Contamination of water is a big concern that is now existing not just in India but also all around the world. In the city of Bhilwara, which is located in India, there is a lack of well-organized drainage and sewer infrastructure, as well as poor management of solid waste. The quality of the water is decreasing as a result of the discharge of these contaminants into the Banas River, which is located nearby, through a variety of different channels. Therefore, the purpose of this study is to evaluate the existing groundwater quality in Bhilwara city by utilizing hadrochemical, multivariate statistical, and Water Quality Index (WQI) status. According to the conclusions of the study, the amount of potable water that is available in this little community is gradually decreasing. The water quality index (WQI) of the source, which can range anywhere from 62 to 74, reveals that the quality of the groundwater is deteriorating on a daily basis. There should be a comprehensive management strategy that includes monitoring cells, according to the findings of this study, in order to protect the water environment in the Bhilwara region.

Cerebral ischemia is a widespread disease and a leading cause of death and disability worldwide. Its complex origins and the mysterious mechanisms behind its development make it a formidable adversary in the field of medicine. PDZ proteins are part of the human proteome with multiple functions and have been identified as key mediators of cell signaling and synaptic transmission. Their interactions with PDZ-binding proteins underlie their role in the pathogenesis of a variety of diseases. In this paper, PDZ domains have been extensively studied, exploring their structural properties and functional roles in cells. This review highlights the importance of these domains in signal transduction pathways, which are essential for the normal function of the nervous system. It also highlights emerging evidence linking PDZ proteins to the regulation of angiogenesis in cerebrovascular diseases, a key process in the development of ischemic disease. In addition, we further discuss the potential of PDZ proteins in neuronal regeneration, an area that is expected to play a role in stroke development and subsequent rehabilitation. This review also discusses the link between PDZ proteins and excitatory synaptic transmission, further exploring the mechanisms involved in excitatory toxicity. By analyzing the complex relationship between PDZ proteins and their binding partner, this paper aims to reveal the molecular basis of cerebral ischemia. This suggests that a deeper understanding of these interactions could pave the way for innovative therapeutic interventions for stroke management. The review concludes by advocating continued research into PDZ proteins, recognizing their potential as building blocks for the development of new treatment and prevention strategies for stroke and related disorders.

The aim of the work was the simultaneous determination of hydrocarbon biochemical oxygen demand - cBOD and nBOD (nitrogen) in the same water sample without using a nitrification inhibitor by the manometric method. Daily measurements of cBOD are determined by recording the pressure drop resulting from the absorption of carbon dioxide released by the oxidation of hydrocarbon organic matter by microorganisms with KOH (potassium hydroxide). Here, the processes of oxidation of mineral substances in water and especially the developing nitrification processes, which absorb oxygen dissolved in water and cause an additional pressure drop in the vessel, are a disturbing factor, for the measurement of which, in the daily 24-hour cycle of registrations, it is recommended to close the absorption hole of the vial with KOH for 8 hours. The 24-hour nBOD and cBOD results are calculated from the result of the pressure drop in these 8 hours. In the paper, in the form of a table, the detailed form of calculation of the recorded results of BODs at two pH-s of a natural water sample within 1-20 days is given. The possibility of anthropogenic impact assessment using this method is shown on the example of natural water. It is concluded that with the proposed method of measuring BODs records the complete and separate results of cBOD are recorded under conditions of developing nitrification in water. All information from both nitrification and BOD-full is recorded simultaneously, which gives a complete picture of the overall oxygen balance in the water. The proposed method is practically applicable and fully comparable with the results obtained by the standard manometric method.

Coffee is the most popular beverage in the world and the most consumed caffeinated beverage after water and tea. It contains a combination of several chemical components that, with the health benefits, most consumers start the day with at least one cup of coffee after eating and end the working day with coffee. It is considered an important part of modern-day life because it has an alarming effect on the human brain. In contrast, different groups report. They face unequal health risks and are therefore reluctant to drink coffee, suggesting individual differences in coffee intolerance. The purpose of this study was to briefly summarize the health benefits and risks of coffee consumption. Most informative reports suggest that long-term consumption of coffee and decaffeinated coffee can reduce the risk of many diseases. Among them, it is used to improve our physical performance, burn fat, reduce the risk of stroke, liver, prostate and colorectal cancer by 20%, the risk of Parkinson's disease by 25%. the risk of dementia and protect our mind, brighten our mood, help fight depression and minimize the risk of suicide by 50%. In addition, coffee drinkers have a lower risk of heart disease, with highly integrated DNA. It has also been reported that coffee consumption naturally lengthens sleep latency, decreases total sleep duration and efficiency, and worsens putative sleep functions. However, from the positive health perspective of coffee consumption, a recent study reveals that coffee consumption does not always provide protective benefits, since excessive consumption is associated with a negative impact or risk to our health. Some negative effects of coffee consumption on our health: reduces appetite, affects pregnant women, people with cholesterol, causes insomnia and restlessness, breast tissue cysts in women, digestive disorders related to incontinence and risk of headache In addition, it reduces the likelihood of fertility in women and men, causes allergies and abortions, violent heart contractions, anxiety, depression and the need for anti-anxiety drugs, inhibits the production of collagen in human skin, improves the hearing loss. it does not help with prolonged sleep deprivation, it interferes with ossification and may even lead to an increased risk of bone fracture. Finally, more recent studies have reported that the consumption of coffee is beneficial for our health when it is optimal, about four glasses on average. Further research will be crucial to clarify the health benefits and risks of coffee consumption.

