AbstractTo develop environmentally friendly acetylene hydrochlorination catalysts with high efficiency to replace HgCl2, copper-based catalysts were prepared by the impregnation method. The catalyst with the best performance was finally obtained by adding organic additives NHP. The acetylene conversion rate of the catalyst reached 89%, and the test conditions were T = 150 °C, GHSV(C2H2) = 90 h−1, VHCl/VC2H2 = 1:1.08. The characterization results of XRD, TEM, and ICP showed that NHP improved the dispersion of Cu and reduced the loss of Cu. In addition, from the results of TPR and XPS, the NHP inhibited the reduction of Cuα+ to Cu0, thereby preserving the long-term stability of the catalyst. The BET and TGA results show that the addition of organic additives greatly suppressed the formation of carbon deposits during the catalyst reaction process. Overall, this research provided a series of high-performance Cu-based catalysts obtained by the addition of organic additives NHP. Graphical Abstract