As part of the European contribution to the International Space Station (ISS) Programme, ESA has developed a number of complex, pressurised and unpressurised payloads for conducting scientific investigations in a variety of disciplines, such as the life and physical sciences, technology and space science. The majority of these payloads will already be installed in ESA's Columbus Laboratory when it is launched in 2006. Many of them are ready for flight, whilst the others are approaching final acceptance. The development of these payloads and their utilisation on the ISS can be considered as a bridge to ESA's future Exploration activities.

One of the key contributions to the development and operation of the International Space Station (ISS) is ESA's Columbus Laboratory Module. It will be transported to the ISS, together with its payload complement, on Space Shuttle Assembly Flight 1E in 2006. Columbus's readiness for launch requires the availability not only of the Module itself, but also three other major elements being provided by ESA, namely: the Ground Segment, consisting of the Columbus Control Centre and the User Support and Operations Centres (USOCs), the Operations products, and the Crew Training.

The processes by which the European Space Agency develops new technologies are reviewed.

European Space Agency studies of the effects of space flight on the visual/vestibular system are described. Using the Neurolab, astronauts conducted experiments to compare eye response to centrifugation and linear acceleration in space to that generated during experiments on Earth.

The article reviews the first 25 years of the European Space Agency's involvement in human space flight. The article explores the evolution of ESA's participation, including cooperative programs with NASA and with the Soviet Union/Russia. Current and future activities planned for the European Astronaut Centre are discussed. Interviews with Ulf Merbold and Vladimir Remek are included along with comments by Claude Nicollier, Frank De Winne, Umberto Guidoni, and Claudie Haignere.

The International Space Station (ISS) is the largest international cooperative science and technology project ever undertaken. Involving the United States, Russia, Japan, Canada and 10 ESA Member States, it is now rapidly becoming a reality in orbit, offering unprecedented access for research and applications under space conditions. Europe has invested heavily in this endeavour and plans to exploit that investment by a vigorous utilisation of the ISS for life and physical sciences research and applications, space science, Earth observation, space technology development, the promotion of commercial access to space, and the use of space for educational purposes. In recent years, ESA has engaged in an intensive promotional effort to encourage potential user communities to exploit the novel opportunities that the ISS offers. It has also made significant financial commitments to develop both multi-user facilities for life and physical sciences studies in the Columbus Laboratory, and observational and technology exposure instruments using the external Columbus mounting locations, as well as giving financial support to promote commercial and educational activities. ESA has now elaborated a European Strategy for the efficient utilisation of the ISS by European scientists and other users, which is being coordinated with the Agency's Member States contributing to the ISS Programme, and with the European Science Foundation (ESF). In cooperation with the European Commission, ESA is also fostering synergy with the European Commission's Framework Programmes in terms of shared R&D objectives. This article describes the plan that has been evolved to integrate all of these various elements.

'Telemedicine' can be defined in various ways, but the underlying concept is based on the simple fact that, thanks to modern telecommunications links, diagnostic and therapeutic medical information can be passed between patient and doctor without either of them having to travel. Initially and for quite a long period, voice communication, via telephone or radio, was used to solicit the opinion of a doctor in the case of an emergency, but the potential of Telemedicine was boosted dramatically by the widespread introduction of modern information and communication technology (ICT) into the healthcare sector. Today we are at the point where the boundary separating Telemedicine and medical ICT is somewhat blurred. The prospect of using satellite communications technologies and associated connectivity services to support even wider application of the benefits of Telemedicine was the reason why ESA began actively pursuing activities in this challenging domain back in 1996.

