Meibomian gland dysfunction (MGD) is one of the main causes of dry eye disease. To better understand the physiological functions of human meibomian glands (MGs), the present study compared MGs with free sebaceous glands (SGs) and hair-associated SGs of humans using morphological, immunohistochemical, and liquid chromatography-mass spectrometry (LCMS)-based lipidomic approaches. Eyelids with MGs, nostrils, lips, and external auditory canals with free SGs, and scalp with hair-associated SGs of body donors were probed with antibodies against cytokeratins (CK) 1, 8, 10, and 14, stem cell markers keratin 15 and N-cadherin, cell-cell contact markers desmoglein 1 (Dsg1), desmocollin 3 (Dsc3), desmoplakin (Dp), plakoglobin (Pg), and E-cadherin, and the tight junction protein claudin 5. In addition, Oil Red O staining (ORO) was performed in cryosections. Secretions of MGs as well as of SGs of nostrils, external auditory canals, and scalps were collected from healthy volunteers, analyzed by LCMS, and the data were processed using various multivariate statistical analysis approaches. Serial sections of MGs, free SGs, and hair-associated SGs were 3D reconstructed and compared. CK1 was expressed differently in hair-associated SGs than in MGs and other free SGs. The expression levels of CK8, CK10, and CK14 in MGs were different from those in hair-associated SGs and other free SGs. KRT15 was expressed differently in hair-associated SGs, whereas N-cadherin was expressed equally in all types of glands. The cell-cell contact markers Dsg1, Dp, Dsc3, Pg, and E-cadherin revealed no differences. ORO staining showed that lipids in MGs were more highly dispersed and had larger lipid droplets than lipids in other free SGs. Hair-associated SGs had a smaller number of lipid droplets. LCMS revealed that the lipid composition of meibum was distinctively different from that of the sebum of the nostrils, external auditory canals, and scalp. The 3D reconstructions of the different glands revealed different morphologies of the SGs compared with MGs which are by far the largest type of glands. In humans, MGs differ in their morphology and secretory composition and show major differences from free and hair-associated SGs. The composition of meibum differs significantly from that of sebum from free SGs and from hair-associated SGs. Therefore, the MG can be considered as a highly specialized type of holocrine gland that exhibits all the histological characteristics of SGs, but is significantly different from them in terms of morphology and lipid composition.

Computed tomography (CT) is a powerful method for non-destructive testing (NDT) in various industrial testing scenarios. Conventional laboratory based CT systems require that the object that is to be inspected can be placed between the X-ray source and the detector in the inspection cabinet and that the areas to be inspected are easily accessible to the X-ray tube and detector. To surmount the constraints imposed by such setups, robotic CT systems have gained traction in the recent past. This approach facilitates the preemptive planning of robotic paths, thereby guaranteeing the determination of collision-free trajectories, the optimal alignment of imaging perspectives, and eventually enabling 2D stitching of larger samples such as automotive body parts. Addressing the intricacies of robot positioning, which involves considerations of accessibility and the scanned object absorption characteristics, we introduce a refined inspection planning workflow tailored for 2D X-ray imaging task. Utilizing available resources, such as CAD models or the object's boundary geometry, in conjunction with task-specific relevance criteria, we ascertain the most advantageous viewpoints for 2D inspection utilizing a CT robotic system. This methodology enables proactive path planning for the robot, ensuring the establishment of collision-free routes and the precise calibration of imaging angles for optimal inspection outcomes.

Precise coating processes demand sensitive drying processes. The present work investigates the operation of hybrid convective drying nozzles for combining impingement nozzles with impingement-free nozzles. Impingement-free nozzles show good uniformity, whereas impingement nozzles are characterized by higher heat transfer but greater non-uniformity across the pitch. Volumetric flow ratio between the nozzle types, lateral distance, substrate distance and angle of impingement are the parameters of this study. Compared with purely impingement-free nozzles, the combination can achieve increased heat transfer with moderate losses in distribution uniformity. A divergent impingement jet with a small lateral distance and a small substrate distance proves to be advantageous. In addition, a consideration of energy requirements shows that impingement-free nozzles, due to their lower resistance, can deliver the same volume flow rates with lower blower power. As a result, the reduction of the impingement component in the hybrid nozzle is advantageous in terms of energy.

At the beginning of the COVID-19 pandemic, with a lack of knowledge about the novel virus and a lack of widely available tests, getting first feedback about being infected was not easy. To support all citizens in this respect, we developed the mobile health app Corona Check. Based on a self-reported questionnaire about symptoms and contact history, users get first feedback about a possible corona infection and advice on what to do. We developed Corona Check based on our existing software framework and released the app on Google Play and the Apple App Store on April 4, 2020. Until October 30, 2021, we collected 51,323 assessments from 35,118 users with explicit agreement of the users that their anonymized data may be used for research purposes. For 70.6% of the assessments, the users additionally shared their coarse geolocation with us. To the best of our knowledge, we are the first to report about such a large-scale study in this context of COVID-19 mHealth systems. Although users from some countries reported more symptoms on average than users from other countries, we did not find any statistically significant differences between symptom distributions (regarding country, age, and sex). Overall, the Corona Check app provided easily accessible information on corona symptoms and showed the potential to help overburdened corona telephone hotlines, especially during the beginning of the pandemic. Corona Check thus was able to support fighting the spread of the novel coronavirus. mHealth apps further prove to be valuable tools for longitudinal health data collection.