Piper capense, widely known as Timiz, is an important spice from the Piperaceae family, native to East Africa, particularly in Ethiopia’s southwestern areas. Traditionally used for a myriad of health issues, Timiz holds a significant place in Ethiopian cuisine, embodying cultural traditions. The plant is distinctive in its morphology, with "timiz" in Amharic indicating its curly form. The flavor profile of Timiz is notably unique, exhibiting a milder and sweeter taste that is reminiscent of cloves and cardamom, which enhances its culinary versatility. Typically, the harvested and dried seed spikes are appreciated for their aromatic properties, which are further enhanced through traditional smoking methods. This review explores the traditional medicinal uses of Timiz, relying on ethnobotanical data that illustrate its employment among various African communities for treating ailments like digestive issues, respiratory infections, and other health problems. The results of research on the collection, conservation of accessions, agronomic practices such as watering frequency and media types, as well as propagation methods, are also highlighted. Furthermore, the review identifies challenges within the value chain, such as a lack of awareness regarding processing methods and quality control, stressing the necessity for improved practices to boost Timiz's marketability. Future directions for research, production, and market integration of Timiz in Ethiopia are also discussed, underscoring the multifaceted significance of this spice in Ethiopian culture and medicine while advocating for sustainable agricultural methods to support its cultivation and conservation.

Photocatalysis has garnered significant attention for its potential in environmental remediation, energy conversion, and sustainable chemistry. Metal-organic frameworks (MOFs) have emerged as promising photocatalytic materials due to their tunable structures, high surface areas, and unique optical properties. Among them, a newly synthesized copper-benzene-1, 3, 5-tricarboxylic acid (Cu-BTC) MOF, [Cu<sub>3</sub>(C<sub>9</sub>H<sub>3</sub>O<sub>6</sub>)<sub>2</sub>].<sub>3</sub>H<sub>2</sub>O{18H<sub>2</sub>O} has shown remarkable potential as a photocatalyst. In this work, the synthesis and characterization of a novel [Cu<sub>3</sub>(C<sub>9</sub>H<sub>3</sub>O<sub>6</sub>)<sub>2</sub>].<sub>3</sub>H<sub>2</sub>O{18H<sub>2</sub>O} for its photocatalytic applications is described. The synthesis of [Cu<sub>3</sub>(C<sub>9</sub>H<sub>3</sub>O<sub>6</sub>)<sub>2</sub>].<sub>3</sub>H<sub>2</sub>O{18H<sub>2</sub>O} was achieved through a solvothermal method employing Copper (II) Nitrate trihydrate and benzene-1, 3, 5-tricarboxylic acid as precursors in a suitable solvent. The synthesized [Cu<sub>3</sub>(C<sub>9</sub>H<sub>3</sub>O<sub>6</sub>)<sub>2</sub>].<sub>3</sub>H<sub>2</sub>O{18H<sub>2</sub>O}) was characterized by Fourier transform infrared (FTIR), X-ray diffraction (XRD), Scanning electron microscope-energy dispersive X-ray spectroscopy (SEM-EDS), Single crystal and Thermogravimetric (TGA) analysis. The photocatalytic activity of ([Cu<sub>3</sub>(C<sub>9</sub>H<sub>3</sub>O<sub>6</sub>)<sub>2</sub>].<sub>3</sub>H<sub>2</sub>O{18H<sub>2</sub>O}) was evaluated in the transformation of Lissamine green SF (LGSF) and Tetraethylrhodamine (TeRh) under solar light irradiation. The intermediate compounds obtained during the transformation of LGSF under photocatalysis were detected using a gas chromatography-mass spectrometer (GC-MS). The recyclability of [Cu<sub>3</sub>(C<sub>9</sub>H<sub>3</sub>O<sub>6</sub>)<sub>2</sub>].<sub>3</sub>H<sub>2</sub>O{18H<sub>2</sub>O}was investigated to demonstrate its stability, robustness and potential for practical applications. Conclusively, the [Cu<sub>3</sub>(C<sub>9</sub>H<sub>3</sub>O<sub>6</sub>)<sub>2</sub>].<sub>3</sub>H<sub>2</sub>O{18H<sub>2</sub>O} was proven to be an effective catalyst in the mineralization of LGSF and TeRh.

