Clinical & Experimental AllergyVolume 43, Issue 11 p. 1299-1299 Forthcoming Meetings Forthcoming meetings First published: 24 October 2013 https://doi.org/10.1111/cea.12198Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume43, Issue11November 2013Pages 1299-1299 RelatedInformation

Clinical & Experimental AllergyVolume 43, Issue 8 p. 975-975 Forthcoming Meetings Forthcoming Meetings First published: 29 July 2013 https://doi.org/10.1111/cea.12150Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume43, Issue8August 2013Pages 975-975 RelatedInformation

Clinical & Experimental AllergyVolume 43, Issue 5 p. 578-578 Miscellaneous Forthcoming Meetings First published: 22 April 2013 https://doi.org/10.1111/cea.12105Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume43, Issue5May 2013Pages 578-578 RelatedInformation

Clinical & Experimental AllergyVolume 43, Issue 4 p. 379-379 Editor's ChoiceFree Access The Editor takes a closer look at some of this month's articles First published: 21 March 2013 https://doi.org/10.1111/cea.12103AboutSectionsPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Angioedema: does progesterone work? Angioedema is a distressing and unpleasant condition. Bradykinin-mediated angioedema, including the common ACE inhibitor induced and the rare hereditary (HAE) forms, is potentially life-threatening and difficult to treat. The spectrum of angioedema, particularly the bradykinin associated forms, is reviewed in this issue by Busse and Buckland (pp. 385–394) and new developments in treatment are reviewed by Xu et al. (pp. 395–405). In addition, we report a study by Saule et al. (pp. 475–482), accompanied by a commentary by Hilary Longhurst (pp. 380–382), which describes the potential benefit of progesterone in women with mainly HAE. This group identified over 50 women who had been given progesterone treatment and found a convincing improvement in the frequency and severity of attacks after being started on this hormonal therapy. Time for a double-blind placebo-controlled trial. Anne Gompel Bradykinin binds to the B2 receptor [see Figure 2 in Y.-Y. Xu et al. (pp.395–405)] Probiotics: immunology backs up the clinical findings Building on a previous clinical trial of probiotics in eczema which had shown a reduced risk of eczema at two years 1, Forsberg et al. (pp. 434–442) have now investigated whether there is an immunological explanation. They measured cytokine responses in mononuclear cells after allergen stimulation up to two years of age. They found a general reduction in the generation of both Th1 and Th2 cytokines in the subjects treated with Lactobacillus reuteri suggesting an overall lowering of allergen responsiveness by the probiotic treatment that could explain the reduction in eczema. Anna Forsberg Cat-allergen-induced IL-5 [see Figure 1 in A. Forsberg et al. (pp. 434–442)] Asthma and the environment: intruder in the dust Bacteria as well as eukaryotic cells generate extracellular vesicles (EV) which are thought to facilitate intercellular communication 2. In a thorough and original study involving both mice and humans, Kim et al. (pp. 443–454) have investigated whether such vesicles in house dust can promote an inflammatory response in the lung. They found that repeated administration of purified EV to the airway of mice resulted in a Th1-Th17-mediated neutrophilic inflammatory response. They went on to demonstrate that IgG antibodies against EV were higher in asthmatics compared with control subjects and speculate that bacteria-derived EV could be responsible in part for neutrophilic airway inflammation in asthma. You-Sun Kim Confocal microscopic images of MH-S cells [see Figure 5 in Y.-S. Kim et al. (pp. 443–454)] References 1Abrahamsson TR, Jakobsson T, Bottcher MF et al. Probiotics in prevention of IgE-associated eczema: a double-blind, randomized, placebo-controlled trial. J Allergy Clin Immunol 2007; 119: 1174– 80. CrossrefCASPubMedWeb of Science®Google Scholar 2van der Pol E, Boing AN, Harrison P, Sturk A, Nieuwland R. Classification, functions, and clinical relevance of extracellular vesicles. Pharmacol Rev 2012; 64: 676– 705. CrossrefCASPubMedWeb of Science®Google Scholar Caption to cover illustration C1-inhibitor (C1-INH) inhibits the activation of Factor 12 (FXII), Pre-Kallikrein to Kallikrein, plasminogen to plasmin, the first component of complement (C) from activating C4 and the production of bradykinin from high-molecular weight kininogen (HMWK). C1-INH also affects factor XI, but to a minimal extent. [see figure 2 in Y.-Y. Xu et al. (pp. 396–406)]. This logo highlights the Editor's Choice articles on the cover and the first page of each of the articles. Volume43, Issue4April 2013Pages 379-379 ReferencesRelatedInformation