(1) Background: With the conventional contour surface method (KfM) for the evaluation of cardiac function parameters, the papillary muscle is considered to be part of the left ventricular volume. This systematic error can be avoided with a relatively easy-to-implement pixel-based evaluation method (PbM). The objective of this thesis is to compare the KfM and the PbM with regard to their difference due to papillary muscle volume exclusion. (2) Material and Methods: In the retrospective study, 191 cardiac-MR image data sets (126 male, 65 female; median age 51 years; age distribution 20-75 years) were analysed. The left ventricular function parameters: end-systolic volume (ESV), end-diastolic volume (EDV), ejection fraction (EF) and stroke volume (SV) were determined using classical KfW (syngo.via and cvi42 = gold standard) and PbM. Papillary muscle volume was calculated and segmented automatically via cvi42. The time required for evaluation with the PbM was collected. (3) Results: The size of EDV was 177 mL (69-444.5 mL) [average, [minimum-maximum]], ESV was 87 mL (20-361.4 mL), SV was 88 mL and EF was 50% (13-80%) in the pixel-based evaluation. The corresponding values with cvi42 were EDV 193 mL (89-476 mL), ESV 101 mL (34-411 mL), SV 90 mL and EF 45% (12-73%) and syngo.via: EDV 188 mL (74-447 mL), ESV 99 mL (29-358 mL), SV 89 mL (27-176 mL) and EF 47% (13-84%). The comparison between the PbM and KfM showed a negative difference for end-diastolic volume, a negative difference for end-systolic volume and a positive difference for ejection fraction. No difference was seen in stroke volume. The mean papillary muscle volume was calculated to be 14.2 mL. The evaluation with PbM took an average of 2:02 min. (4) Conclusion: PbM is easy and fast to perform for the determination of left ventricular cardiac function. It provides comparable results to the established disc/contour area method in terms of stroke volume and measures "true" left ventricular cardiac function while omitting the papillary muscles. This results in an average 6% higher ejection fraction, which can have a significant influence on therapy decisions.

The evolution of wireless communication points to increasing demands on throughput for data-intensive applications in modern society. Integrated millimeter-wave systems with electrical beam-steering capabilities are promising candidates for wireless technologies of the future and are currently the subject of widespread academic and commercial research. The <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$D$ </tex-math></inline-formula> -band, ranging from 110–170 GHz, offers high aggregate bandwidths (BWs), low atmospheric absorption, and multi-GHz operation at amenable fractional BWs. It, therefore, has the potential to foster efficient, highly integrated wireless-communication systems with data rates approaching 100 Gb/s. This article reviews all aspects of hardware integration against the backdrop of an extensive literature review and outlines the challenges and possible solutions for practical 6G wireless systems in the <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$D$ </tex-math></inline-formula> -band. To this end, this article covers a number of related topics in depth, which includes system definition, possible radio architectures and array configurations, the scope and potential of integrated circuit (IC) technologies, the design and characterization of key circuit blocks, advances in antenna and packaging technologies for high-frequency systems, and an overview of measurement techniques currently employed at <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$D$ </tex-math></inline-formula> -band frequencies. A system-level study based on radio-link simulations of different single-carrier quadrature amplitude modulation (QAM) schemes is presented, which quantifies that the impact physical nonidealities, such as signal-to-noise ratio, phase noise, intermodulation distortion, and amplitude and phase imbalances in quadrature signal paths, have on bit-error rates in broadband <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$D$ </tex-math></inline-formula> -band communication systems. This is followed by a comparative assessment of different arrayed-system configurations that include traditional phased arrays, the use of polarization diversity for the transmission of different or identical data streams, and multiple input multiple output (MIMO) operation. The article also presents an overview of possible transceiver architectures for implementing beam-steering arrays and an outline of the associated tradeoffs. The beam-squinting effect seen in large arrays is also investigated in detail. On the implementation front, we present a comparison between different integrated-circuit technologies for high-frequency applications. These include CMOS and SiGe bipolar complementary metal oxide semiconductor (BiCMOS) heterojunction bipolar transistors (HBTs) in silicon technologies, and MOSFETs, HBTs, and HEMTs in III–V technologies, such as InP and GaAs. Implementation challenges are then addressed, and these include the design of high-frequency circuits in the latest IC technologies, current advances in antenna and packaging technologies, and emerging solutions for hybrid integration. The article also details the design and characterization of critical <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$D$ </tex-math></inline-formula> -band transceiver circuit blocks, namely, power and low-noise amplifiers, mixers, phase shifters, passive components for quadrature-phase generation, and radiators exploring hybrid antennas, which we have developed over the course of the past five years. These results compliment the literature survey with comparisons with state-of-the-art designs and are applied to radio-link simulations to predict the performance of practicable wireless links.