This case report describes the diagnosis, medical management, and surgical correction of congenital entropion with secondary trichiasis, blepharitis, and conjunctivitis in a 3-month-old male Syrian hamster ( Mesocricetus auratus ). The patient presented with chronic left ocular discharge and eyelid inflammation that persisted despite medical therapy, including topical and systemic antibiotics, anti-inflammatory medications, and environmental modifications. A sedated ocular examination confirmed entropion and trichiasis, which were deemed the primary causes of ongoing ocular irritation. Surgical intervention, utilizing a modified Hotz-Celsus technique, was performed to correct the anatomical defect. Postoperative recovery was uneventful, with resolution of clinical signs and no recurrence observed during follow-up. Based on the literature search described below, this is the first reported case of surgical entropion correction in a Syrian hamster. The case highlights the challenges of diagnosing and managing ophthalmic conditions in small rodents, including limitations in ophthalmic examination, the importance of husbandry modifications, and the risks associated with anesthesia in these species. This report underscores the feasibility of surgical intervention in hamsters when medical management fails and provides insights into the multifactorial etiology of ocular disease in this species. Further research is needed to evaluate long-term outcomes and refine treatment protocols for ophthalmic conditions in hamsters.