Acta PaediatricaVolume 112, Issue 7 p. 1364-1365 ISSUE HIGHLIGHTS Issue highlights Anna Käll, Corresponding Author Anna Käll [email protected] Acta Paediatrica, Solna, Sweden Correspondence Anna Käll, Acta Paediatrica, Solna, Sweden. Email: [email protected]Search for more papers by this authorHugo Lagercrantz, Hugo Lagercrantz orcid.org/0000-0002-5079-3008 Acta Paediatrica, Solna, SwedenSearch for more papers by this author Anna Käll, Corresponding Author Anna Käll [email protected] Acta Paediatrica, Solna, Sweden Correspondence Anna Käll, Acta Paediatrica, Solna, Sweden. Email: [email protected]Search for more papers by this authorHugo Lagercrantz, Hugo Lagercrantz orcid.org/0000-0002-5079-3008 Acta Paediatrica, Solna, SwedenSearch for more papers by this author First published: 05 June 2023 https://doi.org/10.1111/apa.16849Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL No abstract is available for this article. REFERENCES 1Strömberg Celind F, Goksör E, Carlén E, Schilling B, Alm B, Wennergren G. Infants were introduced to complementary feeding earlier in 2018 compared with 2003. Acta Paediatr. 2023; 112(7): 1485- 1492. 2Guernsey D, Kostin S, Silver M, Vazquez H, Zerzan J. The evolving relationship between COVID-19 and serious bacterial infection evaluation in febrile neonates. Acta Paediatr. 2023; 112(7): 1398- 1403. 3Ohlin A. The febrile infant: is it COVID-19 or a serious bacterial infection? Acta Paediatr. 2023; 112(7): 1366- 1367. 4Kuitunen I. Why do we fear bottles and pacifiers? Acta Paediatr. 2023; 112(7): 1392- 1394. 5Vidović Roguljić A, Matas J, Zakarija-Grković I. Croatian mothers were 11 times more likely to give their newborn infants formula in hospital if they had used it for their older children. Acta Paediatr. 2023; 112(7): 1493- 1503. 6Cabanillas-Barea S, Jiménez-del-Barrio S, Carrasco-Uribarren A, Ortega-Martínez A, Pérez-Guillén S, Ceballos-Laita L. Systematic review and meta-analysis showed that complementary and alternative medicines were not effective for infantile colic. Acta Paediatr. 2023; 112(7): 1378- 1388. 7Byard RW, Tan L. The San Diego SIDS definition—20 years on. Acta Paediatr. 2023; 112(7): 1389- 1391. Volume112, Issue7July 2023Pages 1364-1365 ReferencesRelatedInformation

Acta PaediatricaAccepted Articles PERSPECTIVE Rescuing the newborn brain Hugo Lagercrantz, Corresponding Author Hugo Lagercrantz [email protected] orcid.org/0000-0002-5079-3008 Acta Paediatrica, Solna, Sweden Correspondence Email: [email protected]Search for more papers by this author Hugo Lagercrantz, Corresponding Author Hugo Lagercrantz [email protected] orcid.org/0000-0002-5079-3008 Acta Paediatrica, Solna, Sweden Correspondence Email: [email protected]Search for more papers by this author First published: 12 May 2023 https://doi.org/10.1111/apa.16839 This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi:10.1111/apa.16839. AboutPDF ToolsExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Accepted ArticlesAccepted, unedited articles published online and citable. The final edited and typeset version of record will appear in the future. RelatedInformation

Acta PaediatricaVolume 112, Issue 6 p. 1131-1135 ISSUE INFORMATIONFree Access Issue Information First published: 08 May 2023 https://doi.org/10.1111/apa.16390AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Volume112, Issue6June 2023Pages 1131-1135 RelatedInformation