Clinical & Experimental AllergyVolume 43, Issue 1 p. 1-1 Editor's ChoiceFree Access The Editor takes a closer look at some of this month's articles First published: 24 December 2012 https://doi.org/10.1111/cea.12061 This logo highlights the Editor's Choice articles on the cover and the first page of each of the articles. AboutSectionsPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Obesity and asthma: does weight loss help? Hayley Scott Bathroom scales, courtesy of Elinor D, Wikimedia Commons In this issue, two original papers, an excellent review by Dr Boulet (pp. 8-21) and an insightful editorial by Chapman and Salome (pp. 2-4), address various aspects of the link between obesity and asthma. The association between obesity and asthma is well established, but whether this is due to obesity causing symptoms through deconditioning and dysfunctional breathing or is due to a more direct and causal effect is not clear 1-9. The extent to which weight loss helps disease control is also not clear. Scott and colleagues (pp. 36-49) have shed light on this issue in a study in which dietary and exercise interventions were correlated with changes in airway inflammation. They demonstrated that a modest degree of weight loss over ten weeks in overweight and obese adults with asthma improved measures of both asthma quality of life and symptoms as well as the numbers of neutrophils and eosinophils in sputum. Further encouragement to focus on this aspect of management in our asthma clinics. Obesity and asthma: what can epidemiology tell us? Ed Mitchell Prevalence of overweight and obesity (combined) in children 13–14-year-old children in ISAAC centres. The obesity–asthma link is present in children as well as adults. Mitchell and colleagues (pp. 73-84) have taken advantage of the ISAAC database to further confirm this association as well as determine if it extends to other manifestations of allergic disease. Their study of over 76 000 children aged 6–7 years and over 200 000 adolescents, as well as showing a worrying global rate of obesity in children, confirmed the link between increased BMI and asthma and demonstrated that this extended to eczema, but not rhinitis. Excess television viewing (> 5 h) was also associated with asthma in both adults and children. Although this points to the importance of exercise in children, the authors also noted a link between allergic disease and vigorous exercise in adolescents but not the 6–7-year olds. This was also seen for eczema and rhinitis so this observation cannot be simply explained by exercise provoking exercise induced asthma. A case of epidemiology begging as many questions as it answers. Peach allergy: a new kid on the block Lisa Tuppo Peamaclein (Pru p 7) – A new risky, self-hiding, very stable peach allergenImage by Adriano Mari Severe food allergic reactions to peach are a common problem, particularly in Mediterranean. Pru p 3, a lipid transfer protein found mainly in the skin of the peach, is thought to be the major allergen involved. Tuppo and colleagues (pp. 128-140) explored the possibility that there are other important anaphylaxis causing allergens in peach, prompted by observations that some patients with allergic reactions to this fruit were negative to Pru p 3 in the ISAC 103 microarray. After much work, they have identified a new peach allergen which they have called Peamaclein which appears to be a member of a new family of proteins related to a potato antimicrobial peptide. The clinical importance of this allergen now needs to be fully characterized. References 1Agondi RC, Bisaccioni C, Aun MV, Ribeiro MR, Kalil J, Giavina-Bianchi P. Spirometric values in elderly asthmatic patients are not influenced by obesity. Clin Exp Allergy 2012; 42: 1183– 9. Wiley Online LibraryCASPubMedWeb of Science®Google Scholar 2Bergstrom A, Melen E. On childhood asthma, obesity and inflammation. Clin Exp Allergy 2012; 42: 5– 7. Wiley Online LibraryCASPubMedWeb of Science®Google Scholar 3Fenger RV, Gonzalez-Quintela A, Vidal C et al. Exploring the obesity-asthma link: do all types of adiposity increase the risk of asthma? Clin Exp Allergy 2012; 42: 1237– 45. Wiley Online LibraryCASPubMedWeb of Science®Google Scholar 4Fitzpatrick S, Joks R, Silverberg JI. Obesity is associated with increased asthma severity and exacerbations, and increased serum immunoglobulin E in inner-city adults. Clin Exp Allergy 2012; 42: 747– 59. Wiley Online LibraryCASPubMedWeb of Science®Google Scholar 5Fukutomi Y, Taniguchi M, Tsuburai T et al. Obesity and aspirin intolerance are risk factors for difficult-to-treat asthma in Japanese non-atopic women. Clin Exp Allergy 2012; 42: 738– 46. Wiley Online LibraryCASPubMedWeb of Science®Google Scholar 6Holguin F. Obesity as a risk factor for increased asthma severity and allergic inflammation; cause or effect? Clin Exp Allergy 2012; 42: 612– 3. Wiley Online LibraryCASPubMedWeb of Science®Google Scholar 7Murray CS, Canoy D, Buchan I, Woodcock A, Simpson A, Custovic A. Body mass index in young children and allergic disease: gender differences in a longitudinal study. Clin Exp Allergy 2011; 41: 78– 85. Wiley Online LibraryCASPubMedWeb of Science®Google Scholar 8Salome CM, Marks GB. Sex, asthma and obesity: an intimate relationship? Clin Exp Allergy 2011; 41: 6– 8. Wiley Online LibraryCASPubMedWeb of Science®Google Scholar 9Wang TN, Lin MC, Wu CC et al. Role of gender disparity of circulating high-sensitivity C-reactive protein concentrations and obesity on asthma in Taiwan. Clin Exp Allergy 2011; 41: 72– 7. Wiley Online LibraryCASPubMedWeb of Science®Google Scholar Caption to cover illustration Prevalence of overweight and obesity (combined) in children 6–7-year-old children in the International Study of Asthma and Allergies in Childhood (ISAAC) centres. The symbols indicate prevalence values of < 10% (blue square), 10 to < 20% (green circle), 20 to < 30% (yellow diamond) and ≥ 30% (red star) [see figure 1 in E. A. Mitchell et al. (pp. 73–84)]. Volume43, Issue1January 2013Pages 1-1 ReferencesRelatedInformation