Bone tumours constitute about 0.5% of documented cancer incidence. A previous study conducted in our hospital showed an incidence of 0.53% for primary malignant bone tumour (PMBT). Some of the predisposing factors to the development of these bone tumours include trauma, irradiation, foreign bodies, and genetic malfunctioning or mutation. They present symptoms, such as bone pain, swelling and tenderness of the affected bone, and weight loss, and in some cases, the first presentation may be a pathological fracture through the bone tumour. The last review of primary malignant bone tumours carried out in our centre was in September 2007; therefore, this study is designed to provide an update on the current pattern of these tumours. The aim and objectives of this study are to provide an update on the current pattern of primary malignant bone tumours. To determine their relative frequencies, age and sex distributions, anatomical sites of occurrence as well as the histological types of the tumours. This is a retrospective hospital-based study to re-evaluate the incidence of primary malignant bone tumour at the University College Hospital, Ibadan, Oyo State, Nigeria. The histopathology records of patients with primary malignant bone tumours were reviewed through the Cancer Registry of the University College Hospital, Ibadan from January 2007 to December 2022. The information retrieved from the Cancer Registry records includes the age of the patient, the sex, the histological type of tumour, and the bone involved. The data retrieved were analysed using version 23 of the Statistical Package for the Social Sciences. The results revealed that data from 170 patients with primary malignant bone tumours were reviewed within the study period. In all, there were 93 males and 77 females with a male-to-female ratio of 1.2:1. However, 145 patients had complete records and were reviewed. Primary malignant bone tumours occurred more in the second and third decades of life, and the most common primary malignant bone tumour was osteosarcoma. This study concludes that the annual average occurrence of primary malignant bone tumour seems to be on the increase when compared with previous studies with a higher preponderance in the male gender with osteosarcoma being the most common PMBT. The younger age group, especially teenagers and young adults within the second and third decades of life are the most affected.

Understanding the relationship between central cornea thickness and glaucoma severity will help in assessing individualised risk and will enhance evidence-based decision-making in the early diagnosis and management of glaucoma. We aimed to determine the correlation between central corneal thickness (CCT) and the severity of glaucoma at different stages of primary open-angle glaucoma (POAG) at the Federal Medical Centre (FMC), Lokoja, Nigeria. A cross-sectional study of POAG patients at presentation to FMC, Lokoja. Biodata, use of anti-glaucoma medications, and family history of glaucoma were obtained. Examinations included visual acuity, central visual fields, slit lamp examination, pachymetry, gonioscopy, indirect fundoscopy, and fundus photograph. The correlation between CCT and the above parameters was ascertained. Using the mean deviation, the severity of glaucoma was classified: as mild glaucoma <-6 dB, moderate glaucoma -6 to -12 dB, severe glaucoma -12 to -18 dB, and end-stage glaucoma >-18 dB. A total of 242 eyes of 121 POAG patients were studied. The male-to-female ratio was 1.5:1. The mean age was 55 ± 10 years (range = 40-78 years). Most (65.7%) had not used anti-glaucoma medications and 17.4% gave a positive family history of glaucoma. There was no clinical correlation between positive family history and CCT (P = 0.71) and no correlation between family history and glaucoma severity (P = 0.96). The patients were classified as mild glaucoma 63(29.9%), moderate glaucoma 95(45%), severe glaucoma 30 (14.2%), and end-stage glaucoma 23 (10.9%). The mean CCT was 508.0 ± 32μm. There was a decrease in CCT from 517.94 ± 26μm in mild glaucoma to 504.96 ± 40μm in end-stage glaucoma; this difference was statistically significant (P = 0.031). The mean intraocular pressure (IOP) was 24 ± 7 mm Hg, whereas the mean corrected IOP was 27 ± 8 mm Hg. There was a negative significant correlation between CCT and glaucoma severity and between CCT and true IOP. CCT did not correlate with age, sex, family history, or laterality of POAG.

