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Addiction in Adolescents from Past to Present: A Bibliometric Analysis

ABSTRACT This research aimed to examine the basic and conceptual structure of the research area about addiction in adolescents by examining studies in an international index (Web of Science (WoS) database: SCI-Expanded, SSCI, AHCI, ESCI) through bibliometric analysis. Research on addiction in adolescents has been examined using bibliometric analysis and mapping techniques. Accordingly, a total of 5558 studies from the WoS database were analyzed in line with the criteria for inclusion. Although there were partial decreases in some years for adolescent studies about addiction, the general progression was increasing. Regarding resource categories, first were addictive behaviors, followed by drug and alcohol dependence. Although smoking is related to substance use, it differs from other types of addiction. In addition, Internet addiction, one of the behavioral addictions, are among the strong research themes. University of Pittsburgh produced most institution-based publications, and the USA was the country with most publications and most cited publications in the world. Research about adolescent addiction focuses mostly on substance abuse/use and psychiatry disciplines. Since publications in the research area are not within the limits of Lotka’s law, authors in this research area need more publication productivity for two or more publications.

Role of MicroRNAs in Alcohol-Related Liver Disease

ABSTRACT Alcohol-related liver disease (ARLD) is the most prevalent type of chronic liver disease and one of the most serious health problems worldwide. Individuals consuming more than 40 g of alcohol per day can develop alcoholic fatty liver (AFL). Progression of AFL to alcoholic steatohepatitis leading to ARLD. The risk factors such as oxidative stress, inflammatory response, and genetic and epigenetic factors might explain considerable variation in ARLD pathogenesis. Diagnosis of patients with ARLD involved assessing alcohol use disorder and signs of advanced liver disease. Increasing number of patients with advanced stages of ARLD is observed due to failure in early detection and treatment. Alcohol abstinence, nutritional therapy and corticosteroids are the best treatment for all stages of ARLD. Therapies targeting IL-22/STAT3, TNF receptor superfamily, antioxidant signal, LPS, inflammasomes, hormones and microRNAs are used in treatment of ARLD as translational research. MicroRNAs are non-coding RNAs mainly involved in underlying mechanisms of development and pathogenesis of ARLD. The current review summarizes the role of aberrant regulation of microRNAs involved during oxidative stress, epigenetic modulations and inflammatory response in ARLD and also focused on the underlying mechanism of microRNAs in different stages of liver diseases such as liver fibrosis, liver cirrhosis and hepatocellular carcinoma.