Acta PaediatricaVolume 112, Issue 6 p. 1136-1137 ISSUE HIGHLIGHTS Issue highlights Anna Käll, Corresponding Author Anna Käll [email protected] Acta Paediatrica, Solna, Sweden Correspondence Anna Käll, Acta Paediatrica, Solna, Sweden. Email: [email protected]Search for more papers by this authorHugo Lagercrantz, Hugo Lagercrantz orcid.org/0000-0002-5079-3008 Acta Paediatrica, Solna, SwedenSearch for more papers by this author Anna Käll, Corresponding Author Anna Käll [email protected] Acta Paediatrica, Solna, Sweden Correspondence Anna Käll, Acta Paediatrica, Solna, Sweden. Email: [email protected]Search for more papers by this authorHugo Lagercrantz, Hugo Lagercrantz orcid.org/0000-0002-5079-3008 Acta Paediatrica, Solna, SwedenSearch for more papers by this author First published: 08 May 2023 https://doi.org/10.1111/apa.16793Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL No abstract is available for this article. Volume112, Issue6June 2023Pages 1136-1137 RelatedInformation

Each year since 2006, the Foundation Acta Paediatrica and the Swedish Paediatric Society have awarded the title of Young Investigator to one or more promising young Swedish researchers, who have been the lead author of a paper published in the Journal during that period. We are delighted to announce that the winners of the 2022 Swedish Young Investigator Award are Daniela Nosko and Carin Skogastierna. Both papers deal with studies of children born preterm. Daniela Nosko was the joint author of Discrete white matter abnormalities at age 8–11 years in children born extremely preterm are not associated with adverse cognitive or motor outcomes1 with Marika Strindberg. The research team investigated the prevalence of discrete white matter abnormalities (WMA) by using magnetic resonance imaging (MRI). Signs of discrete WMA were common at 8–12 years of age, especially in those with neonatal white matter injuries. But they were not related to cognitive or neuromotor outcomes at 12 years of age. This information is useful in clinical settings, where children who were born preterm may undergo MRIs for other clinical conditions. Carin Skogastierna receives the award for her paper Impaired renal clearance among Swedish adolescents born preterm.2 Skogastierna and her co-authors aimed to determine whether adolescents born before 28 weeks of gestation had an increased risk of renal impairment. Most of the participants were found to have normal blood pressure. However, 25% had low clearance, which indicated reduced kidney function. They authors concluded that all children born before 28 weeks should be assessed during adolescence.

Hans Asperger is best known for Asperger syndrome, but has been accused of knowingly referring patients to a Viennese children's home notorious for murdering disabled children during the Nazi occupation. Two of the 13 children he referred there died. Tatzer et al.1 assessed original documents and found no evidence that Asperger was aware of the ‘euthanasia’ programme when he referred them. Czech strongly criticises the paper and says Asperger must have known about the ‘euthanasia’ programme early on, because he worked with the doctor responsible for the murders.2 Gillberg shares his thoughts on Asperger and meeting his daughter.3 A review by de Boer et al.4 looks at parents' perspectives about making prenatal decisions regarding treatment for babies born at the limit of viability. It is accompanied by a perspective, where the parents of an infant born at 24 weeks of gestation share their experiences5 after an unexpected pregnancy was discovered at 18 weeks. They faced the risk of an extremely premature birth at 22 weeks and agreed with the physicians to initiate intensive care treatment if their infant was born in the grey zone. Poor sleep has been associated with poor physical and mental health, including increased risks of heart disease and type 2 diabetes and higher levels of symptoms of depression and anxiety. Balfour et al.6 looked at the parent-reported sleep trajectories of 1192 young Australians from 5 to 17 years of age and the subject's self-reported sleep problems. They found no relationships between these sleep-related reports and measures of epigenetic age acceleration at 17 years of age, after adjusting for depressive symptoms. Størksen et al.7 reviewed the literature on Internet-based interventions that aim to support the parents of young children aged 0–5 years. They found that more interventions focused on mental health than somatic health, with developmental disorders and obesity being the most frequently studied conditions in those respective categories. Several gaps were identified, such as the need for more research outside English-speaking countries. The authors suggest that program developers should consider using more audio-visual technology to avoid reinforcing social inequalities in access to healthcare. Holter comments on the findings.8 Researchers in many medical fields are increasingly reporting outcomes that are important to patients who have shared their lived experiences with their illnesses. Thivierge et al.9 explored the pulmonary outcomes that were important to parents after extremely preterm birth and created a list that could be considered by future respiratory outcome studies. These reflected outcomes during the infants' neonatal intensive care hospitalisation and after discharge. The 285 parents described numerous important pulmonary events, but the authors were interested to note that bronchopulmonary dysplasia was not on the list, despite being the main respiratory outcome investigated in neonatology. Figure 1: Alamy, Figure 2-5: Istockphoto

