Introduction. Recently, the incidence of brain glial tumours has increased significantly worldwide. Gliomas are among the most malignant types of tumours of the central nervous system. Patients diagnosed with glial tumours have a very unfavourable prognosis leading to death, and the course of the disease itself has a negative impact on their physical, mental and social condition. Aim. The aim of this study was to determine the effect of the results of histological and genetic tests as well as the degree of resection of primary CNS tumours on the survival of patients undergoing neurosurgery and complementary oncological treatment — pharmacology and radiotherapy. Material and Methods. The research was carried out on the basis of an analysis of medical records (2019–2021) of 63 adult patients from the Department of Neurosurgery of the Specialist Municipal Hospital of Nicolaus Copernicus in Toruń. The study group included patients who had been diagnosed with a primary brain tumour and had undergone neurosurgery and complementary oncological treatment. The analysis of medical documentation consisted in comparing the results of histopathological tests with the results of specialized molecular tests and correlating them with the survival time of patients. The statistical analysis was carried out using the Pearson correlation, statistical inference was made at the significance level of p=0.05. Results. Based on the obtained results, it was found that the presence of MGMT gene promoter methylation (r=0.30, p=0.018) and IDH mutation (r=0.38, p=0.002) correlated positively with survival. The extent of resection also had a significant impact on patient survival (r=0.55, p<0.001). Patients who underwent complete tumour resection survived an average of 19.34 months, while those who underwent biopsy survived for 7.94 months. Conclusions. The data collected during the conducted analyses may be important for the prognosis perspective and the selection of the optimal treatment strategy for both current and future patients. (JNNN 2022;11(4):162–166)

Introduction. Adverse events (AE) in the process of pharmacotherapy can have direct consequences on the health and life of a patient. Factors leading to AE are categorized in human and systematic ones. Among the latter ones, the most important are significant shortages of nursing staff as well as stress, fatigue and the Occupational Burnout Syndrome. Reporting of AE is a crucial pillar of prevention of adverse events in drug administration in nursing.
 Aim. The aim of the study was to identify and analyse the factors leading to adverse events in the pharmocotherapy process and to present methods of prevention AE.
 Material and Methods. The research was lead among 100 hospital nurses from Pomeranian region. A research and research questionnaire was based on the study “Attitudes and beliefs of health services about the causes and reporting of treatment errors in the British intensive care unit”. The project was conducted between January to April 2020.
 Results. Detailed analysis showed that the most important factors influencing the occurrence of adverse events in the drug administration are: nurses shortage (14%), stress and burnout syndrome (11%), incorrect labelling (13%). 85% of medical personnel are convinced that it is essential to monitor the situation of adverse events in drug administration. The Kruskal–Wallis test did not confirm the existence of a relationship between the: occurrence of adverse events in the area of pharmacotherapy and age (K – W = 0; p = 1), level of education (K – W = 3.6328; p = 0.3039) and work experience of the surveyed respondents (K – W = 0.3651484; p = 0.5457). Similarly, no significant relationships were found between the occurrence of adverse events and the department profile (K – W = 0.330; p = 0.5652).
 Conclusions. The level of education, professional experience and age are not significantly related to making mistakes in the area of drug administration; the factors that significantly affect the occurrence of AD in the area of drug administration are: reduced nursing staff on duty, performing one’s duties under stress and time pressure, insufficient variety of labels on medicinal products; the best method of prevention in the area of drug management and administration is the presence of a reporting and monitoring system; the was the majority of nurses reported the occurrence of a drug-related adverse event to the rest of the therapeutic team. (JNNN 2022;11(2):65–73).

