Lozenges are solid, flavored medicated dosage forms designed for slow dissolution in the oral cavity, offering both localized and systemic drug delivery. They provide a convenient alternative to conventional tablets and syrups, enhancing patient compliance, especially in pediatric and geriatric populations. This study focuses on the formulation and evaluation of medicated lozenges using different pharmaceutical excipients to optimize drug release, stability, and organoleptic properties. Lozenges were formulated using various base materials such as sucrose, sorbitol, and hydrocolloids, along with active pharmaceutical ingredients (APIs) targeting conditions like sore throat, cough, or fungal infections. The formulations were developed using the molding, compression, and heating methods to achieve desired characteristics. Excipients such as sweeteners, flavors, and binders were incorporated to enhance palatability and stability.The prepared lozenges were subjected to extensive evaluation, including hardness, friability, weight variation, drug content uniformity, dissolution profile, and stability studies. Results indicated that the optimized formulation exhibited adequate mechanical strength, uniform drug distribution, and a controlled release profile, making it suitable for therapeutic applications. The study concludes that lozenges provide an effective and patient-friendly drug delivery system, particularly beneficial for treating localized oral and throat infections. Further research can explore advanced formulation techniques and novel excipients to enhance the efficacy and patient acceptability of medicated lozenges.
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