Acta PaediatricaVolume 112, Issue 5 p. 887-891 ISSUE INFORMATIONFree Access Issue Information First published: 08 April 2023 https://doi.org/10.1111/apa.16389AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Volume112, Issue5May 2023Pages 887-891 RelatedInformation

Acute Epstein-Barr virus (aEBV) and cytomegalovirus (CMV) infections frequently have similar manifestations. We aim to evaluate the characteristics of aEBV infection, risk factors for hospitalisation and differences according to CMV IgM detection (EBV-CMV co-detection) in children. Retrospective, single-centre study including patients <16 years diagnosed with aEBV infection (positive anti-EBV IgM/Paul-Bunnell test and acute symptomatology). EBV-CMV co-detection was defined as positive CMV IgM. Factors associated with age, hospitalisation and EBV-CMV co-detection were analysed in a multivariate analysis. A total of 149 patients were included (median age 4.6 years). Most frequent manifestations were fever (77%), cervical lymphadenopathy (64%) and elevated liver enzymes (54%). Younger children had lower rate of positive Paul-Bunnell test (35% vs. 87%; p < 0.01), but higher rate of EBV-CMV co-detection (54% vs. 29%; p = 0.03). These children tended to have less typical symptoms of infectious mononucleosis and higher hospitalisation rate. The overall antibiotic prescription was 49%. Hospitalisation (27 children; 18%) was independently associated with prior antibiotic therapy and anaemia. Sixty-two cases (42%) had EBV-CMV co-detection, which was independently associated with elevated liver enzymes and younger age. In this study, younger children with aEBV infection presented more frequently with atypical clinical symptoms, had higher EBV-CMV co-detection rates and were more often hospitalised. Hospitalisation was associated with prior antibiotic prescription.

The present study aimed to develop age- and sex-specific anthropometric reference growth curves for the Pakistani children, aged 1-60 months. The weight and height of 60 595 children including 30 885 (50.96%) boys and 29 710 (49.04%) girls from Pakistan were collected through a cross-sectional study. Growth reference charts about weight-for-age, length/height-for-age, and body BMI-for-age were constructed for boys and girls using the generalised additive model for location, scale and shape (GAMLSS) with the Box-Cox power exponential distribution. The 3rd, 5th, 15th, 25th, 50th, 75th, 85th, 95th and 97th smoothed percentile values with L, M and S for weight, length/height, and BMI for boys and girls from aged 1 to 60 months are presented. The median percentile for all indicators increases as the age increases in both sexes. The median percentiles of the Pakistani children are lower than the WHO 2006 standards for both sexes. This study provides the first references for the Pakistani children from 1 to 60 months. The reference values could be taken as a starting point for examining the secular change in the Pakistani population.

The aim of the study was to describe amplitude integrated electroencephalography (aEEG) cyclicity, background pattern, voltage margins and maturation scores in extremely low gestational age neonates (ELGANs) in the first 72 h. Fifty infants with gestational age (GA) 23+0-27+6 weeks were prospectively studied. Infants with intraventricular haemorrhage ≦ Grade I and no disorders of transition (persistent pulmonary hypertension, hypotension, pulmonary haemorrhage) belonged to the 'Uncomplicated' group and those with intraventricular haemorrhage > Grade I and/or disorders of transition, to the 'Complicated' group. Thirty-six infants without opioid exposure were included: 23 with GA 25.9 (23.1-27.7) weeks in the 'Uncomplicated' group and 13 with GA 24.6 (23.3-27.4) weeks in the 'Complicated' group. Cyclicity was more common in the 'Uncomplicated' group [20/23 (87%) vs. 7/13 (54%), p = 0.045] with more cycles/hour [0.2 (0-0.78) vs. 0.03 (0-67), p = 0.036]. Age at appearance of cyclicity was similar [20 (7.7-40.7) hours in 'Uncomplicated' vs. 23.7 (5.4-60) hours in 'Complicated' group, p = 0.8]. In the 'Uncomplicated' group, maturation scores (p = 0.02), high (p < 0.0001) and low (p = 0.03) base voltage increased over time. During the first 72 h, clinically stable ELGANs without neurological injury demonstrate increased cyclicity compared to those with a complicated course. Maturation score, high and low base voltage increase over time.