Genome-wide association studies (GWAS) of multiple myeloma in populations of European ancestry (EA) identified and confirmed 24 susceptibility loci. For other cancers (e.g., colorectum and melanoma), risk loci have also been associated with patient survival. We explored the possible association of all the known risk variants and their polygenic risk score (PRS) with multiple myeloma overall survival (OS) in multiple populations of EA [the International Multiple Myeloma rESEarch (IMMEnSE) consortium, the International Lymphoma Epidemiology consortium, CoMMpass, and the German GWAS] for a total of 3,748 multiple myeloma cases. Cox proportional hazards regression was used to assess the association between each risk SNP with OS under the allelic and codominant models of inheritance. All analyses were adjusted for age, sex, country of origin (for IMMEnSE) or principal components (for the others) and disease stage (ISS). SNP associations were meta-analyzed. SNP associations were meta-analyzed. From the meta-analysis, two multiple myeloma risk SNPs were associated with OS (P < 0.05), specifically POT1-AS1-rs2170352 [HR = 1.37; 95% confidence interval (CI) = 1.09-1.73; P = 0.007] and TNFRSF13B-rs4273077 (HR = 1.19; 95% CI = 1.01-1.41; P = 0.04). The association between the combined 24 SNP MM-PRS and OS, however, was not significant. Overall, our results did not support an association between the majority of multiple myeloma risk SNPs and OS. This is the first study to investigate the association between multiple myeloma PRS and OS in multiple myeloma.

Environment, Colonization, and the Baltic Crusader States. Terra Sacra I, and Ecologies of Crusading, Colonization, and Religious Conversion in the Medieval Baltic. Terra Sacra II. Edited by Aleksander Pluskowski. Turnhout: Brepols Publishers n.v., 2019. Author’s studies funded by the National Science Centre, Poland’s (NCN) PRELUDIUM grant no. 2016/23/N/HS3/00660.

Introduction. Growth depends on genetic, metabolic and also hormonal factors. Growth depends on health, the supply of nutrients and a properly functioning nervous system. Growth hormone deficiency is a disorder that does not cause typical somatic symptoms, but has a negative impact on a child’s life and functioning in society.Aim. The aim of the study was to evaluate the satisfaction of parents with the treatment with human recombinant growth hormone in children with somatropin-induced pituitary insufficiency.Material and Methods. The studies were conducted among parents of children with somatropin-induced pituitary insufficiency treated with human recombinant growth hormone in the Provincial Complex Hospital of Rydygier in Toruń at the Department of Paediatrics, Endocrinology, Diabetology and Paediatric Neurology, from 1.12.2019 to 1.02.2020. 69 parents of children treated with recombinant growth hormone were included in the study. The mean age of parents of children participating in the study was 11.77 ± 3.53 years. The research tools were: a record, self-questionnaires and the standardized KIDSCREEN-52 health questionnaire for children and adolescents in the version for parents.Results. The highest mean values of the standardized KIDSCREEN-52 scale in the version for parents were shown for the following areas: moods and emotions (84.55 ± 12.73), relationships with parents and home (81.83 ± 10.88) and social acceptance (89.86 ± 12.86). It was found that the higher the quality of the area of physical well-being and health, the lower the need for mental preparation of the child for hospital visits in connection with treatment — rS = 0.254, p = 0.035. The analyses showed that the higher the quality of the area of social support and colleagues, the smaller the difficulty resulting from the treatment-related visits to the hospital ward — rS = 0.266, p = 0.027, there was also a lower need to mentally prepare the child for hospital visits — rS = 0.261, p = 0.030.Conclusions. Satisfaction with treatment with recombinant growth hormone depends on the duration of treatment and the growth results achieved. Parents of children with hypopituitarism are satisfied with the treatment with recombinant growth hormone and assess the treatment positively. (JNNN 2021;10(3):120–125)

The main goal of the study was to assess the doctor’s communication with the patient. The detailed goals concerned the assessment of satisfaction with the way the physician communicates with the patient, the assessment of the communication methods used, the duration of the visit to a physician’s office, understanding of the information provided to patients, the physician’s personal culture, and the subjectivity of the patient. A questionnaire developed specifically for the study objectives was used. The analysis used data from 238 questionnaires completed correctly by cancer patients treated in a specialist hospital. The database was created in Excel and the analysis was performed using Statistica software. The analysis of the data shows that the physician’s communication with the patient is a very important aspect in the treatment process. Not all respondents were satisfied with the way the physician communicated information about the further treatment process, which increased the sense of security loss and undermined confidence in the physician’s decisions. Most patients understood the recommendations and advice provided by the physician, but there was a group of respondents who did not understand all the words used by the physician, which may lead to the non-compliance of the patient to the treatment recommendations. Patients highly appreciated the personal culture of physicians but they expected greater subjectivity in their treatment. The analysis of statements indicated that the patients’ expectations in the area of physician – patient communication are growing, which obliges physicians to broaden their knowledge in communication techniques.