Chronic liver disease (CLD) in the clinical context is a disease process affecting the liver, which involves a process of progressive destruction and regeneration of the liver parenchyma, leading to fibrosis and cirrhosis. Both FibroScan, which is an ultrasound study also known as transient elastography, and Hyaluran test (biochemical test) are rapid safe non-invasive examinations of the liver, which can be used to monitor the degree and progression of fibrotic changes in the liver. The purpose of this study was to compare the degree of liver fibrosis, as measured on ultrasound-based FibroScan and Hyaluran tests in CLD. This was a two-stage comparative study carried out on patients with clinically diagnosed CLD and non-CLD subjects at Jos University Teaching Hospital (JUTH) from January to June 2022. The first stage involved the use of ultrasound-based FibroScan to assess the degree of tissue stiffness in the liver of both CLD and non-CLD subjects. The unit of measurement of FibroScan is kilopascals (Kpa). In the second stage, blood samples were collected from CLD and non-CLD subjects for Hyaluran tests. The unit of measurement of Hyaluran tests is expressed in nanograms per milliliter (ng/mL). This study comprises of 75 apparently normal subjects and 75 CLD patients. The mean FibroScan level was significantly higher (17.55 ± 7.5 kPa) in patients with CLD compared to apparently normal subjects (5.06 ± 3.1 kPa), t = 5.783; P < 0.001. The mean Hyaluran value in the patients with CLD was 30.01 ± 20.39 ng/mL, which was significantly higher than that in the normal subjects with the mean value of 20.39 ± 8.27 ng/mL, t = 3.784; P < 0.001. In evaluating the correlation between FibroScan and Hyaluran in assessing the degree of fibrosis using the Spearman correlation coefficient, it was observed that the degree of fibrosis at the earlier stage (minimal) signifies a positive but weak correlation (P = 0.151), but this was not statistically significant (P = 0.492). However, mild/moderate and severe fibrosis demonstrate moderate positive (P = 0.505 and 0.550) and statistically significant correlation with P value of 0.020 and 0.011, respectively. The study demonstrated a statistically significant difference in the mean FibroScan value in non-CLD and CLD cases. The results also indicated statistically significant difference in the mean Hyaluran value in non-CLD and the CLD cases. The study demonstrated a significant correlation between Hyaluran and FibroScan in assessing the degree of moderate and severe fibrosis in CLD.

Urethrography is a radiologic procedure that optimizes imaging evaluation of the urethra, particularly in settings of difficulty with micturition or urethral injury. Urethrography remains the gold standard imaging tool, providing reliable and accurate diagnosis and staging of urethral stricture disease. A 10-year review of patients' archive who had retrograde urethrography or combined urethrography examinations in a peripheral facility from January 2014 to December 2023 was carried out. A total of 247 patients with complete records who met the inclusion criteria were included in this study. Demographic data, clinical indications, and the imaging findings were documented. The data were collated, entered into a computer, and processed by the use of Statistical Package for Social Sciences (SPSS), version 23, to determine frequencies (means ± standard deviations). The results are presented using frequency tables and percentages as appropriate. A P value of <0.05 was considered statistically significant with a confidence interval of 95%. The examination was normal in 89 (36.0%) patients. Urethral stricture was the commonest abnormality (44.5%) and commonly affects the bulbar urethra (70.9%). About 83.6% of the patients with stricture had 1-2 strictures while 16.4% had multiple urethral strictures. About 63.6% of patients with urethral strictures had short segment stricture, which was common at the bulbar urethra. Urethrography is an effective and cheap means of imaging the urethra mostly indicated on account of strictures and lower urinary tract symptoms. The urethral stricture is the commonest abnormal finding, which commonly affects the bulbar urethra.