The performance of an organic solar cell is strongly influenced by the structure of the photosensitizer. In this work, the open-circuit voltage (<I>V<SUB>OC</SUB></I>) and conversion efficiency (<i>η</i>) of a series of coumarin dyes are quantitatively related to the structure of nine coumarin derivatives. The Quantitative Structure Property Relationship (QSPR) is performed using the statistical method of multiple linear regression. In addition, descriptors determined from the ground state at the Cam_B3lyp/6-31G(d, p) level of theory and from the 2D structure of the molecules are mathematically related to the photovoltaic properties. These VOC and <i>η </i>models are accredited with very good statistical indicators (<I>R<sup>2</sup></I> = 0.906 and 0.918; Q<sub>cv</sub><sup>2</sup>= 0.845 and 0.849; S= 0.045 and 0.112; F = 14.524 and 16.846). These statistical indicators confirm the robustness and performance of the models developed. The results show that Voc improves with decreasing surface tension (<i>ts</i>) and increasing number of cycles (<i>cycle</i>). As for the conversion efficiency of light radiation into electrical energy, it is optimal when the light harvesting efficiency (<i>LHE<sub>th</sub></i>) and the excited state lifetime (<i>τ<sub>th</sub></i>) are high. In conclusion, these models have good predictive capabilities and can be used to predict and explain the open-circuit voltage and efficiency of coumarin derivatives that belong to the same field of application.

Soil is an important part of agriculture applications. An understanding of physical and chemical condition of any soil is essential for proper implementation of the other soil management practices. Therefore the physico-chemical study of soil is very important because both physical and chemical properties which affect the soil productivity. This physico-chemical study of soil is based on various parameters like pH, electrical conductivity, moisture, soil organic matter, and soil organic carbon. This knowledge will create awareness among the farmers about economic productivity. In this study the physicochemical properties of soil samples obtained from Tepi campus was determined. Their value could be pH 6, Electrical conductivity 7.31µS/m, moisture content 5.038%, organic matter content 4.1% and organic carbon content 3.3%. Physical and chemical properties listed above indicate that this soil sample is productive and suitable for agricultural use. Based on the result in this study soil sample in the Tepi campus garden is slightly acidic, wet, and high organic matter content. Most of the south western parts of Ethiopia get high rain fall through the year more than eight month and its forest area. This makes the soil in this area high moisture content and organic matter content. Corn, maize, sugar cane and coffee are the most cultivated crops in this area.

In order to investigate the corrosion of carbon steel (C38) in acidic media, experimental studies (weight loss measurements, electrochemical methods, thermodynamic adsorption isotherms and field emission scanning electron microscopy coupled with energy dispersive X-ray) and computational approach were adopted to study the newly synthesized and simple Schiff base structure, namely 4-((phenylimino)methyl) phenol (PIMP) as a corrosion inhibitor for C38 steel in 1M HCl. Characterization techniques (Fourier Transform Infrared spectroscopy, mass spectrometry, proton nuclear magnetic resonance) showed that PIMP was successfully synthesized with a yield of 63%. Experimental methods (weight loss, open circuit potential (OCP), electrochemical impedance spectroscopy (EIS), potentiodynamic polarization (PDP)) showed that PIMP is a mixed-type inhibitor with an inhibition percentage of 91.1% under optimal conditions (7.5 mM PIMP at 30°C). These experimental results were supported by surface analysis (Field Emission Scanning Electron Microscopy (FESEM) coupled with Energy Dispersive X-Ray (EDX)), where PIMP molecules are adsorbed on the steel surface and form a protective barrier against aggressive ions, thereby limiting steel oxidation. The adsorption of PIMP on the carbon steel surface followed the Langmuir adsorption isotherm along with a mixture of physical and chemical adsorption, forming a complete and dense protective film on the C38 steel surface. Theoretical results using density functional theory (DFT) calculations showed that PIMP contains highly reactive centers and confirmed the experimental results obtained.

A gradual shift to biofuels development was considered advantageous in reducing the pollution and other challenges associated with fossil fuels. Specifically, biodiesel production is one of those options prioritized in the literature. Herein, we demonstrated how a modified activated charcoal sample and chromium oxide can catalyze the upgrading of groundnut oil into fuel-grade biodiesel at the laboratory scale via trans-esterification with methanol. The charcoal-based catalyst was characterized mainly at mole ratio: 3:1 (methanol: oil) reaction time of 1hr and reaction temperature at 60°C. The yield of biodiesel produced were found 71.50% for activated modified charcoal, 59.30% for chromium oxide and 49.45% for charcoal only, which is a little lower than that obtained by some researchers, and the density was found to be 0.56/cm<sup>3</sup> for active modified charcoal, 0.43g/cm<sup>3</sup> for chromium oxide and 0.33g/cm<sup>3</sup> for charcoal only which is within the ASTM approved limits. The viscocity was found to be 3.39mm<sup>2</sup>/s, 2.52 mm<sup>2</sup>/s and 1.85 mm<sup>2</sup>/s for modified activated charcoal chromium oxide and charcoal respectively at 40°C. The free fatty acid was found to be 0.01%, 0.04% and 0.02% for modified activated charcoal, chromium oxide and charcoal respectively and the values are within the range approved by ASTM. The saponification values obtained were 0.56mgKOH/g, 0.84mgKOH/g and 1.12mgKOH/g for modified activated charcoal, chromium oxide and charcoal respectively. Trans-esterification method is found to be good in producing by biodiesel from groundnut oil as corroborated by several investigations.