The purpose of this paper is to characterise some aspects of housing policy applicable in the People’s Republic of Poland with particular consideration of new legal regulations concerning the housing market in the post-Stalinist period. Also, to present a more complete picture (of the situation), key aspects of the housing policy in the Stalinist period are presented/discussed. The article also presents the actual condition of the housing economy using the examples of selected towns. Sources included subject matter literature, legal acts, and archival documents linked with the social and economic history of selected towns/cities. In the beginnings of communist Poland, the decree of 7 September 1944 and of 21 December 1945 from strictly political and even ideological perspective as they constituted the frame for the actual control over the making over an important sphere of life such as housing management, of great significance in cities and towns. The political thaw of the mid-1950s created better prospects. The state was now able to finance the constructions sector on a much broader scale. The culminating point of the changes introduced by the postOctober team with respect to the legal foundations of the housing policy was the Act of 30 January 1959, the Tenant Law. The Landlord and Tenant Law repealed the following: Decree of 21 December 1945 on Public Flat Management, Decree of 28 July 1948 on Flat Rental and Decree of 18 February 1955 on Authorities and Their Jurisdictions with Respect to Public Flat Management.

Exposing the miracles of healings performed by Jesus Christ was a constant element of the interpretation of the Gospel of St. Luke in the Patristic period. The perspective of the Third Gospel shows the person of the Savior as a physician of souls and bodies, which allowed ancient Christian authors to weave threads and medical terminology. The article contains a synthesis of the most important issues considered by the Fathers of the Church about Luke 14:2–4. Dropsy was considered an incurable disease. In ancient times, the comparison between a vicious person and living a sinful life as suffering from dropsy was quite widespread. The ancient exegetes emphasized the symbolic and moral value of dropsy. The interpretation of the healing of the man with dropsy however appears with sober and sparse indications. Christian preachers used common beliefs to exhort conversion and show the way of life worthy of Christians. These are the common reflections present in the systematic commentaries and the occasional sermons in Greek and Latin Christian authors.

The role of immune dysregulation in the course and prognosis of COVID-19 is not clearly established. In particular, immune status in specific populations such as haematological patients, who have an impaired immunological system, has not been described so far. Here, we performed a comprehensive analysis of peripheral blood lymphocyte subsets in 27 SARS-CoV-2-infected patients, including 16 patients with haematological malignancies. We identified T cell subpopulations, B cells, NK cells and TCR α/ß and ɣ/ƍ-expressing T cells during COVID-19 infection, with significant changes observed in immune profiles during the course of disease, especially in haematological patients. We observed an increase in activated T lymphocytes (CD3+HLA-DR+ and CD3+CD8+HLA-DR+) in the early stages of SARS-CoV-2 infection with a concomitant decrease in the CD4/CD8 ratio in haematological patients compared to non-haematological patients affected by COVID-19. We also found a decrease in ɣ/ƍ T cells in both studied groups of patients, with lower numbers of CD25+ T cells and CD16+CD56+ NK cells in haematological patients compared to non-haematological patients with COVID-19. Our findings demonstrate, for the first time, impaired adaptive immunity in patients with haematological malignancies infected with COVID-19, resulting in impaired cellular immune responses to SARS-CoV-2. This warrants further investigation of this disease group in COVID-19 patient cohorts

The aim of the article is to analyse the pedeutological texts published in the era of the Partitions of Poland in the pages of the oldest Galician pedagogical periodical, which “Szkoła” was. The journal, edited by teachers and educational activists, addressed mainly to folk school teachers, published uninterruptedly for 70 years, is for today’s researchers an invaluable source of knowledge about the functioning of Galician education and its employees. The editors and collaborators of the journal often took up such important subjects as vocation, role models of folk teachers, relations with pupils’ family homes or difficult realities of teacher’s work. Teachers received a lot of specific advice concerning the upbringing and education of pupils, frequently from older and experienced colleagues. They could also learn a catalogue of traits and attitudes expected from folk teachers, concerning also their own families or taking up additional work.