Intestinal obstruction is a common surgical emergency. It has many causes, which may be either benign or malignant. However, appendicitis is not a common cause of intestinal obstruction, hence the challenge in making a diagnosis. Radiological and clinical diagnoses of this could be difficult; hence, diagnosis is mostly intraoperative. This case study involved a 54-year-old male, who presented at Edward Francis Small Teaching Hospital with features of acute intestinal obstruction for 5 days. During surgery, a gangrene of a loop of the bowel was found with an inflamed and partly gangrenous appendix, forming a tourniquet around the loop of the bowel. Appendicectomy and resection of the gangrenous bowel were performed. The postoperative period was uneventful. The patient was discharged on postoperative day 12. We publish this case report to add to the existing literature. In addition, no such case has been reported in the subregion. Appendicitis is not common in the age group in our case study, which makes it different from other cases presented in literature.

To evaluate the output of a child eye health programme in terms of identification, referral, and volume of paediatric cataract surgeries in Kaduna State, Nigeria. This was a retrospective review of the North-West Nigeria Child Eye Health Initiative programme referral registers at primary, secondary and tertiary hospitals in Kaduna State. Theatre registers of children 0-16 years who had cataract surgery at National Eye Centre Kaduna between 2016 and 2019 were also reviewed. Information on numbers of children, age, sex, laterality of cataract and programme status were summarised as frequencies, percentages and mean ± standard deviation. The initial 2 years of the programme (2018-2019) were compared with the 2 years (2016-2017) preceding them. Between January 2018 and December 2019; primary health workers screened 41,552 children and referred 2,316 (5.6%). Of those referred 1772 (76.5%) presented at one of three zonal secondary hospitals where nurses identified 492 (27.8%) with leukocoria using torchlights and referred them to the tertiary hospital. At the tertiary hospital, 364 (74.0% of 492) attended and 262 (72.0% of 364) were confirmed to have operable cataracts after dilated slit lamp examination by ophthalmologists. Between 2016 and 2017 (pre-programme years), 201 children had cataract surgery compared to 352 in 2018 and 2019 (programme years) of whom 239 (67.9% of 352) were beneficiaries of the programme. The proportion of girls who had cataract surgery declined from 39.8% to 35.0%, while mean age increased from 5.7 ± 4.2 years to 7.5 ± 4.1 over 4 years. More children with unilateral cataracts (214 [60.8%]) presented during the programme years (Fishers exact test, P = 0.004), whereas unilateral cataract (207 [60.2%]) was significantly more common in males than females (Fisher's exact P = 0.017). The programme has resulted in improved case detection of childhood leukocoria at primary eye care level. additionally, the eye health referral system in Kaduna State has been strengthened with increasing numbers of children accessing services: majority boys, older children, and unilateral cataracts.

[This corrects the article DOI: 10.4103/jwas.jwas_38_24.].

Human immunodeficiency virus (HIV) is a lentivirus. It is transmitted through sexual intercourse, shared intravenous drugs, contaminated needle use, blood transfusion, and mother-to-child transmission. Of the patients with HIV, 50%-75% have ocular manifestations and this may be the primary presentation. This study was carried out in two prevention of mother-to-child transmission (PMTCT)/HIV clinics. The aim was to determine the incidence, patterns of presentation, and determinants of ocular and adnexal diseases in HIV-positive pregnant women attending HIV clinics to develop an eye care protocol for them. The study was a cross-sectional study of HIV-positive pregnant women attending the PMTCT/HIV Clinics at University College Hospital and Adeoyo Maternity Teaching Hospital, Ibadan. Patients were interviewed using a structured questionnaire. Blood samples were taken for CD4+ count and viral load. The stage of the disease, type of antiretroviral therapy (ART), and the interval between HIV diagnosis and commencement of ART were recorded. Comprehensive ocular examination, which included visual acuity check unaided and with pinhole, lid, anterior segment examination with slit lamp and posterior segment examination with dilated binocular indirect ophthalmoscopy, was conducted. Statistical Package for Social Sciences version 23 was used to analyse the data. A total of 153 pregnant women aged 23-42 years (mean, 33.5; standard deviation, ±5.6) were recruited. One hundred and fifteen (75.2%) of them were married in a monogamous setting. Multiple sexual partners (48.4%; n = 74-some women married in monogamous settings at the time of recruitment for this study had multiple sexual partners in the past) and the use of unsterilised objects (46.4%; n = 71) were major high-risk behaviours. Ocular and adnexal diseases were found in 81 (53%) participants. HIV-related ocular and adnexal diseases were found in 16 (10%) participants. Of the 16 HIV-related diseases, optic atrophy was found in seven (43.8%), presumed toxoplasmosis in three (18.7%), presumed cytomegalovirus retinitis in three (18.7%) lid warts in two (12.5%), and conjunctival microangiopathy in one (6.3%) participant. The association between HIV- related ocular and adnexal diseases and gestational age, CD4+ count, viral load and type of ART was not statistically significant. The few HIV-related findings in this study could be a result of the improved CD+ count/low viral load of most of the recruited participants. Ensuring that patients attending PMTCT/HIV clinic have at least one ocular examination during pregnancy by collaborating with eyecare professionals could ensure prompt detection and treatment of eye diseases, to improve the quality of life of HIV-positive pregnant women.

