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Immunogenicity of Mix-and-Match CoronaVac/BNT162b2 Regimen versus Homologous CoronaVac/CoronaVac Vaccination: A Single-Blinded, Randomized, Parallel Group Superiority Trial.

(1) Background: This study aimed to compare the immunogenicity of the mix-and-match CoronaVac/BNT162b2 vaccination to the homologous CoronaVac/CoronaVac regimen. (2) Methods: We conducted a simple-blinded randomized superiority trial to measure SARS-CoV-2 neutralization antibodies and anti-spike receptor binding domain (RBD) IgG concentrations in blood samples of participants who had received the first dose of CoronaVac vaccine followed by a dose of BNT162b2 or CoronaVac vaccine. The primary endpoint for immunogenicity was the serum-neutralizing antibody level with a percentage of inhibition at 90% at 21-35 days after the boost. A difference of 25% between groups was considered clinically relevant. (3) Results: Among the 240 eligible participants, the primary endpoint data were available for 100 participants randomly allocated to the mix-and-match group versus 99 participants randomly allocated to the homologous dose group. The mix-and-match regimen elicited significantly higher levels of neutralizing antibodies (median level of 96%, interquartile range (IQR) (95-97) versus median level of 94%, IQR (81-96) and anti-spike IgG antibodies (median level of 13,460, IQR (2557-29,930) versus median level of 1190, IQR (347-4964) compared to the homologous group. Accordingly, the percentage of subjects with a percentage of neutralizing antibodies > 90% was significantly higher in the mix-and-match group (90.0%) versus the homologous (60.6%). Interestingly, no severe events were reported within 30 days after the second dose of vaccination in both groups. (4) Conclusions: Our data showed the superiority of the mix-and-match CoronaVac/BNT162b2 vaccination compared to the CoronaVac/CoronaVac regimen in terms of immunogenicity, thus constituting a proof-of-concept study supporting the use of inactivated vaccines in a mix-and-match strategy while ensuring good immunogenicity and safety.

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End-to-End Deep Learning for Multipair Two-Way Massive MIMO with PA Impairments

Multipair (MP) massive multiple-input–multiple-output (MIMO) two-way relaying system is a promising solution that is able to provide excellent spectral efficiency performance. It consists in multiple pairs ( <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex-math notation="LaTeX">$2K$</tex-math></inline-formula> ) of single-antenna user terminals that exchange information through of a relay using a large number of antennas <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex-math notation="LaTeX">$M_{t}\gg 2K$</tex-math></inline-formula> . The relay is equipped with a large number of energy-efficient power amplifiers (PAs) and ensure the multipair two-way forwarding. In this article, we first present an analytical study focused on the effects of PAs on the considered system over block fading Rayleigh channel. We derive closed-form expressions for the symbol error rate. Then, we develop a new efficient distributed learning approach for MP two-way massive MIMO. Specifically, we design the MP two-way massive MIMO system by leveraging the concept of the autoencoder, whereas the end-to-end communication system is designed using one deep neural network (NN). Interestingly, the proposed scheme, referred to as AE-MP-mMIMO, is suited for varying block fading Rayleigh channel scenarios. Indeed, we propose to adopt one stage precoder/decoder for each UE and two-stage precoding scheme for the relay: 1) an NN-Tx is used to address the PA nonlinearity and 2) a linear zero-forcing precoder is adopted to remove the multiuser interference. The NN-Tx and the UE's precoder/decoder are trained off-line and when the channel varies, only the zero-forcing precoder changes on-line. Numerical simulations show the capability of the proposed approach to achieve competitive performance with a significantly lower complexity compared to existing literature.

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