Since Yuri Gagarin's historic first flight into space in April 1961, it has quickly become evident that the space environment influences the human body in many different ways and causes it to adapt in ways that can lead to problems when returning to Earth's gravity. Much research has been performed in the meantime and our understanding of what happens to our bodies in space improved considerably during the Mir space station and Space Shuttle/Spacelab era. However, many questions, particularly regarding how to counteract those changes that we now know take place, still need to be addressed through studies on the International Space Station (ISS) and through simulations on the ground. As we enter an era in which crews will spend longer periods in space on the ISS and of longer term plans by almost every space-faring nation for missions to Mars, it is clear that much more knowledge is needed, and quickly. Although a few hundred men and women have already travelled into space, the operating environment severely limits the amount of systematic research that can be performed--a situation that is unlikely to change. Other avenues for addressing specific scientific questions in a controlled research environment must therefore be found. One of these complementary alternatives is head-down-tilt bed-rest studies in which volunteers are confined to beds that are tilted -6 deg below the horizontal at the head end. Every activity, including eating, reading, showering, etc., is performed in this position for the duration of the study. This leads to changes in the human body that are very similar to those seen during spaceflight, such as bone-mass and muscle-mass loss, cardiovascular and neuro-sensory deconditioning. The controlled bed-rest setting therefore allows meaningful research into the bodily consequences of spaceflight and possible countermeasures. It also gives the scientific community interested in space-related medical research more ready access to a clinical model. The benefits of these studies go far beyond their space application. Patients bed-ridden because of illness or accidents suffer the same symptoms and can thus also profit from the studies. As a clear indication of this link, the clinicians and researchers involved in the bed-rest campaigns typically spend the majority of their time exploring "terrestrial" problems.

Following the great success of the Student Parabolic Flight Campaigns that it organised in 1994 and 1995, ESA decided to make them an annual event for students from the Agency's Member States. An initiative of ESA's Education Office, the campaigns give talented students a unique opportunity to experience weightlessness whilst performing their own scientific experiments, and hopefully encourage them to consider pursuing a career in space. The fifth Student Parabolic Flight Campaign (SPFC) took place from Bordeaux-Merignac Airport in southwest France in the first weeks of September 2002, with more than 120 students participating. Their thirty-two experiments had been selected in a Europe-wide competition and covered a wide variety of disciplines. The great enthusiasm shown by the students and the wide coverage that the campaign received in the media demonstrated the growing interest in space education and the promotional value of the campaign.

After several years of planning and preparation, ESA's ISS training programme has become operational. Between 26 August and 6 September, the European Astronaut Centre (EAC) near Cologne gave the first ESA advanced training course for an international ISS astronaut class. The ten astronauts who took part--two from NASA, four from Japan and four from ESA--had begun their advanced training programme back in 2001 with sessions at the Johnson Space Center (JSC) in Houston and at the Japanese Training Centre in Tsukuba. During their stay in Cologne, the ten astronauts participated in a total of 33 classroom lessons and hands-on training sessions, which gave them a detailed overview of the systems and subsystems of the Columbus module, the Automated Transfer Vehicle (ATV), and the related crew operations tasks. They were also introduced to the four ESA experiment facilities to be operated inside the Columbus module. After their first week of training at EAC, the astronauts were given the opportunity to see the flight model of the Columbus module being integrated at the site of ESA's ISS prime contractor, Astrium in Bremen. The second week of training at EAC included hands-on instruction on the Columbus Data Management System (DMS) using the recently installed Columbus Crew Training Facility. In preparation for the first advanced crew training session at EAC, two Training Readiness Reviews (TRR) were conducted there in June and August. These reviews were supported by training experts and astronauts from NASA, NASDA and CSA (Canada), who were introduced to ESA's advanced training concept and the development process, and then analysed and evaluated the training flow, content and instructional soundness of lessons and courses, as well as the fidelity of the training facilities and the skills of the ESA training instructors. The International Training Control Board (ITCB), made up of representatives from all of the ISS International Partners and mandated to control and coordinate all multilateral training for ISS crew and ground-support personnel, testified to ESA's readiness to provide Advanced Training by declaring the EAC TRR successful. The completion of this first training course was therefore a good opportunity for the Astronaut Training Division to assess the status of its training programme. The comments and recommendations of the training experts and the astronauts who took part have been carefully evaluated and the results are being fed back into the ongoing training development process.