The article deals with the study of transformation processes in the view of using geospatial information in Russia. Attention is focused on the problems of legal regulation in the field of geospatial data and knowledge. The author analyzes Russian state standards (GOSTs), determines the levels of their coherence and identifies contradictions in terminology. The study is based on the theory and practice of transition from simple geodata to full-fledged geospatial knowledge necessary for effective territorial management and decision-making. A gradation of the certainty of terms that helps to identify weak points in the existing regulatory framework is proposed. A conclusion is made on the need to modernize the standards and bring them closer to the requirements of the digital economy, which can increase the abilities of the state and accelerate the pace of its development. The results of the study are relevant for a wide range of specialists involved in the management of geospatial information and its legal support

A series of new aminomethylpyridinium hexafluoridosilicate salts with the formula (RH)2[SiF6] (where R = 2-amino-3-methylpyridine (1), 2-amino-4-methylpyridine (2), 2-amino-5-methylpyridine (3) and 2-amino-6-methylpyridine (4)) were prepared by the reaction of various methyl-substituted 2-aminopyridines with hydrogen fluoride solution of silica. The crystal packing of these ionic salts is compared with respect to the position of the methyl group on the aromatic ring. The crystal structures are dominated by the non-covalent interactions: the N–H···F hydrogen bonds and π-π interactions between aromatic rings. The potential of the corresponding ionic salts to enable supramolecular associations was investigated. Compounds 1–4 were also characterized by 1H, 19F NMR and IR spectroscopy.

BACKGROUND The adoption of telehealth services surged after the coronavirus disease 2019 pandemic, revolutionizing traditional healthcare delivery models. Amazon Clinic's recent nationwide launch marks a significant milestone in this trend. This study aims to offer a strengths, weaknesses, opportunities, and threats (SWOT) analysis of Amazon Clinic and compare its features with leading virtual healthcare platforms. AIM To evaluate Amazon Clinic's telehealth services through a SWOT analysis and compare its features with other leading virtual healthcare platforms. METHODS The initial search terms included were, amazon clinic odds ratio (OR) amwell OR Teladoc OR Walmart virtual health service OR CVS minute clinic OR CirrusMD OR brightside health, from 2000 to 2023. This search yielded 111 articles, from which duplicates were removed, and unrelated titles were filtered out. Eight articles were retained for a final review, including comparative studies, usability research, retrospective analyses, observational studies, and review articles. The data was organized and analyzed using Rayyan software and summarized in a table and PRISMA flowcharts. RESULTS The review included eight articles focusing on various aspects of telehealth. Comparative studies highlighted differences between Teladoc and traditional physician offices, noting lower diagnostic imaging orders and antibiotic prescriptions for Teladoc. User demographics for Teladoc showed younger, less engaged patients. Usability studies emphasized the importance of website design for telemedicine adoption. Tele-mental health platforms like Brightside showed superior outcomes in treating depression compared to traditional methods. Telemedicine for specialized fields like skin reconstruction demonstrated cost efficiency and reduced waiting times. The SWOT analysis identified Amazon Clinic's strengths, such as its vast consumer base and transparent pricing, and weaknesses like the lack of pediatric care. Opportunities included potential partnerships and service expansions, while threats involved competition and regulatory challenges. CONCLUSION Amazon Clinic's entry into the telehealth sector represents a significant development with various strengths and opportunities. However, it faces challenges from established healthcare providers and regulatory landscapes. The future success of Amazon Clinic will depend on strategic collaborations, addressing service gaps, and navigating competition and regulations. Telemedicine's impact will hinge on its ability to effectively leverage these opportunities and overcome inherent challenges in the ever-evolving healthcare landscape.

The gut microbiome, a complex ecosystem of microorganisms, has a significant role in modulating pain, particularly within orthopaedic conditions. Its impact on immune and neurological functions is underscored by the gut-brain axis, which influences inflammation, pain perception, and systemic immune responses. This integrative review examines current research on how gut dysbiosis is associated with various pain pathways, notably nociceptive and neuroinflammatory mechanisms linked to central sensitization. We highlight advancements in meta-omics technologies, such as metagenomics and metaproteomics, which deepen our understanding of microbiome-host interactions and their implications in pain. Recent studies emphasize that gut-derived short-chain fatty acids and microbial metabolites play roles in modulating neuroinflammation and nociception, contributing to pain management. Probiotics, prebiotics, synbiotics, and faecal microbiome transplants are explored as potential therapeutic strategies to alleviate pain through gut microbiome modulation, offering an adjunct or alternative to opioids. However, variability in individual microbiomes poses challenges to standardizing these treatments, necessitating further rigorous clinical trials. A multidisciplinary approach combining microbiology, immunology, neurology, and orthopaedics is essential to develop innovative, personalized pain management strategies rooted in gut health, with potential to transform orthopaedic pain care.

Статья посвящена исследованию заболеваемости и инвалидности среди детей с психическими расстройствами в возрасте до 18 лет в Республике Беларусь за период с 2020 по 2024 г. В условиях растущей актуальности проблемы психического здоровья среди детей исследование направлено на анализ динамики и структуры инвалидности, что имеет важное значение для понимания масштабов проблемы и совершенствования стратегий вмешательства и поддержки детей с психическими расстройствами. За последние пять лет в Республике Беларусь среди детей наблюдается значительный рост общей и первичной заболеваемости расстройствами аутистического спектра (РАС). В Республике Беларусь за последние пять лет общая заболеваемость РАС увеличилась с 115,1 до 309,5 случая на 100 тыс. детского населения, первичная заболеваемость возросла с 13,0 до 44,2 случая на 100 тыс. детского населения. На основе анализа ретроспективных данных выполнен расчет прогноза показателей на предстоящие годы. В структуре детской инвалидности лидирующие позиции занимают РАС. Установлен восходящий тренд линейного характера для общей и первичной инвалидности, связанной с РАС. Накопление числа детей-инвалидов вследствие РАС происходит быстрыми темпами, что подчеркивает необходимость совершенствования комбинированных программ диагностики, лечения, медико-психолого-педагогической коррекции, социального сопровождения и реабилитации, также расширения мер социальной поддержки для детей с РАС и их семей. The article is devoted to the study of morbidity and disability among children with mental disorders under the age of 18 in the Republic of Belarus for the period from 2020 to 2024. In the context of the growing relevance of the mental health problem among children, the study is aimed at analyzing the dynamics and structure of disability, which is important for understanding the scale of the problem and improving strategies for intervention and support for children with mental disorders. Over the past five years, there has been a significant increase in the overall and primary incidence of autism spectrum disorders (ASD) among children in the Republic of Belarus. Over the past five years, the overall incidence of ASD in the Republic of Belarus has increased from 115.1 to 309.5 cases per 100 thousand children, the primary incidence has increased from 13.0 cases to 44.2 cases per 100 thousand children. Based on the analysis of retrospective data, a forecast of indicators for the coming years was calculated. ASD occupies a leading position in the structure of childhood disability. An upward linear trend has been established for overall and primary disabilities associated with ASD. The number of children with disabilities due to ASD is increasing rapidly, which emphasizes the need to improve combined programs for diagnosis, treatment, medical-psychological-pedagogical correction, social support and rehabilitation, as well as expanding social support measures for children with ASD and their families.