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  • New
  • Research Article
  • 10.1021/acsmedchemlett.5c00611
The Development of UM-203, A Reversible Covalent STING Antagonist
  • Dec 4, 2025
  • ACS Medicinal Chemistry Letters
  • Leonard Barasa + 14 more

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Development and Evaluation of 1-Hydroxypyridin-2(1 <i>H</i> )-one Derivatives as Antibacterial Agents against Pathogenic <i>Pseudomonas aeruginosa</i>
  • Dec 2, 2025
  • ACS Medicinal Chemistry Letters
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Discovery of Novel Furan-type Phenylahistin Derivatives for Anticancer through P53-Mediated Mitochondrial Apoptosis and Microtubule Inhibition
  • Nov 28, 2025
  • ACS Medicinal Chemistry Letters
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  • 10.1021/acsmedchemlett.5c00569
Characterization of Novel Angiotensin-Converting Enzyme Inhibitory Peptides
  • Nov 26, 2025
  • ACS Medicinal Chemistry Letters
  • Camila Innocente-Alves + 6 more

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Synthesis and Evaluation of Novel Aza-Aromatics as Dual 5-HT2A and 5-HT2C Receptor Agonists
  • Nov 26, 2025
  • ACS Medicinal Chemistry Letters
  • Amit Singh Adhikari + 12 more

  • New
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  • 10.1021/acsmedchemlett.5c00462
Recent Developments in Cyclin-Dependent Kinase (CDK) PROTAC in Cancer Therapy
  • Nov 24, 2025
  • ACS Medicinal Chemistry Letters
  • Arijit Nandi + 3 more

  • New
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  • 10.1021/acsmedchemlett.5c00539
OpioidBias: A Machine Learning Tool for Predicting the Biased Agonism of Opioid Ligands
  • Nov 24, 2025
  • ACS Medicinal Chemistry Letters
  • Rajkumar R + 4 more

  • New
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  • 10.1021/acsmedchemlett.5c00593
Structure–Activity and Cationic Amphiphilic Drug-like Behavior of Aromatic Triamino Glycosylated Antitumor Ether Lipids with Cytotoxicity in 2D and 3D Models
  • Nov 24, 2025
  • ACS Medicinal Chemistry Letters
  • Rajat Arora + 5 more

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  • 10.1021/acsmedchemlett.5c00682
Novel Substituted 1,1′-Biphenyl Compounds as Glucagon Receptor Agonists for Treating Type 2 Diabetes Mellitus and Obesity
  • Nov 24, 2025
  • ACS Medicinal Chemistry Letters
  • Ram W Sabnis

  • New
  • Research Article
  • 10.1021/acsmedchemlett.5c00601
Design, Synthesis, and Biological Evaluation of C2-(N-Substituted Amino) Truncated 4′-Thioadenosine Derivatives as A <sub>2A</sub> AR and A <sub>3</sub> AR Dual Ligands
  • Nov 14, 2025
  • ACS Medicinal Chemistry Letters
  • Misuk Joung + 9 more