in respiratory isolation wards This can be done by determining the difference between the prognosis of stressed & non-stressed patients. Design: A longitudinal design was used to accomplish the above-mentioned goals. Methods: A purposive sample of 140 patients with Covid-19 who were hospitalized in respiratory isolation wards in two public hospitals, in Baghdad city. The data collection process started December 25th - 2020 – April 15th 2021. Two measures were conducted at seven-days intervals. The Depression Anxity Stress scales (DASS) was the selected tool to examine the study main variables. Result: There is a statistically significant difference of respiratory rate in response to psychological stress between the 1st and 2nd measures (P=0.004, Sig=0.001 ). Concluation: The study show, There is a statistically significant difference of respiratory rate in response to psychological stress between the 1st and 2nd measures (P=0.004, Sig=0.001 ). Recommendation: mointoring vital signes, Provide psychological support to the patient with covid-19. And all adult age groups must be careful of infection with the virus. Keywords: Covid-19, vital signs, prognosis, psychological stress.