Approximately 80% of ductal carcinoma in situ (DCIS) cases are asymptomatic and manifest as microcalcifications, usually detected on screening mammograms. Stereotactic biopsy is used as the primary modality for histopathologic diagnosis. Ultrasonography has been relied upon as a potentially viable alternative for early breast cancer detection, especially in low- and medium-income countries. Determine the role and reliability of breast ultrasonography in the evaluation of screen-detected microcalcifications using histologically proven calcified DCIS as a case study. Cross-sectional evaluation of records of patients recalled for M3-M5 (indeterminate to malignant) type microcalcifications on screening mammograms, with a histological diagnosis of pure DCIS, in an NHS Trust Hospital, Kent, England, from March 2021 to April 2023. Eighty women included were within the age range of 46-79 years, with mean age of 60 years. Background breast density was predominantly fatty in 51/80 (63.8%), without any correlation with mammographic abnormalities. Microcalcifications were classified as indeterminate (M3) in 42/80 (52.5%), while suspicious (M4) and malignant (M5) types were seen in 38/80 (47.5%). No targeted sonographic abnormalities were noted in 69 (86.2%) of the patients, while 11 (13.8%) had sonographic abnormalities. The predominant sonographic feature was non-mass hypoechogenicity in 6/11(55%). There was a correlation between mammographic code, lesion size, and ultrasonic abnormality, with 9/11 (81.8%) patients with sonographic lesions having suspicious and malignant type calcifications. The mean mammographic lesion size was significantly greater in women with abnormal ultrasound findings, 42 vs. 20 mm. Histological tumour grade was high grade in 10/11 (90.9%) lesions. The accuracy of breast ultrasonography as an adjunct in the detection of screen-detected microcalcifications and subsequent guided biopsy is higher when dealing with malignant type microcalcifications >15 mm in size.

Avascular necrosis (AVN) of the femoral head is a devastating complication of sickle cell disease characterised by hip pain and dysfunction. The prevalence of this condition in patients with sickle cell disease in Ghana is unknown. This study aims to look at the demographics of sickle cell disease patients presenting with AVN, the pattern of the disease on presentation, and the severity of the disease. Data were collected from patients referred to the Orthopaedic clinic over three years. Data collection forms were created and filled out for all patients. Analysis was done with Microsoft Excel (Windows 10 version), and the ensuing data were represented with descriptive statistics such as proportions, ratios, percentages, tables, and histograms. A total of 134 patients were seen over a 3-year study period. The vast majority, 109 (85.3%), were below 40 years of age. The sex distribution of the patients was predominantly female (78%). Genotype SS was in the majority (89), representing (66.4%).The majority of the patients, 104 (77.6%), were regular attendees of the Ghana Institute of Clinical Genetics or other specialised sickle cell disease clinics. The main reason for referral was on account of X-ray changes seen by the referring doctor (90, 67.1%). Unilateral disease was seen in 94 (70%) patients. Seventy (52.2%) presented with stage III disease, and 42 (31%) had symptoms for more than 2 years. Most of our patients were young, predominantly with genotype SS. They presented late with advanced disease stages and were referred to the orthopaedic clinic only after X-ray changes were seen.